Clinical trials: Knee, open to volunteers
Postoperative Outcomes, Postoperative Complications
The Effect of Perioperative Nutritional Care on Recovery After Knee and Hip Replacement Surgery
This prospective observational study will assess the impact of standardized perioperative nutritional care on postoperative outcomes in patients undergoing elective total hip (THA) or knee arthroplasty (TKA) at the First…
- Conditions
- Postoperative Outcomes, Postoperative Complications, Length of Hospital Stay
- Trial name
- NCT06989229
- Where
- Czechia
- Volunteers
- 1,000 people
- Sponsor
- St. Anne's University Hospital Brno, Czech Republic
Knee Osteoarthritis
Effect of an Information- and Self-management App for People With Knee Osteoarthritis
The primary aim of the trial is to assess if an information- and self-management app provided in the period between referral and consultation in specialist healthcare can improve knowledge about osteoarthritis and decision…
- Trial name
- OA-AID (NCT07603973)
- Testing
- Information- and self-management app, Control
- Where
- Norway
- Volunteers
- 204 people
- Sponsor
- Diakonhjemmet Hospital
Above Knee Amputation, Amputation
Gait Training and Balance Using Artificial Intelligence
Effect of Using Artificial Intelligence on Gait Training and Balance in Above Knee Amputation Patients
- Trial name
- NCT07265154
- Testing
- Artificial Intelligence
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- South Valley University
Surgical Stress Response, Stress Physiological
Feasibility of Breathwork Intervention With Older Adults After Knee Surgery
Postoperative complications after surgical procedures, including following total knee arthroplasty (TKA), have a negative impact on the health and well-being of surgical patients.
- Conditions
- Surgical Stress Response, Stress Physiological, Stress Physiology, Stress Psychological
- Trial name
- NCT07464860
- Testing
- A 5-minute Asynchronous Breathwork Intervention, A 5-minute Asynchronous Card Game Video
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Knee Osteoarthristis
Feasibility of Resting Intervals During Exercise Programs for Individuals With Knee Osteoarthritis
This pilot randomize trial tests the feasibility of administering two different exercise programs in people with knee osteoarthritis.
- Trial name
- CaRE (NCT06857123)
- Testing
- Exercise with Rest, Exercise without Rest
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Pittsburgh
Pain (Knee), Pain and Anxiety
A Comparison of Heart Rate Variability Biofeedback, Mindfulness, and Psychoeducation-based Interventions on Clinical Recovery Outcomes in Patients Undergoing Total Knee Arthroplasty
The goal of this clinical trial is to compare the effects of heart rate variability biofeedback (HRVB), mindfulness meditation, and psychological education in patients undergoing total knee arthroplasty (TKA).
- Conditions
- Pain (Knee), Pain and Anxiety, TKA
- Trial name
- NCT07896954
- Testing
- Heart rate variability biofeedback, Mindfulness, psychoeducation
- Where
- 2 sites in Taiwan
- Volunteers
- 120 people
- Sponsor
- Chang Gung Memorial Hospital
Inflammation, Osteoarthritis
Photobiomodulation Therapy in Patients Receiving Total Knee Arthroplasty
Photobiomdoulation is the use of near-infrared light to relieve pain, stimulate healing and reduce inflammation. Swelling and inflammation is a common condition after orthopedics surgeries over extremity and spine.
- Conditions
- Inflammation, Osteoarthritis, Post Operative Pain
- Trial name
- NCT06426251
- Testing
- Photobiomodulation
- Where
- Taiwan
- Volunteers
- 15 people
- Sponsor
- National Taiwan University Hospital Hsin-Chu Branch
Knee Osteoarthritis
The Effect of a Group Exercise Intervention on Balance in People With Knee Osteoarthritis: a Pilot Study
In this study, the investigators want to find out if a 12-week exercise program improves balance in people with knee osteoarthritis.
- Trial name
- NCT06807541
- Testing
- Exercise intervention
- Where
- 2 sites in Canada
- Volunteers
- 32 people
- Sponsor
- University of the Fraser Valley
Degenerative Joint Disease of Knee, Rheumatoid Arthritis
Intra-Articular Adelmidrol 2%/Hyaluronic Acid 1% With or Without m/umPEA, in Knee Pain Due to Joint Degeneration.
Degenerative knee joint diseases are characterized by chronic pain, inflammation, and functional impairment. In these conditions, mast cell density in the synovial membrane is increased, resulting in an excessive release of…
- Trial name
- NCT07680101
- Testing
- Adelmidrol 2% / Hyaluronic Acid 1%, micronized Palmitoylethanolamide (mPEA) 300mg + ultramicronized Palmitoylethanolamide (umPEA) 600mg
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Universita di Verona
Knee Osteoarthritis, Musculoskeletal Diseases
Bone Marrow Aspirate Concentrate (BMAC) Treatment for Knee Osteoarthritis
The purpose of the ACCELERATE3 trial is to assess the efficacy of a single intra-articular (IA) injection of autologous BMAC, in one or both knees, compared to a single IA injection of Standard of Care (SOC) in patients with mild…
- Trial name
- ACCELERATE3 (NCT06216028)
- Testing
- Autologous Bone Marrow Aspirate Concentrate
- Where
- Canada
- Volunteers
- 374 people
- Sponsor
- CELL Technologies Inc.
Therapeutic Exercise, Physical Therapy Techniques
Exercise With Audible Cues on Motor Unit Behavior in Athletes With Anterior Cruciate Ligament Reconstruction
The closed kinetic chain (CKC) of terminal knee extension exercise (TKE) is designed to activate VM activity for knee injury training.
- Conditions
- Therapeutic Exercise, Physical Therapy Techniques, Neuromuscular Function
- Trial name
- ACLR (NCT06662955)
- Testing
- audible cues, Exercise
- Where
- Thailand
- Volunteers
- 40 people
- Sponsor
- Mahidol University
Knee Arthroplasty, Total
Comparison Between Combined Biceps Femoris Short Head Block and Adductor Canal Block Versus Genicular Nerve Block
The purpose of this study is to compare the analgesic outcomes (time to first analgesic request, total amount of analgesic consumption, and pain scores) following total knee arthroplasty by either combined biceps femoris short…
- Trial name
- NCT07418307
- Testing
- Combined biceps femoris short head block and adductor canal block, Genicular nerve block
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Zagazig University
Osteoarthritis of the Hip or Knee
Implementing a Guideline-based Model of Care for Hip and Knee Osteoarthritis in Finland. A Benchmarking-controlled Trial (FIN-OA)
This project aims to bridge the gap between guideline recommendations and clinical practice in osteoarthritis (OA) management. By implementing a systematic, evidence-based model of care, the project seeks to improve patient…
- Trial name
- FIN-OA (NCT06904885)
- Testing
- Implementation of a guideline-based model of care for hip and knee osteoarthritis
- Volunteers
- 10,000 people
- Sponsor
- University of Jyvaskyla
Knee Osteoarthritis, Knee Osteoarthritis in Varus
Total Knee Arthroplasty in Varus Deformity
For the first time, a comparative analysis of the limb axis in patients with unilateral knee OA will be conducted compared to the contralateral uninjured side using Multisliced computed tomography (MSCT) and vertical CT…
- Trial name
- TKA in varus (NCT07465484)
- Testing
- Total knee arthroplasty using active robotic surgical system
- Where
- Russia
- Volunteers
- 300 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Wound Surgical, Diabetes
Negative Pressure Wound Therapy Devices in Total Knee Arthroplasty
This study is a single-center, prospective, randomized, open-label clinical trial evaluating three commercially available closed-incision negative pressure wound therapy (ciNPWT) devices: NPseal, PICO, and Prevena, in adult…
- Conditions
- Wound Surgical, Diabetes, Obesity, Chronic Kidney Diseases
- Trial name
- NCT07770633
- Testing
- NP Seal, PICO, Prevena
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Stroke, Traumatic Brain Injury
Targeting Osteosarcopaenia and Multimorbidity for Frailty Prevention
The aging population and its accompanying burden from non-communicable chronic diseases predicts an increasing impact imposed by frailty on healthcare systems.
- Conditions
- Stroke, Traumatic Brain Injury, Knee Osteoarthritis, Breast Cancer
- Trial name
- OPTIMA-C (NCT06073106)
- Where
- Singapore
- Volunteers
- 500 people
- Sponsor
- Tan Tock Seng Hospital
Postoperative Pain After a Total Knee Arthroplasty
Post-operative Analgesic Effect of Oral Nefopam
Primary knee arthroplasty by total prosthesis is a painful surgery, performed on patients with advanced gonarthrosis (stage III), thus already presenting hyperalgesia and hyperalgesia and allodynia.
- Trial name
- NefPO (NCT04576078)
- Testing
- Oral nefopam
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Hospices Civils de Lyon
Total Knee Anthroplasty, Epidural Analgesia
Programmed Intermittent Epidural Bolus Versus Continuous Epidural Infusion for Postoperative Analgesia After Total Knee Arthroplasty
The goal of this clinical trial is to compare two different epidural analgesia delivery methods for pain control after total knee arthroplasty in adults undergoing elective surgery.
- Trial name
- NCT07605208
- Testing
- Programmed intermittent epidural bolus 6 ml, continuous epidural infusion
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Sakarya University
Osteo Arthritis Knee, Osteoarthritis
Arthrosamid vs. Steroid for the Management of Knee Osteoarthritis
This study will be a randomised control trial of the use of intra-articular Arthrosamid® a novel intraarticular hydrogel vs. standard of care (steroid and local anaesthetic) for the non-operative management of knee osteoarthritis.
- Conditions
- Osteo Arthritis Knee, Osteoarthritis, Intraarticular Injection
- Trial name
- NCT07489521
- Testing
- Arthrosamid® 2.5% iPAAG injectable implant, Steroid Drug
- Where
- Ireland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Cappagh National Orthopaedic Hospital
Knee Osteoarthristis
Gender Based Comparison of the Effects of Sensory Modulated Graded Weight Bearing Physiotherapy In Adults With Knee Osteoarthritis
This comparative experimental study aims to evaluate the effectiveness of Sensory-Modulated Graded Weight-Bearing Physiotherapy (SMGWBP) in patients with knee osteoarthritis and compare treatment outcomes between male and female…
- Trial name
- GSMGWBP (NCT07784998)
- Testing
- Sensory-Modulated Graded Weight-Bearing Physiotherapy
- Where
- Pakistan
- Volunteers
- 52 people
- Sponsor
- Shifa Tameer-e-Millat University
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