Clinical trials: Knee Arthritis Disease
Knee Osteoarthritis
Responsiveness and Minimal Clinically Important Difference (MCID) of Knee Injury and Osteoarthritis (KOOS-12) in (OA)
Osteoarthritis (OA) is a common and disabling constant Musculoskeletal Disorder that causes significant weight on individual, Health Care Systems, and social economy.
- Trial name
- NCT06901921
- Testing
- PT-intervention
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Superior University
Prolotherapy
Combined Effect of Prolotherapy and Personalized Physical Activity on Knee Osteoarthritis Progression
The aim of this clinical trial is to assess whether prolotherapy combined with personal physical activity is effective in managing pain (measured using the VAS and WOMAC scales) and improving the quality of life in participants…
- Trial name
- NCT07355712
- Testing
- Prolotherapy Only, Prolotherapy, Personalized Physical Activity Program
- Where
- Indonesia
- Volunteers
- 74 people
- Sponsor
- Gadjah Mada University
Postmenopausal, Knee Osteoarthritis
Comparative Effects Of Dynamic And Static Stretching In Postmenopausal Females With Knee Osteoarthritis
As the aging population continues to grow, there is a pressing need to explore effective interventions to alleviate the symptoms of osteoarthritis, particularly in postmenopausal women who may experience unique challenges.
- Trial name
- NCT06658327
- Testing
- Dynamic stretching, Static stretching
- Where
- Pakistan
- Volunteers
- 58 people
- Sponsor
- Riphah International University
Pain, Osteoarthritis, Knee
A Dose-Finding Study to Evaluate the Efficacy and Safety of GSK3858279 in Adults With Knee Osteoarthritis (OA) Pain
This is dose-finding study of GSK3858279 in participants with moderate to severe knee osteoarthritis pain. The purpose of this study is to investigate and provide the data necessary to select the optimal effective and safe…
- Trial name
- MARS-17 (NCT05838742)
- Testing
- GSK3858279
- Where
- 93 sites in United States, Argentina and 11 more
- Volunteers
- 314 people
- Sponsor
- GlaxoSmithKline
Osteoarthritis, Knee, Insomnia
Added Value of Cognitive Behavioural Therapy for Insomnia in Persons With Knee Osteoarthritis
Knee osteoarthritis (KOA) is the leading and fastest increasing cause of disability in older adults. It is a serious health issue related with a high health care utilisation.
- Trial name
- PREMEO (NCT05387473)
- Testing
- Cognitive behavioral therapy for insomnia (CBT-I) integrated in best-evidence usual care (CBTi-UC), Best-evidence usual care (UC) plus information sessions
- Where
- Belgium
- Volunteers
- 128 people
- Sponsor
- Vrije Universiteit Brussel
Osteo Arthritis of the Knee, Pain
The PERK Study: Predicting and Evaluating Response to Knee RFA Using fNIRS
The goal of this clinical trial is to understand whether changes in brain activity, measured using functional near-infrared spectroscopy (fNIRS), are related to how well patients with knee osteoarthritis respond to genicular…
- Trial name
- PERK (NCT07835269)
- Testing
- Radiofrequency ablation alone, Genicular Nerve Block
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Total Knee Arthroplasty, Osteoarthritis
A Study to Compare the NexGen LPS and LPS-Flex Knee Implants
The purpose of this study is to test for significant differences in functional outcomes obtained by using a NexGen LPS versus a NexGen LPS-Flex knee implant.
- Trial name
- NCT00763386
- Testing
- NexGen LPS-Flex Fixed Bearing Knee, NexGen Legacy Posterior Stabilized Knee
- Where
- 15 sites in United States, Canada
- Volunteers
- 331 people
- Sponsor
- Zimmer Biomet
Osteoarthritis
Randomized Study of the Efficacy and Safety of a Single Dose of Synvisc-One® in Chinese Patients With Symptomatic Osteoarthritis of the Knee
Primary Objective: -To evaluate the efficacy of a single 6-milliliter (mL) intra-articular (IA) injection of Hylan G-F 20 measured by Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Numerical Rating Scale…
- Trial name
- C-SOUND (NCT03190369)
- Testing
- Hylan G-F 20 (GZ402662/SAR402662)
- Where
- 21 sites in China
- Volunteers
- 440 people
- Sponsor
- Genzyme, a Sanofi Company
Knee Osteoarthritis
Autologous Adipose Tissue Derived Mesenchymal Stem Cells Therapy for Patients With Knee Osteoarthritis
Two injections in total and 3 ml autologous adipose-tissue-derived stem cells(haMSCs) for each injection; time-points for intervention: 1) initial injection; 2) 3 weeks following initial injection.
- Trial name
- NCT01809769
- Testing
- Mesenchymal stem cells low-dose group, Mesenchymal stem cells mid-dose group, Mesenchymal stem cells high-dose group
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Shanghai AbelZeta Ltd.
Osteoarthritis, Knee
Safety and Efficacy of Pre-emptive Tapentadol vs Pregabalin in Post Operative Pain Following Surgery
Preemptive analgesia is a treatment modality which starts even before the surgery, so that the central sensitization is prevented due to incisional injury at the time of surgery, so it covers the period of surgery and initial…
- Trial name
- NCT03604354
- Testing
- Tapentadol 100 MG Oral Tablet, Pregabalin 150mg
- Where
- India
- Volunteers
- 95 people
- Sponsor
- All India Institute of Medical Sciences, Bhubaneswar
Osteoarthritis, Knee
Comparison of Heated vs. Pulsed Radiofrequency Treatment of the Genicular Nerves for Osteoarthritis Knee Pain
This is a prospective, randomised, interventional, double blinded study to compare the clinical outcomes of thermal vs. pulsed radiofrequency (RF) treatment of the genicular nerves in patients with painful osteoarthritis (OA) of…
- Trial name
- NCT04379895
- Testing
- Radiofrequency ablation
- Volunteers
- 60 people
- Sponsor
- Rambam Health Care Campus
Osteoarthritis, Knee
Effects of Blood-flow Restricted Exercise Compared to Standard Rehabilitation in Patients With Knee Osteoarthritis
The purpose of this study is to investigate the effect of low-intensity BFR exercise on joint pain, muscle mass, and mechanical muscle function compared to standard rehabilitering in adults with knee-OA.
- Trial name
- NCT05437770
- Testing
- BFR (Blood-Flow Restricted exercise), Standard rehabilitation
- Where
- Denmark
- Volunteers
- 96 people
- Sponsor
- Bispebjerg Hospital
Osteoarthritis of the Knee Joint
Correlation Between Alignment of Lower Limb and Clinical Outcome After Total Knee Prosthesis.
Evaluation of the clinical results after total knee prosthesis, and correlation with the alignment of the lower limb. Radiological measurements by means of 3D technology will be performed.
- Trial name
- NCT01666873
- Testing
- patients that undergo a total knee prosthesis
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- University Hospital, Ghent
Osteo Arthritis Knee
Effectiveness of Pain Science Education in People With Symptomatic Knee Osteoarthritis
The aim of this study is to determine the effectiveness of the program integrated with pain science education for people with painful knee osteoarthritis (OA).
- Trial name
- NCT05649995
- Testing
- Pain science education driven physiotherapy program, Biomedical education driven physiotherapy program
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Marmara University
Osteoarthritis, Knee, Rheumatoid Arthritis
Early Biomarkers for ARthritic PAIN to Guide Improved Treatments for Arthritis
Osteoarthritis (OA) is a condition affecting the whole joint and is a major cause of pain and disability worldwide. Although OA is very common, the initial steps which lead to the development of pain and tissue damage are not…
- Conditions
- Osteoarthritis, Knee, Rheumatoid Arthritis, Spondyloarthritis, Psoriatic Arthritis
- Trial name
- ARPAIN (NCT03533569)
- Testing
- Intra-articular corticosteroid injection
- Where
- United Kingdom
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- St George's, University of London
Osteoarthritis, Knee
Effect of Patellar Denervation on Post-operative Knee Pain and Knee Function in Total Knee Arthroplasty
This study is a double-blind randomized controlled trial aiming to investigate the effects of patellar denervation using electrocautery on postoperative knee pain and knee function in patients undergoing primary total knee…
- Trial name
- PD (NCT07342166)
- Testing
- Patellar Denervation
- Where
- Thailand
- Volunteers
- 64 people
- Sponsor
- Queen Savang Vadhana Memorial Hospital, Thailand
Knee Osteoarthritis
Effects of Platelet-Rich Plasma and Ozone Therapy in Knee Osteoarthritis
Knee osteoarthritis can frequently occur with advancing age. In cases of pain that persists despite hot/cold applications, drug therapy and exercise, intra-articular injections are considered.
- Trial name
- NCT06631456
- Testing
- PRP injection, Ozone therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Osteoarthritis, Knee
CBD for Knee Osteoarthritis
Osteoarthritis is a disease that affects millions of Americans and is the leading cause of persistent pain and physical disability in the older adult population.
- Trial name
- SLACK-OA (NCT06414473)
- Testing
- Cannabidiol (CBD) Extract
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Florida
Knee Osteoarthritis
Stability of Contemporary Knee Arthroplasty
Total joint replacement is an efficacious treatment for osteoarthritis of hips and knees. Both total knee replacement (TKR) and total hip replacements (THR) have excellent implant survivorship.
- Trial name
- NCT02861794
- Testing
- Medacta International, GMK Sphere medially stabilized knee
- Where
- Norway
- Volunteers
- 44 people
- Sponsor
- Oslo University Hospital
Knee Osteoarthritis, Edema
Control of Edema in the Knee in Patients With Knee Osteoarthritis
The aim of this study was to compare the effectiveness of exercise and classical massage in the control of knee edema in patients with knee osteoarthritis.
- Conditions
- Knee Osteoarthritis, Edema, Edema Leg
- Trial name
- NCT06010394
- Testing
- conventional physiotherapy, exercises for the knee area, payment oriented massage
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Uskudar University
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