Clinical trials: Knee Disease
Pain, Osteoarthritis
Brain Morphometry in OA Patients Treated With Duloxetine
This is a two week,single-blind study evaluating pain response and changes in brain imaging upon treatment with placebo in people with knee OA.
- Trial name
- NCT02903238
- Testing
- Duloxetine
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Northwestern University
Pain, Function
Preventing Persistent Post-Surgical Pain and Dysfunction
Primary Aim: To examine the superior efficacy of ACT versus Attention Control (AC) on postoperative pain intensity and functioning in at-risk Veterans undergoing TKA.
- Conditions
- Pain, Function, Anxiety, Depression
- Trial name
- PrePARE (NCT03965897)
- Testing
- Acceptance and Commitment Therapy (ACT), Attention Control (AC)
- Where
- United States
- Volunteers
- 402 people
- Sponsor
- University of Iowa
Osteoarthritis of the Knee
Hydroxychloroquine/Atorvastatin in the Treatment of Osteoarthritis (OA) of the Knee
The purpose of this study of a combination therapy of hydroxychloroquine and atorvastatin is to learn about the effects in inflammation and pain in patients with Osteoarthritis of the knee.
- Trial name
- NCT01645176
- Testing
- Hydroxychloroquine/Atorvastatin
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Stanford University
Osteoarthritis, Knee
Comparison of Surgical Time and Efficiency of Total Knee Arthroplasty
This study is designed to compare the surgical efficiency of TruMatch® Personalized Solutions surgical technique compared to conventional surgical technique.
- Trial name
- NCT01301950
- Testing
- Custom Patient Instrumentation, Conventional Instruments
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- DePuy Orthopaedics
Osteoarthritis
Study of Safety and Efficacy of 6 mL Synvisc-One (Hylan G-F 20) in Indian Patients With Symptomatic Osteoarthritis of Knee(s) After Initial and Repeat Treatment
Primary Objective: To evaluate the safety and efficacy of a single 6 mL intraarticular (IA) injection of Synvisc-One in participants in India with symptomatic osteoarthritis (OA) of the knee(s).
- Trial name
- OASIS (NCT02389452)
- Testing
- Synvisc-One
- Volunteers
- 394 people
- Sponsor
- Genzyme, a Sanofi Company
Osteoarthritis, Knee
Validation of a Stress Device for the Knee
X-rays are the most frequently used imaging test when evaluating the knee for joint replacement. They are non-invasive, safe and cost effective.
- Trial name
- NCT02444663
- Testing
- Clinician Valgus, Clinician Varus, Device Valgus - 0 Newton
- Volunteers
- 9 people
- Sponsor
- Oxford University Hospitals NHS Trust
Osteoarthritis, Rheumatoid Arthritis
Randomized Fixed Bearing vs Mobile Bearing Cruciate Substituting TKA
The study will evaluate the clinical performance of the rotating platform and fixed bearing implants through patient questionnaires, outcomes scoring and radiographic assessment.
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Other Inflammatory Arthritis, Post-Traumatic Arthritis
- Trial name
- NCT00289107
- Testing
- Total Knee Arthroplasty, Total knee replacement
- Where
- 3 sites in United States
- Volunteers
- 149 people
- Sponsor
- DePuy Orthopaedics
Osteoarthritis, Knee
Prediction of Response to Intra-articular Injections of Hyaluronic Acid for Knee Osteoarthritis
The purpose of this study is to evaluate whether the investigators can develop a computer algorithm to predict which individual patients will respond to injections of hyaluronic acid (HA) products for knee osteoarthritis.
- Trial name
- NCT01557868
- Testing
- hylan G-F 20, 1% sodium hyaluronate
- Where
- United States
- Volunteers
- 198 people
- Sponsor
- American Orthopaedic Society for Sports Medicine
Knee Osteoarthritis
Using Intraoperative Sensing Technology to Evaluate Revision Total Knee Arthroplasty
This study will attempt to draw relationships between the soft-tissue related complications contributing to early TKA revision and the loading and positional patterns from intraoperative tibial trial sensors.
- Trial name
- NCT03023410
- Testing
- VERASENSE
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Orthosensor, Inc.