Clinical trials: Knee Joint Loading
Amputation of Lower Limb Below Knee, Amputation, Traumatic
REsistance and LOADing Exercise for Bone Health
Lower limb amputation, often resulting from military conflict and road traffic accidents, is associated with reduced hip bone mineral density (BMD) and increased risk of hip fractures.
- Conditions
- Amputation of Lower Limb Below Knee, Amputation, Traumatic, Amputation, Limb Loss
- Trial name
- RELOAD (NCT07817381)
- Testing
- Resistance and high-impact exercise training
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Defence Medical Rehabilitation Centre, UK
Knee Osteoarthritis
Comparison of Three Tourniquet Application Methods in Primary Total Knee Arthroplasty Surgery
Different strategies of tourniquet application during elective primary total knee arthroplasty are thought to be associated with different outcomes.
- Trial name
- NCT01355900
- Testing
- Total knee arthroplasty performed under tourniquet
- Where
- Lithuania
- Volunteers
- 120 people
- Sponsor
- Vilnius University
Foot; Deformity, Valgus, Congenital, Foot; Deformity, Valgus (Acquired)
Effect of Medial Wedge on Static Balance in Pronated Feet
The use of heel wedges is often recommended as a clinical routine in individuals with foot pronation. However, there is a lack of information for examining the immediate effect of supports used to restore foot biomechanics on…
- Conditions
- Foot; Deformity, Valgus, Congenital, Foot; Deformity, Valgus (Acquired), Foot Deformities, Flatfoot
- Trial name
- NCT05437042
- Testing
- Medial calcaneal wedge
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Pamukkale University
ACL Tear
ACL Bone Health and Loading Study
The purpose of this study is to look at the effects of bone density on lower extremity loading mechanics using Blood Flow Restriction (BFR) to provide the control group for bone health.
- Trial name
- ACLBONE (NCT04682392)
- Testing
- Delfi's PTS Personalized Tourniquet System for Blood Flow Restriction Group, Standard ACL rehab
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Candice Dunkin, MS, LAT, ATC
Arthrogenic Muscle Inhibition, Knee Injuries
Effect of LL-BFRE Training on Volitional Muscle Activation in Subjects with Knee Joint Impairment
The aim of this study was to investigate whether 4 weeks of exercise training against low mechanical resistance in combination with partial blood flow restriction has an additional therapeutic effect on the patients\' ability…
- Conditions
- Arthrogenic Muscle Inhibition, Knee Injuries, Knee Surgery
- Trial name
- NCT06603532
- Testing
- low-load blood flow restriction (BFR) training, low-load resistance training
- Where
- 2 sites in Slovenia
- Volunteers
- 36 people
- Sponsor
- University of Ljubljana
Osteoarthritis Knee
Effect of Biomechanical Correction in Medial Tibiofemoral Joint Osteoarthritis
Effect of Biomechanical Correction of Tibia on Medial Joint space loading, Varus deformity and functional tasks in patients with medial tibiofemoral joint osteoarthritis in which participants will be taken.
- Trial name
- NCT04324931
- Testing
- Biomechanical corrections, Conventional Physiotherapy
- Where
- India
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Asir John Samuel
Knee Osteoarthritis
Effect of Tai Chi Exercise on Mechanical Joint Loading in Knee Osteoarthritis
This project is designed to identify the biomechanical mechanisms of Tai Chi (TC) exercise and test a novel optimized TC intervention by modifying newly identified mechanisms for those with knee osteoarthritis (OA) and to assess…
- Trial name
- NCT03621631
- Testing
- Optimized Tai Chi intervention, Traditional Tai Chi intervention
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Edward Via Virginia College of Osteopathic Medicine
Osteoarthritis, Knee Infection
Articulating Versus Static Antibiotic Loaded Spacers for the Treatment of Prosthetic Knee Infection
Infection remains a difficult-to-treat complication of total knee arthroplasty. The gold standard treatment is two-stage removal of the prosthesis with later replacement of permanent implants.
- Conditions
- Osteoarthritis, Knee Infection, Prosthetic Joint Infection, Complications; Arthroplasty, Infection or Inflammation
- Trial name
- NCT01373112
- Testing
- Static Spacer, Articulating Spacer
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Rush University Medical Center
Knee Osteoarthritis
Etodolac Nanogel as an Adjunct to Physiotherapy for Knee Osteoarthritis
Brief Summary: Knee osteoarthritis (OA) is a common, disabling condition affecting the weight-bearing knee joint, leading to pain, reduced function, and muscle weakness, particularly of the quadriceps.
- Trial name
- NCT07308470
- Testing
- Etodolac-Loaded Solid Lipid Nanoparticle Gel
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Pharos University in Alexandria
Anterior Cruciate Ligament Injury, Quadriceps Dysfunction
Exercise Loading Biology Post-Traumatic OsteoArthritis Study - a Pilot and Feasibility Study
FROM RISK FACTORS TO THE PREVENTION OF LONG-TERM CONSEQUENCES AFTER CRUCIATE LIGAMENT INJURY (ACL injury) - This is a research project where we seek new knowledge about why some people have a high risk and others a low risk of…
- Conditions
- Anterior Cruciate Ligament Injury, Quadriceps Dysfunction, Knee Joint Loading, Anterior Cruciate Ligament Reconstruction
- Trial name
- ExeLoadBioPTOA (NCT06892899)
- Where
- Norway
- Volunteers
- 40 people
- Sponsor
- May Arna Risberg
Periprosthetic Fracture Around Prosthetic Joint Implant
Weight-Bearing CT and Conventional Periprosthetic Distal Knee Fractures
Total knee arthroplasty (TKA) is a surgical procedure commonly conducted for patients with end-stage knee osteoarthritis, often leading to improved pain relief and function.
- Trial name
- NCT06909916
- Testing
- Periprosthetic Fracture Knee Repaired CT Scans
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Knee Osteoarthritis
The Effects of Specialized Footwear in Osteoarthritis
This study evaluates the effects of specialized footwear on pain and knee loading in knee osteoarthritis. The hypothesis is that this footwear will lead to decreased knee loading and knee pain.
- Trial name
- NCT01597830
- Testing
- Mobility shoe, control shoe
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Rush University Medical Center
Healthy
Effects of Heavy-load Resistance Training
The study aims to investigate effects of 8-weeks of heavy-load resistance training on mechanical muscle function and functional performance in elite female team handball players from the Danish Women's Handball League.
- Trial name
- NCT06356935
- Testing
- RT, CON
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark
Osteoarthritis, Knee
The Effect on Knee Joint Loads of Analgesic Use Compared With Exercise in Patients With Knee Osteoarthritis - An RCT
The purpose of this study is to compare the effects of neuromuscular exercise and analgesic use on knee joint load, in patients with mild to moderate knee osteoarthritis (OA).
- Trial name
- EXERPHARMA (NCT01638962)
- Testing
- Instruction on analgesic use for pain relief (acetaminophen and NSAIDs), Neuromuscular exercise
- Where
- Denmark
- Volunteers
- 93 people
- Sponsor
- University of Southern Denmark
Osgood-Schlatter Disease, Sever's Disease
Individualized Rehabilitation for Osgood-Schlatter or Sever Pain in Youth Athletes
The goal of this clinical trial is to learn if a 12-week individualized rehabilitation program is feasible and helpful for children and adolescents with lower-extremity apophyseal pain, including Osgood-Schlatter-related knee…
- Conditions
- Osgood-Schlatter Disease, Sever's Disease, Apophyseal Pain, Sinding-Larson and Johansson Syndrome (SLJ)
- Trial name
- LEAP-REHAB (NCT07521280)
- Testing
- Individualized Load-Based Rehabilitation Pathway
- Where
- Poland
- Volunteers
- 45 people
- Sponsor
- Medical University of Gdansk
Osteoarthritis, Knee
Muscle Property, Alignment and Joint Loading in People With Knee Osteoarthritis
Knee osteoarthritis (KOA) is a common chronic painful musculoskeletal condition among older adults. It poses great challenge to the health care system due to its inability to be cured.
- Trial name
- NCT03628508
- Testing
- Exercise
- Where
- Hong Kong
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Knee Osteoarthritis
Loaded and Unloaded Magnetic Resonance (MR) Imaging of Meniscus-Cartilage-Trabecular Bone in Osteoarthritis
The objective of this project is to determine the effects of gait-retraining on articular cartilage composition, gait mechanics, pain and function in persons with mild to moderate knee osteoarthritis (OA).
- Trial name
- NCT01919736
- Testing
- Gait Retraining
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, San Francisco
ACL, Anterior Cruciate Ligament
Michigan Split-belt Treadmill Training Program to Improve Long-Term Knee Biomechanics After ACL Reconstruction
The goal of this study is to gather pilot data to help inform a future clinical trial. As such, the investigators will employ a randomized clinical trial design, but data will only be collected on 9 total subjects.
- Conditions
- ACL, Anterior Cruciate Ligament, ACL Injury
- Trial name
- Mi-SPA (NCT06529692)
- Testing
- Split-Belt Training
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Michigan
Sports Injury, Orthopedic Disorder
Training of Falling Techniques on Landing Mechanics
The overall purpose of this study is to quantify the effect and retention of one-week training of falling techniques on landing biomechanics associated with anterior cruciate ligament (ACL) loading compared to soft-landing…
- Conditions
- Sports Injury, Orthopedic Disorder, Knee Injuries, Anterior Cruciate Ligament Injuries
- Trial name
- NCT04768088
- Testing
- Falling Training
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Wyoming
Tendinopathy
Exercise Therapy for Patellar Tendinopathy Evaluated With Advanced UTE-MRI
Patellar tendinopathy is a frequent overuse injury that causes pain and impaired performance in jumping athletes. Exercise therapy is considered the best initial treatment option for tendinopathies as clinical improvements in…
- Trial name
- NCT02938143
- Testing
- Exercise, Exercise (usual care)
- Where
- Netherlands
- Volunteers
- 76 people
- Sponsor
- Erasmus Medical Center