Clinical trials: Knee Injuries
Articular Cartilage Injury
Evaluation of an Acellular Osteochondral Graft for Cartilage LEsions Pilot Trial
The Kensey Nash Corp. Cartilage Repair Device is a bioresorbable scaffold designed to promote repair of knee cartilage and subchondral bone.
- Trial name
- EAGLE Pilot (NCT01183637)
- Testing
- Kensey Nash Corp. Cartilage Repair Device, Microfracture
- Where
- 2 sites in United States
- Volunteers
- 2 people
- Sponsor
- Kensey Nash Corporation
Thrombosis, Venous
A Study to Evaluate the Efficacy and Safety of Fondaparinux for the Prevention of Venous Blood Clots in Patients With a Plaster Cast or Other Type of Immobilization for a Below-knee Injury Not Needing Surgery
The purpose of this study is to evaluate the efficacy and safety of fondaparinux in comparison with a heparin (nadroparin) in preventing deep vein thrombosis (blood clots in the leg veins), whether symptomatic or detected by…
- Trial name
- FONDACAST (NCT00843492)
- Testing
- Fondaparinux sodium, Nadroparin
- Where
- 122 sites in France, Germany and 4 more
- Volunteers
- 1,351 people
- Sponsor
- GlaxoSmithKline
Multiligament Knee Injuries
OrthoPureXT Multiligament PMCF Study
To monitor residual risks in the post-market phase and to ensure continued clinical evaluation of the device safety and performance to ensure that no new or unexpected risks arise when used during multi-ligament knee…
- Trial name
- NCT05655156
- Testing
- OrthoPure XT
- Where
- United Kingdom
- Volunteers
- 28 people
- Sponsor
- Tissue Regenix Ltd
Knee Injury
Evaluation of a Composite Cancellous and Demineralized Bone Plug (CR-Plug) for Repair of Knee Osteochondral Defects
The objective of this study is to determine how effective a plug made out of human bone (called "CR-Plug") will be in the treatment of smaller, focal defects (like the injury the patient has to their knee).
- Trial name
- NCT00984594
- Testing
- Primary injury site, Backfill site
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- RTI Surgical
Anterior Cruciate Ligament Injuries
Jewel ACL Post Market Clinical Follow Up Study
The objective of the study is to assess re-rupture rates and patient outcomes from subjects with at least 5 year follow up, treated with the JewelACL device for ACL reconstruction.
- Trial name
- NCT04580290
- Testing
- JewelACL
- Where
- Poland
- Volunteers
- 120 people
- Sponsor
- Xiros Ltd
Wound Healing, Scarring
The Effects of Topical Calcium Glycerophosphate on Surgical Wound Healing and Residual Scarring
The purpose of this study is to determine whether topical application of calcium glycerophosphate will result in superior wound appearance and scar minimization.
- Trial name
- TOPCGP-2008 (NCT01264588)
- Testing
- Topical calcium glycerophosphate lotion
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- AkPharma Inc.
Amputation, Amputation; Traumatic, Leg, Lower
Clinical Outcomes With Passive MPKs vs. Powered Prosthetic Knees
The goal of this proposed project is to gather community-based data from the K4-level Transfemoral Amputee (TFA) population to aid in evidence-based prescription of powered prosthetic knees (i.e., choosing the right device to…
- Conditions
- Amputation, Amputation; Traumatic, Leg, Lower, Limb; Absence, Congenital, Lower, Prosthesis User
- Trial name
- NCT05267639
- Testing
- Power Knee
- Where
- 2 sites in United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Liberating Technologies, Inc.
Lower Limb Amputation Below Knee (Injury)
Wear and Tear Evaluation of New Nike Sport Sole for Runnnig Prosthesis
Running Specific Feet are based on the original Flex-Foot design using the energy storage and release function as the main design feature. Running specific prosthetic feet are intended for running and jogging.
- Trial name
- NCT04787640
- Testing
- Nike Sport Sole
- Volunteers
- 3 people
- Sponsor
- Össur Iceland ehf
Bursitis, Tendinitis
Efficacy and Safety of Etoricoxib/Betamethasone Combination in Acute Bursitis, Tendinitis and Synovitis
Phase III, multicenter, prospective, randomized, double-blind, parallel-group study to evaluate the efficacy and safety of a fixed-dose combination of etoricoxib/betamethasone compared with etoricoxib alone in patients with an…
- Conditions
- Bursitis, Tendinitis, Synovitis
- Trial name
- NCT07328022
- Testing
- Fixed Dose Etoricoxib + Betamethasone, Monotherapy Etoricoxib
- Where
- Mexico
- Volunteers
- 89 people
- Sponsor
- Laboratorios Silanes S.A. de C.V.
Tendonitis, Bursitis
Ketoprofen Topical Patch 20% in the Treatment of Pain Associated With Shoulder, Elbow or Knee Tendonitis or Bursitis
The purpose of this study is to evaluate the effect of a ketoprofen topical patch on the pain associated with tendonitis or bursitis of the shoulder, elbow or knee.
- Trial name
- NCT00352625
- Testing
- Ketoprofen Topical Patch 20%
- Where
- United States
- Volunteers
- 330 people
- Sponsor
- Alkemira SA
Articular Cartilage Disorder, Degeneration; Articular Cartilage
Chondrofix Osteochondral Allograft Prospective Study
The overall study objective is to evaluate Chondrofix Osteochondral Allograft ("Chondrofix") for the repair of osteochondral lesions in the knee.
- Conditions
- Articular Cartilage Disorder, Degeneration; Articular Cartilage, Chronic Cartilage Injury, Acute Cartilage Injury
- Trial name
- NCT01410136
- Testing
- Chondrofix Osteochondral Allograft
- Where
- 5 sites in United States
- Volunteers
- 29 people
- Sponsor
- Zimmer Orthobiologics, Inc.
Knee Injuries
Efficacy and Safety of OMS103HP in Patients Undergoing Autograft Anterior Cruciate Ligament (ACL) Reconstruction
The anterior cruciate ligament (ACL) is an important stabilizer of the knee. Orthopedic surgeons replace the torn ligament during ACL reconstruction surgery.
- Trial name
- NCT00226772
- Testing
- OMS103HP, Vehicle
- Where
- 18 sites in United States, Canada
- Volunteers
- 326 people
- Sponsor
- Omeros Corporation
Knee Injuries, Anterior Cruciate Ligament (ACL) Reconstruction
OrthoPure™ XT Pilot Clinical Study
To evaluate the clinical safety and obtain preliminary effectiveness data for OrthoPure™ XT device in a small group of US patients at 12 and 24 months.
- Trial name
- NCT03562299
- Testing
- OrthoPure™ XT
- Where
- 3 sites in United States
- Sponsor
- TRX Orthopedics
Lower Limb Amputation Above Knee (Injury)
C-Leg 3 and C-Leg 4 Study in Transfemoral Amputees
The aim of this post-market study is to confirm that the microprocessor controlled prosthetic knee components (C-Leg 3 and C-Leg 4) in comparison to mechanical knee joints can bring additional benefit to the users primarily on…
- Trial name
- NCT02765035
- Testing
- C-Leg 4, C-Leg 3
- Where
- 2 sites in Austria, Belgium
- Volunteers
- 18 people
- Sponsor
- Otto Bock Healthcare Products GmbH
Fracture, Joint Dislocation
Clinical Validation of RBfracture for Diagnosing Trauma-related Musculoskeletal Injuries
The goal of this study is to determine if the computer software, RBfracture, developed by Radiobotics, helps primary care, emergency, and radiology clinicians more easily identify bone injuries caused by a traumatic impact (such…
- Conditions
- Fracture, Joint Dislocation, Joint Effusion, Knee Lipohemarthrosis
- Trial name
- NCT07421791
- Testing
- RBfracture
- Volunteers
- 415 people, healthy volunteers welcome
- Sponsor
- Radiobotics
Arthroplasty, Replacement, Hip, Arthroplasty, Replacement, Knee
Benchmarking the iOS Balance Application Against the Berg Balance Test
This study aims to benchmark the performance of an iOS application against the Berg Balance Scale (BBS), which is the most commonly used assessment tool by clinicians for measuring balance across the continuum from acute care to…
- Conditions
- Arthroplasty, Replacement, Hip, Arthroplasty, Replacement, Knee, Ankle Injuries, Knee Injuries
- Trial name
- BBAaBBT (NCT02705690)
- Testing
- iOS Balance Application
- Where
- 2 sites in United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Stannah Stairlifts
Osteoarthritis, Knee
A Telehealth Study of a Wearable Electroceutical & Sports Sleeve for Knee Osteoarthritis Pain Relief & Improved Function
The purpose of this telemedicine 24-person open-label study is to evaluate the safety and usability of a proprietary wearable microcurrent electroceutical (a device that delivers micro-ampere electronic pulses) made by Healables…
- Trial name
- HEAL01WMCOA1 (NCT04938271)
- Testing
- HEAL-122 microcurrent electroceutical with e-textile sports knee sleeve
- Where
- Israel
- Volunteers
- 24 people
- Sponsor
- Healables Ltd.
ACL Injury
ACL Reconstruction with a New Generation of LARS Artificial Ligament
This clinical investigation is intended to demonstrate the safety of the new generation of LARS ligaments and compare this new generation (grafted ligament) of artificial ligament to the LARS current artificial ligament…
- Trial name
- NCT06571955
- Testing
- Implantation of LARS artificial grafted ligament to treat ACL injury, Implantation of LARS artificial non-grafted ligament to treat ACL injury
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- MOVMEDIX
Chondral Defect, Articular Cartilage Defect
A Comparison of JointRep® and Microfracture in Repair of Cartilage Lesions on the Femoral Condyle or Trochlea,
The aim of the study is to compare whether JointRep® plus microfracture is more effective than microfracture alone when treating symptomatic focal articular cartilage lesions in the knee (femoral condyles or trochlea).
- Conditions
- Chondral Defect, Articular Cartilage Defect, Articular Cartilage Disorder of Knee
- Trial name
- JMAC (NCT04840147)
- Testing
- JointRep®, Microfracture
- Where
- 8 sites in Australia, Canada
- Volunteers
- 185 people
- Sponsor
- Oligo Medic Pty Ltd
Shoulder Injuries, Knee Injuries
SportsPro: Post-Market Clinical Follow Up Study
Retrospective, multi-center, chart review (only to include data that is part of the surgeons' standard practice)
- Conditions
- Shoulder Injuries, Knee Injuries, Hip Injuries
- Trial name
- NCT06320925
- Testing
- Standard of Care Treatment
- Where
- 3 sites in United States
- Volunteers
- 1,500 people
- Sponsor
- Stryker Endoscopy