Clinical trials: Knee Ligament Injury
Anterior Cruciate Ligament Tear
Bone Marrow Aspirate Concentrate for Anterior Cruciate Ligament Tear Treatment.
A single armed multicenter study enrolling 20 patients using autologous bone marrow aspirate concentrate (which is done under local or general anesthesia to aspirate around 1-2 cc/kg body weight then concentration which is done…
- Trial name
- NCT06353503
- Testing
- autologous bone marrow aspirate concentrate
- Where
- Iraq
- Volunteers
- 20 people
- Sponsor
- abdulmajeed hammadi
Anterior Cruciate Ligament Injuries
Jewel ACL Post Market Clinical Follow Up Study
The objective of the study is to assess re-rupture rates and patient outcomes from subjects with at least 5 year follow up, treated with the JewelACL device for ACL reconstruction.
- Trial name
- NCT04580290
- Testing
- JewelACL
- Where
- Poland
- Volunteers
- 120 people
- Sponsor
- Xiros Ltd
Anterior Cruciate Ligament Injury, Rotator Cuff Tear
MDR EZ Pass and Precision Flexible Reamer
The objective of this study is to confirm the safety and performance on the EZPass Suture Passer Instrumentation and the Precision Flexible Reamer Instrumentation.
- Trial name
- NCT03914703
- Testing
- EZ Pass Suture Passer
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- Zimmer Biomet
Anterior Cruciate Ligament Injuries, Posterior Cruciate Ligament Tear
Interference Screw Mectascrew-C Postmarket Study
An observational prospective study with the aim to analyze the presence at 6 months of a specific composite IS (Medacta Mectascrew C) in the reconstructive treatment of ruptured ACL or PCL by means of an autograft or allograft.
- Trial name
- NCT05791656
- Testing
- Mectascrew-C
- Where
- Switzerland
- Volunteers
- 44 people
- Sponsor
- Medacta International SA
Aseptic Loosening, Infection
Maxx Orthopedics' PCK Revision TKA Study of Component Survivorship
The objectives of this clinical investigation are to evaluate the safety and performance of the Freedom Total Knee® PCK System.
- Conditions
- Aseptic Loosening, Infection, Bone Loss, MCL - Medial Collateral Ligament Rupture of the Knee
- Trial name
- NCT03312088
- Testing
- Freedom Knee PCK Components
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Maxx Orthopedics Inc
Anterior Cruciate Ligament Rupture
Safety and Efficacy of the Knee-T-nol Anterior Cruciate Ligament (ACL) Prosthesis
The study is designed to evaluate the safety and efficacy of implanting the Tavor ACL prosthesis in patients with a ruptured ACL by improvement of healing kinetics as well as major adverse treatment events (AEs).
- Trial name
- NCT01450332
- Testing
- Knee-T-Nol
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Tavor Ltd.
ACL Tears
BioBrace® Augmentation in Anterior Cruciate Ligament Reconstruction Procedures
This research study will evaluate mid-term clinical safety and performance outcomes of the BioBrace® Reinforced Implant when used to augment a tissue graft during anterior cruciate ligament (ACL) reconstruction.
- Trial name
- NCT06948591
- Testing
- Anterior cruciate ligament reconstruction with BioBrace® augmentation, Arthroscopic anterior cruciate ligament reconstruction
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- CONMED Corporation
Anterior Cruciate Ligament, Knee Injuries
SeriACL™ Device Trial for Anterior Cruciate Ligament (ACL) Reconstruction
The SeriACL device was developed as an alternative to an autograft (i.e., tissue that is taken from a patient's own body) or an allograft (i.e., tissue that is taken from a cadaver) for ACL reconstruction.
- Trial name
- NCT00490594
- Testing
- ACL Reconstruction (SeriACL™ Device)
- Where
- 3 sites in Germany, Norway
- Volunteers
- 30 people
- Sponsor
- Serica Technologies, Inc.
Knee Injuries
Clinical Evaluation of dCELL® ACL Scaffold for Reconstruction of the Anterior Cruciate Ligament
The safety and performance of dCELL® ACL Scaffold will be evaluated in 40 patients who have been implanted with the investigational product following a ruptured anterior cruciate ligament (ACL) of the knee.
- Trial name
- NCT02540811
- Testing
- dCELL® ACL Scaffold
- Where
- 8 sites in Poland, Spain and 1 more
- Volunteers
- 40 people
- Sponsor
- Tissue Regenix Ltd
ACL Injury, ACL Tear
Comparison of Six-Month Functional Outcomes Following Anterior Cruciate Ligament (ACL) Reconstruction Using Peroneus Longus Tendon Grafts With Adjunctive Secretome Injection Versus Without Secretome Injection
Anterior cruciate ligament (ACL) reconstruction is commonly performed to restore knee stability after ACL injury; however, graft healing remains a critical determinant of successful outcomes.
- Trial name
- Secretome ACL (NCT07723625)
- Testing
- Secretome
- Where
- Indonesia
- Volunteers
- 24 people
- Sponsor
- PT. Prodia Stem Cell Indonesia
Knee Ligament Injury
Performance and Safety of the Composite Interference Screw Used in Anterior Cruciate Ligament Reconstructions
The evaluation of the clinical data has demonstrated the conformity of the Composite Interference Screw (CIS), with the relevant essential requirements for its use in orthopaedic applications.
- Trial name
- NCT04076956
- Testing
- Anterior Cruciate Ligament Reconstruction
- Where
- France
- Volunteers
- 55 people
- Sponsor
- Biomatlante
Anterior Cruciate Ligament Rupture
Induced ACL Healing With the Ligamys Technique: a Prospective, Multicenter Observational Case Series
The purpose of this study is to evaluate the safety and effectiveness of the Ligamys technique for the treatment of acute ruptures of the anterior cruciate ligament in a multicenter routine clinical setting.
- Trial name
- Ligamys (NCT02203214)
- Testing
- Ligamys
- Where
- 3 sites in Belgium, Germany and 1 more
- Volunteers
- 110 people
- Sponsor
- Mathys Ltd Bettlach
ACL Reconstruction
Efficacy and Tolerability of a Nutritional Supplement, Plactive Progen, in ACL Reconstruction
This was a prospective, multicenter, randomized, open-label, phase IV trial to compare the efficacy of supplementation with plasma proteins, hydrolyzed collagen (CH), a complex of HA-CS (HC-15), and vitamin C combined with a…
- Trial name
- NCT03355651
- Testing
- PROGEN
- Volunteers
- 80 people
- Sponsor
- OPKO Health, Inc.
Knee Ligament Injury
Performance and Safety of the Polylactic Interference Screw Used in Anterior Cruciate Ligament Reconstructions
The evaluation of the clinical data has demonstrated the conformity of the Polylactic Interference Screw (PIS), with the relevant essential requirements for its use in orthopaedic applications.
- Trial name
- NCT04122677
- Testing
- Anterior Cruciate Ligament Reconstruction
- Where
- France
- Volunteers
- 55 people
- Sponsor
- Biomatlante
Sprain
Efficacy Study of a Sensory Feedback Knee Orthosis in Patients Suffering From Unoperated Severe Knee Sprain
Ortheses are commonly used for the repair of damage to the musculoskeletal system. However, immobility, by itself, causes serious side effects that require long and costly rehabilitation.
- Trial name
- ORTHOSENS (NCT01508728)
- Testing
- ORTHOSENS orthosis
- Where
- 3 sites in France
- Volunteers
- 104 people
- Sponsor
- Thuasne
Collateral Ligament Injury of Stifle Joint
Effectiveness of Hydrolyzed Collagen Peptide Injection for the Treatment of Collateral Ligament Pain
Conducted by Binh Luu Thi, Lan Tran Thi, and Minh Hang Hoang Thi at Thai Nguyen National Hospital, the study investigates a new approach to treating persistent collateral ligament pain, common among athletes.
- Trial name
- NCT05971004
- Testing
- Arthrys (Collagen Peptide solution), Depo medrol
- Where
- San Marino
- Volunteers
- 62 people
- Sponsor
- Tiss'You srl
ACL Injury
ACL Reconstruction with a New Generation of LARS Artificial Ligament
This clinical investigation is intended to demonstrate the safety of the new generation of LARS ligaments and compare this new generation (grafted ligament) of artificial ligament to the LARS current artificial ligament…
- Trial name
- NCT06571955
- Testing
- Implantation of LARS artificial grafted ligament to treat ACL injury, Implantation of LARS artificial non-grafted ligament to treat ACL injury
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- MOVMEDIX
Acute Ruptures of the Anterior Cruciate Ligament
L-C Ligament Versus Hamstring Autograft for Primary ACL Reconstruction
The purpose of this study is to compare safety and efficacy outcomes of the L-C Ligament versus Hamstring Autograft for treatment of acute rupture of the ACL.
- Trial name
- NCT02183727
- Testing
- L-C Ligament, Hamstring Autograft
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- Soft Tissue Regeneration, Inc.
Anterior Cruciate Ligament Injuries
A Prospective Cohort Post Market Registry Evaluating Outcomes of Bridge-Enhanced ACL Restoration (BEAR®)
The purpose of the Bridge Registry is to assess real-world performance of the FDA approved BEAR Implant.
- Trial name
- NCT05398341
- Testing
- The BEAR® Implant
- Where
- 8 sites in United States
- Volunteers
- 300 people
- Sponsor
- Miach Orthopaedics
ACL Tears
MRI Evaluation of Graft Maturation Following ACL Reconstruction
Post-surgical ACL Graft maturation will be assessed at 4.5, 6, 7.5, 9, 10.5, and 12 months with MRI.
- Trial name
- NCT07046000
- Testing
- MRI
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Skye Biologics Holdings, LLC