Clinical trials: Knee Arthritis Disease
Knee Osteoarthritis
Intra-articular Pulsed Radiofrequency Neuromodulation Versus Intra-articular Steroids for Painful Knee Osteoarthritis
To compare the efficacy of intra-articular pulsed radiofrequency to intra-articular steroids in patients with moderate-severe painful osteoarthritis of the knee.
- Trial name
- NCT04238598
- Testing
- Pulse Radiofrequency, Standard of Care Intra- Articular Injection
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Center For Interventional Pain and Spine
Osteoarthritis, Knee
PAAG-OA Treatment for Knee Osteoarthritis
This is a multi-centre, prospective, open-label, uncontrolled, clinical investigation followed by an open-label extension clinical investigation to evaluate PAAG-OA in patients with knee osteoarthritis.
- Trial name
- IDA (NCT04179552)
- Testing
- PAAG-OA
- Where
- 3 sites in Denmark
- Volunteers
- 49 people
- Sponsor
- Contura
Osteoarthritis, Knee
Intraosseous With Intra-articular Injection of Platelet Rich Plasma in Treatment of Knee Osteoarthritis
The aim of this study was to compare the efficacy of treatment in three groups of patients with knee osteoarthritis (OA) given a combination of intraosseous with intra-articular injection of platelet rich plasma (PRP)…
- Trial name
- NCT03329235
- Testing
- PRP, HA
- Volunteers
- 86 people
- Sponsor
- Cangzhou Central Hospital
Osteoarthritis
Improving Services and Outcomes for Joint Replacement Patients
Primary total knee or total hip replacement surgeries are costly high volume procedures \& outcomes may be affected by surgical \& care processes \& individual patient characteristics.
- Trial name
- NCT01899443
- Testing
- Observation
- Where
- 18 sites in Australia
- Volunteers
- 1,900 people
- Sponsor
- South West Sydney Local Health District
Osteoarthritis, Knee
Effect of Reparel Knee Sleeve With Knee Injection
The goals of treating knee osteoarthritis (OA) is to improve or maintain quality of life, mobility and function, pain relief, and improve inflammation.
- Trial name
- NCT04859764
- Testing
- Reparel knee sleeve, Corticosteroid injection
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Alabama at Birmingham
Osteoarthritis, Knee, Osteoarthritis, Hip
A Study to Determine the Safety and the Efficacy of Fasinumab Compared to Placebo and Naproxen for Treatment of Adults With Pain From Osteoarthritis of the Knee or Hip
The primary objective of the study is to evaluate the efficacy of fasinumab compared with placebo, when administered for up to 16 weeks in patients with pain due to osteoarthritis (OA) of the knee or hip.
- Trial name
- FACT OA1 (NCT03161093)
- Testing
- Fasinumab, Naproxen
- Where
- 139 sites in United States, Denmark and 10 more
- Volunteers
- 3,307 people
- Sponsor
- Regeneron Pharmaceuticals
Knee Osteoarthritis, Primary Total Knee Arthroplasty
Evaluation of Utility of Ultrasound Guided iPACK Block for Knee Extension After Total Knee Arthroplasty.
The purpose of this study is to learn if using an Interspace between the Popliteal Artery and Capsule of the Knee (iPACK) injection technique (also called a "nerve block") that numbs the nerves going to the back part of the knee…
- Conditions
- Knee Osteoarthritis, Primary Total Knee Arthroplasty, Physical Therapy, Pain
- Trial name
- NCT03353233
- Testing
- Ropivacaine, Interspace Between the Popliteal Artery and Capsule of the Knee (iPACK) Block, Saline
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Duke University
Osteoarthritis of the Knee
Study of Safety and Efficacy of Diractin® for the Treatment of Osteoarthritis (OA) of the Knee
The purpose of this study is to provide replicated evidence of safety and efficacy of 100 mg ketoprofen in Diractin®.
- Trial name
- NCT00722852
- Testing
- ketoprofen in Diractin®
- Where
- 37 sites in United States
- Volunteers
- 555 people
- Sponsor
- IDEA AG
Knee Osteoarthritis
Investigation of the Effectiveness of Wii-Based Exercise Play Therapy in Knee Osteoarthritis Rehabilitation
Osteoarthritis (OA) is a slowly progressive, chronic and degenerative joint disease frequently seen in the knee and hip joints. OA is not only involved in degenerative changes of cartilage, but can also be a result of capsular…
- Trial name
- NCT05601947
- Testing
- Structured Proprioception and Closed Kinetic Chain Exercises Group, Wii Based Balance Training Program Group
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people
- Sponsor
- Istanbul Medipol University Hospital
Knee Osteoarthritis
Comparing One Intraarticular Injection of a Novel HYAJOINT Plus With Synvisc-One for the Treatment of Knee OA
Viscosupplementation has been widely used for the treatment of knee osteoarthritis (OA). There is no well controlled trial comparing one injection regimen of HA for the treatment of knee OA.
- Trial name
- NCT02686047
- Testing
- HYAJOINT Plus, Synvisc-One
- Where
- Taiwan
- Volunteers
- 132 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Osteoarthritis, Knee
Mesenchymal Stem Cell Therapy for Knee Osteoarthritis
The study is a multicentered, randomized, double-blinded, placebo-controlled study conducted on the unilateral knee of 120 patients.
- Trial name
- NCT05288725
- Testing
- Bone Marrow Derived MSCs, Corticosteroid, Bone Marrow Aspirate
- Where
- 3 sites in United States
- Volunteers
- 120 people
- Sponsor
- Next Generation Regenerative Medicine LLC
Osteoarthritis Knees Both Post-Traumatic
Preventing Knee Osteoarthritis Through Exercise and Education Following Knee Injury
This study evaluates the preliminary efficacy of an 8-week exercise and education intervention on musculoskeletal health of young adults with a previous sport-related knee injury that are at high risk of post-traumatic…
- Trial name
- NCT04363476
- Testing
- SHRED Osteoarthritis program
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Sport Injury Prevention Research Centre
Osteoarthritis
Adductor Canal Block Versus Periarticular Bupivicaine Injection in Total Knee Arthroplasty
The objective of the study is to compare the efficacy of adductor canal blocks versus periarticular bupivacaine injections for pain management in total knee arthroplasty.
- Trial name
- NCT02777749
- Testing
- Bupivacaine
- Where
- United States
- Volunteers
- 155 people
- Sponsor
- Columbia University
Knee Osteoarthritis
Home Based Hip Strengthening for Knee OA Patients
In knee osteoarthritis patients, weakness of hip abductor muscles is considered an important contributing factor leading to the progression of the disease.
- Trial name
- NCT05131048
- Testing
- conventional group, experimental group
- Volunteers
- 90 people
- Sponsor
- University of Lahore
Knee Osteoarthritis
Pain Control After Total Knee Arthroplasty
Patients are randomized to receive pain control after Total Knee Arthroplasty with either a regional pain catheter or a local intraarticular pain catheter. Pain, analgetic use and mobility is asessed.
- Trial name
- NCT03032133
- Testing
- Regional pain control, Local pain control
- Where
- Germany
- Volunteers
- 140 people
- Sponsor
- Technische Universität Dresden
Knee Osteoarthritis
The Comparison of Knee Osteoarthritis Treatment With Bone Marrow Aspirate Concentrate , Leukocyte Rich Platelet Rich Plasma and Hyaluronic Acid
The aim of this study is to compare therapeutic and clinical effects of intra-articular injection of Bone Marrow Aspirate Concentrate (BMAC), inta-articular injection of Leukocyte Rich Platelet Rich plasma (LR-PRP) and 3 weekly…
- Trial name
- NCT03825133
- Testing
- Bone Marrow Aspirate Concentrate, Leukocyte Rich Platelet Rich Plasma, Hyaluronic Acid
- Where
- Serbia
- Volunteers
- 180 people
- Sponsor
- Clinical Center of Vojvodina
Osteoarthritis
Efficacy and Safety of Lumiracoxib
This trial assessed the safety and efficacy of a single dose of lumiracoxib 400 mg compared to placebo and to a single dose of celecoxib 200mg.
- Trial name
- NCT00267215
- Testing
- Lumiracoxib
- Where
- Germany
- Volunteers
- 330 people
- Sponsor
- Novartis
Knee Arthritis, Osteoarthritis
Eccentric vs Low-Load Blood Flow Restriction Training in Knee Osteoarthritis in Knee Osteoarthritis
The aim of this randomized controlled trial is to find the effects of eccentric and low-load blood flow restriction training on neuromuscular adaptations, muscle strength, functional performance, and disability in patients with…
- Trial name
- the (NCT07733518)
- Testing
- Eccentric Gastrocnemius Strengthening Exercises, Low-Load Blood Flow Restriction Training
- Where
- Pakistan
- Volunteers
- 48 people
- Sponsor
- Riphah International University
Osteoarthritis, Knee
Somatosensory Stimulation in Knee Osteoarthritis
Worldwide, 9.6% of men and 18% of women aged over 60 years suffer from osteoarthritis (OA), most of which involve the knee. Within the OA patient population, 80% of the OA patients have limitations of movement, and 25% cannot…
- Trial name
- NCT02854176
- Testing
- Somatosensory electrical stimulation, Control
- Volunteers
- 20 people
- Sponsor
- Menno Veldman
Chronic Pain, Lumbar Back Pain
Effectiveness of Acupuncture Clinical Pathway
The study will be described the development and implementation of the Clinical pathway (CPW) for acupuncture treatment in the management of patients with some chronic pain conditions.
- Conditions
- Chronic Pain, Lumbar Back Pain, Osteoarthritis, Knee, Headache
- Trial name
- ACUPATHWAY (NCT04490798)
- Testing
- Electroacupuncture
- Where
- Spain
- Volunteers
- 3,245 people
- Sponsor
- Hospital Son Llatzer
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