Clinical trials: Knee Cartilage Defects
Articular Cartilage
Study of the Treatment of Articular Repair (STAR)
This study is a prospective, longitudinal, multi-center, within patient evaluation of patients with articular cartilage defects of the knee who have had an inadequate response to a prior non-Carticel surgical treatment.
- Trial name
- NCT00158613
- Testing
- Carticel (autologous cultured chondrocyte) implantation
- Where
- 28 sites in United States, Canada
- Volunteers
- 126 people
- Sponsor
- Vericel Corporation
Articular Cartilage Defects in the Knee Joint
Pivotal Study to Evaluate the Safety and Efficacy of GelrinC for Treatment of Cartilage Defects
Multicenter, open-label, controlled, non-randomized, double arm trial with a prospective treatment arm (GelrinC). This study compares the efficacy and safety of GelrinC to a historical control arm (microfracture) in the treatment…
- Trial name
- SAGE (NCT03262909)
- Testing
- GelrinC, Microfracture historical control arm
- Where
- 13 sites in United States
- Volunteers
- 181 people
- Sponsor
- Regentis Biomaterials
Articular Chondral Defect
Results at 10 to 14 Years After Microfracture in the Knee
Articular cartilage lesions are commonly occurring. In a prospective study of 1,000 knee arthroscopies focal chondral or osteochondral defects were found in 19% of the patients (Hjelle 2002).
- Trial name
- NCT01747681
- Testing
- Microfracture
- Where
- Norway
- Volunteers
- 110 people
- Sponsor
- Bergen Orthopedic Study Group
Chondral Lesion of the Knee, Meniscal Injuries
Impact of Bone-Marrow Aspirate Injections in Knee Arthroscopy
This study will examine whether using bone marrow aspirate (BMA) during knee arthroscopy surgery can improve patient outcomes. The investigators will enroll 50 patients who need knee arthroscopy surgery for meniscus injuries or…
- Conditions
- Chondral Lesion of the Knee, Meniscal Injuries, Cartilage Defects of the Knee, Osteoarthritis (OA) of the Knee
- Trial name
- BMA (NCT06893302)
- Testing
- Bone Marrow Aspirate (BMA), Arthroscopic Debridement Surgery, Saline
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Hospital for Special Surgery, New York
Osteoarthritis, Knee
Clinical Trial to Evaluate the Efficacy and Safety of MegaCarti® in Knee Cartilage Defects
The MegaCarti® is the decellularized allogeneic cartilage and acts as a cover after bone marrow stimulation to prevent the loss of blood clots and induces cartilage regeneration by assisting in the location of stem cells derived…
- Trial name
- NCT05440370
- Testing
- MegaCarti®, Microfracture
- Where
- 4 sites in South Korea
- Volunteers
- 90 people
- Sponsor
- L&C Bio
Osteoarthritis, Knee Osteoarthritis
Transplantation of Bone Marrow Stem Cells Stimulated by Proteins Scaffold to Heal Defects Articular Cartilage of the Knee
The purpose of this pilot study is to investigate the efficacy and safety of autologous transplantation, under arthroscopy, of Bone Marrow Mesenchymal stem cells, using, with a cell separator, a fresh non-culture expanded…
- Conditions
- Osteoarthritis, Knee Osteoarthritis, Osteochondritis Dissecans, Osteonecrosis
- Trial name
- NCT01159899
- Testing
- Transplantation of Bone Marrow Stem Cells Activated in Knee Arthrosis
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Michel Assor, MD
Defect of Articular Cartilage, Articular Cartilage Disorder of Knee
the Safety and Efficacy Evaluation of Chondron Compared With Mircrofracture of Knee
The purpose of this study is to evaluate safety and efficacy of Chondron(autologous cultured Chondrocyte) by comparing between Chondron implantation and Microfracture.
- Conditions
- Defect of Articular Cartilage, Articular Cartilage Disorder of Knee, Degeneration; Articular Cartilage, Knee
- Trial name
- NCT02524509
- Where
- South Korea
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Cellontech Co., Ltd.
Defect of Articular Cartilage
Comparison of BioCartilage Versus Marrow Stimulating Procedure for Cartilage Defects of the Knee
Subjects will be selected among the investigators' patient population who are already scheduled to receive a marrow stimulating procedure (MSP), with or without the addition of BioCartilage.
- Trial name
- NCT02203071
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Missouri-Columbia
Articular Cartilage Defect, Articular Cartilage Degeneration
Phase 3 Clinical Trial of CartiLife® in Korea
To evaluate the safety and efficacy of pellet-type extracellular matrix-associated autologous chondrocytes (CartiLife®) obtained by cultivating costal chondrocytes of the subject implanted into articular cartilage defects of the…
- Trial name
- NCT05051332
- Testing
- Autologous Chondrocyte Implantation (CartiLife®), Microfracture Surgery
- Where
- 18 sites in South Korea
- Volunteers
- 104 people
- Sponsor
- Biosolution Co., Ltd.
Cartilage Injury
Treatment of Cartilage Defects With Peripheral Blood Stem Cells
Knee joint cartilage cells metabolize slowly, and it is difficult to repair themselves after injury. Any knee joint trauma or the progression of osteoarthritis may lead to the progression of cartilage or osteochondral defects.
- Trial name
- NCT04953572
- Testing
- autologous peripheral blood mesenchymal stem cell, Microfracture, Microfracture + collagen membrane
- Where
- China
- Volunteers
- 252 people
- Sponsor
- Peking University Third Hospital
Articular Cartilage Defect, Articular Cartilage Degeneration
Phase 2 Clinical Trial of CartiLife® in the United States
To evaluate the safety and efficacy of implanting pellet-type extracellular matrix-associated autologous chondrocytes (CartiLife®) obtained by cultivating costal chondrocytes of the subject with articular cartilage defects of the…
- Trial name
- NCT04744402
- Testing
- Autologous Chondrocyte Implantation (CartiLife®)
- Where
- 5 sites in United States
- Volunteers
- 25 people
- Sponsor
- Biosolution Co., Ltd.
Cartilage Defects of the Knee
Study to Evaluate a New Cartilage Regeneration Platform for Knee Cartilage Repair
The goal of this clinical trial is to learn if a new treatment works to help regrow knee cartilage in people with knee cartilage damage.
- Trial name
- TCW (NCT07639424)
- Testing
- MAECM transplantation, Micronfracture
- Where
- 13 sites in South Korea
- Volunteers
- 104 people
- Sponsor
- ROKIT Healthcare
Cartilage or Osteochondral Defects in the Knee, Up to Moderate Osteoarthritis
Agili-C™ Implant Performance Evaluation
The current study compares the efficacy and safety of the Agili-C implant to Surgical Standard of Care treatment in patients suffering from joint surface lesions of the knee.
- Trial name
- NCT03299959
- Testing
- Agili-C implant, SSOC
- Where
- 26 sites in United States, Belgium and 6 more
- Volunteers
- 251 people
- Sponsor
- Smith & Nephew, Inc.
Articular Cartilage Lesion of the Femoral Condyle
Efficacy and Safety Study of co.Don Chondrosphere to Treat Cartilage Defects
This is a prospective, phase III, multicenter, open label, randomised clinical trial of co.don chondrosphere®, a three-dimensional autologous chondrocyte transplantation product (ACT3D-CS)compared to the procedure of…
- Trial name
- NCT01222559
- Testing
- co.don chondrosphere®, Microfracture
- Where
- 12 sites in Germany, Poland
- Volunteers
- 102 people
- Sponsor
- co.don AG
Cartilage Disease
Non-interventional Study With NOVOCART® Inject in the Reconstruction of the Knee Cartilage Defects
Retrospective non-interventional study to evaluate safety and efficacy of NOVOCART® Inject in patients with full-thickness cartilage defects in the knee joint.
- Trial name
- RENOVO (NCT02941120)
- Where
- 7 sites in Germany
- Volunteers
- 245 people
- Sponsor
- Tetec AG
Cartilage or Osteochondral Defects in the Knee
COPLA® Cartilage Implant Pilot Clinical Trial
This is a first-in-human clinical, open label, non-randomized, prospective investigation to assess the initial safety and performance of the COPLA® cartilage implant.
- Trial name
- NCT05685316
- Testing
- COPLA® cartilage implant
- Where
- 6 sites in Estonia, Finland and 1 more
- Volunteers
- 20 people
- Sponsor
- Askel Healthcare Ltd
Cartilage Defect
ChonDux for Filling Full Thickness Cartilage Defects in the Femoral Condyle of the Knee
The use of ChonDux Cartilage Repair system for the treatment of single cartilage lesions in the femoral condyle of the knee. The primary outcome measure is degree of lesion fill at 6 months.
- Trial name
- NCT01110070
- Testing
- ChonDux
- Where
- 7 sites in Austria, Germany and 1 more
- Volunteers
- 21 people
- Sponsor
- Zimmer Biomet
Articular Cartilage Defects in the Knee Joint
Confirmatory Study of NeoCart in Knee Cartilage Repair
This confirmatory study is a prospective randomized trial comparing the efficacy and safety of an autologous chondrocyte tissue implant (NeoCart) to the surgical intervention microfracture in the treatment of cartilage defects in…
- Trial name
- NCT01066702
- Testing
- NeoCart, Microfracture
- Where
- 31 sites in United States, Canada
- Volunteers
- 245 people
- Sponsor
- Histogenics Corporation
Focal Chondral Defect in Femoro-tibial Compartment of the Knee Joint
Safety and Efficacy Study of HYTOP® in the Treatment of Focal Chondral Defects.
The two-layer bioresorbable HYTOP® matrix consists of an upper layer of highly purified porcine splint-skin which contains natural pores, and a lower layer of highly purified collagen fleece containing hyaluronan (HA).
- Trial name
- NCT01791062
- Testing
- HYTOP®
- Where
- Germany
- Volunteers
- 2 people
- Sponsor
- TRB Chemedica AG
Knee Injury, Cartilage Injury
Autologous Cartilage Implantation vs Arthroscopic Debridement
82 patients aged 18-49 years with an isolated focal cartilage defect in the knee will be randomized to either receive autologous cartilage implantation or arthroscopic debridement.
- Trial name
- ACI (NCT02636881)
- Testing
- Autologous Chondrocyte Implantation, Arthroscopic Debridement
- Where
- Norway
- Volunteers
- 28 people
- Sponsor
- University Hospital, Akershus