Clinical trials: Knee Arthritis Disease
Postsurgical Pain
Multiprofen-CC™ to Reduce Pain After Total Knee Arthroplasty
Total knee arthroplasty is a surgical treatment which involves replacing the damaged articular cartilage of the knee joint with an artificial prosthetic in end-stage knee osteoarthritis.
- Trial name
- MP-TKA (NCT06202989)
- Testing
- Multiprofen-CC™ plus standard treatment
- Where
- Canada
- Volunteers
- 306 people
- Sponsor
- KAZM Pharmaceuticals Inc.
Knee Osteoarthritis
A Study to Evaluate the Safety and Efficacy of CNTX-6970 in Subjects With Knee Osteoarthritis Pain.
The primary objective of this study is to evaluate the safety and efficacy of CNTX-6970 for the treatment of pain related to OA of the knee compared to placebo.
- Trial name
- NCT05025787
- Testing
- CNTX-6970
- Where
- 16 sites in United States
- Volunteers
- 55 people
- Sponsor
- Maurizio Fava, MD
Sleep Initiation and Maintenance Disorders, Osteoarthritis
Sleep in Osteoarthritis Project
Osteoarthritis (OA) is one of the most common diseases and one of the leading causes of disability in the world. People with OA frequently experience sleep disturbances, primarily due to pain.
- Trial name
- SOAP (NCT00592449)
- Testing
- Cognitive behavioral therapy (CBT) for insomnia, Behavioral desensitization treatment for insomnia
- Where
- United States
- Volunteers
- 209 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Osteoarthritis, Knee
A Study Evaluating the Safety, Tolerability, and Range of Biologically Active Doses of ICM-203 in Mild to Moderate Knee Osteoarthritis
The purpose of this study is to determine the safety, tolerability, and activity of ICM-203, a recombinant adeno-associated viral (AAV) vector that expresses a therapeutic gene that promotes cartilage formation, reduces joint…
- Trial name
- NCT04875754
- Testing
- ICM-203
- Where
- 2 sites in Australia
- Volunteers
- 12 people
- Sponsor
- ICM Biotech Australia Pty Ltd.
Osteoarthritis
Comparison of Femoral Nerve Catheter and Adductor Canal Block With Steroid Adjuvant in Total Knee Replacement (TKR)
We hypothesize continuous adductor canal block with steroid adjuvant would offer no inferior analgesics and rehabilitation ability than continuous femoral nerve block for postoperative patients receiving total knee arthroplasty.
- Trial name
- NCT01973530
- Testing
- adductor canal block, femoral nerve block
- Where
- Hong Kong
- Volunteers
- 80 people
- Sponsor
- Queen Elizabeth Hospital, Hong Kong
Knee Osteoarthritis
Post-market Study on TrHCROSS® in Knee Osteoarthritis After a Single Injection
Double-blind study assessing the safety and efficacy of TrHCROSS® in knee osteoarthritis, compared to Hyalone®, using scales such as WOMAC, VAS, and KOOS.
- Trial name
- NCT06975631
- Testing
- TrHCROSS®, Hyalone®
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- i+Med S.Coop.
Osteoarthritis, Knee, Osteoarthritis, Hip
Wound Closure Materials and Techniques in Hip and Knee Arthroplasty
This prospective randomized clinical study aims to evaluate the effects of different suture materials and wound closure techniques on wound healing, functional outcomes, and postoperative complications in patients undergoing…
- Trial name
- NCT07439575
- Testing
- Barbed Suture Wound Closure, Conventional Suture Wound Closure
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Bahattin Kemah
Knee Osteoarthritis
Cellular Matrix Device for the Treatment of Mild to Moderate Knee Osteoarthritis
This is a non-inferiority study on 190 patients to evaluate whether a treatment based on the combination of autologous platelet-rich plasma and hyaluronic acid obtained with Cellular Matrix represents a therapeutic advantage to…
- Trial name
- NCT03328728
- Testing
- Cellular Matrix / A-CP HA Kit, Synvisc-One
- Where
- France
- Volunteers
- 190 people
- Sponsor
- Regen Lab SA
Knee Osteoarthrosis
Use of Extracellular Vesicles (EV) for Knee Osteoarthrosis
Extracellular vesicles (EV) will be injected in patients diagnosed with Knee osteoarthrosis
- Trial name
- NCT06937528
- Testing
- Extracellular vesicles
- Where
- Jordan
- Volunteers
- 50 people
- Sponsor
- University of Jordan
Osteoarthritis
Effectiveness Of Single Doses Of Ibuprofen In Patients With Osteoarthritis Of The Knee
To demonstrate that new drugs work, many complex multidose studies are often required. The intent of this study is to use Ibuprofen as an example of a marketed pain relief drug to validate a simpler single dose model for future…
- Trial name
- NCT00372801
- Testing
- Ibuprofen
- Where
- Australia
- Volunteers
- 36 people
- Sponsor
- GlaxoSmithKline
Knee Osteoarthritis
Combination of PRP and XLHA Prepared With RegenMatrix Medical Device To Treat Moderate to Severe Knee Osteoarthritis
In this clinical trial the investigator assess the safety and efficacy of a single injection of a combination of cross-linked hyaluronic acid (HA) with autologous platelet-rich plasma (PRP) obtained with the RegenMatrix medical…
- Trial name
- NCT05727371
- Testing
- Regen Matrix-PRP-XLHA, Hylan G-F 20
- Where
- 13 sites in France
- Volunteers
- 280 people
- Sponsor
- RegenLab France SAS
Knee Osteoarthritis
Effects of Mulligan Mobilization With Movement as Compared to Kaltenborn Joint Mobilization in the Management of Knee Osteoarthritis
This study is a randomised controlled trial and the purpose of this study is to determine the Effects of Mulligan mobilization with movement as compared to Kaltenborn joint mobilization in the management of knee osteoarthritis."…
- Trial name
- NCT06444945
- Testing
- Heating pad, Transcutaneous electrical nerve stimulation(TENS), Mulligan mobilization with movement (MWM)
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Foundation University Islamabad
Knee Arthroplasty, Total, Robotic Surgical Procedures
ROSA® Knee System V1.5 Pilot Study
This pilot study seeks to evaluate the initial safety and usability of new features for the ROSA® Knee System, v1.5 and plan design modifications as needed. The primary objectives will be assessed by measuring: 1.
- Conditions
- Knee Arthroplasty, Total, Robotic Surgical Procedures, Joint Diseases, Knee Osteoarthritis
- Trial name
- NCT07009912
- Testing
- Total Knee Arthroplasty
- Where
- New Zealand
- Volunteers
- 40 people
- Sponsor
- Zimmer Biomet
Osteoarthritis,Knee
Cryotherapy Associated With Exercise in Pain Control and Physical Function in Individuals With Knee Osteoarthritis
The purpose of this study is to verify the effect of cryotherapy associated with an exercise protocol in pain control, function and quality of life in individuals with knee osteoarthritis
- Trial name
- NCT03360500
- Testing
- EXERCISE PROTOCOL + CRYOTHERAPY, EXERCISE PROTOCOL
- Where
- Brazil
- Volunteers
- 120 people
- Sponsor
- Universidade Federal de Sao Carlos
Knee Osteoarthritis
Zurich Multiple Endpoint Vitamin D Trial in Knee OA Patients
This is a 2-year double-blind randomized controlled trial in 287 community-dwelling individuals age 60 years or older undergoing uni-lateral total knee replacement due to severe OA of the knee.We compare an oral dose of 2000 IU…
- Trial name
- NCT00599807
- Testing
- Vitamin D3 (cholecalciferol)
- Where
- Switzerland
- Volunteers
- 273 people
- Sponsor
- University of Zurich
Osteoarthritis, Degenerative Joint Disease
The Study of Physical Activity Rewards After Knee Surgery
The objectives of this research are to conduct a proof of concept randomized controlled trial with 200 patients undergoing primary total knee replacement (TKR) at Brigham and Women's Hospital (BWH).
- Trial name
- SPARKS (NCT01970631)
- Testing
- Motivational Interviewing (MI), Financial Incentives
- Where
- United States
- Volunteers
- 202 people
- Sponsor
- Brigham and Women's Hospital
Knee Osteoarthritis
Electromyographic Biofeedback on Performance of Vastus Medialis Oblique Muscle in Knee Osteoarthritis
This study intends to determine the Effects of Electromyographic biofeedback on performance of vastus medialis oblique muscle in knee osteoarthritis.
- Trial name
- NCT04194853
- Testing
- Electromyographic Biofeedback, Quadriceps Isometric exercises
- Where
- Pakistan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Arthritis Knee, Gait Biomechanics
Muscles Strength and Gait Parameteres After TKA
Total Knee Arthroplasty (TKA) is actually the most effective treatment option for patients with end-stage osteoarthritis (OA). However, nearly 20% of patients who underwent TKA remain unsatisfied with their clinical outcome.
- Conditions
- Arthritis Knee, Gait Biomechanics, Total Knee Arthroplasty, Muscle Strength
- Trial name
- NCT06061367
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Medical University of Warsaw
Knee Osteoarthritis (Knee OA)
Randomized Controlled Study Evaluating Genicular Artery Embolization Against Intra-Articular Corticosteroid Knee Injection for Osteoarthritic Knee Pain
Multi-center, prospective, randomized trial of GAE using Nexsphere-F against steroid injection
- Trial name
- RESORB (NCT06872567)
- Testing
- genicular artery embolization, Corticosteroid Injection
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- North American Science Associates Ltd.
Knee Osteoarthritis
the New Biomarker of the Knee Osteoarthritis Knee Osteoarthritis Occurrence and Progression
It was previously proved an association of TGF-β1 and PDGF-BB with the pathogenesis of osteoarthritis (OA) by experiments of OA animal models.
- Trial name
- NCT03015688
- Testing
- x-ray images
- Volunteers
- 460 people, healthy volunteers welcome
- Sponsor
- Shihezi University
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