Clinical trials: Knee Joint
Osteoarthritis, Knee
Safety and Feasibility of Umbilical Cord Wharton's Jelly Allograft Injections for Knee Osteoarthritis
This is a Pilot Study which is randomized, prospective, open label, dose escalation, non-controlled evaluating safety and feasibility of intra-articular Wharton's Jelly (WJ) allograft will be evaluated in patients suffering with…
- Trial name
- NCT06608134
- Testing
- Umbilical Cord Wharton's Jelly Allograft Intra-articular Knee Injection
- Where
- 5 sites in United States
- Volunteers
- 120 people
- Sponsor
- R3 Medical Research
Knee Osteoarthritis
AposTherapy for Singaporean Patients With Knee Osteoarthritis (OA)
Osteoarthritis (OA) is the most prevalent form of arthritis in the elderly. It is estimated that 7% of men and 11% of women over the age of 65 have KOA.
- Trial name
- NCT01562652
- Testing
- AposTherapy (All Phases of Step-cycle {APOS} system, APOS-Medical and Sports Technologies Ltd. Herzliya, Israel)
- Where
- Singapore
- Volunteers
- 60 people
- Sponsor
- Apos Medical and Sports Technology Ltd.
Osteoarthritis
An Investigation of ReNu™ Knee Injection in Patients With Osteoarthritis
This is a Prospective, Randomized study evaluating the efficacy of ReNu for the treatment of Kellgren-Lawrence grade 2 or 3 osteoarthritis.
- Trial name
- NCT02318511
- Testing
- Knee injection, ReNu amniotic allograft, Hyaluronic Acid
- Where
- 12 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- NuTech Medical, Inc
Arthroscopy
Effect of Celecoxib Versus Placebo Before and After Knee Surgery on Overall Use of Analgesics After Surgery
To compare total analgesic use at 24 hours after arthroscopic knee surgery in celecoxib-treated versus placebo-treated patients
- Trial name
- NCT00633438
- Testing
- Celecoxib
- Where
- 18 sites in United States
- Volunteers
- 204 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Arthritis, Osteoarthritis
Tanezumab In Osteoarthritis Of The Knee (2)
The purpose of this study is to test the efficacy and safety of 2 doses of tanezumab compared with naproxen and placebo in patients with osteoarthritis.
- Trial name
- NCT00830063
- Testing
- tanezumab 10 mg, tanezumab 5 mg, naproxen
- Where
- 94 sites in United States
- Volunteers
- 832 people
- Sponsor
- Pfizer
Osteoarthritis, Knee
Treatment and Duration Effect of Pentosan Polysulfate Sodium (PPS) in Participants With Knee Osteoarthritis Pain
The purpose of this study is to measure the duration of treatment effect with subcutaneous injections of pentosan polysulfate sodium (PPS) compared with placebo in adult participants with knee osteoarthritis (OA) pain.
- Trial name
- NCT04814719
- Testing
- Pentosan Polysulphate Sodium
- Where
- 2 sites in United States, Australia
- Volunteers
- 133 people
- Sponsor
- Paradigm Biopharmaceuticals Ltd.
Prosthetic-joint Infection
Evaluation of PLG0206 in Prevention of Recurrent Infection in Patients Undergoing Debridement, Antibiotics, and Implant Retention (DAIR) for Treatment of a Periprosthetic Joint Infection (PJI) Following Knee Arthroplasty
The goal of this clinical trial is to evaluate whether the investigational drug PLG0206 can help reduce recurrence of infection in adults who have undergone total knee replacement and are receiving a DAIR (Debridement…
- Trial name
- RETAIN (NCT07214311)
- Testing
- PLG0206
- Where
- 21 sites in United States, United Kingdom
- Volunteers
- 240 people
- Sponsor
- Peptilogics
Venous Thromboembolism
Efficacy and Safety of TAK-442 in Subjects Undergoing Total Knee Replacement
The purpose of this study is to determine if TAK-442, once daily (QD) or twice daily (BID), is as safe and effective as enoxaparin in preventing the development of blood clots after knee replacement surgery.
- Trial name
- NCT00641732
- Testing
- TAK-442, Enoxaparin
- Where
- 64 sites in United States, Canada
- Volunteers
- 1,045 people
- Sponsor
- Takeda
Osteoarthritis of Knee Joint
Allogeneic Mesenchymal Stem Cells for Osteoarthritis
This study is designed to know the safety and efficacy of 2 different doses of mesenchymal stem cells in patients suffering from osteoarthritis of knee joint.
- Trial name
- NCT01448434
- Testing
- Ex- vivo cultured adult allogeneic MSCs, Plasmalyte-A
- Where
- 4 sites in Malaysia
- Volunteers
- 72 people
- Sponsor
- Stempeutics Research Pvt Ltd
Osteoarthritis, Knee
A Study to Investigate the Safety and Effectiveness of Different Doses of Sprifermin in Participants With Osteoarthritis of the Knee
This was a multicenter, randomized, double-blind, placebo-controlled, parallel-group Phase 2 trial of Sprifermin administered intra-articularly in participants with primary osteoarthritis of the knee and Kellgren-Lawrence Grade 2…
- Trial name
- FORWARD (NCT01919164)
- Testing
- Sprifermin
- Where
- 13 sites in United States, Argentina and 6 more
- Volunteers
- 549 people
- Sponsor
- EMD Serono Research & Development Institute, Inc.
Unilateral Knee Osteoarthritis
Durolane Compared to Saline in Patients With Unilateral Knee Osteoarthritis
This was a study that compared Durolane injections to saline injections in the treatment of unilateral osteoarthritis of the knee.
- Trial name
- NCT01806207
- Testing
- Durolane injection, Saline injection
- Where
- United Kingdom
- Volunteers
- 218 people
- Sponsor
- Galderma R&D
Articular Cartilage Lesion of the Femoral Condyle
RCT of ChondroCelect® (in an ACI Procedure) vs Microfracture in the Repair of Cartilage Defects of the Knee
This is a phase III, multicenter, open-label, randomized controlled trial of ChondroCelect® in an Autologous Chondrocyte Implantation (ACI) procedure compared to the procedure of microfracture (MF) in the repair of symptomatic…
- Trial name
- TIGACT01 (NCT00414700)
- Testing
- ChondroCelect implantation, Microfracture
- Where
- 12 sites in Belgium, Croatia and 2 more
- Volunteers
- 118 people
- Sponsor
- TiGenix n.v.
Knee Osteoarthritis, Post-traumatic Osteoarthritis
Clinical Evaluation of Vanguard DD RP
This is a single cohort, prospective study of performance and safety of the Vanguard Deep Dish Rotating Platform (DD RP) cementless fixation with the goal to acquire clinical outcomes data and evaluate the performance of the…
- Conditions
- Knee Osteoarthritis, Post-traumatic Osteoarthritis, Rheumatoid Arthritis
- Trial name
- NCT04076202
- Testing
- Cementless Vanguard DD RP
- Where
- Austria
- Volunteers
- 113 people
- Sponsor
- Zimmer Biomet
Osteoarthritis
Evaluation of the Latella Knee Implant System for Medial Osteoarthritis Pain Reduction (Latella-2 Study)
The objective of the Latella-2 study is to demonstrate the safety and efficacy of the Latella Knee Implant System for the reduction of medial osteoarthritis knee pain.
- Trial name
- NCT02343705
- Testing
- Latella Knee Implant System
- Where
- 12 sites in Netherlands, Spain and 1 more
- Volunteers
- 67 people
- Sponsor
- Cotera, Inc.
Osteoarthritis, Knee
Efficacy and Safety of PG-530742 in the Treatment of Mild to Moderate Knee Osteoarthritis
Matrix metalloproteinases (MMPs) have been implicated in the cartilage degradation. PG-530742 inhibits some MMPs, potentially limiting cartilage degradation and disease progression.
- Trial name
- NCT00041756
- Testing
- PG-530742, 50 mg PG-530742, 100 mg PG-530742
- Where
- 23 sites in Hungary, United Kingdom
- Volunteers
- 395 people
- Sponsor
- Procter and Gamble
Lower Limb Amputation Below Knee (Injury), Lower Limb Amputation Above Knee (Injury)
Feasibility Study to Evaluate a New Energy Storage and Return Prosthetic Foot
A prospective, interventional, multicenter pilot study to characterize differences in performance and patient reported outcomes between the Taleo, Proflex XC, and the new Revo prosthetic foot.
- Conditions
- Lower Limb Amputation Below Knee (Injury), Lower Limb Amputation Above Knee (Injury), Lower Limb Amputation Knee
- Trial name
- NCT04239222
- Testing
- Revo-M, Taleo, Proflex XC
- Where
- 4 sites in United States
- Volunteers
- 27 people
- Sponsor
- Otto Bock Healthcare Products GmbH
Osteoarthritis
Study Evaluating rhMBP-2/CPM in Open Wedge Osteotomies
To assess the feasibility of using rhBMP-2/CPM in OWO as a surgical model for pharmacodynamic studies, with assessment of the following parameters: Injecting the desired volume of rhBMP-2/CPM within the defect Conducting…
- Trial name
- NCT00243295
- Testing
- rhBMP-2/CPM
- Volunteers
- 6 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Osteoarthitis
Clinical Trial to Assess the Safety and Efficacy of Intra-articular Injection Collagen Versus Hyaluronic Acid on Knee Osteoarthritis
This study was designed to assess the efficacy for pain relief, functional improvement, and safety of intra-articular collagen injections compared to hyaluronic acid injections for knee osteoarthritis.
- Trial name
- NCT07511777
- Testing
- CartiZol, Synovian inj.
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Cellontech Co., Ltd.
Osteoarthritis
To Determine the Safety, Tolerability, Pharmacokinetics and Effect on Pain of a Single Intra-articular Administration of Canakinumab in Patients With Osteoarthritis in the Knee
The purpose of this study was to determine whether, in patients with mild to moderate knee osteoarthritis, canakinumab is safe and tolerable when injected intra-articularly.
- Trial name
- NCT01160822
- Testing
- Canakinumab, Naproxen
- Where
- 13 sites in United States, Finland and 2 more
- Volunteers
- 169 people
- Sponsor
- Novartis Pharmaceuticals
Postsurgical Pain
Study Evaluating the Safety, Efficacy and Pharmacokinetics of CA-008 (Vocacapsaicin)
In the pilot (Part A) of this study, multiple doses of CA-008 (vocacapsaicin) were evaluated for safety, tolerability, and PK. Doses were then selected for the expanded part (Part B) of the study, where CA-008 was compared to…
- Trial name
- NCT04203537
- Testing
- CA-008
- Where
- 4 sites in United States
- Volunteers
- 193 people
- Sponsor
- Concentric Analgesics
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