Clinical trials: Knee Joint Arthroplasty
Esmarch Bandages, Simple Leg Elevation
Adequacy of Exsanguination Between Esmarch Bandages and Simple Leg Elevation in Total Knee Arthroplasty
To compare the adequacy of exsanguination in the surgical field between the use of the Esmarch bandages elevation and the simple leg elevation.
- Trial name
- NCT03989648
- Testing
- Esmarch bandages, simple leg elevation
- Where
- Thailand
- Volunteers
- 100 people
- Sponsor
- Navamindradhiraj University
Osteoarthritis, Rheumatoid Arthritis
Comparison of Rotating vs. Fixed Platform of the COLUMBUS Knee Prosthesis
A population of 100 patients randomised to rotating and fixed PE inlays in the Columbus knee prosthesis received a navigated TKR.
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Post-traumatic; Arthrosis
- Trial name
- NCT00822640
- Testing
- Total Knee Arthroplasty
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Aesculap AG
Total Knee Arthroplasty
NEUROCUPLE™ in TKA Patients to Enhance Pain Management
This is a randomized (1:1) placebo-controlled clinical trial to determine the feasibility and effectiveness of 30-day application of NEUROCUPLE™ patch for pain reduction and opioid consumption following TKA.
- Trial name
- NCT06460350
- Testing
- NEUROCUPLE™ Patch
- Where
- United States
- Volunteers
- 156 people
- Sponsor
- nCap Medical
Venous Thromboembolism
Study to Assess the Safety and Efficacy of SelK2 to Prevent Blood Clots in Patients Undergoing Total Knee Replacement
The main purpose of this study is to determine if an investigational medication called SelK2 works in preventing a condition called "venous thromboembolism" (VTE) in patients having a total knee replacement.
- Trial name
- COURSE (NCT03812328)
- Testing
- SelK2, Enoxaparin
- Where
- 21 sites in Bulgaria, Latvia and 3 more
- Volunteers
- 207 people
- Sponsor
- Tetherex Pharmaceuticals Corporation
Arthritis Knee
Patients With Asymptomatic Hyperuricemia Have Stronger Local Inflammatory Response and Worse Outcome After Total Knee Arthroplasty
We identify all patients who had undergone primary total knee arthroplsty(TKA) from April 1, 2015, to March 30, 2016. Patients are grouped by uric acid level.
- Trial name
- NCT05476367
- Volunteers
- 614 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Osteoarthritis of Knee, Recovery Following Primary Total Knee Arthroplasty
Perioperative Colchicine for TKA
This study is a prospective, randomized, double-blinded, placebo-controlled study of the drug colchicine in the acute postoperative period for patients who are undergoing a total knee arthroplasty (TKA).
- Conditions
- Osteoarthritis of Knee, Recovery Following Primary Total Knee Arthroplasty, Perioperative Pain Control
- Trial name
- NCT06936709
- Testing
- Colchicine 1.8 mg + 0.6 mg
- Volunteers
- 75 people
- Sponsor
- Geisinger Clinic
Osteoarthritis, Knee, Psychological Stress
Positive Cueing in Knee Arthroplasty.
To the knowledge of the investigators, the feasibility of an RCT assessing the use of positive cueing in an information video for patients undergoing primary TKA is currently unclear.
- Conditions
- Osteoarthritis, Knee, Psychological Stress, Mental Stress
- Trial name
- NCT05703087
- Testing
- Positive cueing in the information video before a primary TKA
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Leiden University Medical Center
VAS Score, Quadriceps Strength
Clinical Practice of Hydromorphone in Multimodal Analgesia for Enhanced Recovery After Surgery (ERAS) in Knee Arthroplasty
This study proposes a multimodal analgesia regimen comprising preoperative non-steroidal anti-inflammatory drugs (NSAIDs) for preemptive analgesia, intra-articular injection at the end of surgery, and postoperative adductor canal…
- Trial name
- NCT07722234
- Testing
- Hydromorphone, Ropivacaine
- Where
- China
- Volunteers
- 90 people
- Sponsor
- China-Japan Friendship Hospital
Knee Osteoarthritis, Rheumatoid Arthritis
Computer Navigation vs Conventional Technique in Knee Arthroplasty
Project summary: Background: Computer navigation in knee replacement surgery is increasingly being used around the world, but the documentation of its usefulness is lacking.
- Trial name
- CAOS (NCT00782444)
- Testing
- Computer navigated knee replacement, Conventional knee replacement
- Where
- 4 sites in Norway
- Volunteers
- 192 people
- Sponsor
- Haukeland University Hospital
Arthroplasty, Replacement
Comparison of Comparison of Ropivacaine and Liposomal Bupivacaine for Total Knee Arthroplasty
This is a randomized prospective outcomes study comparing two groups of patients. One group will receive liposomal bupivacaine for a periarticular injection.
- Conditions
- Arthroplasty, Replacement, Knee
- Trial name
- NCT02616367
- Testing
- liposomal bupivacaine Periarticular injection, Ropivacaine Periarticular Injection
- Sponsor
- University of Minnesota
Periprosthetic Joint Infection
Treatment of Acute Periprosthetic Joint Infection Comparing Single and Planned Double-Debridement Antibiotics and Implant Retention Followed by Chronic Antibiotic Suppression
The purpose of this research is to evaluate two different standard of care surgeries in treating periprosthetic joint infection (PJI) after total hip and knee arthroplasty.
- Trial name
- NCT05640336
- Testing
- Single Debridement, Antibiotics and Implant Retention, Planned Double Debridement, Antibiotics and Implant Retention
- Where
- 2 sites in United States
- Volunteers
- 490 people
- Sponsor
- Mayo Clinic
Nerve Block, Regional Anaesthesia
A Comparative Study of Combined Adductor Canal and Interspace Between Popliteal Artery and Knee Capsule Versus Combined Adductor Canal and Genicular Nerve in Total Knee Arthroplasty
The aim of this study is to investigate the effectiveness of combined adductor canal block (ACB) with interspace between popliteal artery and the knee capsule (IPACK) versus combined ACB with genicular nerve block (GNB) for…
- Trial name
- NCT06864663
- Testing
- nerve block with bupivacaine 0.25%
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Ain Shams University
Complications; Arthroplasty
A Comparison Between an Individual Low Tourniquet Pressure Versus a Standard Pressure During Total Knee Arthroplasty
The use of bloodless field is a helpful and important method in orthopedic surgery. The surgery can be done without interrupting bleedings, while keeping an exact overlook of the anatomy.
- Trial name
- NCT01442298
- Testing
- Limb occlusion pressure (LOP), conventional measurement method
- Where
- Sweden
- Volunteers
- 164 people
- Sponsor
- Charlotta Olivecrona
Postoperative Pain Management
Pain Treatment After TKA With LIA and Intra-articular Continuous Infusion Pump
The purpose of this study is to evaluate the effect on postoperative pain and function by adding intraarticular continuous infusion pump with local anesthetic after total knee arthroplasty where local infiltration analgesia has…
- Trial name
- NCT01726686
- Testing
- Ropivacaine
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Region Skane
Lymphedema
Comparison Between a Non-elastic Falcro Device and Current Method After Total Knee Arthroplasty
Swelling is a common problem after knee arthroplasty often leading to delayed wound healing, lasting functional impairment and hematoma. Due to this complications, sometimes the risk for deep venous thrombosis is raised.
- Trial name
- NCT02375945
- Testing
- New non-elastic compression kit, current compression stocking Comprinet®
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Nij Smellinghe Hosptial
Arthroplasty, Replacement, Knee, Blood Transfusion, Autologous
A Clinical Study to Investigate if Transfusion of Patients Own Shed Blood Improves the Immunological Status in Comparison to Transfusion of Donor Blood ("Bank Blood")
The primary objective of the study is to compare the immunological status after either autologous blood transfusion as administered by Bellovac® ABT or allogenic blood transfusion, with regards to change in Natural Killer (NK)…
- Conditions
- Arthroplasty, Replacement, Knee, Blood Transfusion, Autologous, Blood Transfusion
- Trial name
- NCT00839241
- Testing
- Bellovac ABT, Allogenic Blood Transfusion
- Where
- Poland
- Volunteers
- 45 people
- Sponsor
- Wellspect HealthCare
Knee Arthropathy
Quality of Life, Functional Outcomes and Costs in Knee Arthroplasty
This prospective observational study aims to collect and analyse data on functional outcomes, quality of life indicators, and costs in patients undergoing primary total knee arthroplasty (knee replacement) surgery.
- Trial name
- NCT05882669
- Testing
- Questionnaire administration
- Where
- Russia
- Volunteers
- 195 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Spinal Anesthesia, Knee Arthroplasty
Effect of Music Listened During Knee Arthroplasty With Spinal Anesthesia on Anxiety, Pain and Cortisol Levels
The aim of this study is to examine the effects of binaural beat music played during spinal anesthesia knee arthroplasty on anxiety, pain and cortisol levels.
- Trial name
- NCT06729294
- Testing
- Binaural beat music recital
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Nuh Naci Yazgan University
Total Knee Arthroplasty
Return to Activity After Total Knee Arthroplasty
This multicenter research project aims to correlate objective testing of muscle mass, muscle strength, neuromuscular activation, walking speed and other functional tests with everyday activity and subjective quality of life after…
- Trial name
- NCT07006545
- Testing
- Return to Activity Battery
- Where
- 2 sites in Germany
- Volunteers
- 400 people
- Sponsor
- University Hospital, Bonn
Arthritis, Osteoarthritis
A Comparison of Patients Receiving a Total Knee Replacement With Robotic Assistance or With Conventional Instrumentation
A total knee replacement is the removal of parts of the knee joint, that have become damaged due to osteoarthritis, and replacing these with artificial implants.
- Conditions
- Arthritis, Osteoarthritis, Knee, Joint Diseases
- Trial name
- NCT04976972
- Testing
- NAVIO/CORI Surgical System, Non-robotic conventional instrumentation
- Where
- 10 sites in Ireland, United Kingdom
- Sponsor
- Smith & Nephew Orthopaedics AG
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