Clinical trials: Knee Arthritis Disease
Osteoarthritis, Knee
VItamin D Effect on Osteoarthritis Study
Observational evidence suggests that vitamin D deficiency may have a role in the causes of osteoarthritis (OA) and there are biologically plausible mechanisms to explain this.
- Trial name
- VIDEO (NCT01176344)
- Testing
- Vitamin D
- Where
- 2 sites in Australia
- Volunteers
- 413 people
- Sponsor
- Menzies Institute for Medical Research
Osteoarthritis (OA) of the Knee
Collagen-PVP vs Hylan G-F 20 in the Treatment of Knee Osteoarthritis
Abstract Title: "Efficacy of intra-articular polyvinylpyrrilidone collagen in the treatment of Kellgren-Lawrence grade II-III primary knee osteoarthritis compared to Hilano G-F 20: a controlled clinical trial." Investigators…
- Trial name
- 26092023 (NCT07692009)
- Testing
- Collagen-polyvinylpyrrolidone, Hylan G-F 20
- Where
- Mexico
- Volunteers
- 32 people
- Sponsor
- Centro Multidisciplinario para el Desarrollo Especializado de la Investigacion Clinica en Yucatan S.
Knee Osteoarthritis
The Effect of Postoperative "Peanut Ball" Rehabilitation After Total Knee Replacement.
The purpose of this randomized controlled study is to evaluate the effect of postoperative exercise with a "peanut ball" after total knee replacement, on pain, intake of pain killers, knee function, and health-related quality of…
- Trial name
- NCT05137834
- Testing
- Exercise
- Where
- Sweden
- Volunteers
- 300 people
- Sponsor
- Region Skane
Knee Osteoarthritis
Factors Predicting the Duration of Effectiveness of Viscosupplementation in Knee Arthosis
Knee osteoarthritis is a frequent condition whose prevalence is estimated at 7.6% of the French population aged 40 to 75, or approximately 2 million individuals .
- Trial name
- PRESAGE (NCT04988698)
- Testing
- none intervention
- Where
- France
- Volunteers
- 103 people
- Sponsor
- Hopital Nord Franche-Comte
Osteoarthritis of the Knee
Safety and Feasibility Study of Mesenchymal Trophic Factor (MTF) for Treatment of Osteoarthritis
Allogeneic mesenchymal trophic factors (MTF) from human umbilical cord tissue-derived mesenchymal stem cells (UC-MSC) injected into the knee joints of 20 patients (group 1) or injected subcutaneously into 20 patients (group 2) is…
- Trial name
- NCT02003131
- Testing
- Trophic factors from umbilical cord mesenchymal stem cells
- Where
- Panama
- Sponsor
- Translational Biosciences
Degenerative Osteoarthritis, Defect of Articular Cartilage
Follow-Up Study of CARTISTEM® Versus Microfracture for the Treatment of Knee Articular Cartilage Injury or Defect
This is a long term follow-up study to investigate the safety and efficacy of CARTISTEM®, human umbilical cord blood-derived mesenchymal stem cells, in repair of cartilage injury or defects, compared with microfracture.
- Trial name
- NCT01626677
- Testing
- CARTISTEM, Microfracture
- Where
- 10 sites in South Korea
- Volunteers
- 103 people
- Sponsor
- Medipost Co Ltd.
Anemia, Arthritis
Single Versus Multi-Dose Oral Tranexamic Acid in Patients at High Risk for Blood Transfusion After Total Joint Arthroplasty
As tranexamic acid (TXA) becomes more prevalent, all patients are receiving the same dose regardless of their pre-operative risk of transfusion.
- Conditions
- Anemia, Arthritis, Total Knee Arthroplasty, Total Hip Arthroplasty
- Trial name
- NCT02926651
- Testing
- Conventional Oral TXA (Tranexamic Acid), Multi-Dose Oral TXA (Tranexamic Acid)
- Where
- United States
- Sponsor
- Rush University Medical Center
Osteoarthritis, Knee
Use of Perioperative Photograph as a Motivation for Increasing Range of Motion After Primary Total Knee Arthroplasty
Total knee arthroplasty (TKA) is recognized as a successful procedure for treating osteoarthritis (OA) of the knee. One important factor that make the successful surgery is the degree of knee flexion.
- Trial name
- NCT03075319
- Testing
- Received perioperative photograph, Didn't receive perioperative photograph
- Volunteers
- 60 people
- Sponsor
- Thammasat University
Osteoarthritis
A Phase I, Prospective, Randomized, Open-label, Active-Controlled Clinical Trial for Safety Evaluation of Intra-articular Injection of RegenoGel-SP for the Treatment of Moderate to Severe Osteoarthritis
This is a Phase I, prospective, active-controlled, randomized, open-label, clinical trial designed to assess the safety and tolerability of single intra-articular injection of RegenoGel-SP for the treatment of OA.
- Trial name
- NCT02188771
- Testing
- intra-articular administration of RegenoGel-SP or hyaluronic acid (HA)
- Where
- Israel
- Volunteers
- 11 people
- Sponsor
- ProCore Ltd.
Knee Osteoarthritis, Knee Pain Chronic
The Effect of Physical Therapy Modalities and Kinesio Taping in Patients With Knee Osteoarthritis
Osteoarthritis (OA) is the most common degenerative joint disease with pathological structural and functional disorders all over the world. 27 million patients diagnosed with osteoarthritis in the USA alone.(1-2)
- Trial name
- NCT05211544
- Testing
- physical therapy modalities and exercise, kinesio taping and exercise, exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Abant Izzet Baysal University
Osteoarthritis, Knee, Joint Instability
Combined Prospective and Retrospective Post-Market Follow Up of the 'BPK-S Integration' UC as Primary Implant in the Variant CoCr
Patients who received a total knee endoprosthesis BPK-S Integration between 2011 and 2013 will be invited to participate in this PMCF study provided sufficient source data documentation is available regarding preoperative…
- Trial name
- NCT03406637
- Testing
- BPK-S Integration
- Where
- 2 sites in Belgium
- Volunteers
- 62 people
- Sponsor
- Peter Brehm GmbH
Osteoarthritis
Intra-articular Polyacrylamide Hydrogel in Gonarthrosis
The OLE was aimed to assess long-term safety and efficacy of one and two courses of IA HBISA in patients with knee osteoarthritis.
- Trial name
- NCT06429319
- Testing
- Hydrous biopolymer with silver ions "Argiform" (HBISA) endoprosthesis of synovial fluid NOLTREX™
- Where
- 4 sites in Russia
- Volunteers
- 65 people
- Sponsor
- Research Centre BIOFORM
Meniscus Injury, Knee Osteoarthritis
Knee Arthroscopy Cohort Southern Denmark (KACS)
PURPOSE: To investigate the natural time course of patient-reported outcomes after meniscus surgery and identify factors associated with good and bad outcome after surgery.
- Trial name
- KACS (NCT01871272)
- Testing
- Arthroscopic Meniscus Surgery
- Where
- 4 sites in Denmark
- Volunteers
- 491 people
- Sponsor
- University of Southern Denmark
Knee OA, Osteoarthritis
Comparing Exercise Programs for Managing Knee Osteoarthritis
The goal of this clinical trial is to assess and compare the effectiveness of three different exercise modalities-whole-body vibration exercise, progressive resistance exercise, and home-based exercise -in improving quadriceps…
- Conditions
- Knee OA, Osteoarthritis, Osteoarthritis (OA) of the Knee
- Trial name
- NCT06711341
- Testing
- Whole-body Vibration (WBV) Training, Progressive Resistance Exercise (PRE), Home-Based Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 69 people
- Sponsor
- Uludag University
Osteoarthritis, Knee
An Exploratory Clinical Study to Investigate the Effect of autoSTEM-OA and alloSTEM-OA in Participants With Knee Osteoarthritis
A phase 1 exploratory clinical study to investigate safety, tolerance and efficacy of a single intra-articular injection of autoSTEM-OA or alloSTEM-OA in participants with mild to moderate knee osteoarthritis
- Trial name
- NCT05789719
- Testing
- STEM-OA
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- StemMedical A/S
Osteoarthritis, Knee
Study To Assess The Efficacy And Safety Of The Medical Device Iracross Versus Iraline Administered Intra-Articular To Patients With Knee Osteoarthritis
Comparison with a non-inferiority design at 12 and 24 weeks on a larger scale is real to objectively evaluate the composite measurement of ROM, pain and basic activities like walking or performing daily activities (QoL) in a…
- Trial name
- NCT04574453
- Testing
- Iracross, Iraline
- Where
- Romania
- Volunteers
- 103 people
- Sponsor
- I.R.A. Istituto Ricerche Applicate S.p.A.
Osteoarthritis
Evaluation of the Latella™ Knee Implant System for Medial Osteoarthritis Pain Reduction
The objective of the Latella-US study is to demonstrate the safety and efficacy of the Latella Knee Implant System for the reduction of medial osteoarthritis pain.
- Trial name
- Latella-US (NCT02608957)
- Testing
- Latella Knee Implant System
- Where
- 2 sites in United States
- Volunteers
- 1 people
- Sponsor
- Cotera, Inc.
Knee Arthritis, Osteoarthritis
A Single-Center Phase 1 Study of ceAF for Knee Osteoarthritis (KOA)
Approximately 25 participants aged 18-70 years, with knee pain rated 4-7 on a 10-point visual analogue scale (VAS) and a disease duration of 6 months to 10 years, will be enrolled. The study has two parts.
- Trial name
- KOA (NCT07902128)
- Testing
- Animal early embryo extract
- Where
- China
- Volunteers
- 26 people
- Sponsor
- Anhui HygeianCells BioMedical Co., Ltd.
Osteoarthritis, Pain, Postoperative
Liposomal Bupivacaine Versus Standard Bupivacaine Plus Dexamethasone in Quadriceps Sparing Femoral Nerve Block and Wound Infiltration for Total Knee Arthroplasty
The purpose of this study is to compare the efficacy and duration of pain relief after total knee arthroplasty provided by a single injection of liposomal bupivacaine (EXPAREL®) versus standard bupivacaine with an adjuvant…
- Trial name
- NCT02624856
- Testing
- Liposomal bupivacaine, Bupivacaine plus dexamethasone
- Where
- United States
- Sponsor
- Albany Medical College
Osteoarthritis of the Knee
A Study to Evaluate Safety of Three Intra-articular Injections of Ampion in the Knee of Adults With Osteoarthritis Pain
Phase 1 will evaluate the safety of 3 intra-articular injections of Ampion™ administered 2 weeks apart to adults with osteoarthritis of the knee.
- Trial name
- NCT02184156
- Testing
- 4 mL injection of Ampion
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Ampio Pharmaceuticals. Inc.
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