Clinical trials: Knee Cartilage Lesions
Knee Cartilage Defects
Phase 3 Pivotal Trial Comparing CARTISTEM® and Surgical Comparator for Knee Cartilage Lesions and Osteoarthritis
This study will test whether CARTISTEM is safe and works better than debridement (a surgery that cleans out damaged tissue) for people with knee cartilage damage and osteoarthritis.
- Trial name
- CARTISTEM23-01 (NCT07339111)
- Testing
- CARTISTEM® + Debridement, Debridement
- Where
- 35 sites in United States
- Volunteers
- 300 people
- Sponsor
- Medipost, Inc.
Knee Chondral Lesion
PRP vs AD-SVF in Addition to Marrow Stimulation for Knee Chondral Lesion
The goal of this clinical trial is to learn if PRP and adipose-derived stem cells (AD-SVF) enhance healing after knee microfracture for chondral lesions. It will also learn about the safety of the procedure.
- Trial name
- NCT07255547
- Testing
- Bone Marrow Stimulation, stromal vascular fraction (SVF), PRP injection
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Università degli Studi dell'Aquila
Articular Cartilage Disorder of Knee
Radiofrequency-Based Debridement vs. Mechanical Debridement for the Treatment of Articular Cartilage Lesions
The purpose of this study is to evaluate the changes in clinical and imaging outcomes following arthroscopic treatment of chondral lesion(s) by Radiofrequency-Based debridement or Mechanical Debridement in subjects 18-50 years of…
- Trial name
- NCT03678948
- Testing
- Radiofrequency-Based Debridement, Mechanical Debridement
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Christopher Kaeding
Knee Injuries, Joint Surface Knee Lesions
A Post Approval Multicenter 10 Year Follow-up Observational Trial of Marketed Product - MP01 vs. Surgical Standard of Care (SSOC) Used for the Treatment of Joint Surface Lesions of the Knee
The purpose of the study is to support market adoption and global market access via collection of long-term effectiveness, safety, and radiographic data.
- Trial name
- NCT06916728
- Testing
- Marketed Product - MP01, Surgical Standard of Care
- Where
- 8 sites in United States, Belgium and 4 more
- Volunteers
- 170 people
- Sponsor
- Smith & Nephew, Inc.
Knee Injuries
Trial Comparing BST-CarGel and Microfracture in Repair of Articular Cartilage Lesions in the Knee
This study will investigate whether the treatment of damaged cartilage in the knee with BST-CarGel will increase the amount and quality of cartilage repair tissue when compared with microfracture alone.
- Trial name
- NCT00314236
- Testing
- BST-CarGel with Microfracture, Microfracture without BST-CarGel
- Where
- 18 sites in Canada, South Korea and 1 more
- Volunteers
- 80 people
- Sponsor
- Piramal Healthcare Canada Ltd
Defect of Articular Cartilage, Knee Injuries
DeNovo NT Natural Tissue Graft Stratified Knee Study
The purpose of this study is to evaluate the long-term relief of pain and return to function for patients receiving DeNovo NT for cartilage lesions in the knee.
- Trial name
- NCT01670617
- Testing
- Particulated Juvenile Articular Cartilage
- Where
- 18 sites in United States, Canada
- Volunteers
- 90 people
- Sponsor
- Zimmer Orthobiologics, Inc.
Osteoarthritis, Knee
FibroFix Cartilage P Knee Implant Study
This is a multi-center first-in-human prospective clinical investigation to evaluate the safety and performance of the FibroFix™ Cartilage P Implant and Drill Set. The Implant is a medical device designed by Orthox Ltd.
- Trial name
- FFLEX (NCT05560490)
- Testing
- FibroFix Cartilage P Knee Implantation
- Where
- 2 sites in Hungary, United Kingdom
- Volunteers
- 2 people
- Sponsor
- Orthox Limited
Osteochondral Lesions of Knee, Osteo Arthritis
3D-Printed Grafts for Knee Cartilage Repair
Research Title:A study on 3D printing-assisted platelet-rich plasma combined with autologous periosteum-bone grafting in the treatment of knee cartilage injury Objectives:(1) To evaluate the accuracy of cartilage damage repair by…
- Trial name
- 3D-PR-PBG (NCT07312175)
- Testing
- 3D-Printed Scaffold-Assisted PRP Combined with Autologous Periosteal-Bone Grafting, 3D Printing-Assisted Autologous Periosteal-Bone Grafting
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Second Affiliated Hospital of Nanchang University
Degeneration Articular Cartilage Knee
Evaluation of Safety and Exploratory Efficacy of CARTISTEM®, a Cell Therapy Product for Articular Cartilage Defects
The purpose of this study is to determine whether CARTISTEM, a cell therapeutic product, is safe and effective in the treatment of articular cartilage defects of the knee as a result of ageing, trauma, or degenerative diseases.
- Trial name
- NCT01733186
- Testing
- CARTISTEM®
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Medipost, Inc.
Meniscus Tear, Meniscus Lesion
PROPER Trial of Pain and Inflammation After Knee Arthroscopy
The purpose of this study is to determine if ceftriaxone administered postoperatively via intravenous injection reduces postoperative visual analog scale (VAS) pain scores and narcotic consumption in patients undergoing knee…
- Conditions
- Meniscus Tear, Meniscus Lesion, Cartilage Injury
- Trial name
- PROPER (NCT05149287)
- Testing
- Ceftriaxone
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Austin V Stone
Foreign-Body Reaction, Inflammation
IMPACT: Safety and Feasibility of a Single-stage Procedure for Focal Cartilage Lesions of the Knee.
Articular cartilage defects in the knee have a poor intrinsic healing capacity and may lead to functional disability and osteoarthritis.
- Conditions
- Foreign-Body Reaction, Inflammation, Effusion (L) Knee, Knee Pain Swelling
- Trial name
- IMPACT (NCT02037204)
- Testing
- Cartilage repair surgery
- Where
- Netherlands
- Volunteers
- 35 people
- Sponsor
- UMC Utrecht
Degenerative Lesion of Articular Cartilage of Knee
Microfracture Versus Adipose Derived Stem Cells for the Treatment of Articular Cartilage Defects
The purpose of this study is to compare two biologic methods for the treatment of articular cartilage defects in the knee. The first method, microfracture, is the standard of care and is routinely used to recruit cells from the…
- Trial name
- NCT02090140
- Testing
- ADSC Application, Microfracture
- Where
- 3 sites in United States
- Volunteers
- 17 people
- Sponsor
- University of Colorado, Denver
Focal Cartilage Lesions
Prospective Interventional Clinical Trial of an MRI Based Patient Specific Focal Knee Resurfacing Implant
Lesions in the cartilage are common disorders. Arthroscopy lavage and debridement micro fracturing, mosaic plasticity as well as osteochondral autograft transplantation (OATS) are methods used for treatment of the lesions.
- Trial name
- Episealer (NCT04808700)
- Testing
- Follow-up of Episealer implant
- Where
- Belgium
- Volunteers
- 8 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Osteoarthritis
Study of Safety, Tolerability, Preliminary Efficacy of Intra-articular LNA043 Injections in Patients With Articular Cartilage Lesions and Knee Osteoarthritis.
The purpose of this two-part study is to assess the efficacy, safety and tolerability of multiple intra-articular (i.a.) injections of LNA043, in regenerating the articular surface in patients with cartilage lesions of the knee…
- Trial name
- NCT03275064
- Testing
- LNA043
- Where
- 19 sites in United States, Czechia and 1 more
- Volunteers
- 142 people
- Sponsor
- Novartis Pharmaceuticals
Knee Injuries, Cartilage Injury
Biomaterials and Mesenchymal Stem/Stromal Cells in the Treatment of Knee Articular Surface Lesions
The goal of this observational study is to evaluate the combined single-step approach with biomaterials and mesenchymal stem/stromal cells in the treatment of knee articular surface lesions.
- Conditions
- Knee Injuries, Cartilage Injury, Osteochondral Defect
- Trial name
- NCT06078072
- Testing
- Biomaterials augmented with mesenchymal stem/stromal cells
- Where
- Slovenia
- Volunteers
- 90 people
- Sponsor
- University Medical Centre Ljubljana
Torn Meniscus
Knee Articular Cartilage Debridement in Conjunction With Partial Meniscectomy
The aim of this study is to describe changes at the site of the study patient's articular cartilage lesion on the femoral condyle with multiple magnetic resonance imaging (MRI) outcomes 6 months after treatment using one of three…
- Trial name
- MILE (NCT00613535)
- Testing
- Mechanical debridement, Paragon T2, Lavage debridement
- Where
- 10 sites in United States
- Volunteers
- 165 people
- Sponsor
- Smith & Nephew, Inc.
Degenerative Lesion of Articular Cartilage of Knee, Osteochondritis Dissecans
DeNovo NT Longitudinal Data Collection (LDC) Knee Study
The purpose of this study is to evaluate the long-term outcomes of DeNovo NT, a tissue product used for the repair of cartilage damage in the knee.
- Trial name
- NCT01329445
- Testing
- DeNovo NT, Natural Tissue Graft
- Where
- 15 sites in United States
- Volunteers
- 160 people
- Sponsor
- Zimmer Orthobiologics, Inc.
Chondral Defect, Articular Cartilage Defect
A Comparison of JointRep® and Microfracture in Repair of Cartilage Lesions on the Femoral Condyle or Trochlea,
The aim of the study is to compare whether JointRep® plus microfracture is more effective than microfracture alone when treating symptomatic focal articular cartilage lesions in the knee (femoral condyles or trochlea).
- Conditions
- Chondral Defect, Articular Cartilage Defect, Articular Cartilage Disorder of Knee
- Trial name
- JMAC (NCT04840147)
- Testing
- JointRep®, Microfracture
- Where
- 8 sites in Australia, Canada
- Volunteers
- 185 people
- Sponsor
- Oligo Medic Pty Ltd
Meniscus Tear, Tibial
Diagnostic Value of Weight Bearing CT for Detecting Meniscal Tears
This observational study will compare the clinical value of weight-bearing CT arthrography (WBCTa) with that for MRI in evaluating meniscal and cartilage lesions of the knee joint.
- Trial name
- NCT04430829
- Testing
- Weight-Bearing CT arthrography, Knee MRI
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Kansas Medical Center
ACL Injury, Meniscus Lesion
Muscle Function and Traumatic Knee Injury in Sports
The aims of the project are to 1) evaluate different aspects of muscle function and its role as a potential risk and/or protective factor for traumatic knee injury in youth female athletes; 2) develop and evaluate a battery of…
- Conditions
- ACL Injury, Meniscus Lesion, Cartilage Injury, Ligament Injury
- Trial name
- NCT03479775
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Lund University