Clinical trials: Knee Arthropathy
Knee Osteoarthritis
Clinical Investigation to Compare the Safety and Efficacy of Cellular Matrix to Those of Ostenil® Plus and to Those of PRP Only
Platelet-rich plasma (PRP) is an autologous product prepared from the patient's own blood, representing a powerful source of platelet-derived growth factors, particularly useful in the field of regenerative medicine.
- Trial name
- NCT02964143
- Testing
- Cellular Matrix / A-CP HA, Ostenil® Plus, RegenKit-BCT-1
- Volunteers
- 306 people
- Sponsor
- Regen Lab SA
Osteoarthritis
Medacta GMK Sphere® Multicenter Post-Market Outcomes Study
This study is to average Forgotten Knee Score (FJS) of those patients receiving the Medacta GMK Sphere® knee at the two and five year time points.
- Trial name
- NCT02501733
- Testing
- Medacta GMK Sphere® Medial Knee Prosthesis
- Where
- 5 sites in United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Medacta USA
Knee Osteoarthritis (Knee OA)
Knee OsteoArthritis Long-term Assessment
The goal of this clinical study is to learn if Hydrogel OA 2% injection is safe and whether it works to improve symptoms of diagnosed knee osteoarthritis in adults when compared to Hyaluronic Acid (Durolane), a treatment that is…
- Trial name
- KOALA (NCT06839222)
- Testing
- Hydrogel OA 2%, Hyaluronic Acid (Durolane)
- Where
- 5 sites in Belgium
- Sponsor
- Allegro NV/SA
Osteoarthritis, Knee, Joint Disease
Matched Pair Study - Kinematic Vs Mechanical Alignment
The aim of this study is to evaluate postoperative knee function after total knee arthroplasty performed according to the anatomical alignment and compare these results to those of a matched historical cohort of patients operated…
- Trial name
- NCT03446391
- Testing
- Kinematic alignment, Mechanical alignment, GMK Sphere®
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Medacta International SA
Knee Osteoarthritis
A Phase 3 Study to Assess the Efficacy and Safety of PK101 in Patients With Knee Osteoarthritis
The purpose of this study is to compare the efficacy and the safety of PK101 in patients with knee osteoarthritis.
- Trial name
- NCT04858659
- Testing
- PK101, PK101-002
- Where
- South Korea
- Volunteers
- 354 people
- Sponsor
- PMG Pharm Co., Ltd
Osteoarthritis, Rheumatoid Arthritis
Randomized Fixed Bearing vs Mobile Bearing Cruciate Retaining TKA
The purpose of this study is to evaluate the clinical performance of the rotating platform and fixed bearing implants in patients undergoing primary total knee replacement.
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Post-traumatic Arthritis, Juvenile Rheumatoid Arthritis
- Trial name
- NCT00289094
- Testing
- Total Knee Replacement
- Where
- 2 sites in United States
- Volunteers
- 99 people
- Sponsor
- DePuy Orthopaedics
Osteoarthritis
Efficacy Study of PN400 (VIMOVO) Twice Daily and Celebrex Once Daily in Patients With Osteoarthritis
We will evaluate the efficacy of PN 400 and an active comparator in patients that have Osteoarthritis of the knee.
- Trial name
- NCT00665431
- Testing
- PN 400 (VIMOVO), celebrex, Rescue Antacid
- Where
- United States
- Volunteers
- 610 people
- Sponsor
- POZEN
Osteoarthritis
A Retrospective Study of the iTotal CR Knee Replacement System
This study involves retrospective collection of data regarding the first approximately 100 iTotal Knee Replacement System surgeries and their short term outcomes at a small set of centers throughout the US.
- Trial name
- NCT01564654
- Testing
- iTotal KRS
- Where
- 4 sites in United States
- Volunteers
- 89 people
- Sponsor
- Restor3D
Osteoarthritis
Study of Diclofenac Capsules to Treat Osteoarthritis Pain
The purpose of this study is to determine whether Diclofenac [Test] Capsules are safe and effective for the treatment of osteoarthritis pain of the hip or knee.
- Trial name
- NCT01461369
- Testing
- Diclofenac
- Where
- 40 sites in United States
- Volunteers
- 305 people
- Sponsor
- Iroko Pharmaceuticals, LLC
Osteoarthritis, Avascular Necrosis
A Clinical Investigation of the Oxford® Meniscal Unicompartmental Knee System
The purpose of this study is to collect information on complications and survivorship of patients implanted with the Oxford™ Meniscal Unicompartmental Knee System at multiple sites in the United States.
- Trial name
- NCT00578994
- Testing
- Oxford® Meniscal Unicompartmental Knee System
- Where
- 6 sites in United States
- Volunteers
- 388 people
- Sponsor
- Biomet Orthopedics, LLC
Osteoarthrosis of Knee
Clinical and Functional Outcome of the GEMINI SL Fixed Bearing PS Knee Prosthesis
This is a prospective, multicenter, observational study with a planned follow-up period of 10 years to confirm the safety and performance of the GEMINI SL Fixed Bearing PS knee prosthesis in longterm follow-up under routine…
- Trial name
- NCT04858347
- Testing
- Total knee replacement
- Where
- Colombia
- Volunteers
- 350 people
- Sponsor
- Waldemar Link GmbH & Co. KG
Knee Osteoarthritis
A Study Evaluating the Safety and Efficacy of SM04690 for the Treatment of Moderately to Severely Symptomatic Knee Osteoarthritis
This phase 2 study is a placebo-controlled, double-blind, parallel group study of four concentrations of SM04690 (0.03, 0.07, 0.15, and 0.23 mg per 2 mL injection) injected intraarticularly (IA) into the target knee joint of…
- Trial name
- NCT03122860
- Testing
- SM04690
- Where
- 74 sites in United States
- Volunteers
- 700 people
- Sponsor
- Biosplice Therapeutics, Inc.
Knee Osteoarthritis
Evaluation of NMES Therapy for Pain Relief Associated With Knee Osteoarthritis
A roll-over study of the current CM-2019 trial to assess the same preplanned outcomes of CM-2019 at 14 weeks.
- Trial name
- NCT04367597
- Testing
- Home-based Neuromuscular Electrical Stimulation (NMES) therapy
- Where
- 5 sites in United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- CyMedica Orthopedics, Inc
Osteoarthritis, Knee
Evaluation of Mangoselect® in Improvement of Exercise/Activity-induced Knee Joint Discomfort in Subjects Suffering From Osteoarthritis Grade I or II
The aim of the present investigation is to evaluate the efficacy of Mangoselect®, a mangosteen extract, and of a formulation containing Mangoselect®, in subjects suffering from activity/exercise-induced knee joint…
- Trial name
- NCT04765189
- Testing
- Verum A, Verum B, Verum C
- Where
- Spain
- Volunteers
- 95 people
- Sponsor
- Fytexia
Knee Osteoarthritis
Knee Biofeedback Rehabilitation Through Game Therapy
The goal of this study is to learn about the effect of video-game based rehabilitation exercise for patients with knee osteoarthritis.
- Trial name
- KneeBRIGHT (NCT06090097)
- Testing
- KneeBRIGHT System, Control Exercise
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Barron Associates, Inc.
Knee Osteoarthritis
Allogenic Adipose-Derived Mesenchymal Stem Cells for the Treatment of Knee Osteoarthritis
Evaluate the efficacy and safety of Allogenic Adipose Tissue-Derived Mesenchymal Stem Cells Therapy
- Trial name
- NCT06570291
- Testing
- Mesenchymal Stem Cells, Sodium Hyaluronate Injection
- Where
- 2 sites in China
- Volunteers
- 520 people
- Sponsor
- Wuxi Cellular Biopharmaceutical Group Ltd.
Arthroplasty, Replacement, Knee
Evaluation of Triathlon - A New Total Knee Prosthesis System - Triathlon PA vs. Triathlon Pressfit
The objective is to investigate the Clinical, Radiographic, Roentgen Stereophotogrammetric behaviour and patient outcome when using the Triathlon total knee prosthesis in a prospective randomized clinical trial.
- Trial name
- TriathlonRSA (NCT03198533)
- Testing
- Triathlon PA, Triathlon Pressfit
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Stryker Orthopaedics
Osteoarthritis, Knee
A Phase 3 Efficacy and Safety Study of Intra-articular CNTX-4975-05 (Capsaicin) vs Placebo in Subjects With OA Knee Pain
This is a phase 3, randomized, double-blind, placebo-controlled, single injection, 52-week study to evaluate the analgesic efficacy and safety of a single intra-articular (IA) CNTX-4975-05 (capsaicin), compared to IA placebo, in…
- Trial name
- NCT03429049
- Testing
- CNTX-4975-05
- Where
- 33 sites in United States
- Volunteers
- 332 people
- Sponsor
- Centrexion Therapeutics
Osteoarthritis
Study of FLEXISEQ® for Treatment of Osteoarthritis of the Knee in NSAID-compromised Patients
Primary Objective To substantiate the efficacy of 2.2 g FLEXISEQ® for the treatment of pain related to osteoarthritis (OA) of the knee in patients contraindicated for or with clinical intolerance to NSAIDs.
- Trial name
- OANIT (NCT02594176)
- Testing
- FLEXISEQ®
- Where
- Germany
- Volunteers
- 600 people
- Sponsor
- Pro Bono Bio
Osteoarthritis, Osteo Arthritis Knee
An Study to Evaluate Safety and Tolerability of OA-SYS in Subjects With Moderate to Severe Osteoarthritis of the Knee Joint
This study is being conducted to evaluate the safety and tolerability of OA-SYS in patients with moderate to severe OA of the knee joint.
- Trial name
- OA-SYS-01 (NCT06485843)
- Testing
- OA-SYS
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Ageless Biotech, Inc.
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