Clinical trials: Knee Arthritis, Osteoarthritis, open to volunteers
Anterior Cruciate Ligament Injuries
Biologic Therapy to Prevent Osteoarthritis After ACL Injury
Anterior cruciate ligament (ACL) injuries are extremely common. On average, 50% of individuals suffering an ACL injury will develop radiographic osteoarthritis (OA) 10 to 20 years after injury.
- Trial name
- NCT03968913
- Testing
- Anakinra injection, sterile saline injection
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Chronic Pain, Perineural Analgesia
Perineural Prolotherapy in Chronic Knee Osteoarthritis Pain.
The aim of this study is to test whether the addition of dextrose to perineural injections is superior to local anesthetic alone, as some initial data have indicated.
- Conditions
- Chronic Pain, Perineural Analgesia, Prolotherapy, Knee Osteoarthritis
- Trial name
- NCT07245121
- Testing
- Dextrose 5% and Lidocaine, Lidocaine
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- National and Kapodistrian University of Athens
Knee Osteoarthritis
Robotic Assisted Surgery In Total Knee Replacement
The goal of this clinical trial is to compare robotic arm assisted surgery with manual surgery in patients operated with knee replacement.
- Trial name
- NCT05842538
- Testing
- Triathlon
- Where
- 2 sites in Sweden
- Volunteers
- 200 people
- Sponsor
- Sahlgrenska University Hospital
Obesity, Overweight
A Study to Learn About Study Medicine Called Berobenatide in Adults With Knee Pain and Overweight or Obesity (VESPER-OA 1)
The purpose of this clinical study is to learn about the safety and effects of berobenatide (PF-08653944) for the treatment of knee osteoarthritis in adults with overweight or obesity.
- Conditions
- Obesity, Overweight, Osteoarthritis of the Knee
- Trial name
- NCT07919678
- Testing
- Berobenatide
- Where
- 40 sites in United States, Canada
- Volunteers
- 656 people
- Sponsor
- Pfizer
Knee Osteoarthritis
Effects of Sahrmann's Approach Versus Conventional Treatment Oin Patients With Knee Osteoarthritis
Osteoarthritis (OA) of the knee, also referred to as degenerative joint disease, is normally due to wear and tear and progressive cartilage loss in the articular cartilage.
- Trial name
- NCT07642258
- Testing
- Sahrmann's exercises, standard physical therapy treatment
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Riphah International University
Osteoarthritis, Knee, Osteoarthritis, Hip
Promoting Sleep to Alleviate Pain - Arthroplasty
PROSAP-A is a perioperative randomized, controlled trial with a 12-month follow-up period after total knee arthroplasty (TKA) or total hip arthroplasty (THA), aiming to investigate both acute and long-term postoperative effects…
- Conditions
- Osteoarthritis, Knee, Osteoarthritis, Hip, Insomnia, Surgery
- Trial name
- PROSAP-A (NCT06145516)
- Testing
- Cognitive behavioral therapy for insomnia (CBT-I), Sleep education therapy (SET)
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Uppsala University
Osteo Arthritis Knee
Safety and Tolerability of StroMel™ in Subjects with Moderate to Severe Osteoarthritis of the Knee Joint
The aim of this trial is to evaluate the safety and tolerability of autologous StroMel™ for the treatment of moderate to severe OA of the knee joint.
- Trial name
- NCT04750252
- Testing
- StroMel
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Akan Biosciences, LLC
Knee, Osteoarthritis
Amniotic Suspension Allograft Injection for Knee Osteoarthritis
There have been few clinical trials on ASA for the treatment of knee osteoarthritis, and there is currently no literature reporting the optimal treatment dosage.
- Trial name
- ASAIKO (NCT06704893)
- Testing
- ASA injection 40 mg group, ASA injection 20 mg group, HA injection group
- Where
- 2 sites in Taiwan
- Volunteers
- 160 people
- Sponsor
- Chang Gung Memorial Hospital
Knee Osteoarthritis
Hip Abductor Strengthening Exercises in Knee Osteoarthritis
The aim of this randomized controlled trial is to find the effect of hip abductor strengthening exercises on pain, range of motion, functional disability and balance in patient with knee osteoarthritis.
- Trial name
- NCT06845657
- Testing
- Hip Abductor Strengthening Exercises, Conventional Treatment
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Riphah International University
Knee Arthritis Osteoarthritis
Knee Osteoarthritis Rehab: High-Intensity Laser vs Classical Modalities
This study aims to compare the effectiveness and safety of High-Intensity Laser Therapy (HILT) with conventional physical therapy treatments in patients with knee osteoarthritis.
- Trial name
- HILT-CM (KOA) (NCT07551245)
- Testing
- High-Intensity Laser Therapy (HILT), Conventional Physical Therapy Modalities
- Where
- Iraq
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Erbil Polytechnic University
Knee Osteoarthritis, Insomnia
Move and Snooze: Adding Insomnia Treatment to an Exercise Program to Improve Pain Outcomes in Older Adults With Knee Osteoarthritis
This research will compare the effectiveness of a remotely delivered personalized exercise coaching plus an evidence-based sleep improvement intervention to remotely delivered personalized exercise coaching alone for knee…
- Trial name
- NCT06580561
- Testing
- Personalized exercise coaching, Cognitive behavioral therapy for Insomnia
- Where
- United States
- Volunteers
- 288 people
- Sponsor
- University of Michigan
Knee Osteoarthritis (Knee OA)
A Study to Assess the Efficacy and Safety of Vutiglabridin in Knee Osteoarthritis Patients
1. Study Objective To Explore the Efficacy and Evaluate the Safety of Vutiglabridin in Knee Osteoarthritis Patients 2. Background Glaceum Inc.
- Trial name
- NCT06845553
- Testing
- Vutiglabridin
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Glaceum
Knee Osteoarthritis
Knee Pain Ejiao Paste for Knee Osteoarthritis
To explore the analgesic efficacy of Knee Pain Ejiao Paste in the treatment of knee osteoarthritis (Qi and Blood Deficiency Pattern) after 12 weeks, using an Ejiao-free clear paste as a parallel control and incorporating a…
- Trial name
- NCT07504562
- Testing
- Knee Pain Ejiao Paste, Knee Pain Ejiao-free Clear Paste
- Where
- 2 sites in China
- Volunteers
- 60 people
- Sponsor
- ShuGuang Hospital
Knee Osteoarthritis
Etodolac Nanogel as an Adjunct to Physiotherapy for Knee Osteoarthritis
Brief Summary: Knee osteoarthritis (OA) is a common, disabling condition affecting the weight-bearing knee joint, leading to pain, reduced function, and muscle weakness, particularly of the quadriceps.
- Trial name
- NCT07308470
- Testing
- Etodolac-Loaded Solid Lipid Nanoparticle Gel
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Pharos University in Alexandria
Osteoarthritis, Knee
Effect of Anti-inflammatory (ITIS) Diet in Knee Osteoarthritis
To study the effect of anti-inflammatory diet on clinical and biological outcomes in patients with knee osteoarthritis
- Trial name
- NCT05559463
- Testing
- ITIS diet
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, San Diego
Surgeon Physiologic Stress
Surgeon Physiologic Stress During Unicompartmental Knee Arthroplasty: Manual vs Computer-Assisted Technique
This study aims to compare the physiologic stress experienced by the surgeon during unicompartmental knee arthroplasty (UKA) performed using a manual technique versus a computer-assisted technique.
- Trial name
- UKA-STRESS (NCT07495618)
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- ASL Lecce
Osteoarthritis of Knee
Preoperative Rehabilitation Training and Total Knee Arthroplasty Outcomes
Joint replacement surgery is an effective treatment for severe joint diseases, but the postoperative recovery process is complex and lengthy.
- Trial name
- PRTKAO (NCT06983912)
- Testing
- Preoperative Rehabilitation Training
- Volunteers
- 500 people
- Sponsor
- Fuzhou University Affiliated Provincial Hospital
Knee Osteoarthrosis
Use of Extracellular Vesicles (EV) for Knee Osteoarthrosis
Extracellular vesicles (EV) will be injected in patients diagnosed with Knee osteoarthrosis
- Trial name
- NCT06937528
- Testing
- Extracellular vesicles
- Where
- Jordan
- Volunteers
- 50 people
- Sponsor
- University of Jordan
Treatment Outcome
99Tc-MDP Treatment for Knee Osteoarthritis
Osteoarthritis (OA) of knee is the most common form of arthritis in the world1e, and it has received growing attention in the society because of the increase of old age population, disabled people, and medical expenses from this…
- Trial name
- NCT02993029
- Testing
- 99Tc-MDP, Celecoxib
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Osteoarthritis in Postmenopausal Women
Effect of Metformin Iontophoresis on Knee Osteoarthritis in Postmenopausal Women
This study is designed as a randomized, double-blind, placebo-controlled clinical trial with two parallel groups. All participants will receive a standardized physical therapy rehabilitation program.
- Trial name
- NCT07395895
- Testing
- Metformin gel Iontophoresis, Iontophoresis
- Where
- Egypt
- Volunteers
- 68 people
- Sponsor
- Badr University