Clinical trials: Knee Joint
Osteoarthritis (OA) of the Knee, Osteoarthritis Knee Pain
First in Human Study of SakuraBead for Genicular Artery Embolization to Treat Pain Secondary to Knee Osteoarthritis
A prospective, single-centre, single-arm, unmasked, First in Human study that aims to evaluate the safety and efficacy of SakuraBead resorbable microspheres in adult patients suffering from pain secondary to knee osteoarthritis.
- Conditions
- Osteoarthritis (OA) of the Knee, Osteoarthritis Knee Pain, Joint Diseases, Musculoskeletal Diseases
- Trial name
- NCT06718478
- Testing
- SakuraBead Resorbable Microspheres
- Where
- Uzbekistan
- Volunteers
- 15 people
- Sponsor
- CrannMed
Osteoarthritis of the Knee
Safety and Efficacy of Etoricoxib 30 mg Versus Celecoxib 200 mg in Korean Participants With Osteoarthritis
The main purpose of this study is to establish that etoricoxib 30 mg is safe and not inferior to celecoxib 200 mg in the treatment of the signs and symptoms of osteoarthritis in Korean patients.
- Trial name
- NCT01554163
- Testing
- Etoricoxib 30 mg, Celecoxib 200 mg
- Volunteers
- 239 people
- Sponsor
- Organon and Co
Osteoarthritis, Knee, Osteoarthritis, Hip
An Effectiveness, Safety and Quality of Life Measures With Hydromorphone HCL, Dilaudid CR (Controlled Release)
The purpose of this study was to characterize the effectiveness and safety of OROS hydromorphone HCL and OxyContin in patients with chronic osteoarthritis (OA) of the knee or hip who are receiving chronic nonsteroidal…
- Trial name
- NCT00399048
- Testing
- OROS hydromorphone HCL ; OxyContin
- Volunteers
- 140 people
- Sponsor
- Alza Corporation, DE, USA
Non-inflammatory Degenerative Joint Disease
Evaluation of Post-Operative Recovery in ATTUNE® Total Knee Arthroplasty
This post-marketing investigation will evaluate the rate of recovery of the ATTUNE knee from the time of surgery through the 6 month endpoint in patients with severely painful and/or severely disabling Non-inflammatory…
- Trial name
- NCT02339610
- Testing
- ATTUNE Primary, Cemented Total Knee Replacement
- Where
- 4 sites in Netherlands
- Volunteers
- 200 people
- Sponsor
- DePuy Orthopaedics
Osteoarthritis, Pain
Study to Assess MEDI -578 in Patients With Osteoarthritis (OA) of the Knee
The purpose of this study is to evaluate the safety and tolerability of a single intravenous dose of MEDI-578, a monoclonal antibody, in patients with osteoarthritis of the knee.
- Trial name
- NCT01072591
- Testing
- MEDI-578
- Where
- United Kingdom
- Volunteers
- 108 people
- Sponsor
- AstraZeneca
Total Knee Replacement
Fluoroscopic Analysis of Total Knee Replacement With a Kinematic Retaining or a Posterior Stabilized Design
The aim of this study is to evaluate the in vivo kinematics of TKA performed with two different prosthesis: a kinematic retaining (Physica KR) and a posterior-stabilized (Physica PS) design by means of fluoroscopic analysis…
- Trial name
- NCT02706990
- Testing
- Physica KR, Physica PS
- Where
- Italy
- Volunteers
- 34 people
- Sponsor
- Limacorporate S.p.a
Post-Operative Pain
A Multicenter, Randomized, Open-Label, Parallel-Group Trial to Compare the Efficacy and Safety of the Sufentanil NanoTab PCA System/15 mcg (Zalviso™)to Intravenous Patient-Controlled Analgesia With Morphine for the Treatment of Acute Post-Operative Pain
The study is intended to show that the Sufentanil NanoTab PCA System is as effective as morphine intravenous patient-controlled analgesia (IV PCA) for treating pain after surgery.
- Trial name
- NCT01539538
- Testing
- Sufentanil NanoTab PCA System/15 mcg, morphine IV PCA
- Where
- 16 sites in United States
- Volunteers
- 357 people
- Sponsor
- Talphera, Inc
Osteoarthritis
Buprenorphine in the Treatment of Osteoarthritis (OA) in the Elderly
The primary objective is to compare buprenorphine transdermal delivery system (BTDS) with standard- treatment in subjects with osteoarthritis (OA).
- Trial name
- NCT00324038
- Testing
- Buprenorphine, Codeine paracetamol
- Where
- United Kingdom
- Volunteers
- 219 people
- Sponsor
- Napp Pharmaceuticals Limited
Osteoarthritis of the Knee
MINIMALLY INVASIVE SURGERY in Total Knee Arthroplasty
Overall study design: A prospective, randomized, multi-center clinical studies comparing the minimal invasive and the standard surgical total knee replacement technique (control) using the Genesis II total knee system.
- Trial name
- MIS GEN II (NCT00853398)
- Testing
- surgical technique
- Where
- Germany
- Sponsor
- Smith & Nephew Orthopaedics AG
Osteoarthritis of Knee
Assessment of the Safety and Efficacy of 3VM1001 Cream for Treatment of Chronic Pain Caused by Knee Osteoarthritis.
3VM1001 is a topical cream that may be useful for the treatment of chronic osteoarthritis of the knee. This proof of concept study is a randomized, placebo-controlled, double-blind study to compare treatment with 3VM1001 cream to…
- Trial name
- NCT02332148
- Testing
- 3VM1001
- Volunteers
- 50 people
- Sponsor
- CDA Research Group, Inc.
ACL Repair, Posterior Cruciate Ligament (PCL) Repair
BIOSURE™ RG Knee Safety & Performance Study
Safety and Performance of the BIOSURE™ REGENESORB Interference Screw in Knee Ligament Repair and Reconstruction
- Conditions
- ACL Repair, Posterior Cruciate Ligament (PCL) Repair, Medial Collateral Ligament (MCL), Lateral Collateral Ligament (LCL)
- Trial name
- NCT03519555
- Where
- 3 sites in United States
- Volunteers
- 60 people
- Sponsor
- Smith & Nephew, Inc.
Osteoarthritis
14022 ATTUNE Cementless RP Clinical Performance Evaluation
The primary objective of this study is to examine the change from pre-operative baseline to two year postoperative functional performance improvement for the ATTUNE primary, cementless TKA RP system as measured with the KOOS…
- Trial name
- NCT02839850
- Testing
- Cementless Total Knee Arthroplasty
- Where
- 20 sites in United States, Austria and 7 more
- Volunteers
- 540 people
- Sponsor
- DePuy Orthopaedics
Knee Osteoarthritis
Using Intraoperative Sensing Technology to Evaluate Revision Total Knee Arthroplasty
This study will attempt to draw relationships between the soft-tissue related complications contributing to early TKA revision and the loading and positional patterns from intraoperative tibial trial sensors.
- Trial name
- NCT03023410
- Testing
- VERASENSE
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Orthosensor, Inc.
Osteoarthritis, Knee
Cannabinoid Tablets for the Treatment of Pain From Osteoarthritis of the Knee
The purpose of the study is to evaluate the efficacy of PG-OA-10CN and PG-OA-5TH tablets as a better pain reliever in patients with moderate to severe chronic pain due to osteoarthritis of the knee than a placebo.
- Trial name
- NCT04992962
- Testing
- CBD/CBN, CBD/THC
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Pure Green
Osteoarthritis, OA Knee Pain
Open-label Extension Study Of RN624
Study RN624-CL007 is planned to be an open-label protocol to enroll subjects who have previously participated in Study No. RN624-CL006. In this study, subjects will receive RN624 on an open-label basis.
- Conditions
- Osteoarthritis, OA Knee Pain, Arthritis
- Trial name
- NCT00399490
- Testing
- RN624 (PF-04383119)
- Where
- 36 sites in United States
- Volunteers
- 287 people
- Sponsor
- Pfizer
Arthropathy of Knee
Scorpio® Cruciate Retaining (CR) Outcomes Study
The purpose of this study is to evaluate the design and functional performance of the Scorpio® Cruciate Retaining (CR) Total Knee System.
- Trial name
- NCT00965146
- Testing
- Scorpio® CR Total Knee System
- Where
- 5 sites in United States
- Volunteers
- 215 people
- Sponsor
- Stryker Orthopaedics
Arthritis, Rheumatoid, Osteoarthritis
A Clinical Trial Study of Knee System in Primary Total Knee Arthroplasty in China
A clinical trial of total knee system used in Primary Total Knee Arthroplasty in China.
- Conditions
- Arthritis, Rheumatoid, Osteoarthritis, Post-traumatic; Arthrosis
- Trial name
- NCT02399046
- Testing
- Total Knee System made in China (Sigama, CoCr, PFC), Total Knee System made outside of China (Sigama, NP, PFC)
- Where
- 9 sites in China
- Volunteers
- 160 people
- Sponsor
- Johnson & Johnson Medical (Suzhou) Ltd.
Osteoarthritis, Knee
TKA Operating Room Efficiency for TKA Using Customized Implant Techniques
This is a multi-centered prospective, consecutively enrolled study that will be conducted in the United States. Surgeons that are new users of the iTotal Knee system (defined by no experience using the customized Total Knee…
- Trial name
- NCT04180423
- Testing
- Off-the-Shelf Implant Total Knee Replacement, Customized Implant Total Knee Replacement
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Restor3D
Venous Thromboembolism
A Study to Compare the Efficacy and Safety of SRSD107 and Enoxaparin in Adult Subjects Undergoing TKA
This is a Phase 2, multicenter, randomized, open-label, parallel group, blinded endpoint evaluation, active-controlled, dose-finding study.This study is designed to compare the efficacy and safety of 3 dose levels of SRSD107 and…
- Trial name
- NCT07140523
- Testing
- SRSD107, enoxaparin
- Where
- Czechia
- Volunteers
- 450 people
- Sponsor
- Sirius Therapeutics Co., Ltd.
Arthroplasty, Replacement
Study to Evaluate the Safety and Effectiveness of the REAL INTELLIGENCE™ CORI™ in Total Knee Arthroplasty (TKA) Procedure
Background: REAL INTELLIGENCE™ CORI™ (CORI Robotics) is a computer-assisted orthopaedic surgical navigation and burring system. CORI Robotics is designed to help surgeons in planning and executing certain types of knee surgery…
- Conditions
- Arthroplasty, Replacement, Knee
- Trial name
- CORI RCT TKA (NCT04848896)
- Testing
- CORI Robotics, Conventional Procedure
- Where
- 4 sites in Australia, China and 2 more
- Volunteers
- 140 people
- Sponsor
- Smith & Nephew, Inc.
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