Clinical trials: Knee Arthropathy
Osteoarthritis
Efficacy Study of PN400 (VIMOVO) Twice Daily and Celebrex Once Daily in Patients With Osteoarthritis
We will evaluate the efficacy of PN 400 and an active comparator in patients that have Osteoarthritis of the knee.
- Trial name
- NCT00665431
- Testing
- PN 400 (VIMOVO), celebrex, Rescue Antacid
- Where
- United States
- Volunteers
- 610 people
- Sponsor
- POZEN
Joint Disease
A Comparison Between Signature Total Knee Arthroplasty (TKA) to Conventional TKA and Computer Assisted TKA
This is a prospective, randomised clinical outcomes study comparing the Signature Personalised Patient Care, Conventional Total Knee Arthroplasty and Computer Assisted Navigation, using Vanguard Knee System.
- Trial name
- NCT01145157
- Testing
- Signature Knee Guide, Conventional Instrumentation, Computer Assisted Navigation
- Where
- Australia
- Volunteers
- 150 people
- Sponsor
- Zimmer Biomet
Synovitis, Osteoarthritis
Effect of Chondroitin Sulphate on Synovial Inflammation in Patients With Osteoarthritis of the Knee
The purpose of this study is to determine the effect of a chondroitin sulphate conventional treatment on the degree of severity of synovitis, as measured by magnetic resonance in patients with knee OA with clinical synovitis.
- Conditions
- Synovitis, Osteoarthritis, Joint Diseases, Muskuloskeletal Diseases
- Trial name
- NCT00604539
- Testing
- Chondroitin sulphate (Condrosan)
- Where
- 4 sites in Canada
- Volunteers
- 70 people
- Sponsor
- Bioiberica
Osteoarthritis, Knee, Arthritis of Knee
Treatment of Knee Osteoarthritis With Allogenic Mesenchymal Stem Cells
In this study we want to evaluate the clinical use of allogenic mesenchymal stem cells (MSC), obtained from bone marrow of healthy donors, for treatment of knee osteoarthritis.
- Conditions
- Osteoarthritis, Knee, Arthritis of Knee, Knee Osteoarthritis
- Trial name
- MSV_allo (NCT01586312)
- Testing
- Allogenic mesenchymal stromal cells injection, Hyaluronic Acid
- Where
- 2 sites in Spain
- Volunteers
- 30 people
- Sponsor
- Red de Terapia Celular
Osteoarthritis
Study Evaluating the Efficacy and Safety of Topical Diclofenac Spray in Osteoarthritis of the Knee: Trial II
The objective of this study is to evaluate the efficacy and safety of TDS-943 (topical diclofenac spray) compared to oral celecoxib and placebo in subjects with osteoarthritis of the knee.
- Trial name
- NCT00546832
- Testing
- TDS-943 (topical diclofenac sodium 4% spray), celecoxib
- Where
- 49 sites in United States
- Volunteers
- 650 people
- Sponsor
- Mika Pharma GmbH
Osteoarthritis, Avascular Necrosis
Cementless Oxford Partial Knee Controlled Observational Study
The purpose of this study is to evaluate the safety and effectiveness of the Cementless Oxford Partial Knee System.
- Trial name
- GK10 (NCT02350049)
- Volunteers
- 391 people
- Sponsor
- Zimmer Biomet
Knee Osteoarthritis, Synovitis of Knee
A Trial to Investigate the Safety and Efficacy of Intra-articular 4P004 Injection in Subjects With Knee Synovitis and Osteoarthritis
This phase 2a trial is an international, multicenter, randomized, double-blind, placebo-controlled trial to investigate the efficacy and safety of one single intra-articular (IA) injection of 4P004 or placebo in: patients between…
- Trial name
- INFLAM MOTION (NCT07225829)
- Testing
- 4P004
- Where
- 22 sites in United States, Canada and 4 more
- Volunteers
- 130 people
- Sponsor
- 4Moving Biotech
Osteoarthritis of the Knee
A Randomized, Controlled Study to Evaluate Efficacy and Safety of Intra-articular Ampion for Osteoarthritis Pain in Knee
This study will evaluate the efficacy of an Intra-Articular Injection of Ampion™ in Adults with pain due to osteoarthritis of the knee.
- Trial name
- NCT02024529
- Testing
- 4 mL injection of Ampion
- Volunteers
- 538 people
- Sponsor
- Ampio Pharmaceuticals. Inc.
Osteoarthritis, Knee
The Effect of Intra-Articular Injection of RegenoGel-OSP™ (Self-Plasma) and RegenoGel™ on Knee Pain in People Suffering From Osteoarthritis
This study evaluates the efficacy of intra-articular administration of RegenoGel-OSP™ and RegenoGel™ to treat knee pain and effect on subject's activity and quality of life.
- Trial name
- NCT03479749
- Testing
- RegenoGel-OSP, RegenoGel
- Where
- 5 sites in Israel
- Volunteers
- 67 people
- Sponsor
- ProCore Ltd.
Knee Osteoarthritis
A Parallel-group Active Comparator, Double-blind, Multicenter, Randomized, Double-blind, Phase III Clinical Study
A multicenter, randomized, double-blind, parallel-group, placebo-controlled, and active-drug, 12-week, multicenter clinical study.
- Trial name
- SAVE (NCT03936192)
- Testing
- glucosamine sulphate 1500mg and meloxicam 15mg, Glucosamine sulfate 1500mg and chondroitin sulfate 1200mg
- Sponsor
- Eurofarma Laboratorios S.A.
Osteoarthritis, Knee
A Locally Injected Bradykinin Antagonist for TReatment of OSteoarthritiS
The purpose of this study is to determine whether intra-articular (knee joint) administration of MEN16132 is effective reducing the pain from knee osteoarthritis.
- Trial name
- ALBATROSS (NCT01091116)
- Testing
- MEN16132 - 0.125 mg, MEN16132 - 0.25 mg, MEN16132 - 0.5 mg
- Where
- 23 sites in France, Germany and 2 more
- Volunteers
- 423 people
- Sponsor
- Menarini Group
Osteoarthritis, Knee
HKT-500-US12 In Adult Patients With OA Knee Pain
The objective of this study is to characterize the analgesic properties of single dose study of HKT-500 in subjects with pain caused by mild to moderate OA of the knee
- Trial name
- NCT00647231
- Testing
- HKT-500 Topical Patch
- Where
- 29 sites in United States
- Volunteers
- 300 people
- Sponsor
- Hisamitsu Pharmaceutical Co., Inc.
Osteoarthritis of the Knee
Phase IIa, Randomized, Double Blinded, Placebo Controlled, Dose Finding Study for TLC599 in OA Patients
This trial is a Phase IIa, Randomized, Double blinded, Placebo controlled, Dose finding Study to investigate the safety and efficacy of TLC599 in subjects with osteoarthritis of the knee.
- Trial name
- NCT03005873
- Testing
- TLC599 LD group, Normal Saline, TLC599 HD group
- Where
- 13 sites in Australia, Taiwan
- Volunteers
- 76 people
- Sponsor
- Taiwan Liposome Company
Osteoarthritis, Knee
Correlating the Osteoarthritic Knee Microenvironment to Clinical Outcome After Treatment With Regenexx®SD Treatment
Single-center, lab blinded to include up to 400 subjects with knee osteoarthritis. Collection of synovial fluid from diseased knee before and after Regenexx®SD treatment will serve as the experimental condition, i.e.
- Trial name
- KneeOA (NCT02848027)
- Testing
- Regenexx SD® procedure
- Volunteers
- 400 people
- Sponsor
- Regenexx, LLC
Osteoarthritis
Minimally Invasive Total Knee Replacement - Navigated Versus Non-navigated Study
The primary objective of this investigation is to compare the precision of long leg alignment achieved by the two types of procedure.
- Trial name
- NCT00733330
- Testing
- Either P.F.C. Sigma or L.C.S. Complete knee replacement using the conventional surgical approach and manual surgical technique, Either P.F.C. Sigma or L.C.S. Complete knee replacement using minimally invasive surgical approach and computer navigation
- Where
- 5 sites in United States, Australia and 1 more
- Volunteers
- 86 people
- Sponsor
- DePuy International
Knee Osteoarthritis
ACP Max™ PRP System for Knee Osteoarthritis: A Feasibility Trial
This study is a prospective, multicenter (up to 4 sites), randomized, double-blind, two-arm study. Forty-five (45) patients will be randomized to receive a single 4-6 ml intra-articular (IA) injection of either the output of ACP…
- Trial name
- NCT05765266
- Testing
- ACP Max™, Depo-Medrol®
- Where
- 3 sites in United States
- Volunteers
- 45 people
- Sponsor
- Arthrex, Inc.
Osteoarthritis
Etoricoxib vs. Diclofenac in OA (0663-805)(COMPLETED)
To compare the safety and tolerability of etoricoxib and diclofenac sodium in the treatment of osteoarthritis of the knee or hip during a six week period.
- Trial name
- NCT00542087
- Testing
- MK0663, etoricoxib / Duration of Treatment: 6 Weeks, Comparator: diclofenac sodium / Duration of Treatment: 6 Weeks
- Volunteers
- 516 people
- Sponsor
- Organon and Co
Knee Osteoarthritis
Study to Evaluate the Iovera° Device for Temporary Relief From Knee Pain
This purpose of this study is to evaluate the effectiveness and safety of the iovera° device for the temporary reduction of pain associated with knee osteoarthritis.
- Trial name
- NCT02260921
- Testing
- iovera°
- Where
- 17 sites in United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Pacira Pharmaceuticals, Inc
Osteoarthritis of the Hip or Knee
Dexibuprofen 400 mg Sachet Versus Ibuprofen 400 mg Sachet in Patients With Osteoarthritis of the Hip or Knee
Medical condition under investigation: Osteoarthritis of the hip or knee Number of patients planned: 480 adult patients Main objective: To evaluate and compare the tolerability profile of Dexibuprofen Gebro 400 mg powder for oral…
- Trial name
- NCT01066676
- Testing
- Dexibuprofen, Ibuprofen
- Where
- 2 sites in Austria
- Volunteers
- 482 people
- Sponsor
- Gebro Pharma GmbH
Osteoarthritis
Safety Extension Study Of Tanezumab When Administered By Subcutaneous Injection To Patients With Osteoarthritis
An evaluation of the long term safety of tanezumab when administered by subcutaneous injection every 8 weeks for up to 64 weeks
- Trial name
- NCT01127893
- Testing
- Tanezumab
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Pfizer
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