Clinical trials: Knee Arthritis Disease
Unilateral Primary Osteoarthritis of Knee, Osteoarthritis Knee
Microdrilling Surgery for Full Thickness Chondral Lesions of the Knee Augmented With Concentrated Bone Marrow Aspirate, Platelet Rich Plasma and Hyaluronic Acid
This study seeks to evaluate a treatment for multiple full thickness chondral lesions in the knee. Eligible subjects will undergo a microdrilling surgery and up to 12 post operative intra-articular injections of bone marrow…
- Conditions
- Unilateral Primary Osteoarthritis of Knee, Osteoarthritis Knee, Degeneration; Articular Cartilage, Knee, Degenerative Lesion of Articular Cartilage of Knee
- Trial name
- NCT02285725
- Testing
- Microdrilling Surgery, Injections of BMAC + PRP + HA
- Volunteers
- 21 people
- Sponsor
- Joseph E. Broyles
Osteoarthritis, Knee
Fenugreek Wraps in Osteoarthritis of the Knee
This randomised controlled trial aims to investigate the efficacy of fenugreek wraps in the treatment of primary symptomatic osteoarthritis of the knee.
- Trial name
- BoGon (NCT03528824)
- Testing
- Fenugreek wrap, Diclofenac Gel
- Where
- Germany
- Volunteers
- 81 people
- Sponsor
- Universität Duisburg-Essen
Knee Osteoarthritis
Bracing to Treat Knee Osteoarthritis in Elderly
Background: Osteoarthritis (OA) is highly prevalent in the elderly, with the knee being the most commonly affected joint in this population. Knee braces are often used to prevent common problems in knees during daily activities.
- Trial name
- NCT02443974
- Testing
- Brace (Fisiotensor®), Sleeve (Fisiotensor®)
- Where
- Brazil
- Volunteers
- 120 people
- Sponsor
- Federal University of São Paulo
Osteoarthritis, Knee, Orthopedic Disorder
Gait, Pain and Physical Activity After HTO
This study aims to investigate the relationship between pain, gait and activity intensity in HTO patients that are healed and have had their fixation plate removed.
- Trial name
- NCT04619550
- Testing
- High tibial osteotomy
- Where
- United Kingdom
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Winchester
Knee Osteoarthritis, Total Knee Arthroplastry
The Effect of Proprioceptive Neuromuscular Facilitation and Tendon Vibration After Total Knee Arthroplasty
Knee osteoarthritis is a degenerative joint disease characterized by the destruction and progressive loss of articular cartilage.
- Trial name
- NCT05920590
- Testing
- PNF, PNF plus Tendon Vibration, Control
- Where
- Greece
- Volunteers
- 90 people
- Sponsor
- International Hellenic University
Osteoarthritis, Knee
Comparative Effectiveness and Safety of Two Hyaluronic Acid Products in Knee Osteoarthritis
Knee osteoarthritis is a condition that causes pain, stiffness, and difficulty moving the knee. Some people continue to have symptoms despite receiving usual treatments, such as pain medications, exercise, and physical therapy.
- Trial name
- NCT07911696
- Testing
- Hylan G-F 20, Cross-Linked Sodium Hyaluronate
- Where
- Mexico
- Volunteers
- 160 people
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Knee Osteoarthritis
The Effect of Intra-articular Bilateral Knee Injections of Zilretta on Performance Measures in Adults With Knee OA
This study will be an open-label trial to determine the functional effects of bilateral IA injections of Zilretta into knee joints of 70 subjects with bilateral KL grade 2-4 symptomatic knee osteoarthritis (OA).
- Trial name
- NCT03895840
- Testing
- Zilretta
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Kansas Medical Center
Pain, Osteo Arthritis Knee
Clinical Trial to Evaluate the Efficacy and Safety of LEVI-04 in Patients With Osteoarthritis of the Knee
This is a phase 2, randomized, double-blind, placebo-controlled trial of multiple doses and multiple administrations of LEVI-04 for the treatment of pain due to osteoarthritis of the knee.
- Conditions
- Pain, Osteo Arthritis Knee, Knee Osteoarthritis, Arthritis
- Trial name
- NCT05618782
- Testing
- LEVI-04
- Where
- 13 sites in Czechia, Denmark and 3 more
- Volunteers
- 518 people
- Sponsor
- Levicept
Knee Osteoarthritis
Gait Analysis of a Lateral-Pivot Design Total Knee Replacement
Previous motion analysis studies have demonstrated excellent ability to distinguish subtle differences in gait between normal subjects and those suffering from arthritis.
- Trial name
- NCT04275362
- Testing
- DJO Empowr PS Knee System, Stryker Triathlon Total Knee System, Biomet Vanguard Complete Knee System
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- More Foundation
Osteoarthritis
Doxycycline and OA Progression
This study will determine whether doxycycline decreases the severity or rate of progression of osteoarthritis (OA) in the knee. Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most popular agents used to treat OA, but…
- Trial name
- NCT00000403
- Testing
- Doxycycline
- Where
- 6 sites in United States
- Volunteers
- 432 people
- Sponsor
- Indiana University
Knee Osteoarthritis
Treatment of Osteoarthritis by Intra-articular Injection of Bone Marrow Mesenchymal Stem Cells With Platelet Rich Plasma
Purpose: To determine the safety, feasibility and effectiveness (clinical and radiological) of intra-articular administration of autologous mesenchymal stem cells (MSCs) with platelet richa plasma (PRGF) in patients with knee…
- Trial name
- CMM-PRGF/ART (NCT02365142)
- Testing
- 100 million Bone marrow mesenchimal stem cells, Platelet Rich plasma (PRGF)
- Where
- 2 sites in Spain
- Volunteers
- 38 people
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Osteochondritis Dissecans, Osteoarthritis
ACI-C Versus AMIC. A Randomized Trial Comparing Two Methods for Repair of Cartilage Defects in the Knee
ACI-C versus AMIC: A controlled randomized trial comparing Autologous Chondrocyte Implantation ( ACI) and Autologous Matrix Induced Chondrogenesis (AMIC) for repair of cartilage defects in the knee.
- Conditions
- Osteochondritis Dissecans, Osteoarthritis, Cartilage Injury, Osteonecrosis
- Trial name
- NCT01458782
- Testing
- Treatment of cartilage defects in the knee
- Where
- Norway
- Volunteers
- 41 people
- Sponsor
- University Hospital of North Norway
Osteoarthritis, Knee, Exercise
The Effect of Contralateral Isokinetic Lower Extremity Exercises in Unilateral Painful Knee Osteoarthritis
Patients with unilateral knee pain due to knee osteoarthritis presenting to our clinic will be included in a 20-session treatment program, either on an outpatient basis or as inpatients at our clinic.
- Trial name
- NCT06675318
- Testing
- Cross training for quadriceps muscle of contralateral lower limb, Quadriceps isometric exercises, along with hot pack and TENS for painful knee
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Gazi University
Osteoarthritis of the Knee
Pilot Study to Identify and Validate Digital Biomarkers in Osteoarthritis of the Knee
To date, treatment options for knee osteoarthritis remain limited, and their clinical evaluation is complex due to the day-to-day fluctuations in symptoms.
- Trial name
- DigitOAK (NCT07031518)
- Testing
- Syde, The Self-Paced 40-meter Walk Test (SPWT), 30-second chair stand test (30s-CST)
- Where
- Belgium
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Liege
Knee Osteoarthritis
Evaluation of the Efficacy and Safety of Entelon Tab. 150mg in Patients With Osteoarthritis of Knee
This clinical trial is planned to prove Entelon tab. arm is not inferior to Celebrex cap. arm in terms of the efficacy and safety through the change of K-WOMAC's total score sum in patients with osteoarthritis of knee.
- Trial name
- NCT01768520
- Testing
- Enteron tab. 150mg(vitis vinifera extract 150mg) : twice daily for 12 weeks, Celebrex cap. (celecoxib 200mg) : once daily, for 12 weeks
- Where
- South Korea
- Volunteers
- 338 people
- Sponsor
- Hanlim Pharm. Co., Ltd.
Osteoarthritis, Knee
A Clinical Study to Investigate the Effect on Pain Relief of a Single Dose of JNJ-39439335 in Patients With Chronic Osteoarthritis Pain of the Knee
The purpose of this single-center study is to evaluate the potential analgesic effects of a single oral dose (50 mg) of JNJ-39439335, an investigational drug being developed for the treatment of pain in patients with chronic…
- Trial name
- NCT00933582
- Volunteers
- 33 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Knee Osteoarthritis, Arthropathy of Knee Joint
The Effect of Exercise Training on Muscle Mass in Patients With Total Knee Arthroplasty
Background: Total knee arthroplasty (TKA) is one of the most common operations in orthopedics. After surgery, the decline of bone mineral density and muscle mass was proved, oral bisphosphonate is commonly used to prevent BMD…
- Trial name
- NCT03339323
- Testing
- Exercise
- Where
- Taiwan
- Volunteers
- 210 people
- Sponsor
- Chang Gung Memorial Hospital
Osteoarthritis, Knee, Knee Injuries
Motor-Sparing Femoral Nerve Block Dose
Femoral nerve blocks are commonly used to provide pain control for total knee replacement, anterior cruciate ligament (ACL) reconstruction.
- Trial name
- NCT02909257
- Testing
- Same Bupivacaine Concentration, Lower Bupivacaine Concentration
- Where
- Chile
- Volunteers
- 31 people
- Sponsor
- University of Chile
Knee Osteoarthritis, Musculoskeletal Diseases
Bone Marrow Aspirate Concentrate (BMAC) Treatment for Knee Osteoarthritis
The purpose of the ACCELERATE3 trial is to assess the efficacy of a single intra-articular (IA) injection of autologous BMAC, in one or both knees, compared to a single IA injection of Standard of Care (SOC) in patients with mild…
- Trial name
- ACCELERATE3 (NCT06216028)
- Testing
- Autologous Bone Marrow Aspirate Concentrate
- Where
- Canada
- Volunteers
- 374 people
- Sponsor
- CELL Technologies Inc.
Osteoarthritis of Knee
Human Autologous MSCs for the Treatment of Mid to Late Stage Knee OA
Osteoarthritis (OA) is one of the most common forms of arthritis. It is a lasting condition in which the material that cushions the joints, called cartilage, breaks down.
- Trial name
- NCT02351011
- Testing
- 1 x 10^6 MSCs, 10 x 10^6 MSCs, 50 x 10^6 MSCs
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- Jas Chahal
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