Clinical trials: Knee Joint
Knee Arthroplasty, Total
Evaluation of Navigation-Assisted TKA Using Mechanical vs. Restricted Kinematic Alignment
The purpose of this study is to evaluate both clinical measures and PROMs in patients undergoing total knee arthroplasty (TKA) using restricted inverse kinematic alignment (iKA) compared to mechanical alignment (MA), both using…
- Trial name
- NCT05516381
- Testing
- Optetrak Logic CR Knee System
- Where
- Spain
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Exactech
Osteoarthritis of the Knee
A Study of the Safety and Efficacy of REGN475(SAR164877) in Patients With Osteoarthritis of the Knee
This is a double-blind, prospective, randomized study in which patients will be randomized to 1 of 4 treatment arms (3 active and 1 placebo).
- Trial name
- NCT00944892
- Testing
- REGN475
- Where
- 3 sites in United States
- Volunteers
- 200 people
- Sponsor
- Regeneron Pharmaceuticals
Postoperative Pain
Safety of Buprenorphine Transdermal System (BTDS) in Subjects With Acute Postoperative Pain After Total Knee Replacement
The objectives in this study are to evaluate: (1) efficacy of buprenorphine transdermal system (BTDS, Butrans™) on postoperative pain following total knee replacement surgery; (2) the impact of BTDS on functional rehabilitative…
- Trial name
- NCT00403234
- Testing
- Buprenorphine transdermal patch
- Where
- 5 sites in United States
- Volunteers
- 10 people
- Sponsor
- Purdue Pharma LP
Knee Osteoarthritis
A Study to Compare Levels of Capsaicin After Intra-Articular Injection and Topical Application in Patients With Painful Knee Osteoarthritis
This is a Phase 1b, open-label, two-period, randomized crossover study in adult male and female participants with painful knee osteoarthritis.
- Trial name
- NCT03576508
- Testing
- CNTX-4975-05, Qutenza, Lidocaine (without epinephrine)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Centrexion Therapeutics
Pain, Osteoarthritis, Knee
A Comparison of the Analgesic Efficacy and Safety of Once Daily Tramadol OAD Tablets to Twice Daily Tramadol BID for the Treatment of Osteoarthritis of the Knee (Extension Protocol) and Open Label Safety Follow-Up
The purpose of this study is to evaluate the long-term safety (up to one year) of Tramadol Once-A-Day (OAD) tablets at the highest doses: 200-400 mg
- Trial name
- NCT00912015
- Testing
- Tramadol OAD, Tramadol OAD 100mg
- Volunteers
- 238 people
- Sponsor
- Labopharm Inc.
Osteoarthritis, Knee
Clinical Trial of YY1201 for Treatment of Osteoarthritis of the Knee
This is a multicenter, randomized, double-blinded, parallel, placebo-controlled, phase I/IIa clinical trial of YY1201 for treatment of osteoarthritis of the knee.
- Trial name
- NCT02554552
- Testing
- YY1201 2ml, YY1201 3ml
- Where
- South Korea
- Volunteers
- healthy volunteers welcome
- Sponsor
- Yooyoung Pharmaceutical Co., Ltd.
Activity-Related Knee Discomfort, Joint Discomfort
NT-II™ Collagen for Joint Discomfort and Function
The goal of this clinical trial is to learn whether a natural marine supplement called NT-II™ (Salmon Undenatured Type II Collagen) can help lower knee discomfort caused by physical activity in otherwise healthy adults.
- Conditions
- Activity-Related Knee Discomfort, Joint Discomfort, Functional Joint Pain, Functional Knee Pain
- Trial name
- NTII-JOINT (NCT07119645)
- Testing
- NT-II™ (240 mg), NT-II™ 480 mg, Glucosamine/Chondroitin
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Hofseth Biocare ASA
Osteoarthritis, Knee
Safety and Efficacy of Viscosupplementation of Hyaluronic Acid With Addition of Lecithin in Patients With Mild or Moderate Osteoarthrosis of the Knee Joint.
The main objective of this prospective, open-label clinical trial is to assess the effectiveness and safety of intra-articular liposomal gel therapy for knee OA symptoms.
- Trial name
- NCT06433492
- Testing
- Intra-articular injection
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Biovico Sp. z o.o.
Osteoarthritis, Knee
Efficacy and Safety of Rebel Reliever Brace in Patients With Symptomatic Medial Knee Osteoarthritis
The purpose of the study is to evaluate the superiority of Rebel Reliever® knee brace + standard treatment versus standard treatment alone in terms of last 24-hour pain relief after 6 weeks.
- Trial name
- ROTOR (NCT02021136)
- Testing
- Rebel Reliever, Control
- Where
- France
- Volunteers
- 67 people
- Sponsor
- Thuasne
Osteoarthritis, Knee
Osteoarthritis Knee Pain Relief Study of 0.25% 920-CGS-200
This is a study of an over-the-counter, capsaicin-based (0.25%) topical analgesic for management of osteoarthritis knee pain meeting the US Food and Drug Administration's (FDAs) Tentative Final Monograph (TFM) guidance for…
- Trial name
- NCT03124407
- Testing
- Capsaicin Topical Solution, Drug product vehicle
- Where
- 3 sites in United States
- Volunteers
- 120 people
- Sponsor
- Propella Therapeutics
Knee Arthroplasty, Total, Robotic Surgical Procedures
ROSA® Knee System V1.5 Pilot Study
This pilot study seeks to evaluate the initial safety and usability of new features for the ROSA® Knee System, v1.5 and plan design modifications as needed. The primary objectives will be assessed by measuring: 1.
- Conditions
- Knee Arthroplasty, Total, Robotic Surgical Procedures, Joint Diseases, Knee Osteoarthritis
- Trial name
- NCT07009912
- Testing
- Total Knee Arthroplasty
- Where
- New Zealand
- Volunteers
- 40 people
- Sponsor
- Zimmer Biomet
Peripheral Artery Disease
PMCF Study for Peripheral Arteries Below the Knee (BTK)
The rationale of this study is to confirm and support the clinical safety and performance of any of these products in a real-word population of 100 patients who underwent an endovascular intervention within standard-of-care (SOC)…
- Trial name
- NCT05444660
- Where
- 5 sites in Austria, Germany
- Volunteers
- 102 people
- Sponsor
- Cordis US Corp.
Knee Osteoarthritis
Safety and Efficacy of an Injectable Medical Device to Treat Knee Osteoarthritis
The purpose of this study is to determine whether MM-II is effective in the treatment of osteoarthritis, in direct comparison with an approved hyaluronic acid preparation.
- Trial name
- NCT01365260
- Testing
- MM-II, DurolaneTM
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Moebius Medical Ltd.
Total Knee Arthroplasty
Journey II Bi-Cruciate Stabilized (BCS) Total Knee System Retrospective Study
The objective of this study is to estimate the safety and performance of Journey II BCS TKS.
- Trial name
- NCT03292003
- Testing
- Journey II BCS Total Knee System
- Where
- 12 sites in United States, Belgium and 1 more
- Volunteers
- 1,694 people, healthy volunteers welcome
- Sponsor
- Smith & Nephew, Inc.
Knee Osteoarthritis
Outcome Study of Total Knee Arthroplasty in Asian Patients
To determine how the LCS mobile bearing knee system works within the Asian Population.
- Trial name
- DRAGON (NCT00733694)
- Testing
- LCS® Complete™ Mobile Bearing Knee Systems
- Where
- China
- Volunteers
- 607 people
- Sponsor
- DePuy International
Arthroplasty, Replacement, Knee
Multigen Plus H Study and AMF TT Cones
The aim of this study is to assess the clinical, patient-reported, and radiographic outcomes of a revision Total Knee Arthroplasty with Multigen Plus H and AMF TT Cones.
- Trial name
- NCT04884542
- Testing
- Revision Total Knee Arthroplasty
- Where
- 2 sites in Belgium, Slovakia
- Volunteers
- 43 people
- Sponsor
- Limacorporate S.p.a
Peripheral Arterial Occlusive Disease
GORE PROPATEN Vascular Graft vs. Disadvantaged Autologous Vein Graft
The primary patency of the GORE PROPATEN Vascular Graft is equivalent to or better than disadvantaged autologous vein graft in an infragenicular peripheral bypass application at 12 months.
- Trial name
- PRODIGY (NCT00617279)
- Testing
- GORE PROPATEN Vascular Graft, Disadvantaged Autologous Vein Graft
- Where
- 17 sites in United States
- Volunteers
- 31 people
- Sponsor
- W.L.Gore & Associates
Arthroplasty, Replacement, Knee
Long-term Study of the DePuy Low Contact Stress (LCS) Complete Total Knee System
The main objective of this study is to evaluate how the LCS Complete mobile-bearing total knee system and surgical instrumentation performs.
- Trial name
- NCT00733915
- Testing
- L.C.S. Complete Knee (DePuy Low Contact Stress Complete Knee System)
- Where
- Ireland
- Volunteers
- 241 people
- Sponsor
- DePuy International
Chronic Limb Ischemia
Temsirolimus Adventitial Delivery to Improve Angiographic Outcomes Below the Knee (TANGO)
This is a prospective, multi-center, randomized, dose escalation study to document the effects of adventitial delivery of temsirolimus (Torisel) after revascularization of lesions below the knee in symptomatic patients with…
- Trial name
- TANGO (NCT02908035)
- Testing
- Temsirolimus, Saline
- Where
- 8 sites in United States
- Volunteers
- 100 people
- Sponsor
- Mercator MedSystems, Inc.
Osteoarthritis, Knee
A Clinical Study to Test Efficacy and Safety of Repeat Doses of CNTX-4975-05 in Patients With Osteoarthritis Knee Pain
This is a randomized, double-blind, placebo-controlled, 2-injection, 52-week study to evaluate the efficacy and safety of intra-articular injections of CNTX-4975-05 in subjects with chronic, moderate-to-severe osteoarthritis knee…
- Trial name
- NCT03660943
- Testing
- CNTX-4975-05
- Where
- 30 sites in United States
- Volunteers
- 332 people
- Sponsor
- Centrexion Therapeutics