Clinical trials: Knee Arthritis Disease
Hip Osteoarthritis, Knee Osteoarthritis
What Matters to Patients With Severe Hip or Knee Osteoarthritis?
This clinical trial aims to investigate if shared decision-making, and the use of an in-consultation patient decision aid (PtDA), increases the decisional quality and therefore treatment satisfaction and outcome of patients with…
- Trial name
- PATI-Project (NCT05972525)
- Testing
- Shared decision-making supported by an in-consultation PtDA to patients with severe osteoarthritis in their hip or knee
- Where
- 3 sites in Denmark
- Volunteers
- 615 people
- Sponsor
- Vejle Hospital
Knee Osteoarthritis
Inulin Supplementation for Reducing Inflammation and Knee Pain in Older Adults With Osteoarthritis
This study will test whether inulin, a type of dietary fiber, can reduce inflammation in older adults with knee osteoarthritis. Inflammation in the body may contribute to both joint pain and the progression of osteoarthritis.
- Trial name
- OA-INULIN (NCT07189585)
- Testing
- inulin
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Yale University
ACL Injury
Evaluation of Thermographic Images of the Knee in Patients With Anterior Cruciate Ligament Reconstruction Outcome
The Thermo-LCA study is a diagnostic interventional study for assessment of knee temperature of asymptomatic patients with ACL reconstruction compared with unoperated healthy contralateral knee.
- Trial name
- NCT06048991
- Testing
- Thermographic assessment
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Istituto Ortopedico Rizzoli
Osteoarthritis of Knee
A Clinical Trial to Evaluate the Safety and Efficacy of Retreatment With Intra-articular LBSA0103 Injections in the Patients With Osteoarthritis of the Knee
To assess the safety and efficacy of LBSA0103 (BDDE cross-linked sodium hyaluronate gel) when it is administered for the second time 26 weeks after its first administration in patients with osteoarthritis of the knee.
- Trial name
- NCT02122601
- Testing
- LBSA0103 (BDDE cross-linked sodium hyaluronate gel)
- Where
- South Korea
- Volunteers
- 174 people
- Sponsor
- LG Life Sciences
Osteoarthritis
Imaging Biomarkers of Knee Osteoarthritis
This study aims to develop, evaluate and translate highly accelerated imaging sequences (each protocol under 5 minutes) for in-vivo knee Osteoarthritis applications on a standard clinical 3T scanner using novel compression…
- Trial name
- NCT02888119
- Testing
- PRISMA 3T MRI scanner (Siemens Medical Solutions)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Knee Osteoarthritis
Effects of Mulligan Mobilization With Movement as Compared to Kaltenborn Joint Mobilization in the Management of Knee Osteoarthritis
This study is a randomised controlled trial and the purpose of this study is to determine the Effects of Mulligan mobilization with movement as compared to Kaltenborn joint mobilization in the management of knee osteoarthritis."…
- Trial name
- NCT06444945
- Testing
- Heating pad, Transcutaneous electrical nerve stimulation(TENS), Mulligan mobilization with movement (MWM)
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Foundation University Islamabad
Osteoarthritis of the Knee
KineSpring® System Patient Preference Study
The primary objectives of the survey are to obtain patient preference information that can be useful during the benefit-risk assessment of the KineSpring System.
- Trial name
- NCT02934672
- Testing
- Survey
- Volunteers
- 323 people
- Sponsor
- Moximed
Knee Osteoarthritis
Multi-Center Study Evaluating the Efficacy of Wobenzym(R)N in Treating Knee Osteoarthritis
The objective of this study is to determine the most effective dose of Wobenzym® N versus placebo at reducing pain severity as measured by the WOMAC pain score in subjects with symptomatic knee osteoarthritis (OA) at 6 weeks of…
- Trial name
- NCT00974428
- Testing
- Wobenzym® N
- Where
- 4 sites in Canada
- Sponsor
- Atrium Innovations
Osteoarthritis, Knee
APOS Therapy for Osteoarthritis of the Knee: a Randomized Controlled Trial BIOTOK
Painful knee osteoarthritis is common and treatments, short of knee replacement, are limited. The investigators plan to test the efficacy of a novel promising device for treatment of knee osteoarthritis affecting the inner part…
- Trial name
- BIOTOK (NCT02363712)
- Testing
- APOS shoe
- Where
- Switzerland
- Volunteers
- 220 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Osteoarthritis of the Knee
PRP Treatment of Osteoarthritic Knee With a New Autologous Blood Product (CytoRich)
This study is aimed at evaluating the efficacy and safety of Cytorich compared to platelet-rich plasma (PRP) in alleviating pain and improving function in subjects with knee OA.
- Trial name
- NCT03543800
- Testing
- Cytorich PRP kit, PRP kit
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Antnor
Osteoarthritis
A Randomized Control Trial to Assess Early Clinical and Functional Outcome of the ROCC and LCS Total Knee Implant Designs
This is a prospective Randomised Control Trial to compare the Early Clinical and Functional Outcome of the ROCC and LCS total knee arthroplasty implant designs.
- Trial name
- NCT00755144
- Testing
- LCS Knee, ROCC Knee
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- Zimmer Biomet
Gonarthrosis, Coxarthrosis
Radiotherapy 3 vs 6 Gy in Gonarthrosis and Coxarthrosis
This is a non-inferiority study in which the investigators compare two low-dose radiotherapy schemes, which are recommended from DEGRO Clinical Practice Guidelines (3 Gy vs 6 Gy) for the treatment of osteoarthritis and other…
- Trial name
- RAGOCO (NCT04424628)
- Testing
- Low dose radiotherapy A, Low dose radiotherapy B
- Where
- Spain
- Volunteers
- 338 people
- Sponsor
- Fundacion GenesisCare
Osteoarthritis of Knee
Efficacy and Safety of DKM420 in Patients With Osteoarthritis of Knee
To prove the non-inferiority of DKM420 by evaluating the injecting efficacy and safety DKM 420 and control for patients who have osteoarthritis of Knee.
- Trial name
- NCT06021444
- Testing
- DKM420, Conjuran
- Where
- South Korea
- Volunteers
- 250 people
- Sponsor
- Dongkook Pharmaceutical Co., Ltd.
Osteoarthritis of the Knee
Phase 2 Efficacy Trial of OLT1177 Gel in Subjects With Moderate to Severe Pain Associated With OA of the Knee
The purpose of this trial is to investigate the efficacy and safety of OLT1177 Gel in subjects with moderate to severe pain associated with osteoarthritis of the knee following cessation of pain therapy.
- Trial name
- NCT01768975
- Testing
- OLT1177 Gel
- Where
- 3 sites in United States
- Volunteers
- 79 people
- Sponsor
- Olatec Therapeutics, Inc.
Knee Osteoarthritis, Survey, Family Life
Prevalence of Self-disclosed Knee Trouble and Use of Treatments Among Elderly Individuals
Although knee pain is prevalent among community-dwelling older adults, little is known about how people in general handle their pain.
- Conditions
- Knee Osteoarthritis, Survey, Family Life, Complementary Therapies, Pain
- Trial name
- NCT03472300
- Testing
- Survey about knee pain and treatment
- Where
- Denmark
- Volunteers
- 9,600 people, healthy volunteers welcome
- Sponsor
- Frederiksberg University Hospital
Osteoarthritis, Knee
Functional Outcome and Analgesia in TKA: Radiofrequency vs Continuous Adductor Canal Block
This randomized, double blind controlled trial is designed to investigate the potential benefits of radiofrequency in terms of analgesia and functional outcome, compared to the conventional continuous adductor canal block, for…
- Trial name
- NCT02680392
- Testing
- Pulsed and Continuous Radiofrequency, Continuous Adductor Canal Block
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Knee Osteoarthritis
Cryoneurolysis Versus Radiofrequency in Knee Osteoarthritis
The project will evaluate the effectiveness of Cryoneurolysis versus radiofrequency procedures in adult patients who are resistant to traditional treatment for knee pain. They are a drug-free pain management procedure.
- Trial name
- NCT07664371
- Testing
- Cryoneurolysis, pulsed radiofrequency (RF), cooled radiofrequency
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Tanta University
Knee Osteoarthritis
Development and Improvement of an Acceptance and Commitment-based Treatment for the Prevention of Chronic Pain After Total Knee Arthroplasty
Reducing the incidence of chronic post-surgical pain after Total Knee Arthroplasty (TKA) is paramount. NOPAIN, a technology-enhanced Acceptance and Commitment-based treatment, will be developed, tested and improved for this…
- Trial name
- NOPAIN (NCT05769998)
- Testing
- Acceptance and Commitment-based treatment, Treatment as usual
- Where
- Italy
- Volunteers
- 210 people
- Sponsor
- Istituto Auxologico Italiano
Total Knee Anthroplasty, Osteoarthritis(Primary)
COntralateral CorticoSTeroid Injection in Total Knee Arthroplasty
Through a triple-blinded randomized control trial, the primary purpose of this pilot study is to assess the efficacy of administering peri-operative contralateral corticosteroid injection in patients undergoing TKA.
- Conditions
- Total Knee Anthroplasty, Osteoarthritis(Primary), Osteoarthritis (OA) of the Knee, Bilateral Knee Osteoarthritis
- Trial name
- COSTI (NCT06809998)
- Testing
- Corticosteroid Injection - 80mg methylprednisolone (total volume 2ml) with 6 mL of 1% Bupivacaine without epinephrine (Total Volume 8 mL)., Band-Aid
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Unity Health Toronto
Pain, Osteoarthritis of the Knee
A Proof-of-Concept Study Assessing NEO6860 in Osteoarthritis Pain
The purpose of this study is to assess NEO6860, a modality selective TRPV1 antagonist, in patients with pain associated with osteoarthritis of the knee.
- Trial name
- NCT02712957
- Testing
- NEO6860, Naproxen
- Where
- 3 sites in Canada
- Volunteers
- 54 people
- Sponsor
- Neomed Institute
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