Clinical trials: Knee Arthropathy
Knee Osteoarthritis
Multi-Center Study Evaluating the Efficacy of Wobenzym(R)N in Treating Knee Osteoarthritis
The objective of this study is to determine the most effective dose of Wobenzym® N versus placebo at reducing pain severity as measured by the WOMAC pain score in subjects with symptomatic knee osteoarthritis (OA) at 6 weeks of…
- Trial name
- NCT00974428
- Testing
- Wobenzym® N
- Where
- 4 sites in Canada
- Sponsor
- Atrium Innovations
Osteoarthritis, Knee
Treatment Effects of Subcutaneous Injections of Pentosan Polysulfate Sodium vs Placebo in Participants With Knee OA Pain
The purpose of this study is to measure the change in pain and function with subcutaneous injections of pentosan polysulfate sodium (PPS) compared with subcutaneous injections of placebo in participants with knee osteoarthritis…
- Trial name
- NCT04809376
- Testing
- Pentosan Polysulfate Sodium twice weekly, Pentosan Polysulfate Sodium Fixed Dose, Pentosan Polysulfate Sodium once weekly
- Where
- 33 sites in United States, Australia
- Volunteers
- 602 people
- Sponsor
- Paradigm Biopharmaceuticals USA (INC)
Knee Osteoarthritis
Evaluating the Efficacy and Safety of Intra-articular Injection of HS-20116 in Patients With Knee Osteoarthritis
The purpose of this trial is to evaluate the efficacy and safety of HS-20116 for intra-articular use in patients with symptomatic knee osteoarthritis.
- Trial name
- NCT07047196
- Testing
- HS-20116, Medical Chitosan (for intra-articular injection)
- Where
- China
- Volunteers
- 192 people
- Sponsor
- Jiangsu Hansoh Pharmaceutical Co., Ltd.
Knee Osteoarthritis
A Multicenter, Postmarket Surveillance Study of Subjects With the Canary canturioTM te Tibial Extension
The objectives of this prospective observational cohort study are to evaluate the safety, reliability, reproducibility, and accuracy of the Canary canturioTM te post-TKA.
- Trial name
- NCT06040827
- Testing
- Total Knee Arthroplasty
- Where
- 7 sites in United States
- Volunteers
- 626 people
- Sponsor
- Canary Medical
Degeneration Articular Cartilage Knee
Evaluation of Safety and Exploratory Efficacy of CARTISTEM®, a Cell Therapy Product for Articular Cartilage Defects
The purpose of this study is to determine whether CARTISTEM, a cell therapeutic product, is safe and effective in the treatment of articular cartilage defects of the knee as a result of ageing, trauma, or degenerative diseases.
- Trial name
- NCT01733186
- Testing
- CARTISTEM®
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Medipost, Inc.
Osteoarthritis, Knee
Efficacy of UniRelieverTM Offloading Brace in the Management of Knee Osteoarthritis
The objective of this study is to assess the efficacy and performance of a new semi-rigid offloading brace in the management of knee osteoarthritis.
- Trial name
- UNIBRACE (NCT05905809)
- Testing
- UniRelieverTM offloading brace (THUASNE), Unloader One® X brace (Össur)
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Thuasne
Osteoarthritis, Knee
A Study Evaluating the Safety, Tolerability, and Activity of ICM-203 in Subjects With Knee Osteoarthritis.
The purpose of this study is to determine the safety, tolerability, and activity of ICM-203, a recombinant adeno-associated viral (AAV) vector that expresses a therapeutic gene that promotes cartilage formation, reduces joint…
- Trial name
- NCT05454566
- Testing
- ICM-203
- Sponsor
- ICM Co. Ltd.
Osteoarthritis of the Knee
Efficacy and Safety of Imotun Capsule in Osteoarthritis of the Knee
Efficacy and safety of Imotun capsule in osteoarthritis of the knee
- Trial name
- ABSOLUTE-R (NCT01756937)
- Testing
- Imotun
- Where
- 9 sites in South Korea
- Volunteers
- 287 people
- Sponsor
- Chong Kun Dang Pharmaceutical
Osteoarthritis of the Knee
A Four-Week Study Comparing Acetaminophen Extended Release and Rofecoxib in the Treatment of Osteoarthritis of the Knee
To compare acetaminophen (Tylenol) with rofecoxib (Viox) for the treatment of Osteoarthritis of the Knee
- Trial name
- NCT00568295
- Testing
- acetaminophen, Rofecoxib
- Volunteers
- 403 people
- Sponsor
- Johnson & Johnson Consumer and Personal Products Worldwide
Osteoarthritis, Knee
Study of StimRouter for Chronic Knee OA Pain
The goal of this study is to evaluate the use of StimRouter Neuromodulation System (StimRouter) in adult subjects with an established diagnosis of primary femorotibial osteoarthritis in the target knee (Kellgren-Lawrence ≥1) who…
- Trial name
- GLEAM (NCT05644639)
- Testing
- StimRouter Neuromodulation System
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Bioventus LLC
Osteoarthritis
Ketoprofen Topical Patch, 20% in the Treatment of Pain Associated With Osteoarthritis Flare of the Knee
The purpose of this study is to evaluate the effect of a ketoprofen topical patch on the pain associated with Osteoarthritis Flare of the Knee.
- Trial name
- NCT00365586
- Testing
- Ketoprofen Topical Patch , 20%
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Alkemira SA
Osteoarthritis
Study of Safety, Tolerability, Preliminary Efficacy of Intra-articular LNA043 Injections in Patients With Articular Cartilage Lesions and Knee Osteoarthritis.
The purpose of this two-part study is to assess the efficacy, safety and tolerability of multiple intra-articular (i.a.) injections of LNA043, in regenerating the articular surface in patients with cartilage lesions of the knee…
- Trial name
- NCT03275064
- Testing
- LNA043
- Where
- 19 sites in United States, Czechia and 1 more
- Volunteers
- 142 people
- Sponsor
- Novartis Pharmaceuticals
Knee Osteoarthritis
Fasitibant Intra-articular Injection in Patients With Symptomatic Osteoarthritis of the Knee
This study is designed as a double-blind, randomised, placebo-controlled, four parallel arm, dose-finding study, to be conducted in approximately 26 sites, to evaluate the efficacy, safety, tolerability, and pharmacokinetics of…
- Trial name
- ALBATROSS-3 (NCT02205814)
- Testing
- Fasitibant- low dose, Fasitibant- intermediate dose, Fasitibant- high dose
- Where
- 25 sites in United States, Czechia and 2 more
- Volunteers
- 436 people
- Sponsor
- Menarini Group
Osteoarthritis, Knee
Umbilical Cord Derived Wharton's Jelly for Knee Osteoarthritis
The purpose of this study is to determine the safety and efficacy of intraarticular injection of umbilical cord derived Wharton's Jelly for treatment of knee osteoarthritis symptoms.
- Trial name
- NCT04719793
- Testing
- Umbilical Cord-derived Wharton's Jelly
- Volunteers
- 12 people
- Sponsor
- BioIntegrate
Osteoarthritis, Knee, Osteoarthritis, Hip
Autologous Adipose Tissue-Derived Mesenchymal Stem Cells (AdMSCs) for Osteoarthritis
This is a phase 2 open-label, 6 arms (1 study group and 1 control group for each joint category), randomized control group clinical study with 300 subjects diagnosed with osteoarthritis of knees (n=100), hips (n=100) and…
- Conditions
- Osteoarthritis, Knee, Osteoarthritis, Hip, Osteoarthritis Shoulder
- Trial name
- AdMSCs (NCT04448106)
- Testing
- Celltex- AdMSCs
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Celltex Therapeutics Corporation
Osteoarthritis, Rheumatoid Arthritis
Randomized Controlled Clinical Outcomes of the Vanguard XP Bicruciate Knee System
Randomized Controlled Study to determine if preservation of ligaments provides increased functional ability post-operatively in comparison to traditional TKA which sacrifices soft tissue.
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Traumatic Arthritis, Lower Limb Deformity
- Trial name
- GK9B (NCT02175576)
- Testing
- Vanguard XP Bicruciate Knee System, Vanguard CR Knee System
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Zimmer Biomet
Osteoarthritis, Knee
A Phase Ib/II Clinical Trial to Evaluate the Safety and Efficacy of LG00034053 in Patients With Knee OA
This study is a multi-center, randomized, placebo-controlled, double-blind clinical study, consisting of Part 1 (Phase 1b) in a sequential, dose-escalating design and Part 2 (Phase 2) in a parallel design.
- Trial name
- NCT05237752
- Testing
- LG00034053
- Where
- 2 sites in Australia, South Korea
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- LG Chem
Osteoarthritis of Knee
Efficacy of Flavocoxid 500 mg Compared With Naproxen 500 mg in Subjects With Moderate-severe Osteoarthritis of the Knee
To compare flavocoxid with naproxen for patients with moderate to severe osteoarthritis of the knee.
- Trial name
- NCT00790985
- Testing
- flavocoxid, Naproxen
- Volunteers
- 223 people
- Sponsor
- Primus Pharmaceuticals
Osteoarthritis
A Single Center 2-way Crossover Study to Investigate the Mechanism of Action of Etoricoxib in Subjects With Osteoarthritis Knee Pain
The purpose of this study is to investigate which pain mechanisms that can be affected by etoricoxib compared to placebo (inactive medication)in subjects with painful knee osteoarthritis af 4 weeks of treatment.
- Trial name
- NCT01619150
- Where
- Denmark
- Volunteers
- 39 people
- Sponsor
- C4Pain
Knee Osteoarthritis
Veteran Affairs Osteoarthritis Knee Study
A clinical study at the Dallas Veterans Affairs, is being proposed to test the efficacy of a novel electrical stimulation platform named the Pro-Sport Ultra® device by AVAZZIA to reduce pain and increase activity level in…
- Trial name
- NCT04698733
- Testing
- BEST™ HVPC microcurrent electrical stimulation Pro-Sport Ultra® device
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Avazzia, Inc
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