Clinical trials: Knee Arthroplasty
Preoperative Period, Nutritional Status
Preoperative Nutritional Status in Patients Undergoing Elective Total Knee Arthroplasty and In-hospital Postoperative Complications
Malnutrition has long been linked to postoperative complications and adverse outcomes in a variety of surgical fields , such as increased susceptibility to infection, delayed wound healing, and increased frequency of decubitus…
- Conditions
- Preoperative Period, Nutritional Status, Arthroplasty Knee
- Trial name
- NUTR TKA (NCT03549962)
- Testing
- TKA
- Where
- 2 sites in Hong Kong
- Volunteers
- 626 people
- Sponsor
- Chinese University of Hong Kong
Osteoarthritis, Knee, Arthropathy of Knee Joint
Comparison of Cruciate Retaining and Posterior Stabilized Total Knee Arthroplasty
Several authors and large registries have suggested the potential for an increased risk of all-cause revision with the use of posterior cruciate-substitution (PS) total knee arthroplasty (TKA).
- Trial name
- NCT06124651
- Testing
- Total knee replacement with cruciate retaining femoral component, Total knee replacement with cruciate substituting femoral component
- Volunteers
- 300 people
- Sponsor
- Ewha Womans University
Osteoarthritis
The HIHO Study: Hospital Inpatient vs Home Rehabilitation After Total Knee Replacement
Total knee replacement (TKR) surgery is a common and highly effective treatment option for alleviating the pain and disability caused by chronic arthritis.
- Trial name
- HIHO (NCT01583153)
- Testing
- Hospital Inpatient Rehabilitation, Hybrid Home Programme (HO)
- Where
- 3 sites in Australia
- Volunteers
- 165 people
- Sponsor
- Mark Buhagiar
Total Knee Arthroplasty
Analgesic Effect of Adductor Canal Block, IPACK Block, and Genicular Nerve Block
Patients with total knee arthroplasty (TKA) experience severe postoperative pain. This reduces patient satisfaction, delays mobility, and prolongs hospital stay.
- Trial name
- NCT06686095
- Testing
- Group Adductor canal block, Group Genicular Nerve Block, Group IPACK Block
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Hitit University
Orthostatic Hypotension, Orthostatic Intolerance
Orthostatic Intolerance and Hypotension After Administration of Morphine in Patients Prior to Hip or Knee Arthroplasty
Incidence of orthostatic intolerance and orthostatic hypotension after intravenous administration of morphine in patients prior to hip or knee arthroplasty.
- Trial name
- NCT04902222
- Testing
- Morphine
- Where
- Denmark
- Volunteers
- 26 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Osteoarthritis, Knee
Conventional Alignment System Versus Surgical Navigation System in Total Knee Arthroplasty
This is a randomized, controlled, blinded prospective study comparing the use of the usual cutting guides with a palm-sized digital surgical navigation system in unilateral total knee arthroplasty.
- Trial name
- NCT01797731
- Testing
- Digital hand-held surgical navigation system, Conventional tibial extramedullary alignment system
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Hospital for Special Surgery, New York
Osteoarthritis, Degenerative Joint Disease
The Study of Physical Activity Rewards After Knee Surgery
The objectives of this research are to conduct a proof of concept randomized controlled trial with 200 patients undergoing primary total knee replacement (TKR) at Brigham and Women's Hospital (BWH).
- Trial name
- SPARKS (NCT01970631)
- Testing
- Motivational Interviewing (MI), Financial Incentives
- Where
- United States
- Volunteers
- 202 people
- Sponsor
- Brigham and Women's Hospital
Mastectomy, Upper Limb Amputation Below Elbow
Cryoanalgesia to Prevent Acute and Chronic Pain Following Surgery: A Randomized, Double-Masked, Sham-Controlled Study
The ultimate objective of the proposed line of research is to determine if cryoanalgesia is an effective adjunctive treatment for pain in the period immediately following various painful surgical procedures; and, if this…
- Conditions
- Mastectomy, Upper Limb Amputation Below Elbow, Upper Limb Amputation Above Elbow, Lower Limb Amputation Below Knee
- Trial name
- NCT03578237
- Testing
- Cryoneurolysis (active)
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- University of California, San Diego
Joint Diseases
EVOLUTION® Revision STEMMED CS Post Market Clinical Follow-up Study Protocol
MicroPort (MPO) is conducting this PMCF study to evaluate the safety and effectiveness of its EVOLUTION® Revision Tibial System and EVOLUTION® Revision STEMMED CS Femur with the EVOLUTION® MP CS Tibial Insert.
- Trial name
- NCT06142669
- Testing
- EVOLUTION® Revision Tibial System and EVOLUTION® Stemmed CS Femur with the EVOLUTION® MP CS Tibial Insert
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- MicroPort Orthopedics Inc.
Fast Track, Tranexamic Acid Adverse Reaction
Implementation of a Rapid Recovery Protocol in Total Knee Arthroplasty
Patients undergoing total knee arthroplasty will follow two different rehabilitation protocols. In one of them, they will start walking the day of surgery and discharged on a 48 hours basis.
- Conditions
- Fast Track, Tranexamic Acid Adverse Reaction, Knee Osteoarthritis
- Trial name
- NCT03823573
- Testing
- Walk within 24 hours
- Where
- Spain
- Volunteers
- 175 people
- Sponsor
- Ignacio Aguado Maestro
Knee Pain Chronic, Osteoarthritis
Persona Total Knee Arthroplasty Outcomes Study
The primary objective of this study is to obtain implant survivorship and clinical outcomes data for commercially available Persona fixed bearing knee implants used in total knee arthroplasty.
- Conditions
- Knee Pain Chronic, Osteoarthritis, Rheumatoid Arthritis, Traumatic Arthritis
- Trial name
- NCT02255383
- Testing
- Zimmer Persona Total Knee System
- Where
- 14 sites in United States
- Volunteers
- 737 people
- Sponsor
- Zimmer Biomet
Osteoarthritis
Early Neuromuscular Electrical Stimulation For Quadriceps Muscle Activation Deficits Following Total Knee Replacement
The purpose of this study is to determine whether early intervention with neuromuscular electrical stimulation (NMES) for muscle strengthening immediately after total knee arthroplasty (TKA) is more effective than voluntary…
- Trial name
- NCT00800254
- Testing
- Neuromuscular Electrical Stimulation (NMES), Standard Rehabilitation Protocol
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- University of Colorado, Denver
Osteoarthritis Knee, Total Knee Replacement
How Total Knee Prosthesis Dessigns Influence in Quality of Live
The purpose of this study is to determine whether different kind of prostesis designs influences in the quality of life of patients
- Trial name
- NCT02050438
- Testing
- Total Knee Arthroplasty
- Where
- Spain
- Volunteers
- 135 people
- Sponsor
- Corporacion Parc Tauli
Osteoarthritis, Knee
Liposomal Bupivacaine Versus Standard of Care in Total Knee Surgery
The purpose of this study is to determine whether liposomal bupivacaine is effective in the management of pain following total knee arthroplasty, as compared to standard of care analgesia.
- Trial name
- NCT02219087
- Testing
- Liposomal bupivacaine, Standard of Care
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- OhioHealth
Postoperative Pain Management in Total Knee Arthroplasty
Phase Ⅱ Study of Adductor Canal Block With HR18034 for Postsurgical Pain Management in TKA
Phase Ⅱ, randomized, double-blind, comparator-controlled study to evaluate the efficacy, safety and pharmacokinetics of single injection adductor canal block with HR18034 for postoperative pain management in total knee…
- Trial name
- NCT06509958
- Testing
- HR18034, Ropivacaine Hydrochloride Injection
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Shanghai Hengrui Pharmaceutical Co., Ltd.
Total Knee Replacement Surgery
Postoperative Pain in Total Knee Arthroplasty: a Comparison Between General and Spinal Anesthesia
Total knee arthroplasty may be conducted either under general anesthesia or spinal block. previous studies have shown that spinal block leads to less complications.
- Trial name
- NCT03176758
- Testing
- Spinal Block, General anesthetic, Total knee replacement
- Volunteers
- 60 people
- Sponsor
- Meir Medical Center
Osteoarthrosis, Knee
Total Knee Replacement With the Attune vs. the Press Fit Condylar (PFC) Sigma.
100 knees with primary osteoarthritis and scheduled for a total knee replacement (TKR) will be recruited from our waiting list. The patients will be randomized to become operated with the Attune or PFC total knee arthroplasty.
- Trial name
- Att16SM (NCT03077958)
- Testing
- Total Knee Replacement (2 different design)
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Sahlgrenska University Hospital
Postoperative Delirium
The Neuro-epigenetics Biomarkers of Postoperative Delirium in Elderly Patients Undergoing Hip/Knee Replacement
Introduction: Postoperative delirium (POD), an acute, transient, fluctuating disturbance in attention, cognition, and level of consciousness, is a common (15-53%) postoperative complication, and it is associated with longer…
- Trial name
- NCT04923243
- Testing
- hip/knee replacement
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Zhongnan Hospital
Total Knee Replacement
Bone Wax Use for Hemostasis During Primary Unilateral Total Knee Arthroplasty
The purpose of this study is to assess whether the application of bone wax to exposed cancellous bone, after the cemented implants are in place, will provide superior hemostasis in total knee arthroplasty (TKA) patients compared…
- Trial name
- NCT04992052
- Testing
- Bone wax
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Northwell Health
Total Knee Arthroplasty, Pain
Protracted Effect of Combined Nerve Blocks After Total Knee Arthroplasty
Purpose: The purpose of this study is to evaluate the postoperative analgesic effect of a combined Saphenous nerve block and Obturator nerve block with local infiltration analgesia in the tissue around the knee after surgery with…
- Conditions
- Total Knee Arthroplasty, Pain, Nerve Blocks
- Trial name
- Hobsali (NCT02067078)
- Testing
- Dexamethasone 4 mg + Clonidine 75 microgram + Marcaine 90 mg + Adrenaline 90 microgram, Dexamethasone 2 mg + Clonidine 37,5 microgram + Marcaine 45 mg + Adrenaline 45 microgram, Ropivacaine + Toradol + Adrenaline
- Where
- Denmark
- Volunteers
- 75 people
- Sponsor
- Regionshospitalet Silkeborg
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