Clinical trials: Knee Osteoarthrosis
Knee Pain Chronic, Rheumatoid Arthritis
Cemented vs Cementless Persona Keel RCT
The main objective of this study is to evaluate the safety, performance, and clinical benefits of the Persona Keel cementless and cemented knee.
- Conditions
- Knee Pain Chronic, Rheumatoid Arthritis, Osteoarthritis, Traumatic Arthritis
- Trial name
- NCT05630053
- Testing
- Cementless Persona Knee System, Cemented Persona Knee System
- Where
- 7 sites in United States
- Volunteers
- 300 people
- Sponsor
- Zimmer Biomet
Osteoarthritis, Knee, Osteoarthritis
The Three-dimensional Gait Analysis of Medial Knee Osteoarthritis
Static imaging has been commonly and clinically accepted to assess the severity of medial knee osteoarthritis (KOA), especially the radiography.
- Trial name
- NCT02878239
- Testing
- Steps 1, Steps 2
- Where
- China
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
Osteoarthritis
Methotrexate in Symptomatic Knee Osteoarthritis
Osteoarthritis (OA) is a common disabling condition, for which no effective therapy currently exists.Synovitis is commonly demonstrated in knee OA imaging.
- Trial name
- NCT01654575
- Testing
- Methotrexate
- Where
- Egypt
- Volunteers
- 88 people
- Sponsor
- University of Alexandria
Knee Cartilage Defects
Phase 3 Pivotal Trial Comparing CARTISTEM® and Surgical Comparator for Knee Cartilage Lesions and Osteoarthritis
This study will test whether CARTISTEM is safe and works better than debridement (a surgery that cleans out damaged tissue) for people with knee cartilage damage and osteoarthritis.
- Trial name
- CARTISTEM23-01 (NCT07339111)
- Testing
- CARTISTEM® + Debridement, Debridement
- Where
- 35 sites in United States
- Volunteers
- 300 people
- Sponsor
- Medipost, Inc.
Osteoarthritis, Unicompartmental Knee Arthroscopy
A Single-Center, Epidemiological Study of the Survivorship of the DePuy Sigma HP Unicompartmental Knee Prosthesis
This study will be conducted to assess the survivorship of a particular prosthesis used in unicompartmental knee arthroplasties.
- Trial name
- NCT01656694
- Testing
- DePuy Sigma HP Partial Knee
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Mississippi Sports Medicine and Orthopaedic Center
Osteoarthritis of the Knee or Hip
Long-Term Safety and Efficacy Study of Fasinumab in Patients With Pain Due to Osteoarthritis (OA) of the Knee or Hip
The primary objective of the study is to describe the safety and tolerability of fasinumab, including adverse events of special interest (AESIs), in patients with pain due to radiographically-confirmed OA of the knee or hip.
- Trial name
- FACT LTS & OA (NCT02683239)
- Testing
- Fasinumab
- Where
- 149 sites in United States, Bulgaria and 19 more
- Volunteers
- 5,331 people
- Sponsor
- Regeneron Pharmaceuticals
Knee Osteoarthritis
Study on Efficacy and Safety of Chondroitin Sulfate + Glucosamine Hydrochloride Versus Celecoxib in Knee Osteoarthritis
The purpose of this study is to determine whether the combination of Chondroitin sulfate (CS) and Glucosamine Hydrochloride (GH) has similar efficacy to Celecoxib (CE) in the treatment of patients with moderate to severe knee…
- Trial name
- MOVES (NCT01425853)
- Testing
- Chondroitin/Glucosamine (Droglican), Celecoxib
- Where
- Spain
- Volunteers
- 606 people
- Sponsor
- Bioiberica
Osteoarthritis, Knee
Comparison of Hylastan to Methylprednisolone Acetate in Patients With Symptomatic Osteoarthritis of the Knee
This is a clinical study to investigate the safety and efficacy of hylastan in treating patients with symptomatic osteoarthritis (OA) of the knee.
- Trial name
- NCT00139295
- Testing
- Hylastan
- Where
- 24 sites in United States, Canada and 3 more
- Sponsor
- Genzyme, a Sanofi Company
Knee Osteoarthritis
Dose-Escalation of Botulinum Toxin in Subjects With Osteoarthritis of the Knee
The purpose of the study is to evaluate the safety and tolerability of the drug product at each dose level.
- Trial name
- NCT02139319
- Testing
- Botulinum toxin
- Where
- United Kingdom
- Volunteers
- 22 people
- Sponsor
- Galderma R&D
Osteoarthritis
Standard Total Knee Arthroplasty Using Platelet Rich Plasma (PRP)
Clinical study to determine if there is a difference in hemoglobin level between patients undergoing total knee arthroplasty with and without platelet-rich plasma.
- Trial name
- NCT01075230
- Testing
- Total knee arthroplasty
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Exactech
Osteoarthritis of the Knee or Hip
Comparison Between Blocks or Not in Joint Arthroplasty
The purpose of this study is to evaluate the effect on postoperative pain, opioid consumption and function by adding a combination of regional blocks with local anaesthetic before total hip- and knee arthroplasty compared to…
- Trial name
- BLAST (NCT06230081)
- Testing
- Ropivacain 5 mg/ml + Clonidine
- Where
- Sweden
- Volunteers
- 400 people
- Sponsor
- Region Skane
Osteoarthritis, Knee
Intra-articular Injection of MSC-derived Exosomes in Knee Osteoarthritis (ExoOA-1)
The study aim to evaluate safety of exosomes (sEVs) from allogeneic mesenchymal stromal cells delivered by an intra-articular injection in the knee of patients with mild to moderate symptomatic osteoarthritis.
- Trial name
- ExoOA-1 (NCT05060107)
- Testing
- Exosomes (sEVs)
- Volunteers
- 10 people
- Sponsor
- Francisco Espinoza
Osteoarthritis
Early Mobilization After Total Knee Arthroplasty
Patients undergoing elective total knee arthroplasty are randomized to either intrathecal anesthesia, wound infiltration with local anesthetics and standardized postoperative care (NA = neuraxial anesthesia) or general…
- Trial name
- NCT01604382
- Testing
- General Anesthesia, Neuraxial anesthesia
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Region Skane
Osteoarthritis, Knee
Proximal Tibial Open Wedge Osteotomy. A Clinical Prospective, Randomized RSA-trial.
In the treatment of osteoarthritis of the medial compartment of the knee, Open wedge high tibial osteotomy is a good choice of treatment for the young and active patient.
- Trial name
- NCT00319280
- Testing
- bonesubstitution (Calcibon, Iliac Crest Bonegraft, control)
- Where
- Denmark
- Volunteers
- 45 people
- Sponsor
- Northern Orthopaedic Division, Denmark
Osteoarthritis of the Knee
A Study of Duloxetine (LY248686) in Participants With Chronic Osteoarthritis and Knee Pain in Japan
The main purpose of this study is to evaluate the efficacy of the study drug known as duloxetine in participants with chronic osteoarthritis (OA) and knee pain in Japan.
- Trial name
- NCT02248480
- Testing
- Duloxetine
- Where
- Japan
- Volunteers
- 354 people
- Sponsor
- Eli Lilly and Company
Knee Osteoarthritis
Investigating the Role of Motivational Interviewing in Swedish Patients Undergoing Knee Arthroplasty
Knee arthroplasty is a successful surgical treatment for end-stage osteoarthritis. Most patients are satisfied with the result, however, 10% of the patients have remained dissatisfied over the last decades despite the advantages…
- Trial name
- NCT05940246
- Testing
- Motivational Interviewing
- Where
- Sweden
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- Region Stockholm
Osteoarthritis, Knee
Oxford Partial Knee Comparative Instrument Pilot Study
The purpose of this prospective clinical data-collection is to document the performance and clinical outcomes of the Oxford Partial Knee System using Signature Custom Guides and Conventional Instrumentation.
- Trial name
- NCT01410786
- Testing
- Conventional Instrumentation, Signature Custom Guides
- Where
- New Zealand
- Volunteers
- 35 people
- Sponsor
- Zimmer Biomet
Total Knee Arthroplasty
The Use of Continuous Wound Infusion Analgesia in Total Knee Arthroplasty
The main purpose of this study is to determine if there is improvement in pain and other patient outcomes when using a continuous wound analgesia system after total knee replacement, compared to usual methods of pain control.
- Trial name
- NCT00724074
- Testing
- On-Q PainBuster with Bupivacaine, Usual Care
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Capital Health, Canada
Osteoarthritis, Knee
Safety of Intra-Articular Sc-rAAV2.5IL-1Ra in Subjects With Moderate Knee OA
This study seeks to determine the safety of three different doses of sc-rAAV2.5IL-1Ra delivered by intra-articular injection into one knee joint of patients with moderate OA of the knee.
- Trial name
- AAVIL-1Ra (NCT02790723)
- Testing
- sc-rAAV2.5IL-1Ra
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Mayo Clinic
Knee Osteoarthritis
In-home Versus Hospital Preoperative Training for Patients Undergoing Total Knee Replacement
In this work the importance of the potentiation and recovery of the balance with a physiotherapeutic intervention that begins in the early preoperative phase is compared with the conventional postoperative rehabilitation.
- Trial name
- home_ATR (NCT03100890)
- Testing
- Preoperative training (hospital), Preoperative training (home)
- Where
- Spain
- Volunteers
- 67 people
- Sponsor
- University of Valencia
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