Clinical trials: Knee Joint
Venous Thromboembolism
Multicenter Registry for Effectiveness Analysis of ActiveCare+S.F.T® Mobile Compression Device for Thrombosis Prevention in Hip and Knee Arthroplasty
Venous thromboembolic events (VTE), either deep vein thromboses or pulmonary emboli, are important complications in patients undergoing knee or hip arthroplasty.
- Trial name
- ACOR (NCT01984190)
- Where
- 10 sites in United States
- Volunteers
- 411 people
- Sponsor
- Medical Compression Systems
Journey II BCS Total Knee System
Safety and Performance of Journey II BCS Total Knee System Patient Reported Outcome Measures
Safety and Performance of Journey II BCS Total Knee System. A Retrospective, Multicenter Study. Patient Reported Outcome Measures.
- Trial name
- JIIPROMS (NCT03903731)
- Testing
- Total knee arthroplasty with Journey II BCS Total Knee System
- Where
- 5 sites in United States, Belgium and 1 more
- Volunteers
- 600 people
- Sponsor
- Smith & Nephew, Inc.
Knee Osteoarthritis, Knee Osteoarthritis (OA)
Knee Osteoarthritis and Spa Therapy
The aim of this clinical trial is to assess the efficacy of the 18-day balneotherapy program (therapeutic indication: Rheumatology) in terms of functional incapacity and the disorders (pain, joint stiffness) induced by…
- Trial name
- SANTIAGO (NCT06617975)
- Testing
- Balneotherapy program in rheumatology indication
- Where
- France
- Volunteers
- 80 people
- Sponsor
- CEN Biotech
Osteoarthritis
Transcatheter Arterial Micro-Embolization (TAME) Using Nexsphere-F in Patients With Knee Degenerative Osteoarthritis
Among knee degenerative osteoarthritis patients aged 50 or older, it will prove the therapeutic effect and safety of Nexsphere-F embolization for patients who need additional treatment because pain is not controlled even if…
- Trial name
- NCT05917028
- Testing
- Transcatheter Arterial Micro-Embolization
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Next Biomedical Co., Ltd.
Revision Total Knee Arthroplasty
ATTUNE Revision System in the Revision Total Knee Arthroplasty Population
Five-year, Prospective, multi-center, non-randomized, non-controlled study of the ATTUNE® Revision total knee prostheses, utilizing the fixed bearing (FB) and rotating platform (RP) tibial component with the posterior stabilizing…
- Trial name
- NCT03153475
- Testing
- ATTUNE Revision Knee System in Revision Total Knee Arthroplasty
- Where
- 38 sites in United States, Australia and 11 more
- Volunteers
- 400 people
- Sponsor
- DePuy Orthopaedics
Knee Osteoarthritis
Evaluation of Safety and Efficacy of ReHub in Patients Who Underwent Primary Total Knee Arthroplasty
This is a randomized, non-blinded, parallel assignment, clinical trial for the evaluation of safety and efficacy of ReHub, a telerehabilitation system made up of a cloud platform and an exercise kit with smart sensors, for…
- Trial name
- REHAPT (NCT04155957)
- Testing
- Rapid Recovery Rehabilitation Programme, ReHub
- Where
- Spain
- Volunteers
- 52 people
- Sponsor
- Bio-Sensing Solutions S.L. (DyCare)
Arthritis of the Knee
Unity Total Knee Replacement Using Two Different Surgical Techniques
This study will compare two different surgical methods used in total knee replacement with the Unity Total Knee Replacement System.
- Trial name
- NCT02145455
- Testing
- Unity Total Knee Replacement System
- Where
- United Kingdom
- Volunteers
- 111 people
- Sponsor
- Corin
Osteoarthritis, Knee
A Single Intra-articular Injection of aMAT vs PRP in Patients With OA of the Knee
The study proposes to compare performances and safety of intra-articular injections of aMAT with those of a control group (PRP injections) for the treatment of symptomatic OA of the knee.
- Trial name
- LIPOJOINT (NCT03117608)
- Testing
- injection of autologous micro-fragmented adipose tissue (aMAT), injection of Platelet-rich Plasma (PRP)
- Where
- Italy
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Lipogems International spa
Postoperative Complications, Memory Disorders
A Study to Determine if Carbon Dioxide Lavage During Total Knee Surgery Reduces Intraoperative Embolic Events
The purpose of this study is to determine if the use of a carbon dioxide lavage device (CarboJet) to clean bone surfaces during total knee surgery decreases intraoperative embolic events when compared with standard orthopedic…
- Trial name
- NCT00736125
- Testing
- pulsatile saline lavage, carbon dioxide lavage
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Kinamed Incorporated
Osteoarthritis, Total Knee Arthroplasty
Use of Cold and Compression Therapy With Total Knee Replacement Patients
The purpose of the study is to evaluate the effectiveness of a device that delivers cold and intermittent compression as compared to ice and compressive wraps on patients who have undergone knee replacement.
- Trial name
- NCT00712816
- Testing
- Game Ready Injury Treatment System (CoolSystems Inc.), Ice with compressive bandages
- Where
- 11 sites in United States, Australia
- Volunteers
- 224 people
- Sponsor
- CoolSystems, Inc.
Osteoarthritis
Osteoarthritis Topical Treatment
This is a phase 2a clinical trial performed to evaluate the efficacy of a topical treatment of ibuprofen compared to the use of a placebo topical treatment. A multi-center, double-blinded, randomized placebo controlled study.
- Trial name
- ANTIPAIN (NCT01496326)
- Testing
- Ibuprofen
- Where
- 5 sites in Switzerland
- Volunteers
- 75 people
- Sponsor
- BioChemics, Inc.
Osteoarthritis, Knee, Osteoarthritis, Hip
Study of REGN475 in Patients With Pain Due to Osteoarthritis of the Knee or Hip
The primary objective of this study is to evaluate the effectiveness of REGN475 compared to placebo in participants with pain due to osteoarthritis (OA) of the knee or hip and a history of inadequate joint pain relief or…
- Trial name
- NCT02447276
- Testing
- REGN475
- Where
- 72 sites in United States
- Volunteers
- 421 people
- Sponsor
- Regeneron Pharmaceuticals
Osteoarthritis, Knee
Study of SI000413 in Knee Osteoarthritis Patients
The purpose of this study is to evaluate efficacy and safety of SI000413 in patients with knee osteoarthritis by orally administration and to determine optimal dose.
- Trial name
- NCT01525758
- Testing
- SI000413, microcrystalline cellulose
- Where
- 3 sites in South Korea
- Volunteers
- 152 people
- Sponsor
- Dong-A Pharmaceutical Co., Ltd.
Knee Osteoarthritis
Clinical Investigation to Compare the Safety and Efficacy of Cellular Matrix to Those of Ostenil® Plus and to Those of PRP Only
Platelet-rich plasma (PRP) is an autologous product prepared from the patient's own blood, representing a powerful source of platelet-derived growth factors, particularly useful in the field of regenerative medicine.
- Trial name
- NCT02964143
- Testing
- Cellular Matrix / A-CP HA, Ostenil® Plus, RegenKit-BCT-1
- Volunteers
- 306 people
- Sponsor
- Regen Lab SA
Osteoarthritis, Knee
Efficacy and Safety of G001 in Patients With Osteoarthritis (OA) of the Knee
Phase 2 multicenter, double-blind, randomized, parallel-group, vehicle-controlled study to evaluate the efficacy, safety, and local tolerability of G001 topical gel compared to matching Vehicle topical gel in patients with…
- Trial name
- NCT05007808
- Testing
- G001 Topical Gel, Vehicle
- Where
- 10 sites in Canada
- Volunteers
- 210 people
- Sponsor
- BUZZZ Pharmaceuticals Limited
Chronic Knee Pain
Clinical Trial of the MiniStim PNS for Knee Pain- "FLEX" Study
This is a prospective, multi-center, randomized, study in which 300 evaluable subjects will be randomized 1:1 to receive active or delayed therapy with Moments PNS.
- Trial name
- NCT04580732
- Testing
- MiniStim PNS
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- MiniStim LLC
Meniscus; Degeneration, Knee Osteoarthritis
NUsurface Implant Registry
The purpose of this active post-market surveillance clinical registry study is to further characterize the therapeutic effect, the long-term safety and effectiveness of the NUsurface® meniscus implant in the real-world…
- Conditions
- Meniscus; Degeneration, Knee Osteoarthritis, Knee Pain Chronic
- Trial name
- NIR (NCT03953846)
- Where
- 6 sites in Belgium, Germany and 2 more
- Volunteers
- 36 people
- Sponsor
- Phoenix Kinetics
Moderate Pain in Knee Osteoarthritis, Severe Pain in Knee Osteoarthritis
A Phase Ib Study to Evaluate the Efficacy and Safety of HRS-2129 in Patients With Knee Osteoarthritis
Primary Objective: To explore the effectiveness of different doses of HRS-2129 in the treatment of patients with moderate to severe pain in knee osteoarthritis.
- Trial name
- NCT07351968
- Testing
- HRS-2129 Tablet, Celecoxib capsule
- Where
- China
- Volunteers
- 202 people
- Sponsor
- Shandong Suncadia Medicine Co., Ltd.
Arthritis, Osteoarthritis
A Study of the Effect on Pain Control of Treatment With Fentanyl, Administered Through the Skin, in Patients With Rheumatoid Arthritis or Osteoarthritis
The purpose of this study is to assess the degree of pain control achieved by treatment with fentanyl, administered via adhesive patches applied to the skin ('transdermal system") in patients with rheumatoid arthritis or…
- Conditions
- Arthritis, Osteoarthritis, Rheumatoid Arthritis
- Trial name
- NCT00524160
- Testing
- Fentanyl transdermal patch
- Volunteers
- 264 people
- Sponsor
- Janssen Pharmaceutica N.V., Belgium
Arthroplasty, Replacement, Knee
Polyethylene Wear Study on the Triathlon Total Knee Prosthesis
Comparison of conventional UHMWPE (ultra-high-molecular-weight polyethylene) with highly cross-linked polyethylene (X3) in a condylar stabilizing (CS) fixed bearing total knee prosthesis by means of RSA and clinical evaluation.
- Trial name
- X3vsN2Vac (NCT02525588)
- Testing
- Triathlon CS fixed bearing total knee prosthesis
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Stryker Orthopaedics
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