Clinical trials: Knee Arthritis Disease
Knee Osteoarthritis
Pharmacist-initiated Intervention Trial in OsteoArthritis (PhIT-OA)
Osteoarthritis (OA) is a major public health concern. Currently, there are at least 3 million Canadians afflicted with this condition with a 50% increase predicted by 2020.
- Trial name
- NCT00391859
- Testing
- Pharmacist-Initiated Intervention in OsteoArthritis (PhIT-OA)
- Where
- Canada
- Volunteers
- 135 people
- Sponsor
- University of British Columbia
Septic Arthritis
Surgical Management of Knee Septic Arthritis
Surgical excisional debridement is the mainstay of management in septic arthritis with necessary decompression, lavage, debridement, and partial synovectomy. However, there has been considerable debate over the optimal modality.
- Trial name
- NCT04786379
- Testing
- Arthroscopic Irrigation and Debridement, Open Arthrotomy with irrigation and debridement
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Texas Tech University Health Sciences Center, El Paso
Osteoarthritis, Knee, Osteoarthritis, Hip
Perfusion MRI-targeted Joint Embolization for Chronic Musculoskeletal Pain of the Shoulder, Hip and Knee
In this work the investigators will study the relationship between chronic musculoskeletal pain and abnormal blood flow (neovascularity) around the shoulder, hip and knee.
- Conditions
- Osteoarthritis, Knee, Osteoarthritis, Hip, Osteo Arthritis Shoulders, Synovitis of Knee
- Trial name
- MRI (NCT05700682)
- Testing
- Shoulder/Hip/Knee Embolization with Embozene Microspheres
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Palo Alto Veterans Institute for Research
Knee Osteoarthritis, Arthritis
Energy Dispersive Bracing for Conservative Treatment of Knee Osteoarthritis
The goal of this study is to explore the effectiveness of a commercially available, over-the-counter knee brace in the conservative treatment of knee osteoarthritis.
- Trial name
- NCT02388646
- Testing
- Exercise Only, Brace Only, Bracing + Exercises
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Orthopaedic Research Foundation
Osteoarthritis
Zushima Plaster for Treating Knee Osteoarthritis
The purpose of this study is to further evaluate the clinical efficacy and safety of Zushima plaster for patients in knee osteoarthrosis post-marketing.
- Trial name
- NCT02770950
- Testing
- Zushima plaster with high dose, Zushima plaster with low dose, Indometacin Cataplasms
- Where
- China
- Volunteers
- 396 people
- Sponsor
- Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Osteoarthritis, Knee
SI-613 Study for Knee Osteoarthritis
The objective of the study is to evaluate the efficacy and safety of intra-articular injections of SI-613 compared with placebo for knee OA.
- Trial name
- NCT03209362
- Testing
- SI-613
- Where
- 10 sites in United States
- Volunteers
- 80 people
- Sponsor
- Seikagaku Corporation
Knee Osteoarthritis
Evaluation of the Prognostic Value of Biological Markers, Coll2-1 and Coll2-1NO2 in Patients With Symptomatic Knee Osteoarthritis
The purposes of this study are to assess the prognostic value of serum and urinary biomarkers Coll2-1 and Coll2-1NO2 at baseline, and their change over the first year, on the progression of knee osteoarthritis MRI scores at 12…
- Trial name
- PRODIGE (NCT02070224)
- Testing
- Serum and urine samples collections, Imaging (x-rays and MRI)
- Where
- 2 sites in Belgium, France
- Volunteers
- 120 people
- Sponsor
- Artialis
Knee Osteoarthritis
Gait Analysis of a Lateral-Pivot Design Total Knee Replacement
Previous motion analysis studies have demonstrated excellent ability to distinguish subtle differences in gait between normal subjects and those suffering from arthritis.
- Trial name
- NCT04275362
- Testing
- DJO Empowr PS Knee System, Stryker Triathlon Total Knee System, Biomet Vanguard Complete Knee System
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- More Foundation
Meniscus; Degeneration, Osteoarthritis, Knee
Treatment of the Medial Meniscus With the NUsurface(R) Meniscus Implant
This is a prospective, multi-center, open label, non-randomized study, evaluating the treating of medial meniscus deficiency with the NUsurface Meniscus Implant.
- Trial name
- NCT01712191
- Testing
- NUsurface Meniscus Implant
- Where
- 10 sites in Belgium, Germany and 4 more
- Volunteers
- 128 people
- Sponsor
- Phoenix Kinetics
Knee Osteoarthritis
Lysyl Oxidase and Lysyl Hydroxylase Levels in Knee Osteoarthritis
The aim of this study is to investigate the serum levels of lysyl hydroxylase, lysyl oxidase, and the lysyl oxidase-like enzymes in patients with different stages of knee osteoarthritis and to compare these findings with those of…
- Trial name
- KNEELOX (NCT07875296)
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Afyonkarahisar Health Sciences University
Knee Osteoarthritis, Knee Pain Chronic
iPACK Block for Total Knee Arthroplasty
This randomized, double-blinded, placebo-controlled trial seeks to evaluate the efficacy of the rehabilitation process of the Interspace between the Popliteal Artery and Capsule of the Posterior Knee (iPACK) block in total knee…
- Conditions
- Knee Osteoarthritis, Knee Pain Chronic, Knee Disease
- Trial name
- NCT06087562
- Testing
- Ropivacaine 0.5% Injectable Solution 20mL, 0,9% normal saline 20mL
- Where
- Poland
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Poznan University of Medical Sciences
Arthroplasty, Replacement, Knee, Recovery of Function
The Influence of Rapid Recovery on Sleep Quality Following Total Knee Replacement Surgery
The purpose of this study is to evaluate the influence of rapid recovery on sleep quality following total knee replacement surgery.
- Conditions
- Arthroplasty, Replacement, Knee, Recovery of Function, Arthritis, Rheumatoid
- Trial name
- NCT02845960
- Testing
- rapid recovery
- Where
- China
- Volunteers
- 170 people
- Sponsor
- Southwest Hospital, China
Acute Blood Loss Anemia, Osteoarthritis, Knee
Topical Tranexamic Acid and Acute Blood Loss in Total Knee Arthroplasty
This study aims to assess postoperative blood loss and transfusion rates in total knee replacement after one-time administration of topical tranexamic acid.
- Trial name
- NCT01370460
- Testing
- Tranexamic Acid
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- Henry Ford Health System
Osteoarthritis, Knee
Study of Various Insoles in Patients With Knee Osteoarthritis
It is critical to improve our understanding of knee osteoarthritis and to design better therapeutic options for this disease. The function of the knee during walking is an important factor in the development and progression of…
- Trial name
- NCT02530684
- Testing
- insole
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Lausanne Hospitals
Knee Arthritis, Knee Osteoarthritis
Role of Suzetrigine as a Part of a Multimodal Regimen to Reduce Pain and Opioid Use After Total Knee Arthroplasty
This study is a prospective, single-arm interventional trial enrolling patients undergoing total knee arthroplasty (TKA) for knee arthritis.
- Trial name
- NCT07624526
- Testing
- Suzetrigine
- Where
- 3 sites in United States
- Volunteers
- 75 people
- Sponsor
- Emory University
Osteoarthritis, Knee, Knee Pain Chronic
Finding the Optimal Aim of Correction in Opening Wedge High Tibial Osteotomy
The purpose of this RCT is to investigate whether high tibial osteotomy using 3D printed patient specific guides aiming at 55% correction is non-inferior to aiming at 62%.
- Conditions
- Osteoarthritis, Knee, Knee Pain Chronic, Arthralgia
- Trial name
- NCT06134050
- Testing
- Procedure: HTO using PSI aiming at 55% correction, Procedure: HTO using PSI aiming at 62% correction
- Volunteers
- 70 people
- Sponsor
- Vestre Viken Hospital Trust
Knee Osteoarthritis
Evaluation of the Efficacy of a Home-Use Photobiomodulation Device for the Treatment of Patients With Knee Osteoarthritis: A Prospective Double Blind, Randomized, Sham-Controlled Clinical Study
Osteoarthritis (OA) is a degenerative disease affecting joint cartilage and its surrounding tissue. It is the leading cause of disability in the elderly.
- Trial name
- NCT04276038
- Testing
- B-Cure laser pro
- Volunteers
- 52 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Osteoarthritis, Osteo Arthritis Knee
Functionally Aligned vs Mechanical Axis Aligned Total Knee Arthroplasty
The objective of this study is to compare clinical and radiological outcomes in robotic-arm assisted TKA using mechanical alignment (MA TKA) versus robotic-arm assisted TKA with functional alignment (FA TKA).
- Trial name
- FATKAvsMATKA (NCT04748510)
- Testing
- Functionally Aligned Total Knee Arthroplasty, Mechanically Aligned Total Knee Arthroplasty
- Where
- 2 sites in Australia
- Volunteers
- 100 people
- Sponsor
- Perth Hip and Knee
Knee Osteoarthritis
Efficacy and Safety Evaluation of Acupoint Application in the Treatment of Knee Osteoarthritis Joint Pain
To evaluate the efficacy and safety of acupoint application of Traditional Chinese medicine in the treatment of KOA joint pain through a prospective, randomized, double-blind, placebo-controlled clinical study.
- Trial name
- NCT05449613
- Testing
- acupoint application
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Knee Osteoarthritis
Effects of Glucosamine on Joint Fluid in Osteoarthritis Patients
Osteoarthritis (OA) is the most common joint disease associated with aging. Although many patients take glucosamine supplements as a non-traditional treatment for osteoarthritis, the effectiveness of these supplements is…
- Trial name
- NCT01074476
- Testing
- Glucosamine sulphate
- Where
- 2 sites in Canada
- Volunteers
- 20 people
- Sponsor
- University of British Columbia
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