Clinical trials: Knee Arthritis Disease
Knee Osteoarthritis, Blood Pressure
Decrease in Blood Pressure in PARQVE
The tripod of OA clinical treatment is education, weight loss and exercise. A sedentary lifestyle has been characterized as an independent risk factor for cardiovascular disease.
- Trial name
- NCT04052308
- Testing
- ABPM, The arterial stiffness and endothelial reactivity, Euroqol EQ-5D-5L
- Volunteers
- 63 people
- Sponsor
- University of Sao Paulo General Hospital
Knee Osteoarthritis (Knee OA)
Immediate Effect of Mobilization with Movement on Squat Self-reported Functional Ability, Pain Intensity, and Pain-free Range of Motion in People with Knee Osteoarthritis
Mobilization with movement (MWM) appears to reduce pain, improve knee range of motion, and enhance physical functioning in individuals with knee osteoarthritis (KOA).
- Trial name
- NCT06887868
- Testing
- Mobilization with movement
- Where
- Portugal
- Volunteers
- 40 people
- Sponsor
- Escola Superior de Tecnologia da Saúde do Porto
Knee Osteoarthritis
The Effect of Motivational Messages by "WhatsApp" on Adherence to Home Exercise Program
This study aims to examine the effect of the text message platform (WhatsApp) on the adherence to home exercise programs, pain and physical function among middle age and older adults with knee OA in two public hospitals in Riyadh…
- Trial name
- NCT05453123
- Testing
- telerehabilitation
- Where
- Saudi Arabia
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- King Saud University
Knee Osteoarthritis
Effect of Alexithymia on Response to Physical Therapy in Patients With Knee Osteoarthritis
Knee osteoarthritis is one of the most common degenerative joint diseases and is associated with chronic pain, functional impairment, and reduced quality of life.
- Trial name
- ALEX-KOA (NCT07651410)
- Testing
- Standard Physical Therapy Program
- Volunteers
- 60 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Osteoarthritis, Knee
A Dose-Ranging Study Of Valdecoxib 5 Mg, 10 Mg, And 20 Mg Once Daily Versus Placebo In Patients With Osteoarthritis Of The Knee (Japan)
To determine the therapeutic dose range of valdecoxib by comparing the efficacy of three dosing regimens (5 mg, 10 mg and 20 mg once daily) with placebo for relief of the signs and symptoms of osteoarthritis of the knee.
- Trial name
- NCT00650624
- Testing
- valdecoxib
- Where
- 22 sites in Japan
- Volunteers
- 416 people
- Sponsor
- Pfizer
Knee Osteoarthritis
TKA Using Patient-Specific Instrumentation
The purpose of our study is to determine if anatomic/kinematic total knee arthroplasties (TKAs) are superior to mechanical axis-referenced TKAs with respect to determinants of gait functionality, patient satisfaction and other…
- Trial name
- NCT03117959
- Testing
- Stryker ShapeMatch Technology, Stryker Triathlon Custom Fit Knee
- Where
- Canada
- Sponsor
- Queen's University
Osteoarthritis, Knee, Osteoarthritis, Hip
Digitalization of Osteoarthritis Care
The overall aim of this study is to compare three different care models for patients with hip- and knee osteoarthritis. The primary aim is to evaluate whether an app-based care model is more beneficial for improving function in…
- Trial name
- NCT05584410
- Testing
- Patient information, Smart phone application based exercises, Web based exercises
- Where
- Sweden
- Volunteers
- 315 people
- Sponsor
- Vastra Gotaland Region
Osteoarthritis, Knee
Comparison of Kinesio Taping and Dry Needling in Grade 1, 2 Knee Osteoarthritis
This study's aim was: To determine the effects of kinesio taping and dry needling on pain, ROMs, functional mobility, and quality of life in knee OA patients.
- Trial name
- NCT06086717
- Testing
- Kinesio Taping, Dry Needling
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Riphah International University
Total Knee Arthroplasty, Knee Osteoarthritis
IMProving Outcomes With ACT After Knee Surgery
Regarding psychosocial factors and outcomes in total knee arthroplasty (TKA), most of the current literature and the investigators' previous work suggest that depression, anxiety and pre-operative pain strongly predict worse…
- Trial name
- IMPACTS (NCT06483191)
- Testing
- Acceptance and Commitment Therapy
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Belfast Health and Social Care Trust
Osteoarthritis, Knee
Hyaluronan Versus NaCl 20 Ml Versus Placebo in Knee Osteoarthritis
251 consecutive patients with knee arthrosis were randomized to one of three interventions: Four weekly injections of 2 ml isotonic saline (placebo), 2 ml sodium hyaluronate (hyaluronan) or 20 ml isotonic saline (excessive…
- Trial name
- NCT00144820
- Testing
- Injection of Hyaluronan or Saline
- Where
- Denmark
- Volunteers
- 251 people
- Sponsor
- Glostrup University Hospital, Copenhagen
Blood Flow Restriction
Vascular Occlusion for Optimizing Functional Improvement in Patients With Knee Osteoarthritis
Recent research in strength training physiology revealed that implementation of occlusion garments around the proximal aspect of the lower limbs in combination with low load strength training causes a reduced blood flow and thus…
- Trial name
- VOFIKO (NCT04996680)
- Testing
- Blood Flow Restriction (by using smart-cuff pro devices, acting as pressurized tourniquet) combined low load strengh training, Standardised low load strength training
- Where
- Belgium
- Volunteers
- 120 people
- Sponsor
- University Hospital, Ghent
Osteoarthritis, Knee, Obesity
A Hip Flexion Feedback System for Exercise Monitoring in Individuals With Osteoarthritis and Obesity
Exercise is very important for living healthier and longer lives. For people with obesity and osteoarthritis, exercise is even more important because it can help them feel less pain in their joints.
- Trial name
- NCT05997862
- Testing
- HFFS
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Southern Mississippi
Osteoarthritis of the Knee
Study of FX006 in Patients With Osteoarthritis of the Knee
The purpose of this study was to evaluate the safety, efficacy and pharmacokinetics of FX006 in patients with osteoarthritis of the knee.
- Trial name
- NCT01487161
- Testing
- FX006, TCA IR
- Where
- 21 sites in United States, Australia and 1 more
- Volunteers
- 229 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Osteo Arthritis Knee, Age Related Osteoporosis
Low Frequency Ultrasound for Osteoarthritis Healing and Rehabilitation
The purpose of this study is to determine the safety and effectiveness (how well it works) of a new experimental ultrasound bath device that uses low frequency ultrasound (LFU) that may or may not help healing.
- Conditions
- Osteo Arthritis Knee, Age Related Osteoporosis, Pain, Knee Joint Contracture
- Trial name
- NCT06562374
- Testing
- Low Frequency Ultrasound Therapy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Osteoarthritis, Knee, Obesity
Weight Loss Intervention Before Total Knee Replacement
The purpose of this study is to compare the efficacy in a group of patients who must follow the current procedure for treatment of artificial knee, compared with a group of patients who must undergo an 8-week weight loss program…
- Trial name
- NCT01469403
- Testing
- 8 weeks weight loss program, Cambridge.
- Where
- Denmark
- Volunteers
- 76 people
- Sponsor
- University of Aarhus
Knee Osteoarthritis
Comapre Effects Of Proprioceptive Training And Core Instability Strength Training In Knee Osteoarthritis Patients
This study aims to determine the influence of core instability exercises in comparison to proprioceptive training in relieving pain, improving balance and physical function in general population of knee Osteoarthritis.
- Trial name
- NCT05258227
- Testing
- Conservational Physical Therapy and Proprioceptive Strength Training, Conservational Physical Therapy and Core Instability Strength Training
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Riphah International University
Knee Osteoarthritis
ARTIST: ARThrose Intervention STandardisée
International recommendations (ACR,EULAR) emphasize physical exercise and weight loss for patients suffering from knee osteoarthritis. Nevertheless, number of patients receiving advices for these 2 points still low.
- Trial name
- ARTIST (NCT00462319)
- Testing
- Education, weight reduction and physical exercise
- Where
- France
- Sponsor
- Almirall, SAS
Gonarthrosis; Primary, Genicular Nerve Block
Genicular Nerve Block in Chronic Knee Osteoarthritis
The goal of this clinical trial is to evaluate whether genicular nerve block (GNB) is effective in reducing pain in patients with knee osteoarthritis. It will also assess the comparative efficacy of different injection protocols.
- Conditions
- Gonarthrosis; Primary, Genicular Nerve Block, Gonarthritis
- Trial name
- GNB-KOA-RCT (NCT07174167)
- Testing
- Genicular nerve block with prilocaine, genicular nerve block with prilocaine and triamcinolone
- Where
- Turkey (Türkiye)
- Volunteers
- 81 people
- Sponsor
- Haydarpasa Numune Training and Research Hospital
Knee Osteoarthritis, Rheumatoid Arthritis
Computer Navigation vs Conventional Technique in Knee Arthroplasty
Project summary: Background: Computer navigation in knee replacement surgery is increasingly being used around the world, but the documentation of its usefulness is lacking.
- Trial name
- CAOS (NCT00782444)
- Testing
- Computer navigated knee replacement, Conventional knee replacement
- Where
- 4 sites in Norway
- Volunteers
- 192 people
- Sponsor
- Haukeland University Hospital
Osteoarthritis, Knee
A Study to Investigate the Safety and Effectiveness of Different Doses of Sprifermin in Participants With Osteoarthritis of the Knee
This was a multicenter, randomized, double-blind, placebo-controlled, parallel-group Phase 2 trial of Sprifermin administered intra-articularly in participants with primary osteoarthritis of the knee and Kellgren-Lawrence Grade 2…
- Trial name
- FORWARD (NCT01919164)
- Testing
- Sprifermin
- Where
- 13 sites in United States, Argentina and 6 more
- Volunteers
- 549 people
- Sponsor
- EMD Serono Research & Development Institute, Inc.
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