Clinical trials: Knee
Medial Gonarthrosis
Validating the Clinical Effect of a Knee Orthosis
The aging population is steadily increasing, partly due to increasing life expectancy. At the same time, chronic diseases, including those affecting the musculoskeletal system (e.g., osteoarthritis), whose prevalence increases…
- Trial name
- NCT06655558
- Testing
- custom knee orthosis
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- TOPMED
Injuries, Knee
Controlled Trial to Compare Single Versus Two Portal Knee Arthroscopy Techniques
This randomized, controlled clinical trial will compare the outcomes of single portal versus two portal techniques in patients who have meniscus or articular cartilage pathology.
- Trial name
- NCT02648971
- Testing
- Single Portal Knee Arthroscopy, Two Portal Knee Arthroscopy
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Wake Forest University Health Sciences
Arthroplasty, Replacement, Knee
Comparing Post-Op Narcotic Usage in Patients Receiving Periarticular Exparel vs. Standard Periarticular Joint Inj
This study seeks to determine whether a new sustained-release local anesthetic solution (Exparel - Liposomal Bupivacaine) injected into the soft tissues around the joint after surgery will decrease opioid consumption and adverse…
- Trial name
- NCT02682498
- Testing
- (Bupivacaine Liposome Injectable Suspension), Standard Preparation
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- University of California, Irvine
Venous Thromboembolism, Arthroplasty, Replacement
Pradaxa (Dabigatran Etexilate) VTE Prevention After Elective Total Hip or Knee Replacement Surgery
an open, prospective, observational study to collect data on safety (major bleeding events) and efficacy (symptomatic venous thromboembolism(VTE)) of a switch from Enoxaparin to dabigatran etexilate in patients with total knee…
- Trial name
- NCT01153698
- Testing
- dabigatran
- Where
- 7 sites in Austria
- Volunteers
- 167 people
- Sponsor
- Boehringer Ingelheim
Patellar Instability, Patellar Dislocation
Torsion of the Tibial Tuberosity, a New Factor of Patellar Instability?
Patellar instability (recurrent patellar dislocation) can occur at any age. It is most often seen in young subjects, especially among adolescents. It is commonly accompanied by anatomical factors.
- Trial name
- NCT03304119
- Where
- France
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Osteoarthritis
The Cherokee Study: Cherokee Health for Elderly Residents With Osteoarthritis of the Knee
This study aims to develop and demonstrate the effectiveness of a systematic, practical, cost-effective diet-induced weight loss and exercise intervention in Cherokee, North Caroling that will recruit American Indian…
- Trial name
- Cherokee (NCT04946344)
- Testing
- Diet & Exercise, Attention Control
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- Wake Forest University
Post-Operative Pain Following Total Knee Arthroplasty
Pilot Study of PEMF Therapy in Treatment of Post-operative Pain Following Total Knee Arthroplasty
The purpose of this study is to investigate whether pulsed electromagnetic energy field (PEMF) therapy is effective in the treatment of persistent pain following total knee arthroplasty (TKA)
- Trial name
- NCT02211534
- Testing
- Pulsed Electromagnetic Field Device (Provant)
- Where
- 14 sites in United States
- Volunteers
- 35 people
- Sponsor
- Regenesis Biomedical, Inc.
Knee Injury
Evaluation of the CR Plug for Repair of Defects Created at the Harvest Site From an Autograft in the Knee.
The main objective of this study is to test the ability of an allograft plug to provide a successful repair of an osteochondral defect left at the harvest site during OATS procedure.
- Trial name
- CRB (NCT00821873)
- Testing
- CR Plug
- Where
- 4 sites in United States
- Volunteers
- 9 people
- Sponsor
- RTI Surgical
Osteoarthritis of the Knee
Efficacy and Safety Study Evaluating ADL5859 and ADL5747 in Participants With Pain Due to Osteoarthritis of the Knee
The purpose of this study is to determine the efficacy of ADL5859 versus placebo and ADL5747 versus placebo in relieving pain in participants with osteoarthritis of the knee.
- Trial name
- NCT00979953
- Testing
- ADL5859, ADL5747, Oxycodone CR
- Where
- 11 sites in United States
- Volunteers
- 408 people
- Sponsor
- Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Osteoarthritis, Knee
Efficacy of Cooled and Monopolar Radiofrequency Ablation of the Geniculate Nerves for the Treatment of Chronic Osteoarthritic Knee Pain
This is a single center randomized controlled trial. Approximately 102 patients will be randomized to one of two treatment groups: cooled radiofrequency or conventional monopolar radiofrequency ablation.
- Trial name
- NCT02260869
- Testing
- Genicular nerve radiofrequency ablation, Pain Management Radiofrequency Kit
- Where
- 3 sites in United States
- Volunteers
- 79 people
- Sponsor
- Millennium Pain Center
Lower Limb Amputation Below Knee (Injury), Lower Limb Amputation Above Knee (Injury)
Feasibility Study to Evaluate a New Energy Storage and Return Prosthetic Foot
A prospective, interventional, multicenter pilot study to characterize differences in performance and patient reported outcomes between the Taleo, Proflex XC, and the new Revo prosthetic foot.
- Conditions
- Lower Limb Amputation Below Knee (Injury), Lower Limb Amputation Above Knee (Injury), Lower Limb Amputation Knee
- Trial name
- NCT04239222
- Testing
- Revo-M, Taleo, Proflex XC
- Where
- 4 sites in United States
- Volunteers
- 27 people
- Sponsor
- Otto Bock Healthcare Products GmbH
Lower Extremity Amputation
Pivot-Flex Foot: Optimal Coupling Ratio Between Transverse and Sagittal-plane Motions Using a Torsionally Adaptive Prosthesis for Individuals With Lower Limb Amputation
When prescribing a prosthetic foot, clinicians face a dizzying array of choices as more than 200 different prosthetic feet are available.
- Trial name
- NCT03532100
- Testing
- Torsionally adaptive prosthesis with 0:1 coupling ratio, Torsionally adaptive prosthesis with 1:6 coupling ratio, Torsionally adaptive prosthesis with 1:4 coupling ratio
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- VA Office of Research and Development
Total Knee Arthroplasty
Comparison of Intraoperative Warming Devices
The sublingual (under the tongue) core temperature within 10 minutes of arrival in the post anesthesia care unit (PACU) for patients warmed with the Dynatherm vitalHeat2 (VH2) System under general anesthesia for total knee…
- Trial name
- NCT00711867
- Testing
- VH2, Bair Hugger
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Mayo Clinic
Osteoarthritis, Knee
An Open-Label Long-term Safety Study of Tramadol HCl OAD (Once A Day) 300 mg in the Treatment of Pain Due to Osteoarthritis of the Knee
The purpose of this study is to collect information regarding the long-term (6 and 12 months) safety of Tramadol HCl Once-A-Day(OAD) 300 mg.
- Trial name
- NCT00833911
- Testing
- Tramadol Once A Day
- Volunteers
- 392 people
- Sponsor
- Labopharm Inc.
Osteoarthritis of the Knee
A Study to Evaluate the Safety and Efficacy of Topically Applied TV-45070 (Ointment) in Participants With Primary Osteoarthritis (OA) Affecting a Single Knee
The primary purpose of the study is to evaluate the change from baseline after 4 weeks of topical administration of TV-45070 (4% and 8% ointment) compared with placebo for the relief of symptoms of primary OA affecting a single…
- Trial name
- NCT02068599
- Testing
- TV-45070
- Where
- 42 sites in United States
- Volunteers
- 389 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Critical Limb Ischemia (CLI)
LIFE-BTK Randomized Controlled Trial
The objective of this prospective, single-blinded, randomized controlled clinical investigation is to evaluate the safety and efficacy of the everolimus eluting Esprit BTK System for the planned treatment of narrowed…
- Trial name
- LIFE-BTK (NCT04227899)
- Testing
- Esprit BTK Device, Percutaneous Transluminal Angioplasty (PTA) Device
- Where
- 50 sites in United States, Australia and 4 more
- Volunteers
- 261 people
- Sponsor
- Abbott Medical Devices
Total Knee Replacement, Primary Knee Arthroplasty
Postoperative Knee Strength Following Total Knee Replacement: A Double-Blinded Randomized Comparison Study
Major surgery involving the knee is often associated with severe postoperative pain. Postoperative pain control remains a significant contributor to delayed recovery and length of hospital stay.
- Trial name
- NCT01620047
- Testing
- Fentanyl, Ropivacaine
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of South Florida
Osteoarthritis of the Knee
A Multiple Injection Study Evaluating Safety and Efficacy of Ampion in Osteoarthritis
This study will evaluate the efficacy of three intra-articular injections, given 2 weeks apart, of Ampion™ in Adults with pain due to osteoarthritis of the knee.
- Trial name
- NCT02242435
- Testing
- 4 mL injection of Ampion
- Where
- United States
- Volunteers
- 342 people
- Sponsor
- Ampio Pharmaceuticals. Inc.
Osteoarthritis, Knee
Orthosensor vs Conventional Total Knee Arthroplasty
In a randomized-controlled fashion, this investigation will evaluate the use of the Verasense technology to achieve optimal TKA balance.
- Trial name
- NCT03628378
- Testing
- Verasense
- Where
- 2 sites in United States
- Volunteers
- 130 people
- Sponsor
- Columbia University
Osteoarthritis, Knee, Osteoarthritis, Hip
Study Of "Continuous Use" Of Celecoxib Vs. "Usual or Intermittent Use"
To determine whether "continuous use" of celecoxib over a 6-month period is more efficacious than "usual or intermittent use" in preventing spontaneous osteoarthritis flares of the knee and hip.
- Trial name
- NCT00139776
- Testing
- Celecoxib
- Where
- 124 sites in United States, Belgium and 6 more
- Volunteers
- 875 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
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