Clinical trials: Knee Arthritis Disease
Knee Osteoarthritis, Syndrome
Characteristics of LKDS and PBSS of KOA Based on the Enhancement of Inflammatory Response by TGF-β/Smad Pathway Inhibited
1. Through research and analysis, the levels of upstream and downstream factors related to TGF-β/Smad signaling pathway and inflammatory response factor related factors in serum, blood cells, articular fluid, urine, tongue…
- Conditions
- Knee Osteoarthritis, Syndrome, Traditional Chinese Medicine
- Trial name
- NCT05218122
- Testing
- cross-sectional study without intervention
- Where
- China
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- Dongzhimen Hospital, Beijing
Knee Osteoarthritis, Arthropathy of Knee
The Impaction of Exercise Training on Bone Mineral Density in Patients After Total Knee Arthroplasty
Rehabilitation after total knee arthroplasty (TKA) should consider control of postoperative pain and swelling, protection of the healing graft, restoration of full range of motion symmetric to the contralateral knee…
- Trial name
- NCT02928562
- Testing
- exercise
- Where
- Taiwan
- Volunteers
- 110 people
- Sponsor
- Chang Gung Memorial Hospital
Osteoarthritis (OA) of the Knee
Optimization of Obesity for Total Knee Replacement With Glucagon-like Peptide-1 Receptor Agonist
Studies have shown that obese patients undergoing total knee replacement (TKR) surgery face a higher risk of perioperative issues such as increased use of pain medication, surgical site infections, and the need for revision…
- Trial name
- NPO-OOPS-TKR (NCT06807970)
- Testing
- Glucagon-like peptide-1 receptor agonists (GLP 1 RA), Control (Standard treatment)
- Where
- Hong Kong
- Volunteers
- 54 people
- Sponsor
- The University of Hong Kong
Osteoarthritis, Knee
Prediction of Response to Intra-articular Injections of Hyaluronic Acid for Knee Osteoarthritis
The purpose of this study is to evaluate whether the investigators can develop a computer algorithm to predict which individual patients will respond to injections of hyaluronic acid (HA) products for knee osteoarthritis.
- Trial name
- NCT01557868
- Testing
- hylan G-F 20, 1% sodium hyaluronate
- Where
- United States
- Volunteers
- 198 people
- Sponsor
- American Orthopaedic Society for Sports Medicine
Knee Osteoarthritis, Energy Transfer Capacitative and Resistive Therapy
Efficacy of TECAR Therapy in Patients With Knee Osteoarthritis
Objective: The aim of the present study was to investigate the treatment efficacy of TECAR therapy, a modern application that has been increasingly used in recent years, compared to conventional physical therapy applications in…
- Trial name
- NCT06418360
- Testing
- TECAR, conventional physical therapy; Transcutaneous Electrical Nerve Stimulation, hotpack
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Knee Osteoarthritis
Different Volumes of Durolane in Knee OA
The purpose of the study is to assess the safety and efficacy profiles of new single-injection volumes of Durolane in patients with knee OA.
- Trial name
- NCT01265459
- Testing
- Durolane 3 ml, Durolane 4,5 ml, Durolane 6 ml
- Where
- 3 sites in Sweden
- Volunteers
- 68 people
- Sponsor
- Galderma R&D
Osteoarthritis, Knee
Finnish Unicompartmental and Total Knee Arthroplasty Investigation
Unicondylar knee arthroplasty (UKA) can be used as the treatment of knee OA isolated to a single compartment instead of TKA. Both UKA and TKA have been used for decades as a treatment of knee OA.
- Trial name
- FUNCTION (NCT02481427)
- Testing
- Unicondylar Knee Replacement, Total Knee Replacement
- Where
- 3 sites in Finland
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Arthrosis
Effect of Skanlab Regarding Knee Arthrosis
The purpose is to find out the effect of Skanlab at knee arthrosis.
- Trial name
- NCT02649296
- Testing
- Skanlab bodywave
- Where
- Norway
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Oslo Metropolitan University
Osteoarthritis, Knee
Acupuncture Safety/Efficacy in Knee Osteoarthritis
The goal of this research is to determine the efficacy and safety of Traditional Chinese Acupuncture (TCA) in patients with osteoarthritis of the knee.
- Trial name
- NCT00010946
- Testing
- Acupuncture
- Where
- 3 sites in United States
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Knee Osteoarthritis
The Effectiveness of Low Level Laser Therapy on Particular Joint Points and Acupuncture Points on Knee Joints in Grade III Knee Osteoarthritis
LLLT is in use to treat different musculoskeletal condition. Osteoarthritis is one of the conditions needing LLLT for therapeutic effects.
- Trial name
- LLLT OA (NCT05403931)
- Testing
- Low level laser therapy
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- Universiti Teknologi Malaysia
Knee Osteoarthritis
Pharmacist-initiated Intervention Trial in OsteoArthritis (PhIT-OA)
Osteoarthritis (OA) is a major public health concern. Currently, there are at least 3 million Canadians afflicted with this condition with a 50% increase predicted by 2020.
- Trial name
- NCT00391859
- Testing
- Pharmacist-Initiated Intervention in OsteoArthritis (PhIT-OA)
- Where
- Canada
- Volunteers
- 135 people
- Sponsor
- University of British Columbia
Knee Osteoarthritis
Intraarticular Xylitol Injections for Knee Osteoarthritis
Hypothesis: Intraarticular injections of isotonic Xylitol solution will improve pain in patients with knee osteoarthritis (OA).
- Trial name
- NCT02104596
- Testing
- Xylitol
- Where
- Israel
- Volunteers
- 96 people
- Sponsor
- Hadassah Medical Organization
Osteoarthritis, Knee
Efficacy and Safety of XT-150 in Osteoarthritis of the Knee
This is a Phase 2 safety and efficacy study of XT-150 in adult participants experiencing moderate to severe pain due to osteoarthritis of the knee.
- Trial name
- NCT04124042
- Testing
- XT-150
- Where
- 6 sites in United States, Australia
- Volunteers
- 289 people
- Sponsor
- Xalud Therapeutics, Inc.
Osteoarthritis
Long-term Observational Study of Subjects From Tanezumab Studies Who Undergo a Total Knee, Hip or Shoulder Replacement
A4091064 is a multicenter, long-term observational study of subjects from tanezumab interventional studies (regardless of treatment group) who undergo a total knee, hip or shoulder replacement during participation in the study.
- Trial name
- NCT02674386
- Testing
- Investigational Medical Product (IMP) administered in parent study
- Where
- 79 sites in United States, Australia and 13 more
- Volunteers
- 154 people
- Sponsor
- Pfizer
Osteoarthritis of the Knee, Type 2 Diabetes Mellitus
Study to Assess the Effects of FX006 on Blood Glucose in Patients With OA of the Knee and Type 2 Diabetes
The purpose of this study was to compare the effects of FX006 and Triamcinolone Acetonide Injectable Suspension, United States Pharmacopeia (USP) (referred to as TCA IR in the protocol) on blood glucose (BG) in patients with…
- Trial name
- NCT02762370
- Testing
- FX006 32 mg, TCA IR 40 mg
- Where
- 8 sites in United States
- Volunteers
- 33 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Osteoarthritis, Knee
Randomised Controlled Trial PFC Versus CKS Total Knee Prostheses
The purpose of this study is to compare the functional outcome of two different total knee prostheses in a prospective randomised study.
- Trial name
- NCT00228137
- Where
- Netherlands
- Volunteers
- 90 people
- Sponsor
- Radboud University Medical Center
Pain, Osteoarthritis
Early Ambulation After Adductor Canal Block for Total Knee Arthroplasty
The purpose of this study is to assess early ambulation following total knee replacement in patients receiving continuous adductor canal block with posterior capsular injection compared to continuous femoral nerve block with…
- Trial name
- NCT01459861
- Testing
- Canal Block and Capsular Injection, Femoral Nerve Block with Tibial Nerve Block
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Trinity Health Of New England
Knee Osteoarthritis
The Age of OrthoInfo: A Randomized Controlled Trial Evaluating Patient Comprehension of Informed Consent
This study is a Non-funded, Single Center, Multi-Arm, Parallel Group Randomize Control Trial. In this study, the investigators aim to evaluate the impact of a visual aid on patient comprehension an orthopedic informed consent…
- Trial name
- NCT02416505
- Testing
- Verbal+Anatomic Model, Verbal+Video
- Volunteers
- 67 people
- Sponsor
- University of Missouri, Kansas City
Knee Osteoarthritis
Assessment of Patients Quality of Life Treated With Three ARTHRUM H 2% Joint Injections
The reduction of functional limits and disablilities induced by knee osteoarthritis as well as improvement of patients quality of life is a public health need registered amongst the priorities established by the French law of…
- Trial name
- ART-QUALIVIE (NCT02840422)
- Testing
- ARTHRUM H 2%
- Volunteers
- 138 people
- Sponsor
- LCA Pharmaceutical
Osteoarthritis
Osteoarthritis Bedside Testing Kit
Develop and test a bedside testing kit for evaluating pain and symptoms of osteoarthritis
- Trial name
- NCT00794651
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Analgesic Solutions
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