Clinical trials: Knee Arthritis Disease
Knee Osteoarthritis, Chitosan Nanoparticles Gel
Extracorporeal Shockwave Versus Phonophoresis Using Chitosan-Nanoparticles Gel on Functional and Anatomical Changes Detected With Artificial Intelligence Based Texture Analysis Algorithm in Knee Osteoarthritis Patients: A Double Blind Randomized Controlled Trial
A parallel double blinded randomized controlled clinical trial (RCT) with a 1:1:1 allocation will be conducted in an orthopedic clinic in Cairo and Giza Governments - Egypt.
- Conditions
- Knee Osteoarthritis, Chitosan Nanoparticles Gel, Artificial Intelligence Texture Analysis Bases Algorithm, Subchondral Bone Changes (Anatomical Changes)
- Trial name
- NCT06567301
- Testing
- Ultrasound therapy combined with Chitosan nanoparticles gel
- Where
- 2 sites in Egypt
- Volunteers
- 120 people
- Sponsor
- Cairo University
Hip Arthroplasty, Total, Knee Arthroplasty, Total
Perceptions of De-implementing Routine Follow-ups After Hip and Knee Arthroplasty
After undergoing total hip or total knee arthroplasty, current guidelines recommend routine follow-up with an X-ray within 3 months and again at 1 year.
- Trial name
- HAKA-QUALI (NCT07041528)
- Where
- Netherlands
- Volunteers
- 90 people
- Sponsor
- Tergooi Medical Center
Knee Osteoarthritis
Minimally Invasive Surgical Approaches In Total Knee Arthroplasty
The hypothesis of the proposed study is that performing total knee arthroplasty through a mini subvastus approach results in statistically significant differences in one or more of the above functional outcome measures, when…
- Trial name
- NCT01461356
- Testing
- Minimally invasive total knee replacement, Standard approach total knee replacement
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Mayo Clinic
Knee Osteoarthritis
To Evaluate the Safety and Efficacy of TD0015 Pilulae in Patients with Knee Osteoarthritis
Preclinical trials in animal models have suggested that the estimated dose of TD0015 in clinical presents no safety concerns.The investigational product is TD0015 pilulae, which is based on the traditional prescription named "Độc…
- Trial name
- NCT06657495
- Testing
- TD0015
- Where
- Vietnam
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Sao Thai Duong Joint Stock Company
Osteoarthritis, Rehabilitation
Home Rehabilitation in Patients After Primary Total Knee Arthroplasty
The investigators include patients attending the outpatient clinic in the area of Orthopedics and Traumatology of the investigators hospital with a diagnosis of knee osteoarthritis, which treatment requires surgery.
- Trial name
- NCT02409719
- Testing
- Schedule, Verbal Information and Booklet
- Where
- Mexico
- Volunteers
- 76 people
- Sponsor
- Universidad Autonoma de Nuevo Leon
Osteoarthritis, Knee
Civamide in OA of the Knee(s)
The purpose of this study is to evaluate the safety of Civamide Cream 0.075% as a Treatment in Subjects with Osteoarthritis (OA) of the Knee(s).
- Trial name
- NCT00077935
- Testing
- Civamide
- Where
- 34 sites in United States
- Volunteers
- 351 people, healthy volunteers welcome
- Sponsor
- Winston Laboratories
Joint Disease
Autologous Plasma Rich in Growth Factors (PRGF) Treating the Symptomatic Knee OA
The purpose of this study is to evaluate the efficacy and safety of PRGF infiltrations in the treatment of knee osteoarthritis.
- Trial name
- NCT00782197
- Testing
- PRGF Intraarticular injection, Hyaluronic Acid Intraarticular injection
- Where
- 3 sites in Spain
- Volunteers
- 240 people
- Sponsor
- Biotechnology Institute IMASD
Knee Osteoarthristis
Neuropathic Pain in Knee Osteoarthritis: Pain Severity and Functional Status
Osteoarthritis (OA) is a degenerative joint disease characterized by structural changes such as cartilage loss and osteophyte formation, leading to functional limitations and disability.
- Trial name
- NCT07367126
- Testing
- Clinical and Functional Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Rheumatic Arthritis
Exercise Training and Knee Joint Proprioception in Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a chronic disorder that affects 0.5% to 1% of adults and is the result of an autoimmune attack against joint tissues.
- Trial name
- NCT06887725
- Testing
- Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 19 people
- Sponsor
- Aysima Barlak
Osteoarthritis, Knee
NEO6860, a TRPV1 Antagonist, First in Human Study
This study is a double blind, placebo controlled, ascending single and multiple oral dose study conducted in two parts, aimed at determining the safety and tolerability of single and multiple oral doses of NEO6860 in healthy…
- Trial name
- NCT02337543
- Testing
- NEO6860
- Where
- United Kingdom
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Neomed Institute
Knee Osteoarthritis
To Investigate the Effect of PEMF for Knee OA Patients
Health care costs are increasing alarmingly, which will impose an overwhelming economic burden to an aging society like that of Hong Kong.
- Trial name
- NCT05442697
- Testing
- PEMF treatment
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- Chinese University of Hong Kong
Osteoarthritis, Knee
A Clinical Study to Test Efficacy and Safety of Repeat Doses of CNTX-4975-05 in Patients With Osteoarthritis Knee Pain
This is a randomized, double-blind, placebo-controlled, 2-injection, 52-week study to evaluate the efficacy and safety of intra-articular injections of CNTX-4975-05 in subjects with chronic, moderate-to-severe osteoarthritis knee…
- Trial name
- NCT03660943
- Testing
- CNTX-4975-05
- Where
- 30 sites in United States
- Volunteers
- 332 people
- Sponsor
- Centrexion Therapeutics
Total Knee Arthroplasty, Osteoarthritis
Electrical Stimulation After Total Knee Arthroplasty
Total knee arthroplasty (TKA) is performed more than 300,000 times a year in the United States, most often for osteoarthritis (OA).
- Trial name
- NCT00224913
- Testing
- Neuromuscular electrical stimulation, Voluntary exercise
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Osteoarthritis of Knee
Genicular Radiofrequency Ablation Versus Pulsed Radiofrequency
This study investigates the effectiveness of two treatments-genicular nerve radiofrequency ablation and pulsed radiofrequency-in reducing pain and improving function in osteoarthritis patients.
- Trial name
- GRFT-PRF (NCT06894147)
- Testing
- Genicular nerve pulse radiofrequency
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Ankara City Hospital Bilkent
Knee Osteoarthritis
Comparison of the Efficacy of Duloxetine and Pregabalin in Patients With Knee Osteoarthritis With Mix Type Pain
Osteoarthritis (OA) is a common degenerative joint disorder associated with chronic pain at older age.It is known that patients with osteoarthritis experience nociceptive and neuropathic pain to varying degrees.
- Trial name
- NCT04532684
- Testing
- Duloxetine, Pregabalin
- Volunteers
- 66 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Knee Osteoarthritis
Robot-Assisted Partial Knee Replacement Versus Standard Total Knee Replacement
This is a pilot randomized trial to assess the feasibility of a definitive trial to determine the effect of robot-assisted partial knee replacements versus standard total knee replacements.
- Trial name
- RoboKnees (NCT04378049)
- Testing
- Total knee arthroplasty, Robot-assisted partial knee arthroplasty
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- McMaster University
Knee Osteoarthritis
Individual Differences in Glucosamine Sulfate Exposure Levels
Glucosamine is an important part of the treatment strategy for osteoarthritis, but its effectiveness is still controversial. To explain the efficacy differences of glucosamine, in this study the investigators detect the…
- Trial name
- NCT03201276
- Testing
- Glucosamine Sulfate
- Volunteers
- 400 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Osteoarthritis, Knee
Preoperative Strength Training in Patients With Total Knee Arthroplasty
The purpose of this study is to investigate if preoperative strength training will result in faster recovery and higher level of function six weeks after total knee arthroplasty (TKA).
- Trial name
- NCT01647243
- Testing
- Preoperative strength training
- Where
- Denmark
- Volunteers
- 70 people
- Sponsor
- University of Aarhus
Degenerative Arthritis
To Determine the Gait and Functional Improvement in Total Knee Arthroplasty
This is an observational study to understand the effects of soft-tissue balancing on gait, function and rehabilitation potential after sensor-assisted Total Knee Arthroplasty
- Trial name
- Orthosensor (NCT04057885)
- Testing
- Orthosensor™ VERASENSE™ Knee System
- Where
- United States
- Sponsor
- LifeBridge Health
Osteo Arthritis Knee
The Effect of Semiconductor Knee Sleeves on Pain in Osteoarthritis of the Knee.
To assess the benefits of using semiconductor (germanium and carbon) woven knee sleeves products in patients with osteoarthritis of the knee.
- Trial name
- NCT05255835
- Testing
- Semiconductor Knee Sleeves
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- Herlev and Gentofte Hospital
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