Clinical trials: Knee Arthritis Disease
Knee Osteoarthritis, Total Knee Arthroplasty
Analysis of Competitive Posterior Cruciate Retaining (PCR) and Posterior Stabilized (PS) Total Knee Arthroplasty (TKA)
The purpose of the study is to acquire kinematic in vivo fluoroscopy data from subjects who were implanted with Stryker Posterior Cruciate Retaining (PCR) , Stryker Posterior Stabilized (PS), Zimmer PCR, and Zimmer PS Total Knee…
- Conditions
- Knee Osteoarthritis, Total Knee Arthroplasty, Knee
- Trial name
- NCT04321356
- Testing
- Triathlon PCR TKA, Triathlon PS TKA, Persona PCR TKA
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- The University of Tennessee, Knoxville
Osteoarthritis of the Knee
A Phase 2 Study To Assess The Efficacy, Tolerability, And Safety OF NKTR-181 In Subjects With Chronic OA Knee Pain
NKTR-181 is being developed as an analgesic compound for the treatment of moderate to severe chronic pain - active as a mu agonist, but with inherent molecular properties designed to provide a unique clinical profile, including…
- Trial name
- NCT01619839
- Testing
- NKTR-181
- Where
- 34 sites in United States
- Volunteers
- 296 people
- Sponsor
- Nektar Therapeutics
Knee Arthritis Osteoarthritis
Comparing Pain Science Education to Biomedical Education for People With Knee Osteoarthritis: A Randomized Controlled Trial
Knee osteoarthritis (OA) is a common cause of pain and disability in older adults. Many people with knee OA believe that pain is primarily caused by joint damage or "wear and tear." These beliefs may contribute to fear of…
- Trial name
- NCT07823673
- Testing
- Pain Science Education, Biomedical Education
- Volunteers
- 82 people
- Sponsor
- McMaster University
Osteoarthritis, Post-traumatic Arthritis
Foundation Knee Study - Retrospective
The purpose of this study is to evaluate the use and efficacy of the Encore Foundation Knee System in a group of 200 patients for whom data has already been collected.
- Conditions
- Osteoarthritis, Post-traumatic Arthritis, Inflammatory Tissue Disorders, Arthritis Secondary to Other Diseases
- Trial name
- NCT00764894
- Testing
- Foundation Knee
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Encore Medical, L.P.
Knee Osteoarthritis
Human Umbilical Cord Mesenchymal Stem Cells in the Treatment of Knee Osteoarthritis
This study aims to investigate the effectiveness and safety of human umbilical cord mesenchymal stem cell injection in the articular cavity to treat moderate to severe knee osteoarthritis (OA), and whether it can achieve…
- Trial name
- NCT05160831
- Testing
- Human umbilical cord mesenchymal stem cells
- Volunteers
- 50 people
- Sponsor
- Southwest Hospital, China
Knee Osteoarthritis
Effect of a Patient Education in Pain Coping for Patients Scheduled for Total Knee Arthroplasty
The aim of this study is to investigate, whether a patient education with focus on pain coping is able to improve physical function and experienced pain level in patients with high levels of pain catastrophizing before Total Knee…
- Trial name
- NCT02587429
- Testing
- Patient education
- Where
- Denmark
- Volunteers
- 84 people
- Sponsor
- Regional Hospital West Jutland
Osteoarthritis, Knee
RCT Mesenchymal Stem Cells Versus Hyaluronic Acid in OA Knee):
The purpose of this study is to evaluate the therapeutic effect of adult autologous mesenchymal stem cells (abbreviated as MSCs) in patients with osteoarthritic knee and compare to intra articular injection of Synvisc-One.
- Trial name
- MSC (NCT04326985)
- Testing
- Autologous Mesenchymal Stem Cells Treatment (MSCs), Hyaluronic acid (HA)
- Where
- Hong Kong
- Volunteers
- 20 people
- Sponsor
- Chinese University of Hong Kong
Osteoarthritis, Knee
A Controlled Study of an Herbal Topical Patch in Treating Osteoarthritis (OA) of the Knee
An evaluation of the safety and efficacy of an herbal patch in treating osteoarthritis pain of the right or left knee.
- Trial name
- NCT01183624
- Testing
- Herbal Patch
- Where
- 12 sites in China
- Volunteers
- 626 people
- Sponsor
- Johnson & Johnson Consumer and Personal Products Worldwide
Knee Osteoarthritis, Meniscus Tear
Effects of Kinesiotaping and Physiotherapy in Grade 2 Osteoarthritis Following Degenerative Meniscal Tears
Degenerative meniscal tears are a common cause of osteoarthritis commonly diagnosed in football players and are considered a major risk factor for the development of knee osteoarthritis.
- Trial name
- NCT06227078
- Testing
- Kinesiotaping
- Where
- Saudi Arabia
- Volunteers
- 56 people
- Sponsor
- Gopal Nambi
Osteoarthritis, Knee
Efficacy and Safety of a Intra-articular Injection, ENKO1, in Patients With Symptomatic Knee Osteoarthritis.
Clinical trial with medical device, multicenter, single-blind (blind third party evaluation), randomized, comparative and in two paralell groups, to demonstrate the treatment according to usual clinical practice, of the…
- Trial name
- ENKORE (NCT03762408)
- Testing
- ENKO 1, Durolane
- Where
- 18 sites in Spain
- Volunteers
- 175 people
- Sponsor
- OPKO Health, Inc.
Osteoarthritis, Knee
Muscle Property, Alignment and Joint Loading in People With Knee Osteoarthritis
Knee osteoarthritis (KOA) is a common chronic painful musculoskeletal condition among older adults. It poses great challenge to the health care system due to its inability to be cured.
- Trial name
- NCT03628508
- Testing
- Exercise
- Where
- Hong Kong
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Osteoarthritis (OA) of the Knee
Anti-Diabetic Drug, Exercise and Healthy Diet for Knee Osteoarthritis With Overweight/Obesity
Obesity is associated with increased pain with knee osteoarthritis and increase progression of knee osteoarthritis while weight loss intervention has been shown to reduce pain and requirement of total knee replacement.
- Trial name
- ADDED (NCT07065591)
- Testing
- Metformin
- Where
- Hong Kong
- Volunteers
- 100 people
- Sponsor
- The University of Hong Kong
Osteoarthritis of Knee
Pain Relief for OsteoArthritis Through Combined Treatment (PROACT)
This mechanistic clinical trial proposes to test whether a five-day course of mindfulness meditation training (MMT) and tDCS, and their combination, can enhance pain modulatory balance and pain-related brain function, reduce…
- Trial name
- PROACT (NCT03884374)
- Testing
- Focused Breathing and Attention Training (BAT), Standard Breathing and Attention Training (BAT), Transcranial Direct Current Stimulation (tDCS)
- Where
- 2 sites in United States
- Volunteers
- 317 people
- Sponsor
- University of Florida
Exercise, Osteoarthritis
The Effects of Neuromuscular Exercises Training on Physical Activity, Functionality and Balance in Knee Osteoarthritis
This study was planned to evaluate the effect of neuromuscular exercise program on physical activity, functionality and balance in patients with knee osteoarthritis aged 35-65 years.
- Trial name
- NCT03470090
- Testing
- Neuromuscular Exercises, Conventional Group
- Where
- Turkey (Türkiye)
- Volunteers
- 81 people
- Sponsor
- Inonu University
Knee Osteoarthritis
The Relationship of Serum Uric Acid With Severity of Knee Osteoarthritis
Osteoarthritis (OA) is the most prevalent form of arthritis. Its pathogenesis remains poorly understood. Though historically regarded as a disease of mechanical degeneration, it is now appreciated that inflammation plays an…
- Trial name
- NCT06149078
- Testing
- serum uric acid
- Where
- Egypt
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Sohag University
Total Knee Replacement, Osteoarthritis of the Knee
Effectiveness of Osteopathy in the Preoperative Treatment of Postoperative Pain in Patients Undergoing Total Knee Replacement
Osteopathy is an alternative healthcare that seems effective in relieving the pain of patients. The main purpose of this study is to evaluate the efficacy of preoperative osteopathic care in patients undergoing total knee…
- Conditions
- Total Knee Replacement, Osteoarthritis of the Knee, Preoperative Osteopathic Care
- Trial name
- NCT01989117
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Hospital Ambroise Paré Paris
Knee Osteoarthritis, Pain
Duloxetine and aeRobic Exercise to Improve Function in VEterans With Knee Osteoarthritis (DRIVE)
Knee osteoarthritis (KOA) is one of the most common causes of chronic pain, mobility problems, and disability among United States Veterans.
- Conditions
- Knee Osteoarthritis, Pain, Depression
- Trial name
- DRIVE (NCT07649291)
- Testing
- Exercise, Duloxetine, PT referral
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Knee Osteoarthritis
Benefits of Spa Therapy in Saint-Lary Soulan for Knee Osteoarthritis
The hypothesis is that the use of spa therapy in Saint-Lary Soulan for knee osteoarthritis treatment would have a therapeutic effect on this pathology.
- Trial name
- LARYTHERM (NCT05790824)
- Testing
- Spa therapy
- Where
- France
- Volunteers
- 88 people
- Sponsor
- University of Bordeaux
Osteoarthritis, Knee
Study of Cingal® and Triamcinolone Hexacetonide for the Relief of Knee Osteoarthritis Pain
This is a multi-center, randomized, double-blind, parallel group, placebo controlled trial to compare the safety and effectiveness of a single injection of Cingal® to a single injection of Triamcinolone Hexacetonide (TH) to…
- Trial name
- NCT04231318
- Testing
- Cingal, Triamcinolone Hexacetonide (TH)
- Where
- 26 sites in United States
- Volunteers
- 231 people
- Sponsor
- Anika Therapeutics, Inc.
Pain, Osteoarthritis, Knee
Transdermal Ketoprofen to Treat Mild to Moderate Osteoarthritis (OA) Pain of the Knee
The purpose of the study is to evaluate the safety and effectiveness of the investigational ketoprofen patch with a controlled heating patch, compared to placebo (inactive substance) for the treatment of pain caused by…
- Trial name
- NCT00108810
- Testing
- Transdermal Ketoprofen Patch with CHADD
- Where
- 5 sites in United States
- Volunteers
- 118 people
- Sponsor
- ZARS Pharma Inc.
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.