Clinical trials: Knee Arthroplasty, Total
Knee Prosthesis, Pain, Procedural
Comparison of Different Analgesic Nerve Blocks in Total Knee Replacement Surgery
The goal of this observational study is to compare the equivalent analgesic efficacy of three regional anesthesia techniques in total knee replacement surgery.
- Trial name
- NCT06422585
- Where
- Italy
- Volunteers
- 180 people
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
Acute Infection of Total Knee Replacement
Preoperative Antibiotic Dosing for Total Knee Arthroplasty
To directly compare acute infection rates in patients undergoing total knee replacement with intraosseous regional administration or systemic intravenous administration of prophylactic antibiotics.
- Trial name
- NCT02433704
- Testing
- New Intraosseous, Cefazolin
- Where
- United States
- Sponsor
- Duke University
Total Knee Replacement
Adductor Under Sartorial Canal Catheter (KTT) Versus Femoral Catheter (KTF) in a Quick Rehabilitation Process After Total Knee Replacement
The main objective of this study is to show that postoperative Total Knee Replacement (TKR), an analgesic perineural catheter in position under sartorial (KTSS) best preserves motor quadriceps femoral perineural catheter that…
- Trial name
- KTSS (NCT02873637)
- Testing
- under sartorial catheter, femoral catheter
- Where
- France
- Volunteers
- 44 people
- Sponsor
- Centre Hospitalier Departemental Vendee
Knee Osteoarthritis
Effects of Collagen Peptide Supplementation on Connective Tissue Remodeling, Functional Outcomes, and Wound Healing After Total Knee Arthroplasty (TKA)
Recruiting will be performed via checking the calendar for scheduled TKA procedures in the > 8 weeks by clinical staff in the UAMS orthopedic clinic.
- Trial name
- NCT05823727
- Testing
- SOLUGEL
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Anemia, Arthroplasty, Replacement, Hip
An Intravenous Iron Based Protocol for Preoperative Anaemia in Hip and Knee Surgery - An Observational Study
This observational study follows a cohort of patients scheduled for elective hip- or knee surgery but has preoperative anemia and are treated with Intravenous (IV) iron prior to surgery according to a recently introduced…
- Conditions
- Anemia, Arthroplasty, Replacement, Hip, Arthroplasty, Replacement, Knee
- Trial name
- NCT02385383
- Testing
- Iron-III Isomaltoside 1000, Standard Care
- Where
- 6 sites in Denmark
- Volunteers
- 300 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Fluid Hypovolemia, Cerebrospinal
Assessment of Ultrasonographic Measurement of Inferior Vena Cava Collapsibility Index in Prediction of Hypotension Associated With Tourniquet Release in Total Knee Replacement Surgeries Under Spinal Anesthesia
Administration of intravascular fluids is one of the methods to prevent SA-induced hypotension, but empirical intraoperative volume repletion carries the risk of fluid overload during elective surgery.
- Trial name
- NCT05076929
- Testing
- ultrasound
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Knee Arthroplasty, Total, Analgesia
Shared Decision Aid for Post-Total Knee Arthroplasty Opioid Prescribing
This will be a randomized controlled clinical trial in patients who have undergone primary unilateral total knee arthroplasty at Brigham and Women's Faulkner Hospital, Brigham and Women's Hospital and University of Chicago…
- Conditions
- Knee Arthroplasty, Total, Analgesia, Opioid Use, Unspecified
- Trial name
- NCT04564729
- Testing
- Shared Decision Making
- Where
- 2 sites in United States
- Volunteers
- 142 people
- Sponsor
- Brigham and Women's Hospital
Arthritis, Osteoarthritis, Knee
Switching Drug Therapy for the Prevention of Blood Clot Formation From Enoxaparin to Rivaroxaban After Orthopedic Surgery for Either Total Hip or Total Knee Replacement
The study will describe the short-term effects the study drug, rivaroxaban, has on the body when a patient is switched from enoxaparin injection (by needle) to oral rivaroxaban (by mouth) for the prevention of blood clotting in…
- Conditions
- Arthritis, Osteoarthritis, Knee, Osteoarthritis, Hip, Thromboembolism
- Trial name
- NCT01094886
- Testing
- Rivaroxaban
- Where
- 5 sites in United States
- Volunteers
- 56 people
- Sponsor
- Ortho-McNeil Janssen Scientific Affairs, LLC
Post-operative Pain
Liposomal Bupivacaine for Post Operative Pain After Knee Replacement Surgery
Continuous femoral nerve blocks (CFNB) provide effective pain control to patients undergoing total knee replacement (TKR). However the resulting motor blockade can lead to decreased quadriceps muscle strength and delayed…
- Trial name
- NCT02274870
- Testing
- Liposome Bupivacaine, Bupivacaine HCl
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Northwell Health
Total Knee Arthroplasty
CT Assessment of Minimally Invasive Surgery and Computer Assisted Navigation in Total Knee Arthroplasty
The functional flexion axis of the knee can be established by computer-assisted intra-operative data, through range of motion techniques, not specific landmarks such as epicondyles.
- Trial name
- NCT00409266
- Testing
- Computer assisted navigation
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Stryker Instruments
Osteoarthritis,Knee
Single Adductor-canal-block Versus Peri-articular Infiltration on Outcome After Total Knee Arthroplasty
The purpose of this study is to compare the effect of single adductor-canal-block versus single femoral nerve block on the recovery after total knee arthroplasty.
- Trial name
- NCT02784041
- Testing
- single adductor-canal-block, periarticular infiltration
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Knee Osteoarthritis, Arthroplasty
Effects of Sensorimotor and Core Stabilization Exercises After Total Knee Arthroplasty
Tha aim of the study is to investigate the effects of core stabilization and sensorimotor exercise program on range of motion, proprioception, balance and functional status in patients with total knee arthroplasty.
- Conditions
- Knee Osteoarthritis, Arthroplasty, Joint Replacement
- Trial name
- NCT05248854
- Testing
- Sensorimotor exercise training, Core stabilization exercise training
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Yeditepe University
Osteoarthritis
Kinematic Analysis of a PS, FB Primary Total Knee Arthroplasty (ATTUNE Knee System) Using Dynamic RSA
Background: Across the European Union there are 535,000 Total Knee Arthroplasty (TKA)per year. Statistics indicate that for patients over 60 year old approximately one out of 20 will require corrective reoperations within 10…
- Trial name
- Attune-RSA (NCT02323386)
- Testing
- Primary Total Knee Arthroplasty (ATTUNE Knee System)
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Istituto Ortopedico Rizzoli
Blood Loss, Surgical
Suction Drainage in the Management of Peri-operative Bleeding in Total and Unicomcompartmental Knee Arthroplasty
Although, suction drainage is routinely used in orthopedic clinical practice, there are still no precise guidelines on its use in total joint arthroplasty, particularly in total as well as unicompartmental knee arthroplasty.
- Trial name
- NCT04508101
- Volunteers
- 153 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Osteoarthritis, Degenerative Joint Disease
Comparative Effectiveness of an Activity-specific Monitoring Device- StepRite
Partial or Total Knee Arthroplasty are procedures commonly used in severe degeneration of the knee joint due to osteoarthritis. With an increasing number of Partial or Total Knee Arthroplasty performed in a population that is…
- Trial name
- NCT02900781
- Testing
- Steprite™, Standard of care
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Texas Tech University Health Sciences Center
Aseptic Loosening of Prosthetic Joint, Instability of Prosthetic Joint
The Use of CCK vs PS in Revision TKAs
This study aims to compare the clinical impact of Constrained Condylar versus Posterior Stabilized Knee (PS) bearings on patient satisfaction and surgical outcomes including mid-term survivorship among patients undergoing…
- Conditions
- Aseptic Loosening of Prosthetic Joint, Instability of Prosthetic Joint, Reimplantation for Periprosthetic Joint Infection, Femoral Revision Indicated
- Trial name
- NCT06782295
- Testing
- Constrained Condylar bearing, posterior stabilized bearing
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- Rush University Medical Center
Surgery
Comparison Between Kinesiotaping and Cold Therapy After Total Knee Arthroplasty
The investigators aim was to compare the effectiveness of kinesiotaping and cold therapy on muscle strength and functional performance outcomes in patients with TKA during early postoperative period.
- Trial name
- NCT02747901
- Testing
- KINESIOTAPING, COLD THERAPY
- Where
- Turkey (Türkiye)
- Volunteers
- 111 people
- Sponsor
- Dokuz Eylul University
Total Hip Arthroplasty (THA) or Total Knee Arthroplasty (TKA), Preoperative Adductor Canal Block (ACB)
The Impact of Regional Motor-sparing Blocks on Early Rehabilitation Following Primary Hip or Knee Arthroplasty
The purpose of this study is to determine whether a single nerve block given before surgery can help patients regain independence and mobility more quickly after planned hip or knee replacement surgery for osteoarthritis.
- Conditions
- Total Hip Arthroplasty (THA) or Total Knee Arthroplasty (TKA), Preoperative Adductor Canal Block (ACB), Preoperative Pericapsular Nerve Group (PENG)
- Trial name
- NCT07834619
- Testing
- PENG Block with Ropivacaine, Adductor Canal Block with Ropivacaine, Subarachnoid anesthesia
- Where
- Poland
- Volunteers
- 220 people
- Sponsor
- Poznan University of Physical Education
Venous Thromboembolism, Venous Thromboses
inDividual, Targeted thrombosIS Prophylaxis Versus the Standard 'One Size Fits All' Approach in Patients Undergoing Total hIp or Total kNee replaCemenT
After hip or knee replacement all patients receive a standardized treatment with blood thinners, this medication is called thrombosis prophylaxis.
- Conditions
- Venous Thromboembolism, Venous Thromboses, Pulmonary Embolism, Deep Vein Thrombosis
- Trial name
- DISTINCT (NCT06581965)
- Testing
- Short duration prophylaxis, Higher intensity and longer duration prophylaxis, Control
- Where
- 13 sites in Netherlands
- Volunteers
- 10,078 people
- Sponsor
- Leiden University Medical Center
TKA, Muscle Strength
Effect of Bupivacaine Liposome Injection on Muscle Strength After Total Knee Arthroplasty
This study employs a randomized controlled trial to investigate whether bupivacaine liposome injection for adductor canal block can effectively improve lower limb muscle strength after total knee arthroplasty.
- Trial name
- TKA (NCT07616102)
- Testing
- a single-injection adductor canal block, continuous femoral nerve block
- Where
- China
- Volunteers
- 80 people
- Sponsor
- General Hospital of Ningxia Medical University
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