Clinical trials: Knee Arthritis Disease
Knee Osteoarthritis
Pain Sensitization and Outcome Following Physiotherapy in Patients With Knee Osteoarthritis
Pain is the dominant symptom of knee osteoarthritis and recent evidence suggests factors outside of local joint pathology, such as pain sensitization, can contribute significantly to the pain experience.
- Trial name
- NCT02310945
- Testing
- Physiotherapy
- Where
- 3 sites in Ireland
- Volunteers
- 140 people
- Sponsor
- University College Dublin
Knee Osteoarthritis, Pain, Joint
Pain Function and QOL Undergoing Whole-Body Vibration and Exercise in End-Stage Knee Osteoarthritis
Knee osteoarthritis (KOA) is a chronic progressive disease that imparts substantial socioeconomic burden to society and healthcare systems.
- Trial name
- NCT06183177
- Testing
- Whole-Body Vibration, Exercise
- Where
- Hong Kong
- Volunteers
- 517 people
- Sponsor
- Chinese University of Hong Kong
Osteoarthritis
Midvastus Versus Medial Parapatellar Approach for Minimally Invasive Total Knee Arthroplasty
The purpose of this study is to compare two different surgical approaches for total knee replacement surgery. The mini-midvastus approach involves cutting less of the thigh muscle (quadriceps) tendon than the classic approach…
- Trial name
- NCT01132378
- Testing
- Total knee arthroplasty
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Heekin Orthopedic Research Institute
Osteoarthritis
Low Level Laser Therapy and Interferential Current in Osteoarthritis
This study aims to evaluate the effectiveness of the low level laser therapy and interferential current in 168 patients with knee osteoarthritis
- Trial name
- NCT02898025
- Testing
- Active Interferential Current, Active Laser
- Where
- Brazil
- Volunteers
- 168 people
- Sponsor
- Universidade Cidade de Sao Paulo
Hip Osteoarthritis, Knee Osteoarthritis
Efficacy of a Digital Biofeedback System for Home-based Rehabilitation After Total Joint Replacement
The study was designed to assess the efficacy of a home-based rehabilitation program using a digital kinematic biofeedback system after total hip or knee replacement. This is a single-arm prospective study.
- Trial name
- NCT03648060
- Testing
- Digital kinematic biofeedback system
- Where
- Portugal
- Volunteers
- 88 people
- Sponsor
- Sword Health, SA
Knee Osteoarthritis
Efficacy of High Power Laser Versus Low Level Laser in Ultrasonographic and Functional Outcomes in Patients With Knee Osteoarthritis
this study will be conducted to compare between high power laser and low-intensity laser on ultrasonographic and functional outcomes in patients with knee osteoarthritis
- Trial name
- OA (NCT06419569)
- Testing
- high power laser, low level laser, conventional physical therapy
- Volunteers
- 90 people
- Sponsor
- Cairo University
Knee Osteoarthritis
Efficacy and Safety of a New Formulation of Chondroitin Sulfate and Glucosamine Sulfate to Treat Knee Osteoarthritis
The main objective is to assess the efficacy of a new formulation containing chondroitin sulfate and glucosamine sulfate (CS+GS) compared with placebo in patients with primary osteoarthritis of the knee.
- Trial name
- NCT01893905
- Testing
- CS+SG
- Where
- Spain
- Volunteers
- 158 people
- Sponsor
- Tedec-Meiji Farma, S.A.
Osteoarthritis
Enthesitis in Patients With Knee Osteoarthritis
The current study was conducted to estimate the prevalence of knee cap enthesitis in patients with knee osteoarthritis and its relation to knee function.
- Trial name
- NCT03897829
- Where
- 2 sites in Egypt
- Volunteers
- 200 people
- Sponsor
- Al-Azhar University
Osteoarthritis, Knee
Intra-articular Injections of Platelet-rich Plasma, Hyaluronic Acid, or Corticosteroids for Knee Osteoarthritis
To assess if there are any differences among platelet-rich plasma, hyaluronic acid, and corticosteroid knee intra-articular injection regarding function and pain.
- Trial name
- NCT04980105
- Testing
- Platelet-rich plasma, Hyaluronic acid, Methylprednisolone acetate injectable suspension (DEPO-MEDROL®)
- Where
- Iraq
- Volunteers
- 150 people
- Sponsor
- University of Wasit
Insomnia, Pain
Effectiveness of Healthy Habits for Hospitalized Older Adults to Optimize Rehabilitation
This study aims to evaluate behavioral interventions in conjunction with medical rehabilitation to promote functional health in patients recovering from orthopedic surgery.
- Conditions
- Insomnia, Pain, Osteoarthritis, Knee, Osteoarthritis, Hip
- Trial name
- HH (NCT04269239)
- Testing
- Healthy Habits, Sleep Habits
- Where
- 3 sites in United States
- Volunteers
- 73 people
- Sponsor
- Baylor College of Medicine
Knee Osteoarthritis
Adaptation and Validation of the Exercise Adherence Rating Scale of Knee Osteoarthritis Patients (GONEARS)
The origin of knee osteoarthritis is multifactorial but the disease is strongly related to age. The pain and functional disability are the main reasons for consultation. Non-pharmaceutical treatment is always indicated.
- Trial name
- GONEARS (NCT04465331)
- Testing
- Questionnaires
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Clermont-Ferrand
Osteoarthritis of the Knee
Comparative Study of Olive Oil With Piroxicam Gel in Osteoarthritis of the Knee
this is a randomized double blinded trial which is conducted to measure the efficacy of topical virgin olive oil on osteoarthritis of knee that will be done in contrast to standard piroxicam gel.
- Trial name
- NCT00670475
- Testing
- Piroxicam, Olive Oil
- Where
- Iran
- Volunteers
- 60 people
- Sponsor
- Ardabil University of Medical Sciences
Knee Osteoarthritis
Effect of Knee Bracing on Improving Pain & Disability
The overall purpose of the proposed pilot study is to establish the feasibility of conducting a clinical trial by evaluating the preliminary effects of 8 weeks of knee bracing on physiological measures of self-reported pain and…
- Trial name
- NCT04044612
- Testing
- Medial Unloader Brace
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of North Carolina, Chapel Hill
Osteoarthritis of Knee
RCT on the Performance and Safety of LightForce® Therapy Lasers on Knee Osteoarthritis Pain Reduction (SPARK)
DJO UK Ltd (ENOVIS) is conducting this study to assess the effectiveness of LightForce® Therapy Lasers on pain reduction in subjects with unilateral or bilateral knee osteoarthritis.
- Trial name
- SPARK (NCT06654739)
- Testing
- Laser therapy + physiotherapy/exercise protocol
- Where
- 7 sites in France, Italy and 1 more
- Volunteers
- 64 people
- Sponsor
- DJO UK Ltd
Degenerative Arthritis, Knee Arthritis
Investigator Initiated Trial to Evaluate Cartilage Regeneration by Arthroscopy After JOINTSTEM Administration
The purpose of this study is to confirm cartilage regeneration through arthroscopy after a single administration of autologous Adipose Tissue derived Mesenchymal stem cells(JOINTSTEM) in patients with degenerative arthritis of…
- Trial name
- NCT04821102
- Testing
- JOINTSTEM, Saline
- Where
- South Korea
- Volunteers
- 21 people
- Sponsor
- R-Bio
Knee Osteoarthritis
Knee Malalignment and Thigh Muscle Strengthening in Individuals With Medial Knee Arthritis
To investigate the effects of quadriceps strengthening on the adductor moment in individuals with medial knee OA and whether quadriceps strengthening has a different effect on the adductor moment in individuals with and without…
- Trial name
- NCT00414557
- Testing
- Quadriceps strengthening
- Where
- Australia
- Volunteers
- 107 people
- Sponsor
- University of Melbourne
Osteoarthritis
Cost Efficacy of a Clinical Pathway to Patients Undergoing Hip and Knee Replacement Surgery
In this randomised study a proactive care and rehabilitation intervention is compared to the current care and rehabilitation in patients undergoing primary hip and knee replacement surgery.
- Trial name
- NCT00175201
- Testing
- Proactive care and rehabilitation
- Where
- Denmark
- Volunteers
- 247 people
- Sponsor
- University of Aarhus
Knee Osteoarthritis
Effects Of Maitland's Mobilization At Mid Versus End Range In Knee Osteoarthritis Patients
Knee Osteoarthritis (OA) is the most common form of arthritis affecting mostly elderly people contributing to major cause of disability worldwide.In knee osteoarthritis Maitland's manual therapy technique could be the most…
- Trial name
- NCT06751095
- Testing
- Maitland's Mobilization in End range, Maitland's mobilization in Mid range
- Volunteers
- 44 people
- Sponsor
- Riphah International University
Total Knee Arthroplasty, Knee Osteoarthritis
Bicruciate-retaining (2C) Total Knee Arthroplasty (TKA) Versus Posterior-stabilized (PS) Total Knee Arthroplasty (TKA)
Total knee arthroplasty (TKA) with the sacrifice of the anterior cruciate ligament is the standard treatment for severe knee osteoarthritis.
- Trial name
- NCT05469776
- Testing
- bicruciate-retaining total knee arthroplasty, posterior-stabilized total knee arthroplasty
- Where
- Canada
- Volunteers
- 77 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Osteoarthritis, Knee
A Study to Investigate the Safety and Effectiveness of Different Doses of Sprifermin in Participants With Osteoarthritis of the Knee
This was a multicenter, randomized, double-blind, placebo-controlled, parallel-group Phase 2 trial of Sprifermin administered intra-articularly in participants with primary osteoarthritis of the knee and Kellgren-Lawrence Grade 2…
- Trial name
- FORWARD (NCT01919164)
- Testing
- Sprifermin
- Where
- 13 sites in United States, Argentina and 6 more
- Volunteers
- 549 people
- Sponsor
- EMD Serono Research & Development Institute, Inc.
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