Clinical trials: Knee Ligament Injury
Anterior Cruciate Ligament Injuries
Biomechanical Mechanism of the Change of the Gait Touch Information After ACL Rupture
High incidence rate of knee osteoarthritis and gait analysis are important for early assessment of biomechanics. ACL injury is an ideal clinical model for studying knee osteoarthritis.
- Trial name
- NCT04464330
- Testing
- no intervention
- Where
- China
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Anterior Cruciate Ligament Injury
Arthroscopic Anterior Cruciate Ligament Reconstruction by Hamstring Graft With and Without Platelet-Rich Plasma
No local data exists regarding the outcomes of anterior cruciate ligament reconstruction by hamstring graft with and without platelet-rich plasma.
- Trial name
- NCT07269522
- Testing
- ACL reconstruction by hamstring graft with PRP, ACL reconstruction by hamstring graft
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Muhammad Aamir Latif
Deficiency of Anterior Cruciate Ligament, Injury of Anterior Cruciate Ligament
Clinical Follow-up After ACL Reconstruction
No former studies have done long-term evaluation on patients reconstructed with hamstrings graft, the use of Howells tibial guide and transtibial drilling of the femoral graft tunnel.
- Trial name
- Howell (NCT01607437)
- Where
- Norway
- Volunteers
- 96 people
- Sponsor
- Bergen Knee Group
Anterior Cruciate Ligament Tear
Bridge-Enhanced ACL Repair vs ACL Reconstruction
The goal of this trial is to compare the efficacy of the Bridge-Enhanced Anterior Cruciate Ligament Repair (BEAR™) technique with the current method of treatment for anterior cruciate ligament (ACL) injuries, ACL reconstruction.
- Trial name
- NCT02664545
- Testing
- BEAR Scaffold, Tendon Graft
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Miach Orthopaedics
Rupture of Anterior Cruciate Ligament, Osteoarthritis
Multicenter Orthopaedic Outcomes Network (MOON) ACL Reconstruction (ACLR): Onsite Follow-up
In this study we will examine patients who have undergone unilateral ACL reconstruction surgery to determine which structural and functional characteristics of the knee two and ten years post reconstruction surgery, aspects of…
- Trial name
- MOON-Onsite (NCT00478894)
- Where
- 4 sites in United States
- Volunteers
- 432 people
- Sponsor
- Vanderbilt University
Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture
The PreOperative Management of Patients Awaiting Anterior Cruciate Ligament Reconstruction
Patient experiences of the NHS ACL treatment pathway are unknown. This study aims to explore patient experiences of anterior cruciate ligament ruptures at three different time points on the patient pathway: (1) 12 participants up…
- Conditions
- Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture, Rehabilitation
- Trial name
- POP-ACLR (NCT05529511)
- Testing
- Phase 1 - semi-structured interviews, Phase 2 - consensus meeting
- Where
- United Kingdom
- Volunteers
- 26 people
- Sponsor
- University Hospitals of Derby and Burton NHS Foundation Trust
ACL Injury, Rehabilitation After ACL Reconstruction
Functional Outcomes of an Accelerated Rehabilitation Protocol for ACL Reconstruction in Amateur Athletes
The main goal of a rehabilitation program after an ACL reconstruction is to regain mobility and muscle function and ultimately to return to sports participation.
- Conditions
- ACL Injury, Rehabilitation After ACL Reconstruction, Accelerated Protocol
- Trial name
- ACL (NCT05716529)
- Testing
- rehabilitation protocol
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Delta University for Science and Technology
Anterior Cruciate Ligament Injuries
Clinical Application of the Apex of the Deep Cartilage in Evaluating the Femoral Tunnel of the ACL Reconstruction
With the apex of the deep cartilage (ADC) as the symbol, the consistency of the two methods in the postoperatively computed tomography (CT) and microscopic evaluation of the position of the femoral tract of the anterior cruciate…
- Trial name
- NCT04953546
- Testing
- No Intervention
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Peking University Third Hospital
Anterior Cruciate Ligament Injuries
Neuroplastic Mechanisms Underlying Augmented Neuromuscular Training
The purpose of this study is to determine the neural mechanisms of augmented neuromuscular training (aNMT). Participants will complete a 6-week course of neuromuscular training with either aNMT biofeedback or sham biofeedback.
- Trial name
- NCT04069520
- Testing
- aNMT Biofeedback
- Where
- 2 sites in United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Emory University
ACL Injury, Knee Injuries
Subjective Outcomes After ACL Reconstruction With BQT Autograft
The purpose of the study is to compare short-term patient reported outcome measures (PROM) of Bone-Quadriceps-Tendon (BQT) autograft with Semitendinosus-Gracilis (STG) and Bone-Patellar-Tendon-Bone (BPTB) autografts following…
- Trial name
- NCT04901559
- Testing
- Graft type at ACLR
- Volunteers
- 30,000 people
- Sponsor
- Region Zealand
ACL Injury
MRI Morphology of Femoral Notch in ACL Injury
This study aims to investigate the association between femoral notch morphology, as assessed by MRI, and the risk of ACL injury
- Trial name
- NCT06707285
- Testing
- MRI
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Assiut University
ACL Injury
Multimodal Assessment of Knee Conditions in Rehabilitation
The purpose of this study is to assess ACL injury and other pathological knee conditions from the combination of signals that are known to provide information on the knee joint.
- Trial name
- NCT03608189
- Where
- Finland
- Volunteers
- 20 people
- Sponsor
- University of Oulu
Pain, Postoperative, ACL Injury
Effectiveness of iPACK on Postoperative Pain From Hamstring Autograft Following ACL Repair
Patients undergoing ACL repair with hamstring autograft frequently develop significant post operative pain at the hamstring grafting site.
- Conditions
- Pain, Postoperative, ACL Injury, Anesthesia, Local, Opioid Use
- Trial name
- NCT05080348
- Testing
- Ropivacaine iPACK Injection, Normal Saline iPACK Injection
- Volunteers
- 40 people
- Sponsor
- Brenton Alexander
Anterior Cruciate Ligament Injury, Anterior Cruciate Ligament Reconstruction
STABILITY 2: Anterior Cruciate Ligament Reconstruction +/- Lateral Tenodesis With Patellar vs Quad Tendon
Anterior cruciate ligament (ACL) rupture is one of the most common musculoskeletal injuries in young individuals, particularly those that are active in sports.
- Conditions
- Anterior Cruciate Ligament Injury, Anterior Cruciate Ligament Reconstruction, Joint Instability
- Trial name
- STABILITY 2 (NCT03935750)
- Testing
- Anterior cruciate ligament reconstruction (ACLR), Lateral extra-articular tenodesis (LET)
- Where
- 31 sites in United States, Canada and 6 more
- Volunteers
- 1,272 people
- Sponsor
- University of Pittsburgh
ACL Tear, ACL Injury
The Effect of Fertilized ACL Technique on Outcomes of ACL Reconstruction in Young Adults
A prospective study, with outcomes including re-rupture rate and return to sport will be collected following ACL reconstruction.
- Conditions
- ACL Tear, ACL Injury, Arthroscopy, Anterior Cruciate Ligament Tear
- Trial name
- FACL (NCT04178538)
- Testing
- ACL reconstruction with bone marrow, demineralized bone marix, and internal brace augmentation, Standard ACL reconstruction with all inside technique
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Marshall University
ACL - Anterior Cruciate Ligament Rupture, ACL Injuries
Non-Narcotic Pain Control After ACL Reconstruction
This is a double-blind randomized controlled trial of standard of care therapy, either oral ketorolac (experimental group) or oral oxycodone (control group) to demonstrate efficacy in reducing the percentage of narcotic doses…
- Trial name
- NCT06973785
- Testing
- dispense of study drug, Ketorolac
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- The Cleveland Clinic
ACL Injury
Molecular Imaging Assessment of ACL Viability
The objective of this study is to answer the following questions: 1. Does the appearance of the reconstructed anterior cruciate ligament (ACL) vary in appearance on PET/MRI depending on graft type and time after surgery? 2.
- Trial name
- NCT03491046
- Testing
- PET scan, MRI scan
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- University of Cincinnati
ACL, Anterior Curciate Ligament
Risk of Osteoarthritis of the Knee at Least 5 Years After ACL Reconstruction: Comparative Study Between an Isolated ACL Reconstruction and a Reconstruction Combining ACL and ALL
The main objective of this study is to compare, with a minimum follow-up of 5 years, the prevalence of femoro-tibial osteoarthritis after an isolated ACL ligamentoplasty or after an ACL ligamentoplasty combining ACL and ALL.
- Conditions
- ACL, Anterior Curciate Ligament, Anterolateral Ligament, Knee Injuries
- Trial name
- NCT05123456
- Testing
- Radiography
- Where
- France
- Volunteers
- 180 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Double Leg Vertical Jump (DLVJ), Single Leg Squat (SLS)
ESSKA/ESMA ACL Injury Prevention Program in Czech Sport
This study aims to address the rising incidence of ACL injuries, particularly among adolescents, by developing and implementing a comprehensive prevention program based on the evidence-based "ACL Prevention for ALL" framework…
- Conditions
- Double Leg Vertical Jump (DLVJ), Single Leg Squat (SLS), Single Leg Drop Landing (SLDL), Drop Jump Test (DJ Test)
- Trial name
- NCT07019727
- Testing
- ESSKA/ESMA 'ACL Prevention for All' methodology
- Where
- Czechia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Masaryk University
Female Athletes, Anterior Cruciate Ligament Injuries
ACL Mechanical Property Changes in Female Collegiate Basketball Players During a Competitive Season
This prospective cohort study aims to investigate whether the mechanical properties of the anterior cruciate ligament (ACL) undergo measurable changes throughout a competitive basketball season in female collegiate athletes.
- Conditions
- Female Athletes, Anterior Cruciate Ligament Injuries, Athletic Performance, Sports Injuries
- Trial name
- NCT07486466
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Fu Jen Catholic University Hospital