Clinical trials: Knee Arthritis Disease
Knee Osteoarthritis
An Innovative Mind-motor Exercise Approach to Osteoarthritis Treatment
Osteoarthritis (OA) is a growing burden in an aging society. There are few proven treatments and hence disability contributes to poor quality of life and direct/indirect costs to society.
- Trial name
- NCT02753634
- Testing
- Square-stepping exercise
- Volunteers
- 22 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Synovitis of Knee, Osteoarthritis, Knee
The Role of Synovitis in Osteoarthritis
To determine whether platelet-rich-plasma (PRP) or HA (hyaluronic acid)injection into synovitis in osteoarthritis(OA) knee can achieve improvement in knee function and reduce synovitis.
- Trial name
- NCT03167333
- Testing
- platelet rich plasma, Hyaluronic acid
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Knee Arthropathy, Osteoarthritis, Knee
Investigating the Effectiveness of Vibration Therapy on Sarcopenia in Osteoarthritis Knee Patients
Osteoarthritis (OA) is one of the commonest chronic degenerative conditions affecting our aging population. It limits joint movement and causing disability in elderlies due to discordant symptoms such as pain and stiffness.
- Conditions
- Knee Arthropathy, Osteoarthritis, Knee, Knee Osteoarthritis
- Trial name
- NCT03880344
- Testing
- Vibration Therapy, Physiotherapy
- Where
- Hong Kong
- Volunteers
- 50 people
- Sponsor
- Chinese University of Hong Kong
Knee Osteoarthritis
Effects of Body Awareness Therapy in Knee Osteoarthritis
The aim of this study is to investigate the effect of Body Awareness Therapy (BAT) on pain, balance and functional capacity in patients with knee osteoarthritis.
- Trial name
- NCT04165187
- Testing
- Body Awareness Therapy, Home exercise program
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Bezmialem Vakif University
Knee Osteoarthritis
PSI for Bilateral Simultaneous TKA in Sever Varus
the Purpose of this study was to evaluate the short term outcome of patient specific instrument (PSI) in cases of bilateral simultaneous total knee arthroplasty (TKA) for knee osteoarthritis with sever varus
- Trial name
- NCT01998321
- Testing
- Patient specific instrument, conventional technique for TKA
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- October 6 University
Knee Osteoarthritis
Bespoke vs Standard Instrumentation in TKR
Total knee replacement (TKR) is an established treatment for knee osteoarthritis and leads to a satisfactory outcome in over 75% of patients.
- Trial name
- NCT02845206
- Testing
- Patient specific cutting blocks, Conventional cutting blocks
- Where
- United Kingdom
- Volunteers
- 172 people
- Sponsor
- NHS Lothian
Knee Osteoarthritis
Strengthening Exercise and Quadriceps Force During Walking
This is a longitudinal, randomized, controlled interventional multi centric study on the effects of lower leg strengthening exercise on quadriceps force during walking in people with knee osteoarthritis.
- Trial name
- NCT01538407
- Testing
- Strength Training
- Where
- 2 sites in United States, Denmark
- Volunteers
- 30 people
- Sponsor
- Frederiksberg University Hospital
Knee Osteoarthritis
Evaluating the Effect of Adipose Tissue Processed With the SyntrFuge™ System for Knee Osteoarthritis
This is an multi-center study with the aim of evaluating the efficacy of adipose tissue processed with the SyntrFuge™ system in Orthopedic Surgery, specifically Knee Osteoarthritis.
- Trial name
- NCT05526898
- Testing
- SyntrFuge System, Triamcinolone Injection
- Where
- 2 sites in United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Syntr Health Technologies, Inc.
Osteoarthritis (OA) of the Knee
Postoperative Pain and Analgesic Requirements After Preoperative Methadone for Primary TKA
The goal of this prospective, randomized study is to compare the outcomes of two cohorts of patients undergoing primary Total Knee Arthroplasty (TKA) and to determine whether a single dose of methadone administered preoperatively…
- Trial name
- NCT06691633
- Testing
- Preoperative Methadone, Preoperative Oxycodone
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Louisville
Anesthesia Morbidity, Osteoarthritis, Knee
Evaluation of Anesthetic Techniques in Outpatient Total Joint Replacement Surgery in an Integrated Health Care Delivery System
The study is a retrospective cohort study of adult patients undergoing outpatient primary unilateral total knee or total hip replacement surgeries from 2017 to 2019 assessing for difference in anesthetic techniques and outcomes.
- Conditions
- Anesthesia Morbidity, Osteoarthritis, Knee, Osteoarthritis, Hip
- Trial name
- NCT04203732
- Testing
- Anesthesia Type
- Where
- United States
- Volunteers
- 12,466 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Osteoarthritis, Knee
Is Non Surgical CaRE Using Treat to Target Multimodal meDIcal Strategies aBLE to Delay or Avoid Total Knee Replacement?
Knee is the most common site of osteoarthritis. Treatment of knee osteoarthritis starts with a full course of medical therapy, followed by surgery to replace the knee with a prosthesis if this strategy fails, or in advanced…
- Trial name
- INCREDIBLE (NCT06643845)
- Testing
- arthroplasty, Medical and non-medical treatments
- Where
- 21 sites in France
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Brest
Osteoarthritis, Knee, Knee Replacement
Prediction of Outcomes Following Total Knee Replacement- Pilot
This study seeks to examine multiple risk factors as predictors of pain and function following total knee arthroplasty (TKA). Risk factors will be measured pre-surgically using psychophysical testing procedures, multimodal…
- Trial name
- POKR-p (NCT04328701)
- Testing
- Mindfulness-based Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Brigham and Women's Hospital
Osteoarthritis of the Knee, Pain
A Study to Examine the Efficacy and Safety of REGN5069 in Patients With Pain Due to Osteoarthritis of the Knee
The primary objective of the study is to evaluate the efficacy of REGN5069 compared to placebo in patients with pain due to radiographically-confirmed OA of the knee who have a history of inadequate joint pain relief or…
- Trial name
- NCT03956550
- Testing
- REGN5069
- Where
- 12 sites in United States, Georgia and 3 more
- Volunteers
- 259 people
- Sponsor
- Regeneron Pharmaceuticals
Osteoarthritis, Knee
A Study of GW842166 in Adults With Osteoarthritis Pain
The purpose of this study is to determine whether GW842166 is effective in the treatment of osteoarthritis pain of the knee.
- Trial name
- NCT00447486
- Testing
- GW842166
- Where
- 22 sites in Denmark, Germany and 2 more
- Volunteers
- 308 people
- Sponsor
- GlaxoSmithKline
Knee Osteoarthritis
Resisted Exercise and Kinesiology-Taping in Managing Knee Osteoarthritis
The study aims the Role of Resisted Exercise and Kinesiology Taping in Managing Knee Osteoarthritis in Overweight and Obese Individuals.
- Trial name
- NCT07062822
- Testing
- Resisted exercise, kinesiology tapping
- Volunteers
- 40 people
- Sponsor
- Riphah International University
Degenerative Arthritis, Knee Arthritis
Follow-up Study for Participants of Jointstem Investigator Initiated Trial by Arthroscopy
This clinical trial is conducted to assess the long-term safety of "jointstem" in patients with degenerative knee arthritis who participated in the previous BS-JS-IIT1 investigator initiated trial.
- Trial name
- NCT04825730
- Testing
- JOINTSTEM
- Volunteers
- 14 people
- Sponsor
- R-Bio
Osteoarthritis, Knee
Effect of Patellar Denervation on Post-operative Knee Pain and Knee Function in Total Knee Arthroplasty
This study is a double-blind randomized controlled trial aiming to investigate the effects of patellar denervation using electrocautery on postoperative knee pain and knee function in patients undergoing primary total knee…
- Trial name
- PD (NCT07342166)
- Testing
- Patellar Denervation
- Where
- Thailand
- Volunteers
- 64 people
- Sponsor
- Queen Savang Vadhana Memorial Hospital, Thailand
Osteoarthritis, Knee, Chondral Defect
Evaluation of Treatment of Osteoarthritis of the Knee in the Form of Chondromalacia of the Articular Cartilage Treated in the Arthroscopic Technique With the Use of:Autogenous Transplantation of Fragmented Adipose Tissue,PRP GF,Mesenchymal Cells,Hyaluronic Acid-low Molecular Weight and Cross-linked
The main objective of the research project is to evaluate the results of the treatment of chondromalacia of the cartilage in the knee joint with the use of: autogenous transplantation of fragmented adipose tissue taken from the…
- Conditions
- Osteoarthritis, Knee, Chondral Defect, Chondromalacia, Left Knee, Chondromalacia, Right Knee
- Trial name
- NCT07110402
- Testing
- Autogenous transplant of fragmented adipose tissue taken from abdominal integuments, PRP GF (platelet-rich plasma with growth factors), Mesenchymal cells centrifuged from bone marrow cells taken from the iliac crest
- Where
- Poland
- Volunteers
- 150 people
- Sponsor
- eMKa MED Medical Center
Osteoarthritis, Knee
Knee Osteoarthritis Disabling Pain Program for the Brazilian Unified Health System
This is a Randomized Clinical Trial to compare two interventions for reducing knee pain and improving knee function of patients with knee osteoarthritis.
- Trial name
- NCT05286775
- Testing
- Clinical treatment and Knee educational program, Knee educational program
- Where
- Brazil
- Volunteers
- 71 people
- Sponsor
- Marta Imamura
Knee Osteoarthritis, Obesity
Aquatic Exercise Program for Knee Osteoarthritis
The aim of PICO study is to design an aquatic exercise program specific for obese individuals with knee osteoarthritis which the main goals are OA symptoms management and the improvement of physical fitness.
- Trial name
- PICO (NCT01832545)
- Testing
- Aquatic Exercise, Educational Program
- Where
- Portugal
- Volunteers
- 50 people
- Sponsor
- Technical University of Lisbon
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