Clinical trials: Knee Deformity, open to volunteers
Hemophilia
Feasibility and Safety of Blood-Flow-Restriction Training in Patients With Hemophilia
In the course of a cross-over study design, 12 patients with hemophilic arthropathy will perform a training load on the knee extensor muscles.
- Trial name
- NCT07259356
- Testing
- Control, BFR Exercise (50% of the LOP) while Leg Press Exercise (4 Sets, All out)
- Where
- Germany
- Volunteers
- 12 people
- Sponsor
- University Hospital, Bonn
MRI, Hemophilia
MRI Role in Knee Hemophilic Arthopathy
The aim of this study is to assess role of MRI in detecting synovial, cartilaginous , osseous abnormalities ، bleeding inside knee joint and to use a system for assessing HA as support for therapeutic regimes and for monitoring…
- Conditions
- MRI, Hemophilia, Arthropathy Hemophilic, Arthropathy of Knee
- Trial name
- NCT07233122
- Volunteers
- 95 people
- Sponsor
- Assiut University
Knee Osteoarthritis, Knee Osteoarthritis in Varus
Total Knee Arthroplasty in Varus Deformity
For the first time, a comparative analysis of the limb axis in patients with unilateral knee OA will be conducted compared to the contralateral uninjured side using Multisliced computed tomography (MSCT) and vertical CT…
- Trial name
- TKA in varus (NCT07465484)
- Testing
- Total knee arthroplasty using active robotic surgical system
- Where
- Russia
- Volunteers
- 300 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Osteoarthritis, Knee, Traumatic Arthritis
Physica System Total Knee Replacement Registry Study
The primary objective of this study is to obtain long-term implant survivorship (out to 10 years) and to assess clinical, patient-reported outcome measures, and radiographic data for the commercially available Physica system.
- Conditions
- Osteoarthritis, Knee, Traumatic Arthritis, Avascular Necrosis, Degenerative Joint Disease of Knee
- Trial name
- NCT03048201
- Testing
- Physica Kinematic Retaining Knee System, Physica Cruciate Retaining Knee System, Physica Posterior Stabilized Knee System
- Where
- 5 sites in United States
- Volunteers
- 800 people
- Sponsor
- Limacorporate S.p.a
Osteoarthritis, Musculoskeletal Abnormalities
Prospective Evaluation Assessing U2 MB™ Total Knee System
The goal of this study is to evaluate the safety and effectiveness of the United Orthopaedics Mobile Bearing Total Knee System (U2 MB™ Knee) in patients undergoing total knee replacement surgery due to end-stage knee…
- Trial name
- NCT06996158
- Volunteers
- 150 people
- Sponsor
- MSK Doctors & Associates Ltd
Medial Compartment Osteoarthritis, Genu Varum
TO Plate Fixation vs. External Fixator Comparison (HTO Plate vs. ExFix Study)
This study aims to compare the efficacy, accuracy, and functional outcomes of two different surgical stabilization techniques for medial opening wedge high tibial osteotomy (HTO) in patients with varus deformity and medial…
- Conditions
- Medial Compartment Osteoarthritis, Genu Varum, Varus Deformity, High Tibial Osteotomy
- Trial name
- NCT07220434
- Testing
- Medial HTO Locking Plate, Self-Adjusting HTO External Fixator
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people
- Sponsor
- Muhammed Cagatay Engin
Trauma, Patella Fracture
DePuy Synthes Variable Angle LCP Patella Plating System Study
The Depuy Synthes Locking Compression Plate (LCP) Variable Angle Patella Plating System is an FDA approved device. The purpose of this study is to see how well the Depuy Synthes LCP Variable Plating System work in fixing a broken…
- Conditions
- Trauma, Patella Fracture, Knee Cap, Knee Cap Injury
- Trial name
- NCT05824676
- Testing
- Variable Angle LCP Patella Plating System, Traditional Fixation
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Hartford Hospital
Patellofemoral Pain, PFP, Flatfeet
Comparison Between Foot Segment Mulligan Mobilization and Ilium Mulligan Mobilization in Treatment Patellofemoral Pain Patients With Flatfeet: a Randomized Controlled Comparative Study
This three-arm, parallel-group randomized controlled trial will investigate the comparative effects of adding Mulligan foot-segment mobilization or Mulligan ilium mobilization to a standardized hip-knee focused exercise program…
- Trial name
- PFP (NCT07806929)
- Testing
- mobilization with movement of the foot segment, Mobilization with movement of the Ilium, Hip-knee focused exercises
- Where
- Jordan
- Volunteers
- 90 people
- Sponsor
- Cairo University
Epiphysiodesis, Bone Malalignment
Plate vs. Screw for Guided Growth in Coronal Knee Deformities
The goal of this clinical trial is to compare two surgical techniques, Tension Band Plate (TBP) and Percutaneous Epiphysiodesis by Transphyseal Screw (PETS), in children with coronal angular knee deformities.
- Conditions
- Epiphysiodesis, Bone Malalignment, Lower Extremity Deformities, Congenital, Genu Varum
- Trial name
- PETS vs TBP (NCT06879015)
- Testing
- Tension Band Plate (TBP) Surgery, Percutaneous Epiphysiodesis by Transphyseal Screw (PETS) Surgery
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Flexible Flatfoot, Knee Pain
Effects of Short Foot Exercise on Knee Pain, Muscle Tone, Balance, and Quality of Life in Flexible Flatfoot Patients
This study was a clinical trial to investigate the effects of Short Foot Exercise (SFE) and standard physical therapy on knee muscle tone, knee pain and function, balance ability, and quality of life in adults with flexible flat…
- Conditions
- Flexible Flatfoot, Knee Pain, Balance Impairment, Quality of Life (QOL)
- Trial name
- NCT06861322
- Testing
- Short Foot Exercise, Conventional Physical Therapy
- Where
- South Korea
- Volunteers
- 44 people
- Sponsor
- Sahmyook University
Rhematoid Arthritis, Osteo Arthritis of the Knee
Persona SoluTion PPS Femur PMCF
The goal of this study is to generate clinical evidence and evaluate the safety and performance of the Persona® SoluTion® PPS Femurs in the US market, with data supporting global regulatory submissions, including CE marking under…
- Conditions
- Rhematoid Arthritis, Osteo Arthritis of the Knee, Traumatic Arthritis of Knee (Diagnosis), Polyarthritis
- Trial name
- NCT07286513
- Testing
- Total knee arthroplasty
- Where
- 5 sites in United States
- Volunteers
- 200 people
- Sponsor
- Zimmer Biomet
Cerebral Palsy, Muscular Dystrophy
Evaluating Long-term Use of a Pediatric Robotic Exoskeleton (P.REX/Agilik) to Improve Gait in Children With Movement Disorders
Background: People with cerebral palsy, spina bifida, muscular dystrophy, or spinal cord injury often have muscle weakness and problems controlling how their legs move. This can affect how they walk.
- Conditions
- Cerebral Palsy, Muscular Dystrophy, Spina Bifida, Incomplete Spinal Cord Injury
- Trial name
- NCT05726591
- Testing
- EA-KAFO
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Knee Osteoarthritis, Deformity Knee
Long Term Evaluation of Clinical and Radiologic Results on Femoro-patellar Joint After High Tibial Osteotomy
Osteotomies are among the oldest orthopedic treatments, in use for over 2000 years and still commonly employed. The basic principle involves making a bone cut to allow the realignment of the limb segment affected by deformity.
- Trial name
- NCT06251752
- Testing
- X-rays: load bearing inferior limbs, lateral knee, axial patella
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Istituto Ortopedico Rizzoli
Paediatric Surgery
Residual Torsional Deformity in Pediatric Genu Varum After Coronal Plane Deformity Correction by 8 Plate Hemi Epiphysiodesis.
This study is to evaluate the residual torsional deformity in pediatric Genu Varum after coronal plane deformity correction by 8 plate hemi epiphysiodesis.
- Trial name
- NCT05334862
- Testing
- 8 plate hemiepiphysiodesis
- Where
- Egypt
- Volunteers
- 15 people
- Sponsor
- Assiut University
Abnormalities, Imaging
MRI Study of Musculoskeletal Function
This study will use magnetic resonance imaging (MRI) and ultrasound images to study how muscles, tendons, and bones work together to cause motion.
- Conditions
- Abnormalities, Imaging, Patellofemoral Pain Syndrome
- Trial name
- NCT00051857
- Where
- United States
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Flexible Flatfoot, Flexible Flatfoot or Pes Planus
Effects of Hip-Based Versus Knee-Based Exercises on Medial Longitudinal Arch, Dynamic Balance, and Muscle Strength in Flexible Flatfoot
This study aims to compare the effects of hip-based and knee-based exercise interventions on medial longitudinal arch height, dynamic balance, and lower limb muscle strength in individuals with flexible flat feet.
- Trial name
- NCT07576816
- Testing
- Hip-based Exercise with hot pack and intrinsic foot strengthening exercises, Knee-based exercises with a hot pack and intrinsic foot strengthening exercises
- Where
- Pakistan
- Volunteers
- 46 people
- Sponsor
- University of Faisalabad
Knee Osteoarthritis
Post Market Clinical Follow-Up Study- EVOLUTION® Revision CCK
Sponsor is conducting this post market clinical follow-up (PMCF) study to evaluate the safety and efficacy of its EVOLUTION® Revision CCK Tibia and EVOLUTION® Revision CCK Femur with EVOLUTION® CCK Tibial inserts.
- Trial name
- NCT04145401
- Testing
- Revision Knee implants
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- MicroPort Orthopedics Inc.
Osteoarthritis, Knee, Genu Varum
Adductor Ratio in Severe Varus Gonarthrosis
The restoration of the joint line (JL) is essential for the proper functioning of Total Knee Arthroplasty (TKA). The exact position of JL can be determined using anatomical landmarks such as femoral condylar width (TEW), tibial…
- Conditions
- Osteoarthritis, Knee, Genu Varum, Joint Prosthesis; Complications
- Trial name
- NCT05936814
- Testing
- total knee arthroplasty
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- Saglik Bilimleri Universitesi
Degenerative Osteoarthritis, Rheumatoid Arthritis
Evaluation of the PHENO4U Data Platform in Patients Undergoing Total Knee Arthroplasty
Prospective, multinational pilot study for evaluation of the Pheno4U data platform in Total Knee Arthroplasty (TKA) patients
- Conditions
- Degenerative Osteoarthritis, Rheumatoid Arthritis, Posttraumatic Arthropathy, Chronic Instability of Knee
- Trial name
- Pheno4U Pilot (NCT05302934)
- Testing
- Pheno4U
- Where
- 4 sites in Germany, United Kingdom
- Volunteers
- 600 people
- Sponsor
- Aesculap AG
Hypermobile EDS (hEDS), Hypermobile Ehlers-Danlos Syndrome
Hamstring Strengthening in Hypermobile Conditions
The goal of this clinical trial is to determine how strengthening the hamstring muscles affects the knee joint in people living with hypermobility spectrum disorders (HSD) and hypermobile Ehlers-Danlos syndrome (hEDS).
- Conditions
- Hypermobile EDS (hEDS), Hypermobile Ehlers-Danlos Syndrome, Hypermobile Spectrum Disorder, Hypermobility Type Ehlers-Danlos Syndrome
- Trial name
- NCT07626957
- Testing
- Progressive resistance exercise with an emphasis on eccentric hamstring loading.
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Calgary