Clinical trials: Knee Injury
Anterior Cruciate Ligament Injury
A Novel Analgesia Technique for ACL Reconstruction
A comparison of two anesthetic techniques-- the Adductor Canal Block (ACB) and the Adductor Canal Block with Infiltration of the interspace between the popliteal artery and the capsule of the posterior knee (ACB/IPACK)-- in…
- Trial name
- NCT03292926
- Testing
- Bupivacaine, Ultrasound, Dexamethasone
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Hospital for Special Surgery, New York
Anterior Cruciate Ligament Rupture
Liposomal Bupivacaine for Pain Control Following Anterior Cruciate Ligament Reconstruction
This study will consist of 80 patients ages 18 to 50 at the Emory Orthopaedic and Spine Center who are undergoing Anterior Cruciate Ligament (ACL) reconstruction with a quadriceps tendon autograft or bone patellar tendon bone…
- Trial name
- NCT02189317
- Testing
- Exparel
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Emory University
Knee Osteoarthritis, Hip Osteoarthritis
Use of Knotless Suture for Closure of Total Hip and Knee Arthroplasties
Barbed sutures offer several potential advantages in layered wound closure of hip and knee replacement surgeries. It use is gaining increased acceptance across many of the other surgical disciplines at this time.
- Trial name
- NCT00834483
- Testing
- Knotless suture for wound closure, Layered traditional wound closure (monocryl)
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Complications; Arthroplasty, Knee Injuries
Ultrasound-guided Adductor Canal Block for Total Knee Replacement
Total knee arthroplasty is associated with intense early postoperative pain. Fast track recovery programs including early therapy protocols and early hospital discharge are being implemented at various hospitals.
- Trial name
- NCT02100579
- Testing
- Bupivacaine, Preservative free normal saline
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Northwestern University
Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture
Reliability and Validity of Inline Dynamometry Study for Measuring Knee Extensor Torque
This study will investigate the reliability and validity of an inline 'pull-type' dynamometer for measuring peak knee extensor torque.
- Conditions
- Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture, Anterior Cruciate Ligament Tear
- Trial name
- NCT05109871
- Testing
- KForce Link
- Where
- United Kingdom
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Anterior Cruciate Ligament Injury
MiACLR: Michigan Initiative for Anterior Cruciate Ligament Rehabilitation
This clinical trial evaluates interventions to maximize muscle function and improve cartilage health following anterior cruciate ligament reconstruction.
- Trial name
- MiACLR (NCT03626857)
- Testing
- Neuromuscular Electrical Stimulation (NMES), Eccentric Exercise (ECC)
- Where
- 2 sites in United States
- Volunteers
- 135 people
- Sponsor
- University of Michigan
ACL Injury
Neuromuscular Intervention Targeted to Mechanisms of ACL Load in Female Athletes
Females who participate in cutting and landing sports suffer anterior cruciate ligament (ACL) injuries at a 2 to 10-fold greater rate than males participating in the same high-risk sports.
- Trial name
- NCT01034527
- Testing
- Neuromuscular Training
- Where
- United States
- Volunteers
- 593 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Knee Injuries
Clinical Trial Comparing Three Anterior Cruciate Ligament Reconstructive Procedures
The objective of this prospective study is to assess the clinical, functional and radiological outcomes of three different ACL reconstruction procedures: Bone Patella Bone graft, Single bundle hamstring graft and anatomical…
- Trial name
- NCT00418964
- Testing
- Single bundle hamstring, Double bundle hamstring, Bone patellar tendon bone
- Where
- China
- Volunteers
- 62 people
- Sponsor
- Chinese University of Hong Kong
Anterior Cruciate Ligament Injuries
Blood Flow Restriction Training in ACL Surgery
This will be a randomized pilot study to determine the effectiveness of Personalized Blood Flow Restriction (PBFR) technique in conjunction with prescribed physical therapy (PT) in a cohort of anterior cruciate ligament (ACL)…
- Trial name
- NCT05245864
- Testing
- blood flow restriction, physical therapy standard of care
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Arkansas
Wound Closure
Symmetric on Total Knee Arthroplasty (TKA)
A post-marketing prospective, multicenter, randomized controlled study to evaluate the wound closure efficiency of STRATAFIX™ Symmetric PDS™ Plus Knotless Tissue Control Device (STRATAFIX Symmetric PDS Plus) compared to…
- Trial name
- SFX (NCT03305887)
- Testing
- "STRATAFIX™ Symmetric" Knotless Tissue, VICRYL® PLUS, "STRATAFIX Spiral" sutures
- Where
- 7 sites in China
- Volunteers
- 184 people
- Sponsor
- Johnson & Johnson Medical, China
Foreign-Body Reaction, Inflammation
IMPACT: Safety and Feasibility of a Single-stage Procedure for Focal Cartilage Lesions of the Knee.
Articular cartilage defects in the knee have a poor intrinsic healing capacity and may lead to functional disability and osteoarthritis.
- Conditions
- Foreign-Body Reaction, Inflammation, Effusion (L) Knee, Knee Pain Swelling
- Trial name
- IMPACT (NCT02037204)
- Testing
- Cartilage repair surgery
- Where
- Netherlands
- Volunteers
- 35 people
- Sponsor
- UMC Utrecht
Unilateral Traumatic Amputation, Amputation, Traumatic
Determining the Potential Benefit of Powered Prostheses
The goal of this research is to determine the effectiveness of a powered prosthesis compared to an unpowered prosthesis during short bouts of walking, extended periods of walking (to fatigue), and performance in the community.
- Trial name
- NCT02828982
- Testing
- Powered ankle prosthesis, Dynamic Response Foot
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Deanna H Gates
Knee Injuries
Optimized Loading Response by JOURNEY II BCS Knee Increases Daily Physical Activity and Functions
Smith \& Nephew's first edition of the Journey posterior stabilizing total knee arthroplasty was analyzed by the Center for Musculoskeletal Research in a past research study, and it was determined that subjects experienced more…
- Trial name
- NCT02335710
- Testing
- Journey II BCS TKA
- Where
- 3 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- The University of Tennessee, Knoxville
Knee Injuries
Trial Comparing BST-CarGel and Microfracture in Repair of Articular Cartilage Lesions in the Knee
This study will investigate whether the treatment of damaged cartilage in the knee with BST-CarGel will increase the amount and quality of cartilage repair tissue when compared with microfracture alone.
- Trial name
- NCT00314236
- Testing
- BST-CarGel with Microfracture, Microfracture without BST-CarGel
- Where
- 18 sites in Canada, South Korea and 1 more
- Volunteers
- 80 people
- Sponsor
- Piramal Healthcare Canada Ltd
Cartilage Injury of Knee
A Multicenter Trial of Sprifermin (AS902330 [Recombinant Human Fibroblast Growth Factor-18]) or Placebo After Microfracture Surgery for Cartilage Injury of the Knee
This is a Phase 2, double-blind, multicenter, randomized, placebo-controlled trial to evaluate the efficacy and safety of Sprifermin (AS902330) (recombinant human fibroblast growth factor-18 [rhFGF-18]) as an adjunct treatment to…
- Trial name
- NCT01689337
- Testing
- Sprifermin (AS902330)
- Volunteers
- 1 people
- Sponsor
- EMD Serono
Post-traumatic Osteoarthritis
A Biologic Joint Replacement Strategy to Treat Patients With Severe Knee Trauma and Post-Traumatic Knee Osteoarthritis
With IRB approval and informed consent, patients (n=10) (18-50 years old) with post-traumatic knee OA and requiring a tibial plateau and meniscus arthroplasty plus a femoral condyle arthroplasty will be enrolled in the study.
- Trial name
- NCT03257371
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- James Stannard
Surgical Wound, Revision Total Knee Arthroplasty
Closed Incision Negative Pressure Therapy Versus Standard of Care Surgical Dressing in Revision Total Knee Arthroplasty
This study evaluates surgical site complications in subjects undergoing revision of a total knee arthroplasty when closed incision negative pressure therapy is used to manage the closed incision, as compared to a standard of care…
- Conditions
- Surgical Wound, Revision Total Knee Arthroplasty, Wounds and Injuries, Joint Disease
- Trial name
- PROMISES (NCT03274466)
- Testing
- Closed Incision Negative Pressure Therapy (ciNPT), Standard of Care Dressing
- Where
- 17 sites in United States
- Volunteers
- 294 people
- Sponsor
- KCI USA, Inc
Infection of Total Hip Joint Prosthesis
Evaluating Advantages of Prevena After Hip and Knee Arthroplasty
Determine the extent to which application of the Prevena vacuum system to clean surgical incisions immediately following surgical procedure (total hip or total knee arthroplasty) will reduce the rates of: readmission to hospital…
- Trial name
- NCT01854138
- Testing
- Prevena Incision Management System
- Where
- United States
- Volunteers
- 248 people
- Sponsor
- ProMedica Health System
Injury Leg, Injury, Knee
Serial Movement Assessment in Collegiate Athletes Who Perform Injury Prevention Training
Athletic injury can result in decreased athletic performance or removal from sport participation. There may also be psychological and financial impacts of athletic injury.
- Conditions
- Injury Leg, Injury, Knee, Injury;Sports, Injury, Ankle
- Trial name
- NCT04748718
- Testing
- Exercise-based injury prevention program
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Northern Vermont University
Prosthesis-related Infections, Wound Complications
Evaluation of Wound Management With Negative Pressure Dressing Versus Standard Dressing After Revision Arthroplasty.
The purpose of this study is to determine the efficacy of a negative pressure wound therapy (NPWT) system after revision total knee and hip arthroplasty in patients at high risk for infection.
- Conditions
- Prosthesis-related Infections, Wound Complications, Joint Diseases, Musculoskeletal Diseases
- Trial name
- NCT02127281
- Testing
- Prevena
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- The Cleveland Clinic