Clinical trials: Knee Osteoarthrosis
Osteoarthritis, Knee
Unicompartmental Knee Arthroplasty (UKA) Versus Total Knee Arthroplasty (TKA) of Medial Osteoarthritis
This study allows patients to take part of the decision making between a unicompartment knee (partial ) or a total Knee replacement .
- Trial name
- NCT03457051
- Testing
- Total Knee Arthroplasty (TKA), Unicompartmental Knee Arthroplasty (UKA)
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Acupuncture, Knee Osteoarthritis
Acupuncture Treatment for Knee Osteoarthritis With Sensitive Acupoints and Tender Points
The investigators plan to investigate the effectiveness of acupuncture at highly sensitive points, compared with lowly/non-sensitive points or no acupuncture (waiting-list), in improving pain, joint function and quality of life…
- Conditions
- Acupuncture, Knee Osteoarthritis, Sensitive Acupoints, Tender Points
- Trial name
- NCT03299439
- Testing
- acupuncture
- Where
- 4 sites in China
- Volunteers
- 666 people
- Sponsor
- West China Hospital
Knee Osteoarthritis, Pain, Joint
Pain Function and QOL Undergoing Whole-Body Vibration and Exercise in End-Stage Knee Osteoarthritis
Knee osteoarthritis (KOA) is a chronic progressive disease that imparts substantial socioeconomic burden to society and healthcare systems.
- Trial name
- NCT06183177
- Testing
- Whole-Body Vibration, Exercise
- Where
- Hong Kong
- Volunteers
- 517 people
- Sponsor
- Chinese University of Hong Kong
Osteearthritis, OA
Value of Adding T2 Mapping Routine MRI in Assessment of Knee Articular Cartilage Early Osteoarthritis
This work aims at elucidating the role of MRI complementary T2 mapping in assessment of the articular knee cartilage for improving sensitivity of detection of early stage of osteoarthritis
- Conditions
- Osteearthritis, OA, OA Knee
- Trial name
- T2 mapping OS (NCT07316257)
- Testing
- MRI
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Assiut University
Osteo Arthritis Knee, Pain, Chronic
Radiofrequency Neurotomy In Relieving Chronic Knee Pain
Osteoarthritis (OA) affects aged above 45 years. RF has been used for several painful conditions. There have been a few attempts to use RF current for the treatment of painful conditions of joints of the extremities.
- Trial name
- NCT03224637
- Testing
- radiofrequency, Paracetamol (conventional), Ketorolac Tromethamine (conventional)
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Osteoarthritis, Obesity
Multi-parametric Imaging of the Knee in Obese Patients With Knee Osteoarthritis; Weight Maintenance
This is a substudy to a randomised trial investigating the effect of liraglutide on body weight and pain in overweight or obese patients with knee osteoarthritis (NCT02905864).
- Trial name
- IM-LOSEIT-II (NCT02928679)
- Testing
- Liraglutide 3 mg (Saxenda)
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- Henrik Gudbergsen
Osteoarthritis, Knee
Study to Evaluate the Efficacy and Safety of EP-104IAR in Patients With Osteoarthritis of the Knee
The purpose of this study is to evaluate the safety, efficacy and pharmacokinetics (PK) of EP-104IAR in patients with osteoarthritis (OA) of the knee
- Trial name
- SPRINGBOARD (NCT04120402)
- Testing
- EP-104IAR 25 mg, Vehicle
- Where
- 12 sites in Czechia, Denmark and 1 more
- Volunteers
- 318 people
- Sponsor
- Eupraxia Pharmaceuticals Inc.
Knee Osteoarthritis
Immediate Effects of Manual Therapy Versus TENS in Patients With Knee Osteoarthritis
Patients with knee Osteoarthritis have high prevalence of pain , requiring ever more precise interventions in their management. This study aims to investigate the immediate effects of manual therapy and TENS on pain in patients…
- Trial name
- NCT02947451
- Testing
- Manual Therapy, TENS
- Where
- Brazil
- Volunteers
- 54 people
- Sponsor
- Gabriel Peixoto Leão Almeida
Knee Osteoarthritis, Knee Injuries
Clinical Study of Novel Diagnostic Techniques for Knee Osteoarthritis
The purpose of this study is to clarify the potential of intra-articular ultrasound imaging, non-invasive ultrasound imaging, quantitative MRI imaging, contrast-enhanced CT imaging and arthroscopy for diagnostics of knee…
- Trial name
- NCT01359553
- Testing
- Intra-articular ultrasound imaging of knee joint during arthroscopy, Non-invasive ultrasound imaging of knee, Quantitative MRI imaging of knee
- Where
- Finland
- Volunteers
- 12 people
- Sponsor
- University of Oulu
Knee Osteoarthritis (Knee OA)
A Study to Assess the Efficacy and Safety of Vutiglabridin in Knee Osteoarthritis Patients
1. Study Objective To Explore the Efficacy and Evaluate the Safety of Vutiglabridin in Knee Osteoarthritis Patients 2. Background Glaceum Inc.
- Trial name
- NCT06845553
- Testing
- Vutiglabridin
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Glaceum
Knee Osteoarthritis, Total Knee Arthroplasty
Remimazolam Total Intravenous Anesthesia Under Analgesia Nociception Index-guidance
The investigators hypothesized that intraoperative opioid consumption would be different between remimazolam and propofol if the ANI-guided remifentanil continuous infusion rate was adjusted when the depth of anesthesia was…
- Conditions
- Knee Osteoarthritis, Total Knee Arthroplasty, Remimazolam
- Trial name
- NCT05322902
- Testing
- remimazolam group, propofol group
- Where
- South Korea
- Volunteers
- 84 people
- Sponsor
- Gangnam Severance Hospital
Osteoarthritis, Hip, Osteoarthritis, Knee
A Safety and Effectiveness Study of Acetaminophen (4000 mg/Day) and Naproxen (750 mg/Day) in the Treatment of Osteoarthritis of the Hip or Knee
The purpose of this study is to compare the long-term safety and effectiveness of acetaminophen (4000 mg per day) and naproxen (750 mg per day) in the treatment of osteoarthritis of the hip or knee.
- Trial name
- NCT00240773
- Testing
- acetaminophen, naproxen
- Volunteers
- 581 people
- Sponsor
- Johnson & Johnson Consumer and Personal Products Worldwide
Total Knee Arthroplasty
Clinical Study of Patellar Resurfacing and Non-resurfacing in Total Knee Arthroplasty
The literature regarding resurfacing of the patella in total knee arthroplasty has conflicting conclusions. This study assesses medium-term clinical results of total knee arthroplasties performed with and without the patellar…
- Trial name
- NCT03600922
- Testing
- the patella was resurfaced.
- Volunteers
- 66 people
- Sponsor
- Liaocheng People's Hospital
Knee Osteoarthritis (Knee OA)
Knee OsteoArthritis Long-term Assessment
The goal of this clinical study is to learn if Hydrogel OA 2% injection is safe and whether it works to improve symptoms of diagnosed knee osteoarthritis in adults when compared to Hyaluronic Acid (Durolane), a treatment that is…
- Trial name
- KOALA (NCT06839222)
- Testing
- Hydrogel OA 2%, Hyaluronic Acid (Durolane)
- Where
- 5 sites in Belgium
- Sponsor
- Allegro NV/SA
Gonarthrosis
Efficacy of Ultrasound-Guided Genicular Nerve Radiofrequency Ablation Therapy
The main symptom of knee osteoarthritis, which occurs after damage to the joint cartilage with age, is pain, but this symptom often becomes chronic.
- Trial name
- NCT06914960
- Testing
- 2-point Radiofrequency Ablation, 3-point Radiofrequency Ablation, 5-point Radiofrequency Ablation
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Bengu Turemenogullari
Osteoarthritis of Knee
Efficacy of Intra-Articular Injection of Etanercept for Moderate and Severe Knee Osteoarthritis
Primary aim: evaluate efficacy of intra-articular injection of etanercept for moderate and severe knee osteoarthritis. Second aim: investigate the potentiality of serum cytokines (TNF-α, Interleukin 1-α (IL1-α), IL1-β, matrix…
- Trial name
- EIAIETNKOA (NCT02722772)
- Testing
- Etanercept, Health education, exercise and diet guidance
- Where
- China
- Volunteers
- 60 people
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Necrosis of Femoral Head, Knee Osteoarthritis
MRI Maker of Perioperative Neurocognitive Disorder
Periperative neurocognitive disorder(PND) is consistently associated with increased morbidity and mortality, but its mechanisms remain unclear.
- Conditions
- Necrosis of Femoral Head, Knee Osteoarthritis, Fracture of Lower Limb
- Trial name
- MRIPND (NCT03773627)
- Where
- China
- Volunteers
- 100 people
- Sponsor
- RenJi Hospital
Knee Osteoarthritis, Aging
Effects of Specific Balance Training Prior TKR Surgery in the Early Postoperative Outcomes
Knee osteoarthritis is one of the most common pathologies in old people, and the leading cause of pain and disability. Symptoms include joint pain, stiffness, limited mobility, functional impairment and proprioceptive deficit.
- Trial name
- PRE_TKR_BLC (NCT02995668)
- Testing
- Strength-Function, Balance-Proprioception
- Where
- Spain
- Volunteers
- 82 people
- Sponsor
- University of Valencia
Osteoarthritis, Knee
FibroFix Cartilage P Knee Implant Study
This is a multi-center first-in-human prospective clinical investigation to evaluate the safety and performance of the FibroFix™ Cartilage P Implant and Drill Set. The Implant is a medical device designed by Orthox Ltd.
- Trial name
- FFLEX (NCT05560490)
- Testing
- FibroFix Cartilage P Knee Implantation
- Where
- 2 sites in Hungary, United Kingdom
- Volunteers
- 2 people
- Sponsor
- Orthox Limited
Osteoarthritis, Knee
Safety of Intra-Articular Sc-rAAV2.5IL-1Ra in Subjects With Moderate Knee OA
This study seeks to determine the safety of three different doses of sc-rAAV2.5IL-1Ra delivered by intra-articular injection into one knee joint of patients with moderate OA of the knee.
- Trial name
- AAVIL-1Ra (NCT02790723)
- Testing
- sc-rAAV2.5IL-1Ra
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Mayo Clinic
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