Clinical trials: Knee Arthritis Disease
Knee Osteoarthritis
ACB With S-ESPB Versus ACB With iPACK for Knee Arthroplasty
This study will compare two regional anesthesia strategies for pain management after total knee arthroplasty in adults. Both strategies use an adductor canal block (ACB) to provide analgesia while preserving quadriceps muscle…
- Trial name
- NCT07288970
- Testing
- Adductor Canal Block, Sacral Erector Spinae Plane Block, iPACK Block
- Where
- Poland
- Volunteers
- 80 people
- Sponsor
- Poznan University of Medical Sciences
Knee Osteoarthritis
Homologus PRP in the Infiltrative Treatment of Knee Osteoarthritis in Young Athletic Patients
The study consists of 3 phases (enrollment, infiltrative procedure, and controls): Identification by specialized orthopedic medical staff belonging to the SC Orthopedic and Trauma Clinic II of the Rizzoli Orthopedic Institute of…
- Trial name
- NCT06483269
- Testing
- PRP infiltration
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Istituto Ortopedico Rizzoli
Knee Osteoarthritis, Biofiller PRP
Evaluation of the Effect of Biofiller PRP Application on Knee Osteoarthritis
The aim of this study is to evaluate the effects of biofiller PRP on function, pain level, and femoral cartilage thickness in knee osteoarthritis: a randomized clinical study
- Conditions
- Knee Osteoarthritis, Biofiller PRP, Femoral Cartilage Thickness
- Trial name
- NCT06946056
- Testing
- Biofiller platelet rich plasma
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Necmettin Erbakan University
Knee Osteoarthritis
Physica CR and Physica PS Clinical Trial
Type \& Design: Post-market, international, multicentre Prospective, parallel groups, open-label, baseline controlled Objectives: 1.
- Trial name
- NCT02766231
- Testing
- Physica CR, Physica PS
- Where
- 4 sites in Belgium, Italy and 1 more
- Volunteers
- 157 people
- Sponsor
- Limacorporate S.p.a
Rehabilitation, Excercise
The ACT-ON: A Geriatric 5-Ms-Guided Physical Therapy Intervention for Knee Osteo-Arthritis in Older Adults.
The study is a Random control trail study conducted at King Khalid University Hospital in Riyadh, Saudi Arabia, focusing on Application of 5 framework in rehabilitation program of knee arthritis.
- Conditions
- Rehabilitation, Excercise, Geriatric, Physical Therapy
- Trial name
- 5Ms/PT/KOA/OA (NCT07640529)
- Testing
- Geriatric 5Ms framework, Exercises PT
- Where
- Saudi Arabia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- King Saud University
DVT, Osteoarthritis
Does Thinning the Blood During Surgery Prevent Blood Clots Following Total Knee Replacement Surgery
The goal of this study is to prevent blood clots from forming during surgery and a few days after total knee replacement surgery.
- Trial name
- NCT00253851
- Testing
- unfractionated heparin
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Ottawa Hospital Research Institute
Knee Osteoarthritis
Comparing Effect of Autologous Platelet-Rich Plasma Versus Hyaluronic Acid Treatment on Knee Osteoarthritis
To compare the efficacy and structural change of intraarticular single platelet-rich plasma(PRP) versus novel crosslinked Hyaluronic Acid(HA)(HyajointPlus) for the treatment of early stage knee osteoarthritis(OA).
- Trial name
- NCT04972383
- Testing
- Platelet Rich Plasma, Hyaluronic Acid
- Where
- Taiwan
- Volunteers
- 116 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Knee Osteoarthritis
Evaluation of the Effect of the "CR500 SINGLE-DOSE GEL" Medical Device in Patients With Knee Osteoarthritis (KOA)
Single arm clinical investigation, post-market confirmatory interventional to assess performance, safety and tolerability of "CR500 SINGLE-DOSE GEL" medical device in patients with knee osteoarthritis (KOA).
- Trial name
- NCT05661162
- Testing
- CR 500™ SINGLE-DOSE GEL
- Where
- Italy
- Volunteers
- 38 people
- Sponsor
- Contrad Swiss SA
Osteoarthritis, Knee, Osteoarthritis, Hip
Liposomal Bupivacaine Versus Standard Analgesia in Total Joint Arthroplasty (TJA)
The purpose of this study is to determine whether liposomal bupivacaine is effective in the management of pain following total joint arthroplasty, as compared to standard of care analgesia.
- Conditions
- Osteoarthritis, Knee, Osteoarthritis, Hip, Osteoarthritis, Shoulder
- Trial name
- NCT02197273
- Testing
- Liposomal bupivacaine, Standard of care analgesia
- Where
- United States
- Volunteers
- 211 people
- Sponsor
- OhioHealth
Osteo Arthritis Knee
High Versus Low Adductor Canal Block
The investigators will be comparing the efficacy of two different techniques for performing an adductor canal block to the saphenous nerve as a part of the multimodal pain control regimen for total knee arthroplasty.
- Trial name
- NCT04155983
- Testing
- Ropivacaine
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Carilion Clinic
Knee Osteoarthritis, Mind-body Exercise
Tai Chi for Knee OA Pain Management: a Mechanistic Study
This study is to determine how 8-week Tai Chi intervention alters plasma endocannabinoid and its receptors in monocytes/marcrophages, plasma oxylipinds, plasma brain-derived neurotrophic factor, brain white matter…
- Trial name
- NCT04046003
- Testing
- Tai chi exercise
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Texas Tech University Health Sciences Center
Knee Osteoarthritis
Platform Exercise Training
The purpose of this randomized, controlled trial is to determine whether a vibration platform exercise program will be more effective than a standard platform exercise program in improving quadriceps strength in women age 45-60…
- Trial name
- NCT01239823
- Testing
- Whole Body Vibration Training, Exercise without vibration
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Knee Osteoarthritis
Effects of α MAT Versus Steroid Injection in Knee Osteoarthritis (STα MAT-knee Study)
Knee Osteoarthritis (OA) is a common degenerative knee condition of the knee which is treated symptomatically. Knee cartilage tissue has little regenerative ability With the developments in regenerative medicine, stem cells might…
- Trial name
- NCT04230902
- Testing
- Microfragmented Adipose Tissue Transplant, Corticosteroid injection
- Where
- Lebanon
- Volunteers
- 48 people
- Sponsor
- American University of Beirut Medical Center
Osteoarthritis
The Subvastus Approach in Total Knee Arthroplasty
The purpose of this study is to determine if the observed benefits of minimally invasive total knee arthroplasty, namely decreased hospital stay and increased range of motion, can be achieved with standard knee arthroplasty using…
- Trial name
- NCT00346788
- Testing
- Surgical approach for total knee arthroplasty
- Where
- Canada
- Volunteers
- 126 people
- Sponsor
- Nova Scotia Health Authority
Osteoarthritis
A Study Evaluating the Efficacy of a Single Injection Autologous Adipose Derived Mesenchymal Stromal Cells in Patients With Knee Osteoarthritis
ASCs will be administered via intra-articular use into the knee joint affected by OA where they are expected to exert their therapeutic effects.
- Trial name
- ADIPOA-2 (NCT02838069)
- Testing
- Injection (2x106 ASC/5ml)., Injection (10x106 ASC/5ml).
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Montpellier
Osteoarthritis, Knee
An Evaluation of a Gender Specific Insole to Provide Relief From Knee Pain Due to Osteoarthritis or General Anterior Knee Pain in Male Subjects When Used in Foot Wear Over a Period of Four Weeks
The primary objective of this trial is to demonstrate the ability of a full length foam insole to provide relief from pain due to osteoarthritis of the knee or general knee pain when used in foot wear for a 4-week period of time.
- Trial name
- NCT03556787
- Testing
- BPI 1000013 (Dr Scholls Insole)
- Where
- 2 sites in United States
- Volunteers
- 89 people
- Sponsor
- Bayer
Osteoarthritis, Knee
A Prospective Randomized Trial Using Roentgen Stereophotogrammetric Analysis of the Advance Medial Pivot Knee
The purpose of this study is to determine whether this particular knee replacement is better than those already on the market. By participation, it will further refine the design of future total knee replacements and perhaps…
- Trial name
- NCT00405470
- Testing
- Advance Medial Pivot Knee Arthroplasty
- Volunteers
- 80 people
- Sponsor
- Dalhousie University
Osteoarthritis, Knee
A Proof-of-concept Study to Examine QUC398 in Participants With Knee OA
The purpose of the study was to find out if the investigational treatment named QUC398 had beneficial effects on osteoarthritis (OA) knee pain and knee cartilage, and if it was safe and tolerated.
- Trial name
- NCT05462990
- Testing
- QUC398
- Where
- 14 sites in United States, Australia and 3 more
- Volunteers
- 101 people
- Sponsor
- Novartis Pharmaceuticals
Knee Osteoarthritis
Radio-frequency Ablation in Knee Osteoarthritis by Three Needles Technique
The study is designed to evaluate and compare the efficacy of three needles approach as a new technique in radiofrequency neurotomy of genicular nerve versus the traditional single needle approach as a treatment of advanced knee…
- Trial name
- NCT03613610
- Testing
- Radio-frequency ablation of genicular nerves
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Alaa Fouli Gaber Ebrahim
Osteoarthritis of the Knee
Efficacy and Safety of the Lidoderm Patch Applied to Patients With Osteoarthritis of the Knee
Patients with knee pain due to Osteoarthritis (OA) experiencing sub-optimal pain relief from their current analgesic regimen will participate in a pilot clinical trial to evaluate the effectiveness and tolerability of the…
- Trial name
- NCT00589979
- Testing
- Lidoderm (Lidocaine 5% Patch)
- Where
- 20 sites in United States
- Volunteers
- 169 people
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company
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