Clinical trials: Knee Arthritis Disease
Knee Osteoarthritis
Using Pressure Detecting Insoles to Reduce Knee Loading
The purpose of this study is to determine whether use of a pressure-detecting shoe improve can enhance favorable loading conditions at the knee.
- Trial name
- NCT02955225
- Testing
- Active Moticon OpenGO insole, Passive shoe insole
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Rush University Medical Center
Osteoarthritis, Knee, Cartilage Degeneration
Subchondral and Intra-articular Application of Bone Marrow Concentrate for Knee Unicompartmental OA
Unicompartmental knee osteoarthritis (OA) is a common finding especially in patients with lower limb malalignment and previous meniscectomy.
- Trial name
- MarrowMule (NCT03790189)
- Testing
- Subchondral and intra-articular injection of BMC
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- Istituto Clinico Humanitas
Osteoarthritis, Knee
Evaluation of the Evolution of Imaging Markers of Cartilage Degradation in Patients With Knee Osteoarthritis Receiving DROGLICAN
A previous multicenter trial led by Bioiberica S.A. has confirmed the efficacy and safety of DROGLICAN for the treatment of osteoarthritis (OA) in patients with severe pain.
- Trial name
- DRIP (NCT02821468)
- Testing
- Droglican, Paracetamol or oral NSAIDs excluding COX2 inhibitors
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Bioiberica
Knee Osteoarthritis
Neurofeedback for Pain Sensitization in Knee Osteoarthritis
The goal of this clinical trial is to learn whether a training method called neurofeedback is safe and practical to use in people with knee osteoarthritis (knee OA).
- Trial name
- NCT07832682
- Testing
- FWR Down-Conditioning Neurofeedback
- Volunteers
- 50 people
- Sponsor
- Northeastern University
Knee Osteoarthritis, Dextrose Prolotherapy Injection
The Effect of Dextrose Prolotherapy on Isokinetic Power in the Treatment of Knee Osteoarthritis
Osteoarthritis is a degenerative joint disease characterized by erosion of the articular cartilage, bone hypertrophy at the margins of the joint, subchondral sclerosis, and some biochemical and morphological changes in the…
- Conditions
- Knee Osteoarthritis, Dextrose Prolotherapy Injection, Physical Therapy
- Trial name
- NCT04958213
- Testing
- Dextrose prolotherapy injection, conventional physical therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Mustafa Kemal University
Knee Osteoarthritis
Liposomal Bupivacaine vs Adductor Canal Block in Total Knee Arthroplasty
This study is being done to evaluate the outcomes of patients undergoing total knee replacement with two different methods of local pain control:shots of liposomal bupivacaine, a long acting anesthetic, directly into the knee…
- Trial name
- NCT02863120
- Testing
- liposomal bupivacaine, bupivacaine HCl, Ropivacaine
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Texas Orthopaedics, Sports and Rehabilitation Associates
Hip Osteoarthritis, Knee Osteoarthritis
Leisure Expectations About Physical Activity Study
To pilot test an activity-focused intervention that educates patients undergoing total hip (THA) or total knee (TKA) arthroplasty due to osteoarthritis about the appropriate type, frequency, intensity, and duration of expected…
- Trial name
- LEAP (NCT01938274)
- Testing
- Educational intervention
- Where
- United States
- Sponsor
- West Virginia University
Knee Osteoarthritis (Knee OA)
Efficacy and Safety of Tongren-Dahuoluo Bolus in Patients with Knee Osteoarthritis
The clinical trial has a research cycle of 24 weeks. The first 12 weeks are multicenter, randomized, double-blind, controlled trials.
- Trial name
- NCT06674759
- Testing
- Tongren-Dahuoluo Bolus
- Volunteers
- 72 people
- Sponsor
- Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Knee Osteoarthritis
Knee Pain Ejiao Paste for Knee Osteoarthritis
To explore the analgesic efficacy of Knee Pain Ejiao Paste in the treatment of knee osteoarthritis (Qi and Blood Deficiency Pattern) after 12 weeks, using an Ejiao-free clear paste as a parallel control and incorporating a…
- Trial name
- NCT07504562
- Testing
- Knee Pain Ejiao Paste, Knee Pain Ejiao-free Clear Paste
- Where
- 2 sites in China
- Volunteers
- 60 people
- Sponsor
- ShuGuang Hospital
Osteoarthritis, Osteoarthritis (OA) of the Knee
Feasibility of Choose to Move Replacement Ready
Choose to Move (CTM) is a 3-month, choice-based health-promoting program for low active older adults being scaled-up across British Columbia (BC), Canada.
- Conditions
- Osteoarthritis, Osteoarthritis (OA) of the Knee, Osteoarthritis, Hip, Total Knee Arthroplasty; Total Hip Arthroplasty
- Trial name
- CTM-RR (NCT07069179)
- Testing
- Choose to Move Replacement Ready
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of British Columbia
Knee Osteoarthritis
Dose-Response Effect of Intra-Articular Ozone in Knee Osteoarthritis
The goal of this clinical trial is to evaluate the clinical efficacy of different doses of intra-articular ozone injections combined with exercise in patients aged 40-75 diagnosed with Grade 2-3 knee osteoarthritis.
- Trial name
- NCT07678996
- Testing
- ozone injection, Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Kayseri City Hospital
Osteoarthritis, Knee
Multiple Ascending Doses (MAD) of Anti-A Disintegrin and Metalloproteinase With Thrombospondin Motifs-5 (Anti-ADAMTS-5) Nanobody in Participants With Knee Osteoarthritis (OA)
The study will be conducted in participants with symptomatic knee OA to explore the safety, tolerability, immunogenicity, pharmacokinetics (PK), and pharmacodynamics (PD) of MAD of M6495.
- Trial name
- NCT03583346
- Testing
- M6495
- Where
- Denmark
- Volunteers
- 32 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Knee Osteoarthritis
Feasibility of Pain Informed Movement for Knee OA
The pain experience and its associated mechanisms in people with knee osteoarthritis (OA) are known to be complex and multidimensional.
- Trial name
- NCT04954586
- Testing
- Pain Informed Movement
- Where
- Canada
- Volunteers
- 19 people
- Sponsor
- McMaster University
Knee Osteoarthritis
Clinical Trial to Evaluate the Efficacy and Safety of Conjuran® After First and Second Cycle (Repeat) Administration in Patients With Knee Osteoarthritis
This clinical trial aims to evaluate and compare the efficacy and safety of Conjuran® and Hyruan in patients with knee osteoarthritis following first and second cycle (repeat) administration.
- Trial name
- NCT07646483
- Testing
- Conjuran, Hyruan
- Volunteers
- 180 people
- Sponsor
- PharmaResearch Co.,Ltd
Spine Degeneration, Hip Arthritis
Evaluating the Efficacy of a Mobile Application in Postoperative Rehabilitation
This study aims to evaluate the effectiveness of a mobile application in improving postoperative rehabilitation outcomes among patients undergoing orthopedic surgery.
- Conditions
- Spine Degeneration, Hip Arthritis, Knee Osteoarthritis, Hip Fractures
- Trial name
- NCT06407427
- Testing
- App for in-bed conditioning exercises, Usual care
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Yale University
Osteoarthritis, Knee
Comparison of Mobile-Bearing and Fixed-Bearing All-Polyethylene Tibia Total Knee Designs
This study will be designed to compare prospectively, in a randomized fashion, the clinical, functional, and radiographic results of a nonmodular (all-polyethylene tibi/AP) fixed-bearing posterior cruciate substituting design…
- Trial name
- NCT00894361
- Testing
- TKA surgery with the rotating platform mobile-bearing knee design, TKA surgery with the all-polyethylene tibia knee design
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Minneapolis Veterans Affairs Medical Center
Osteoarthritis of the Knee
Clinical Study of Umbilical Cord Tissue Mesenchymal Stem Cells (UC-MSC) for Treatment of Osteoarthritis
Allogeneic human umbilical cord tissue-derived stem cells injected intravenously (IV) once per day for 3 days or once intra-articularly are a safe and will induce a therapeutic effect in osteoarthritis (OA) patients.
- Trial name
- NCT02237846
- Testing
- Human umbilical cord tissue-derived mesenchymal stem cells
- Where
- Panama
- Sponsor
- Translational Biosciences
Osteoarthritis (OA) of the Knee, Total Knee Arthroplasty
GENicular Nerve Block in KNEE Arthroplasty
The goal of this clinical trial is to learn whether a preoperative genicular nerve block (GNB) can reduce pain after knee replacement surgery in adults with knee osteoarthritis (OA) undergoing total knee arthroplasty (TKA).
- Conditions
- Osteoarthritis (OA) of the Knee, Total Knee Arthroplasty, Genicular Nerve Block
- Trial name
- GENKNEE (NCT07589127)
- Testing
- Preoperative genicular nerve block (GNB)
- Where
- Norway
- Volunteers
- 70 people
- Sponsor
- Helse Møre og Romsdal HF
Knee Osteoarthritis
Impact of Sensor Technology in Knee OA
OBJECTIVES: Physical activity has been established as an important component of rehabilitation for knee osteoarthritis (OA), and is often guided by a physical therapist.(1) Physical therapy for knee OA typically involves 1-3…
- Trial name
- NCT05222503
- Testing
- Knee Brace + OPUM Digital Knee, Knee Brace
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- OPUM Technologies US LTD
Osteoarthritis (OA) of the Knee
Effect of Steroid Injections in a Knee With Osteoarthritis
A steroid (triamcinolone) 40 mg will be compared to placebo in a randomized placebo-controlled clinical trial testing the effect of this steroid versus placebo given into the study knee joint that has osteoarthritis (OA).
- Trial name
- NCT01230424
- Testing
- Triamcinolone Acetonide
- Where
- 2 sites in United States
- Volunteers
- 140 people
- Sponsor
- Tufts Medical Center
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