Clinical trials: Knee Arthritis Disease
Osteoarthritis
Medial vs Lateral Approach for Total Knee Replacement on Valgus Knee: a Randomized Clinical Trial
The most common surgical approach to perform a total knee replacement is called medial parapatellar approach. It's effective and can be applied virtually to all types of knee deformities.
- Trial name
- ValgusKnee (NCT01965886)
- Testing
- Medial approach, Keblish approach
- Where
- Brazil
- Volunteers
- 126 people
- Sponsor
- University of Sao Paulo General Hospital
Knee Osteoarthritis
TENS Effectiveness and Knee Osteoarthritis in Humans
TENS is a non pharmacological intervention to control pain. Both high (>50 Hz) and low (<10 Hz) frequency TENS are used in the clinic and it is thought that each type works through different mechanisms (see for review Sluka and…
- Trial name
- TOPS (NCT01354054)
- Testing
- High Frequency TENS, Low frequency TENS
- Where
- 3 sites in United States, Brazil and 1 more
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Knee Osteoarthritis
Effect of Biomagnetic Therapy on Gonarthrosis
In order to assess the effectiveness of biomagnetic therapy (PST) in the treatment of gonarthrosis, we conducted a randomized, double blind controlled clinical trial comparing one group of patients treated with PST and a second…
- Trial name
- NCT00415662
- Testing
- Pulsed Signal Therapy (PST)
- Where
- Switzerland
- Sponsor
- University of Lausanne Hospitals
Knee Osteoarthritis
Safety of Single Doses of SAR113945 and Efficacy and Safety of a New Formulation Given Into the Knee in Osteoarthritis Patients / Part I
Study objectives: Part 1 TDU11685 To assess in patients with knee Osteoarthritis (OA), the safety, tolerability and pharmacokinetics (PK) of single intra-articular doses of SAR113945.
- Trial name
- NCT01463488
- Testing
- SAR113945
- Where
- Germany
- Volunteers
- 24 people
- Sponsor
- Sanofi
Knee Osteoarthritis
Efficacy of High Power Laser Versus Low Level Laser in Ultrasonographic and Functional Outcomes in Patients With Knee Osteoarthritis
this study will be conducted to compare between high power laser and low-intensity laser on ultrasonographic and functional outcomes in patients with knee osteoarthritis
- Trial name
- OA (NCT06419569)
- Testing
- high power laser, low level laser, conventional physical therapy
- Volunteers
- 90 people
- Sponsor
- Cairo University
Knee Osteoarthritis, Mechanical Traction
MECHANICAL TRACTION APPLIED BEFORE VERSUS AFTER THERAPEUTIC EXERCISES IN PRIMARY KNEE OSTEOARTHRITIS
To study the effect of application of mechanical traction before versus after therapeutic exercises and exercise alone ,on pain severity , disability , knee joint range of motion , knee joint position sense , knee isometric…
- Trial name
- MT-KOA (NCT07613749)
- Testing
- Group A: Therapeutic exercise group, Group B: mechanical traction followed by therapeutic exercise, Group C: therapeutic exercise followed by mechanical traction
- Where
- Egypt
- Volunteers
- 63 people
- Sponsor
- Cairo University
Gonarthrosis, Knee Osteoarthritis
Evaluation of Intra-articular Injection of Autologous Protein Solution ("APS(TM)") for the Treatment of Osteoarthritis (OA)
This prospective single-center study will evaluate the safety and tolerability of a single dose of "APS(TM)" treated patients with OA of the knee who have failed conservative OA therapy.
- Conditions
- Gonarthrosis, Knee Osteoarthritis, Osteoarthritis
- Trial name
- NCT01773226
- Testing
- Autologous Protein Solution "APS(TM)"
- Where
- Netherlands
- Volunteers
- 11 people
- Sponsor
- Zimmer Biomet
Knee Osteoarthritis
ACB and iPACK Blocks With Intravenous Dexamethasone and Perineural Dexmedetomidine in Total Knee Arthroplasty
This prospective randomized controlled trial aims to compare the analgesic efficacy and safety of three adjuvant strategies for ultrasound-guided Adductor Canal Block (ACB) and iPACK block in patients undergoing elective total…
- Trial name
- NCT07677215
- Testing
- Ropivacaine 0.2% Injectable Solution, Dexamethasone, Dexmedetomidine
- Where
- 2 sites in Poland
- Volunteers
- 120 people
- Sponsor
- Poznan University of Medical Sciences
Knee Osteoarthritis
Digital Knee Osteoarthritis Mindset Intervention
The aim of our clinical trial is to test if an online mindset intervention improves mindsets and physical activity levels more than an education intervention in individuals with knee osteoarthritis.
- Trial name
- NCT05698368
- Testing
- Mindset intervention, Active comparator
- Where
- United States
- Volunteers
- 458 people
- Sponsor
- Stanford University
Osteoarthritis, Knee
Safety Study of TissueGene-C in Degenerative Joint Disease of the Knee
The study is being conducted to investigate the safety and activity of TissueGene-C injected into the knee joint of patients with chronic degenerative joint disease (DJD) who will be undergoing total knee replacement.
- Trial name
- TGC-03-01 (NCT00599248)
- Testing
- TissueGene-C
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Kolon TissueGene, Inc.
Knee Osteoarthritis
A 2-year, European Multicentre Study to Describe, Validate, and Predict Phenotypes of Knee Osteoarthritis
Rationale: Despite a large and growing disease burden in osteoarthritis (OA), many pharmaceutical companies have abandoned OA drug development.
- Trial name
- APPROACH (NCT03883568)
- Where
- 5 sites in France, Netherlands and 2 more
- Volunteers
- 297 people
- Sponsor
- F.P.J.G. Lafeber
Osteoarthritis, Knee
Outcome Following Hylan F- 20 (Synvisc) + Corticosteroid Injections for the Treatment of Osteoarthritis of the Knee
The goal of viscosupplementation is to replenish synovial fluid, which will improve patient symptoms and mobility. Viscosupplementation of the knee with hyaluronic acid injections has been shown to improve symptoms in patients…
- Trial name
- NCT00312533
- Testing
- Hylan F- 20
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Steadman Hawkins Research Foundation
Knee Osteoarthritis
Effects of Textured Insoles on Balance, Physical Performance, and Plantar Pressure in Older Adults With Knee Osteoarthritis
This study aims to investigate the effects of textured insoles on balance, physical performance, and plantar pressure distribution in older adults with medial compartment knee osteoarthritis.
- Trial name
- TIKOA (NCT07097649)
- Testing
- Textured lateral wedge insole, Use of lateral wedge flat insole
- Volunteers
- 44 people
- Sponsor
- Esra Nur Turkmen
Knee Osteoarthristis
Wearable Device Guided Exercise for Patients on Total Knee Arthroplasty Wait-list
Total knee arthroplasty (TKA) is a cost effective solution for people with end-stage knee osteoarthritis. Given Hong Kong's large senior population and age as the primary risk factor for osteoarthritis, waiting times for total…
- Trial name
- NCT07912333
- Testing
- Wearable Device, Control
- Where
- Hong Kong
- Volunteers
- 106 people
- Sponsor
- Chinese University of Hong Kong
Knee Osteoarthritis, Replacement, Knee
Exploration of Appropriate BIS Range and Propofol Effect-site Concentration During Total Intravenous Anesthesia With Concomitant Adjuvants.
The goal of this clinical trial is to determine the appropriate Bispectral Index (BIS) range and propofol effect-site concentration required to maintain adequate anesthesia depth during total intravenous anesthesia (TIVA)…
- Conditions
- Knee Osteoarthritis, Replacement, Knee, Elective Surgical Patients, ASA Class I/II Patients
- Trial name
- NCT07736352
- Testing
- Propofol + Remifentanil +Midazolam, Propofol + Remifentanil + Dexmedetomidine, Propofol + Remifentanil + Esketamine
- Where
- China
- Volunteers
- 100 people
- Sponsor
- China-Japan Friendship Hospital
Knee Osteoarthritis
Effect of Mechanical Traction and Therapeutic Exercises in Treatment of Primary Knee Osteoarthritis
The purpose of this study is to compare between therapeutic exercises and therapeutic exercises preceded by mechanical traction in treatment of patients with primary knee osteoarthritis attributed to the outcomes of pain, muscle…
- Trial name
- NCT04830748
- Testing
- Mechanical knee traction, Therapeutic exercises
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Osteoarthritis
Tourniquet vs. no Tourniquet During Total Knee Arthroplasty
The purpose of this study is to correlate functional outcomes and perioperative complications with tourniquet use during total knee arthroplasty.
- Trial name
- NCT02907047
- Testing
- tourniquet inflated, tourniquet not inflated
- Where
- United States
- Sponsor
- Rothman Institute Orthopaedics
Chronic Pain, Osteoarthritis
Effects of tDCS and tUS on Pain Perception in OA of the Knee
The purpose of this study is to investigate the effects of transcranial direct current stimulation (tDCS) in conjunction with transcranial ultrasound (TUS) on pain perception and functional limitations in people with…
- Trial name
- NCT02330315
- Testing
- transcranial direct current stimulation (tDCS), transcranial ultrasound (TUS)
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Spaulding Rehabilitation Hospital
Knee Osteoarthritis, Hip Osteoarthritis
Comparison of Knotless Barbed Suture and Standard Suture in Knee Replacement Patients
Barbed suture use has been gaining increased acceptance and has been reported to offer potential advantages in wound closure of hip and knee replacement surgeries.
- Trial name
- NCT03031314
- Testing
- barbed suture, standard suture
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Washington Hospital Healthcare System
Knee Replacement, Hip Replacement
Perioperative Hyperglycaemia in Primary Total Hip and Knee Replacement
The purpose of this study is to analyze how common stress hyperglycaemia (abnormally high blood glucose) is in primary hip and knee replacement surgeries and which factors predispose to hyperglycaemia.
- Conditions
- Knee Replacement, Hip Replacement, Hyperglycemia
- Trial name
- HyTe-1 (NCT01021826)
- Where
- Finland
- Volunteers
- 193 people
- Sponsor
- Coxa, Hospital for Joint Replacement
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.