Clinical trials: Knee Degenerative Disease
Degenerative Knee Disorders, Knee Osteoarthritis
Artificial Intelligence-Assisted Advanced Analysis of Knee Imaging and Outcome Prediction
This study aims to develop and validate an artificial intelligence (AI)-assisted platform for musculoskeletal knee ultrasonography and to establish an interpretable prediction model for clinical outcomes following…
- Conditions
- Degenerative Knee Disorders, Knee Osteoarthritis, Musculoskeletal Ultrasonography, Artificial Intelligence
- Trial name
- AI; R-CNN (NCT07721116)
- Testing
- artificial intelligence-assisted advanced analysis
- Where
- Taiwan
- Volunteers
- 310 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Articular Cartilage Disorder, Degeneration; Articular Cartilage
Neocartilage Implant to Treat Cartilage Lesions of the Knee
ISTO Technologies, Inc. is proposing a clinical study with 225 subjects, to establish the safety and efficacy of the Neocartilage Implant for the treatment of ICRS Grade 3 and 4 articular cartilage lesions of the knee compared to…
- Conditions
- Articular Cartilage Disorder, Degeneration; Articular Cartilage, Chronic Cartilage Injury, Acute Cartilage Injury
- Trial name
- NCT01400607
- Testing
- Neocartilage Implant/DeNovo® ET (Engineered Tissue Graft), Microfracture
- Where
- 9 sites in United States
- Volunteers
- 14 people
- Sponsor
- ISTO Technologies, Inc.
Gonarthritis, Degenerative Disease
Clinical Performance and Safety of the Unicompartmental Univation® XF Pro Implant
The study is designed as a prospective, observational, mid-term, multi-center follow-up study. It is planned to include 150 patients from 4 different study centres in Germany.
- Trial name
- UNI_XF_PRO (NCT06657248)
- Testing
- univation® XF Pro
- Where
- 4 sites in Germany
- Volunteers
- 150 people
- Sponsor
- Aesculap AG
Degenerative Osteoarthritis, Rheumatoid Arthritis
VEGA Prospective Kiel
Voluntary Post-Marketing Clinical Follow-up (PMCF) as part of the post marketing surveillance plan for the product under investigation.
- Trial name
- NCT02802085
- Testing
- VEGA Knee
- Where
- Germany
- Volunteers
- 84 people
- Sponsor
- Aesculap AG
Osteoarthritis, Degenerative Joint Disease
Comparative Effectiveness of an Activity-specific Monitoring Device- StepRite
Partial or Total Knee Arthroplasty are procedures commonly used in severe degeneration of the knee joint due to osteoarthritis. With an increasing number of Partial or Total Knee Arthroplasty performed in a population that is…
- Trial name
- NCT02900781
- Testing
- Steprite™, Standard of care
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Texas Tech University Health Sciences Center
Knee Degenerative Disease
Evaluation of the 5C® MEDic Knee System
This prospective study wants to demonstrate the safety and clinical performance of the 5C® MEDic Knee System following total knee arthroplasty.
- Trial name
- 5C Knee (NCT07491575)
- Testing
- 5C® Knee System prothesis
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Articular Cartilage Disorder of Knee, Articular Cartilage; Degeneration
Efficacy and Safety Study of Intra-Articular Injections of Autologous Peripheral Blood Stem Cells Following Subchondral Drilling Surgery for the Treatment of Articular Cartilage Injury in the Knee
This is a 24-month, multicenter, randomized, open-label, standard treatment-controlled, parallel-group, Phase 2 study for adults with large or complicated knee articular cartilage lesions and are candidates for knee joint…
- Trial name
- NCT03101163
- Testing
- Autologous peripheral blood stem cells and hyaluronic acid, Hyaluronic acid
- Where
- 2 sites in United States, Malaysia
- Volunteers
- 120 people
- Sponsor
- KLSMC Stem Cells, Inc.
Spine Degeneration, Hip Arthritis
Evaluating the Efficacy of a Mobile Application in Postoperative Rehabilitation
This study aims to evaluate the effectiveness of a mobile application in improving postoperative rehabilitation outcomes among patients undergoing orthopedic surgery.
- Conditions
- Spine Degeneration, Hip Arthritis, Knee Osteoarthritis, Hip Fractures
- Trial name
- NCT06407427
- Testing
- App for in-bed conditioning exercises, Usual care
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Yale University
Degenerative Osteoarthritis
Determine the Efficacy of TT-173. Reducing the the Total Blood Loss Associated With Total Knee Arthroplasty (HESTAT)
The purpose of this study is to determine the haemostatic efficacy of TT-173, reducing the total blood loss associated with the total knee arthroplasty.
- Trial name
- NCT02687399
- Testing
- TT-173
- Where
- Spain
- Volunteers
- 210 people
- Sponsor
- Thrombotargets Europe S.L
Osteoarthritis
A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Osteoarthritis (OA) of the Knee
The GZPT master protocol will support two independent studies, J2A-MC-GZT1 and J2A-MC-GZT2. Each study will see how well and safely orforglipron works in people with obesity or overweight who have osteoarthritis (OA) of the knee…
- Trial name
- ATTAIN-OA PAIN (NCT07153471)
- Testing
- Orforglipron
- Where
- 88 sites in United States, Canada and 5 more
- Volunteers
- 800 people
- Sponsor
- Eli Lilly and Company
Knee Osteoarthritis, Degenerative Joint Disease of Knee
Genicular Artery Embolization Vs Observation for Symptomatic Knee Osteoarthritis
The purpose of this clinical trial is to determine whether genicular artery embolization (GAE) is an effective way to treat knee pain from osteoarthritis. Pain from arthritis is often due to underlying inflammation in the joint.
- Trial name
- GRAVITY (NCT04682652)
- Testing
- Embozene MicroSpheres
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of California, Los Angeles
Osteoarthritis
Quantitative Ultrasonography (US) Evaluation on Femoral Condyle Cartilage
The purpose of this study is to investigate the feasibility of using quantitative ultrasonography (US) evaluation to determine the severity of osteoarthritic femoral condyle cartilage erosion.
- Trial name
- US (NCT00630604)
- Sponsor
- Kaohsiung Medical University
Knee Osteoarthritis, Osteoarthritis of the Knee
Postmarketing Multicenter Study of Intra-Articular DIART ONE / EASYGO ONE for Knee Osteoarthritis
This study looked at how safe and effective a hyaluronic acid-based injection (called DIART ONE or EASYGO ONE) is for people with knee osteoarthritis.
- Conditions
- Knee Osteoarthritis, Osteoarthritis of the Knee, Degenerative Joint Disease
- Trial name
- NCT06927934
- Where
- Ukraine
- Volunteers
- 55 people
- Sponsor
- Yuria-Pharm
Knee Osteoarthritis
Taping Versus Conventional Physiotherapy in Knee Osteoarthritis
The purpose of this study is to determine the effects of kinesio taping versus conventional physiotherapy in women with knee osteoarthritis.
- Trial name
- NCT05606354
- Testing
- Intervention group
- Where
- Pakistan
- Volunteers
- 80 people
- Sponsor
- Dow University of Health Sciences
Osteoarthritis, Post-traumatic Arthritis
A Global Clinical Study Investigating the Safety and Effectiveness of Smith and Nephew's Porous Knee System in Patients Who Need a Total Knee Replacement Due to Degenerative Arthritis, Post-traumatic Arthritis or Inflammatory Arthritis
A clinical trial investigating the safety and effectiveness of Smith and Nephew's FDA-approved Porous Total Knee System, which is used to replace worn away and diseased knee joints.
- Conditions
- Osteoarthritis, Post-traumatic Arthritis, Rheumatoid Arthritis
- Trial name
- NCT05197036
- Testing
- Total Knee Arthroplasty
- Where
- 18 sites in United States, Australia and 3 more
- Volunteers
- 299 people
- Sponsor
- Smith & Nephew, Inc.
Osteoarthritis of Knee, Degenerative Osteoarthritis
Serum Nesfatin-1 and Human Cartilage Glycoprotein-39 Levels in Knee Osteoarthritis
In this study, our objective was to assess the correlation between serum human cartilage glycoprotein-39 (YKL-40) and nesfatin-1 values, the patient's clinical condition, ultrasonographic cartilage thickness measurements, and the…
- Trial name
- NCT06254976
- Testing
- exercise, intraarticular knee PRP injections
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Kayseri City Hospital
Degenerative Arthritis, Osteoarthritis
I-beam and Cruciate Tibial Components Used in Total Knee Replacement
The purpose of this study is to compare the clinical outcomes of using an I-beam or cruciate tibial component in total knee replacement.
- Conditions
- Degenerative Arthritis, Osteoarthritis, Rheumatoid Arthritis, Knee Arthritis
- Trial name
- NCT00588783
- Testing
- I-beam design, Cruciate design
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Biomet Orthopedics, LLC
Knee Osteoarthritis
Balance Training Using Biodex Stability System in Knee Osteoarthritis.
This was a randomized control Trial, conducted with two group of patients, one has received Balance and stability training on Biodex stability system along with conservative protocol of traditional exercises.
- Trial name
- NCT04019366
- Testing
- Balance Training, Conventional Training
- Where
- Pakistan
- Volunteers
- 43 people
- Sponsor
- Riphah International University
Knee Osteoarthritis
Initial Pilot Study to Evaluate the Safety and Temporary Symptom Improvement Efficacy of CKD-981
The purpose of this study is to prove that the temporary symptom improvement effect on knee osteoarthritis using CKD-981
- Trial name
- NCT06954766
- Testing
- CKD-981(1), CKD-981(2), Reference Drug
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Chong Kun Dang Pharmaceutical
Meniscus Tear
The Effect of Therapeutic Exercise on Cartilage Morphology and Physical Function for Individuals at High Risk of Knee Osteoarthritis
This randomized controlled trial aims to evaluate the efficacy of progressive resistance exercises (PRE) versus aerobic exercises on cartilage morphology and physical function in patients with degenerative meniscus tears.
- Trial name
- NCT06532851
- Testing
- Progressive Resistance Exercise (PRE), Aerobic Exercise, Control
- Where
- 2 sites in Jordan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology