Clinical trials: Knee Injury
Anterior Cruciate Ligament Injury
Back in the Game: a Smartphone Application to Support Athletes Returning to Sport After Serious Injury
Returning to sport is one of the primary concerns of athletes following injury. Yet, after serious injury, up to 50% of athletes do not return to competitive sport.
- Trial name
- BANG (NCT03959215)
- Testing
- Back in the Game, Usual rehabilitation care
- Where
- 7 sites in Sweden
- Volunteers
- 169 people
- Sponsor
- Karolinska Institutet
Osteoarthritis (OA), Knee Injury
Investigating the Safety and Regenerative Potential of MSC-Derived Secretome Combined With PRGF in Knee Osteoarthritis
This Phase I/II randomized clinical trial investigates the safety, feasibility, and early regenerative potential of intra-articular administration of mesenchymal stem cell (MSC)-derived secretome combined with Plasma Rich in…
- Conditions
- Osteoarthritis (OA), Knee Injury, Cartilage Degeneration
- Trial name
- PRGFSECKOA (NCT07157891)
- Testing
- MSC-Derived Secretome, MSC-Derived Secretome + Autologous PRGF
- Volunteers
- 25 people
- Sponsor
- University of the Punjab
Anterior Cruciate Ligament Injuries, ACL
Blood Flow Restriction Following ACLR
The purpose of this study is to evaluate the the ability of BFR to reduce muscle loss and improve strength after ACL reconstruction.
- Conditions
- Anterior Cruciate Ligament Injuries, ACL, Physical Therapy
- Trial name
- NCT04086030
- Testing
- Blood Flow Restriction Training
- Volunteers
- healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Patellofemoral Pain Syndrome, Exertional Lower Leg Pain
Prevention of Injuries by an Exercise Program - a RCT
Overuse injuries are a major concern for physical active individuals. Study hypothesis is that an exercise programme based on known intrinsic risk factors can prevent overuse injuries in soldiers undergoing basic military…
- Trial name
- NCT00348647
- Testing
- physical training program to prevent injuries
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Amager Hospital
Articular Cartilage Disorder, Degeneration; Articular Cartilage
Chondrofix Osteochondral Allograft Prospective Study
The overall study objective is to evaluate Chondrofix Osteochondral Allograft ("Chondrofix") for the repair of osteochondral lesions in the knee.
- Conditions
- Articular Cartilage Disorder, Degeneration; Articular Cartilage, Chronic Cartilage Injury, Acute Cartilage Injury
- Trial name
- NCT01410136
- Testing
- Chondrofix Osteochondral Allograft
- Where
- 5 sites in United States
- Volunteers
- 29 people
- Sponsor
- Zimmer Orthobiologics, Inc.
Anterior Cruciate Ligament Injuries
Cartilage Injury and Remodeling After ACL Rupture and Reconstruction: Functional Imaging and Biomarkers
The proposed study will establish novel relationships between intra-articular MSC recruitment, synovial inflammation, biomarkers of cartilage degeneration and joint inflammation, clinical patient factors, and downstream…
- Trial name
- NCT04970706
- Testing
- ACL reconstruction
- Where
- China
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Meniscus Injury
Clinical Related Study on Surgical Treatment of Knee Joint Meniscus Injury
Through the analysis of the data of 8094 patients with knee meniscus injury before December 31, 2008 and more patients with partial meniscus resection, subtotal resection and total resection, we can understand the gender…
- Trial name
- NCT04962555
- Testing
- Meniscus Suture, Partial meniscus resection, Subtotal meniscus resection
- Where
- China
- Volunteers
- 8,778 people
- Sponsor
- Peking University Third Hospital
Total Knee Arthroplasty, Osteo Arthritis Knee
In Vivo Kinematics for Subjects Implanted With Klassic Total Knee Arthroplasty (TKA)
In vivo knee kinematics will be assessed for 20 subjects that have been implanted with a Total Joint Orthopedics Klassic knee system by Dr.
- Conditions
- Total Knee Arthroplasty, Osteo Arthritis Knee, Knee Implant, Knee Injuries
- Trial name
- TKA (NCT04113785)
- Testing
- Klassic Knee System
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- The University of Tennessee, Knoxville
Kinesiophobia, ACL Injury
Kinesiophobia After Anterior Cruciate Ligament Reconstruction.
Anterior cruciate ligament (ACL) rupture is a serious trauma with long-term consequences to the athlete. Psychological and physiological factors may negatively affect patient recovery and increase reinjury rate after anterior…
- Trial name
- NCT05762809
- Testing
- Tampa Scale of Kinesiophobia (TSK-17), Knee injury and Osteoarthritis Outcome Score (KOOS), Oxford Knee Score (OKS) scoring
- Where
- Estonia
- Volunteers
- 144 people
- Sponsor
- Tartu University Hospital
ACL - Anterior Cruciate Ligament Rupture
Soft-tissue Quadriceps Autograft ACL-reconstruction in the Skeletally-immature vs. Hamstrings
To date, the use of the quadriceps tendon as an autograft option in primary paediatric Anterior Cruciate Ligament (ACL) reconstruction has not been well studied.
- Trial name
- SQuASH (NCT03896464)
- Testing
- Soft tissue hamstring autograft, Quadriceps tendon autograft
- Where
- 6 sites in Canada, Japan
- Volunteers
- 352 people
- Sponsor
- McMaster University
Knee Injuries
Effects of Intraarticular IL1-Ra on Pain and Inflammatory Mediators After Knee Arhroscopy
This project investigates the relation between acute pain and local inflammation. Pain reported by the patients for knee arthroscopy are compared with local changes in inflammatory mediators by using microdialysis technique.
- Trial name
- NCT01997138
- Testing
- Anakinra 100 mg in 2 ml saline IA
- Where
- Norway
- Sponsor
- Oslo University Hospital
Complete Tear, Knee, Anterior Cruciate Ligament, Rupture of Anterior Cruciate Ligament
Tibial Tunnel Placement for ACL Reconstruction
Although extensive research has been carried out on Anterior Cruciate Ligament (ACL) femoral tunnel placement, very little attention has been given to the tibial tunnel.
- Trial name
- NCT02374710
- Testing
- ACL Reconstruction: Anterior Tunnel, ACL Reconstruction: Posterior Tunnel
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Virginia
Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture
Analysis of Radiological Features of Lateral Femoral Impaction Fracture / Lateral Femoral Notch Sign
Analysis of Radiological Features of Lateral Femoral Impaction Fracture (LFC-IF) / Lateral Femoral Notch Sign will be performed on MRIs of consecutive patients after anterior cruciate ligament (ACL) injuries and without ACL…
- Conditions
- Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture, Anterior Cruciate Ligament Tear
- Trial name
- NCT05682820
- Testing
- Measurements on knee MRI performed during routine clinical practice
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Artromedical Konrad Malinowski Clinic
Osteochondritis Dissecans, Osteoarthritis
ACI-C Versus AMIC. A Randomized Trial Comparing Two Methods for Repair of Cartilage Defects in the Knee
ACI-C versus AMIC: A controlled randomized trial comparing Autologous Chondrocyte Implantation ( ACI) and Autologous Matrix Induced Chondrogenesis (AMIC) for repair of cartilage defects in the knee.
- Conditions
- Osteochondritis Dissecans, Osteoarthritis, Cartilage Injury, Osteonecrosis
- Trial name
- NCT01458782
- Testing
- Treatment of cartilage defects in the knee
- Where
- Norway
- Volunteers
- 41 people
- Sponsor
- University Hospital of North Norway
Knee Injuries
Efficacy and Safety of OMS103HP in Patients Undergoing Allograft Anterior Cruciate Ligament (ACL) Reconstruction
The anterior cruciate ligament (ACL) is an important stabilizer of the knee. Orthopedic surgeons replace the torn ligament during ACL reconstruction surgery.
- Trial name
- NCT00226759
- Testing
- OMS103HP, Vehicle
- Where
- 20 sites in United States, Canada
- Volunteers
- 321 people
- Sponsor
- Omeros Corporation
ACL Injury
Multimodal Assessment of Knee Conditions in Rehabilitation
The purpose of this study is to assess ACL injury and other pathological knee conditions from the combination of signals that are known to provide information on the knee joint.
- Trial name
- NCT03608189
- Where
- Finland
- Volunteers
- 20 people
- Sponsor
- University of Oulu
Osgood-Schlatter Disease, Apophysitis
A Comparison of Two Different Treatment Approaches for Adolescents With Osgood Schlatter
The most common growth-related injury is Osgood Schlatter, which affects up to 1 in 5 physically active adolescents. It can cause long-term pain and potential discontinuation of sports and physical activity, with sequela well…
- Conditions
- Osgood-Schlatter Disease, Apophysitis, Osteochondrosis; Tibia, Physeal Injury
- Trial name
- SOGOOD (NCT05174182)
- Testing
- A novel treatment approach, Usual care
- Where
- Denmark
- Volunteers
- 130 people
- Sponsor
- Hvidovre University Hospital
Anterior Cruciate Ligament Injuries, Arthroscopy
Functional Outcomes Comparison in Patients Using Knee Brace Post ACL Reconstruction With Autograft Bone Quadricep Tendon
This study is a study looking for the relationship between variables with a prospective cohort design to determine functional outcomes subjectively and objectively in patients with and without braces after ACL reconstruction with…
- Conditions
- Anterior Cruciate Ligament Injuries, Arthroscopy, Braces
- Trial name
- ACL (NCT05457452)
- Testing
- Knee Brace
- Where
- Indonesia
- Volunteers
- 32 people
- Sponsor
- Universitas Indonesia
Hip-surgery, Knee-surgery
Prospective, Randomized Study of 2 Different Wound Dressings
The primary objective of this investigation is to evaluate the performance of a self-adhesive absorbent post-operative dressing coated with a soft silicone layer in minimize the risk of the development of blistering in subjects…
- Conditions
- Hip-surgery, Knee-surgery, Spinal-surgery
- Trial name
- Close (NCT01988818)
- Testing
- Mepilex® Border Post-Op, standard wound dressing
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- University of Cologne
Meniscus Injury, Osteoarthritis, Knee
The Effect of Commercially Available Footwear Interventions in Meniscectomy Patients
Injuries to the meniscus are common in sport. A meniscectomy is often performed to manage symptoms associated with the meniscal injury. Following a meniscectomy individuals are highly likely to develop knee osteoarthritis (OA).
- Conditions
- Meniscus Injury, Osteoarthritis, Knee, Footwear
- Trial name
- MENI-FOOT (NCT03379415)
- Testing
- Footwear, Gait analysis
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Salford