Clinical trials: Knee Arthritis Disease
Knee Osteoarthritis
Factors Predicting the Duration of Effectiveness of Viscosupplementation in Knee Arthosis
Knee osteoarthritis is a frequent condition whose prevalence is estimated at 7.6% of the French population aged 40 to 75, or approximately 2 million individuals .
- Trial name
- PRESAGE (NCT04988698)
- Testing
- none intervention
- Where
- France
- Volunteers
- 103 people
- Sponsor
- Hopital Nord Franche-Comte
Osteoarthritis of the Knee
A Phase 2, Open Label, Pharmacokinetic (PK) Study of TLC599 in Subjects With Osteoarthritis of the Knee
This study is a multi-center, Phase 2, open-label, 1-period, parallel study with 9 cohorts of subjects with osteoarthritis (OA) of the knee enrolled to receive single-dose of TLC599 or Dexamethasone sodium phosphate (DSP) via IA…
- Trial name
- NCT03754049
- Testing
- TLC599, DSP
- Where
- 10 sites in United States, Taiwan
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Taiwan Liposome Company
Osteoarthritis
Assessment of Conventional and Patient-specific Instrumentation in Total Knee Arthroplasty
This study will use a special type of x-ray called radiostereometric analysis (RSA) imaging to determine whether patient-specific instrumentation for total knee arthroplasty (replacement) has an effect on implant loosening…
- Trial name
- NCT02230215
- Testing
- Total Knee Arthroplasty with use of Visionaire Patient-Specific Instrumentation
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Osteoarthritis
Clinical Efficacy of Tranexamic Acid and ε-Aminocaproic Acid in Reducing Blood Loss Following Total Knee Replacement
Tranexamic acid (TXA) and ε-aminocaproic acid (EACA) are two drugs shown to limit blood loss following major surgery, from cardiac to orthopedic procedures.
- Trial name
- NCT01873768
- Testing
- Tranexamic Acid (TXA), ε-Aminocaproic Acid (EACA)
- Where
- United States
- Volunteers
- 194 people
- Sponsor
- Miller Orthopedic Specialists
Osteoarthritis
A Study of the Safety and Effectiveness of Orally Administered CR845 in Patients With Osteoarthritis of the Hip or Knee
To assess the safety and tolerability of orally-administered CR845 in patients with osteoarthritis (OA) of the hip or knee. The study drug is being tested to reduce OA pain, and will be taken twice a day for two weeks, with four…
- Trial name
- NCT02524197
- Testing
- CR845 0.25 mg, CR845 0.50 mg, CR845 1 mg
- Where
- 5 sites in United States
- Volunteers
- 81 people
- Sponsor
- Cara Therapeutics, Inc.
Knee Osteoarthritis, Arthroplasty, Knee Replacement
Comparison of High Intensity Strength Training and Muscle Energy Techniques in TKR Patients
Globally, the prevalence of total joint replacement (TKR) procedures has been rising, providing patients with better joint function, decreased pain, and enhanced quality of life.
- Conditions
- Knee Osteoarthritis, Arthroplasty, Knee Replacement, Resistance Training
- Trial name
- NCT06407778
- Testing
- High Intensity Strength Training, Muscle Energy Technique
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- Riphah International University
Knee Osteoarthritisorconventional Radiofrequencyandgeniculated Nerves
EFFECTIVENESS OF CONVENTIONAL RADIOFREQUENCY OF THE GENICULAR NERVES GUIDED BY SCOPIC VERSUS ULTRASOUND FOR THE TREATMENT OF POSTQUIRURGICAL GONALGIA
Knee osteoarthritis is one of the most common joint conditions in the elderly population, characterized by causing pain, stiffness and functional disability in a significant number of cases.
- Trial name
- NCT06613815
- Testing
- radiofrequency of the geniculate nerves
- Where
- Spain
- Volunteers
- 57 people
- Sponsor
- Fundación Pública Galega Instituto de Investigación Sanitaria.
Osteoarthritis
Comparison of Function and Fit of Standard and Gender-Specific CR High-Flex Total Knee Prostheses
The purpose of this prospective, randomized study was to compare functional outcome, radiographic results, range of motion, patients satisfaction, and fit of the femoral component in patients receiving either a standard posterior…
- Trial name
- CR (NCT00916968)
- Testing
- Standard CR-Flex total knee, Gender specific CR-Flex
- Where
- South Korea
- Volunteers
- 146 people
- Sponsor
- Ewha Womans University
Osteo Arthritis of the Knee, Obesity & Overweight
Alignment Techniques in TKA RCT
The purpose of this research study is to compare two different methods used to align the knee during a total knee arthroplasty (TKA): technology-assisted inverse kinematic alignment, and manual-instrumented gap balancing…
- Trial name
- NCT07646158
- Testing
- Technology-assisted inverse kinematic alignment TKA, Manual-instrumented gap balancing alignment TKA
- Volunteers
- 80 people
- Sponsor
- Jacob M. Elkins
Osteoarthritis, Knee, Rheumatoid Arthritis of Knee
Evaluation of The Safety And Performance of The Freedom Total Knee® System With The PEEK-OPTIMA Femoral Component
Prospective, multi-centre, non-comparative, post-market surveillance clinical study
- Conditions
- Osteoarthritis, Knee, Rheumatoid Arthritis of Knee, Traumatic Arthritis of Knee (Diagnosis), Polyarthritis
- Trial name
- NCT03224689
- Testing
- PEEK-Optima Femoral Component
- Where
- Belgium
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Maxx Orthopedics Inc
Arthritis, Knee Arthropathy
Robotic-Assisted Versus Conventional Total Knee Arthroplasty(TKA)
Robotic-assisted total knee arthroplasty (TKA) was introduced to attempt to enhance the precision of bone preparation, component alignment and ultimately improve clinical results and survivorship of TKA.
- Conditions
- Arthritis, Knee Arthropathy, Robotics
- Trial name
- NCT03659318
- Testing
- Robotic-assisted TKA, Conventional TKA
- Volunteers
- 674 people
- Sponsor
- Ewha Womans University
Exercise Therapy
The Study of Neuromuscular Exercise Therapy and Patients Self-management Program in Knee Osteoarthritis
Osteoarthritis is the most common chronic disabling disease,the importance of patient's self-management in chronic disease has been paid more and more attention internationally.
- Trial name
- NCT03363490
- Testing
- Self-management program, Neuromuscular exercise therapy, Health education
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Peking University People's Hospital
Juvenile Idiopathic Arthritis (JIA)
Short-Term Effects of Intra-Articular Corticosteroid Injection on Knee Function in Juvenile Idiopathic Arthritis
The purpose of this study is to evaluate the short-term clinical effects of intra-articular corticosteroid injections on knee joint functions in children and adolescents diagnosed with Juvenile Idiopathic Arthritis (JIA).
- Trial name
- NCT07709026
- Testing
- Intra-articular Corticosteroid Injection
- Where
- Turkey (Türkiye)
- Volunteers
- 17 people
- Sponsor
- Necmettin Erbakan University
Knee Osteoarthritis, Knee Arthropathy
Clinical Outcomes Between Tibial Preservation Bone Cut and Conventional Tibial Bone Cut Following Medial UKA
The mobile bearing unicompartmental knee arthroplasty has shown excellent clinical outcome and survivorship. However, some studies have shown that the patients still had medial knee pain and shown worst the clinical outcome, even…
- Trial name
- NCT04419116
- Testing
- tibial preservation bone cut
- Where
- Thailand
- Volunteers
- 100 people
- Sponsor
- Thammasat University
Osteoarthritis
Study to Evaluate the Efficacy of Milnacipran in the Treatment of Pain Due to Osteoarthritis
The present study will aim to evaluate the efficacy of milnacipran in the treatment of pain due to osteoarthritis (OA), that is, to determine whether milnacipran provides superior efficacy to placebo in patients with OA.
- Trial name
- NCT01329406
- Testing
- Milnacipran
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Analgesic Solutions
Knee Osteoarthritis
Combined Application of Electrical Stimulation and Volitional Contractions for Muscle Strengthening and Knee Pain Inhibition (Seated Study)
The purpose of this study is to assess the efficacy of a 12-week low-load neuromuscular electrical stimulation with volitional contraction (NMES-VC) training program to improve quadriceps strength and activation, while not…
- Trial name
- NCT02802878
- Testing
- Hybrid Training using Electrodes and Joint Motion Sensors, Isokinetic Training with Isokinetic Dynamometer
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of Kansas Medical Center
Osteoarthritis, Knee
Efficacy and Safety Trial of PTP-001 (MOTYS) for Symptomatic Knee Osteoarthritis
Evaluation of safety, tolerability and efficacy of a single intra-articular (IA) injection of PTP-001, an allogeneic placental tissue particulate, in individuals with knee osteoarthritis (OA).
- Trial name
- NCT05100225
- Testing
- PTP-001
- Where
- 14 sites in Australia, Canada and 1 more
- Volunteers
- 210 people
- Sponsor
- Bioventus LLC
Osteoarthritis, Knee
Dry Needling and Exercise Program in Osteoarthritis
Osteoarthrosis (OA) is a chronic degenerative disease that affects the joints, knee OA is the most prevalent type, affecting 265 million people worldwide, more than 40% of adults over 45 years of age, being one of the greatest…
- Trial name
- NCT06816940
- Testing
- CONTROL GROUP:, EXPERIMENTAL GROUP
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Manuel Albornoz Cabello
Gonarthrosis, Obesity
Adipose Tissue and Symptomatic Gonarthrosis
1. Prevalence of osteoarthritis in France Osteoarthritis (OA) is a very common disease, affecting almost 15% of the population. It is responsible for a significant socio-economic cost in connection with the chronic and disabling…
- Trial name
- TAGS (NCT06314191)
- Testing
- blood sampling, knee radiography
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Osteoarthritis
Comparative Assessment of Viscosupplementation With Polynucleotides and Hyaluronic Acid
The purpose of the study is to assess the validity of the polynucleotide within the intra articular treatment of osteoarthritis of the knee, comparing it with that of hyaluronic acid, the most commonly used.
- Trial name
- PNHA1401 (NCT02417610)
- Testing
- Polynucleotide - PNHA - Newart, Hyaluronic acid - HA - Ialart
- Where
- Italy
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Istituto Ortopedico Rizzoli
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