Clinical trials: Knee Osteoarthrosis
Knee Osteoarthritis
Efficacy of a Home-Use Photobiomodulation Device for the Treatment of Patients With Knee Osteoarthritis
Osteoarthritis is a degenerative disease affecting joint cartilage and its surrounding tissue. It is the leading cause of disability in the elderly.
- Trial name
- PBM&KOA-02 (NCT05357703)
- Testing
- Standard treatment + Active B-Cure laser
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Erika Carmel ltd
Intraarticular, Ozone
Effect of Intraarticular Ozone, Prolotherapy or Dexmedetomidine in Pain Limitation in Knee Osteoarthritis
This study aimed to compare intraarticular ozone injection, prolotherapy, or dexmedetomidine effectiveness in knee osteoarthritis patients.
- Conditions
- Intraarticular, Ozone, Prolotherapy, Dexmedetomidine
- Trial name
- NCT06909305
- Testing
- Ozone, Dextrose prolotherapy, Dexmedetomidine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Tanta University
Preoperative Period, Nutritional Status
Preoperative Nutritional Status in Patients Undergoing Elective Total Knee Arthroplasty and In-hospital Postoperative Complications
Malnutrition has long been linked to postoperative complications and adverse outcomes in a variety of surgical fields , such as increased susceptibility to infection, delayed wound healing, and increased frequency of decubitus…
- Conditions
- Preoperative Period, Nutritional Status, Arthroplasty Knee
- Trial name
- NUTR TKA (NCT03549962)
- Testing
- TKA
- Where
- 2 sites in Hong Kong
- Volunteers
- 626 people
- Sponsor
- Chinese University of Hong Kong
Osteoarthritis, Knee, Arthropathy of Knee Joint
Comparison of Cruciate Retaining and Posterior Stabilized Total Knee Arthroplasty
Several authors and large registries have suggested the potential for an increased risk of all-cause revision with the use of posterior cruciate-substitution (PS) total knee arthroplasty (TKA).
- Trial name
- NCT06124651
- Testing
- Total knee replacement with cruciate retaining femoral component, Total knee replacement with cruciate substituting femoral component
- Volunteers
- 300 people
- Sponsor
- Ewha Womans University
Osteoarthritis
The HIHO Study: Hospital Inpatient vs Home Rehabilitation After Total Knee Replacement
Total knee replacement (TKR) surgery is a common and highly effective treatment option for alleviating the pain and disability caused by chronic arthritis.
- Trial name
- HIHO (NCT01583153)
- Testing
- Hospital Inpatient Rehabilitation, Hybrid Home Programme (HO)
- Where
- 3 sites in Australia
- Volunteers
- 165 people
- Sponsor
- Mark Buhagiar
Obesity, Osteoarthritis
Symptomatic, Biomechanical and Radiographic Outcomes in Knee Osteoarthritis Following Gastric Bypass Surgery
Weight is a risk factor for knee osteoarthritis Knee osteoarthritis is associated with abnormal gait biomechanics Gait biomechanics are evaluated in gastric bypass patients before and after losing 100 pounds.
- Trial name
- NCT00194051
- Testing
- gastric bypass surgery
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University Hospitals Cleveland Medical Center
Osteoarthritis, Knee
Conventional Alignment System Versus Surgical Navigation System in Total Knee Arthroplasty
This is a randomized, controlled, blinded prospective study comparing the use of the usual cutting guides with a palm-sized digital surgical navigation system in unilateral total knee arthroplasty.
- Trial name
- NCT01797731
- Testing
- Digital hand-held surgical navigation system, Conventional tibial extramedullary alignment system
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Hospital for Special Surgery, New York
Osteoarthritis, Degenerative Joint Disease
The Study of Physical Activity Rewards After Knee Surgery
The objectives of this research are to conduct a proof of concept randomized controlled trial with 200 patients undergoing primary total knee replacement (TKR) at Brigham and Women's Hospital (BWH).
- Trial name
- SPARKS (NCT01970631)
- Testing
- Motivational Interviewing (MI), Financial Incentives
- Where
- United States
- Volunteers
- 202 people
- Sponsor
- Brigham and Women's Hospital
Joint Diseases
EVOLUTION® Revision STEMMED CS Post Market Clinical Follow-up Study Protocol
MicroPort (MPO) is conducting this PMCF study to evaluate the safety and effectiveness of its EVOLUTION® Revision Tibial System and EVOLUTION® Revision STEMMED CS Femur with the EVOLUTION® MP CS Tibial Insert.
- Trial name
- NCT06142669
- Testing
- EVOLUTION® Revision Tibial System and EVOLUTION® Stemmed CS Femur with the EVOLUTION® MP CS Tibial Insert
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- MicroPort Orthopedics Inc.
Osteoarthritis, Knee
Radio- KO Radiotherapy for Knee Osteoarthritis Clinical Trial
The primary aim of this study is to investigate whether low-dose radiotherapy is an effective treatment to reduce the pain of knee osteoarthritis.
- Trial name
- RADIO-KO (NCT06887829)
- Testing
- Low dose radiotherapy
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- Mayo Clinic
Osteoarthritis, Knee
Safety and Tolerability of PG110 in Patients With Knee Osteoarthritis Pain
The purpose of this study is to evaluate the safety and tolerability of a single intravenous dose of PG110, a monoclonal antibody that inhibits the effects of the naturally occurring substance, nerve growth factor (NGF).
- Trial name
- NCT00941746
- Testing
- PG110
- Where
- Netherlands
- Volunteers
- 56 people
- Sponsor
- Abbott
Fast Track, Tranexamic Acid Adverse Reaction
Implementation of a Rapid Recovery Protocol in Total Knee Arthroplasty
Patients undergoing total knee arthroplasty will follow two different rehabilitation protocols. In one of them, they will start walking the day of surgery and discharged on a 48 hours basis.
- Conditions
- Fast Track, Tranexamic Acid Adverse Reaction, Knee Osteoarthritis
- Trial name
- NCT03823573
- Testing
- Walk within 24 hours
- Where
- Spain
- Volunteers
- 175 people
- Sponsor
- Ignacio Aguado Maestro
Knee Pain Chronic, Osteoarthritis
Persona Total Knee Arthroplasty Outcomes Study
The primary objective of this study is to obtain implant survivorship and clinical outcomes data for commercially available Persona fixed bearing knee implants used in total knee arthroplasty.
- Conditions
- Knee Pain Chronic, Osteoarthritis, Rheumatoid Arthritis, Traumatic Arthritis
- Trial name
- NCT02255383
- Testing
- Zimmer Persona Total Knee System
- Where
- 14 sites in United States
- Volunteers
- 737 people
- Sponsor
- Zimmer Biomet
Osteoarthritis, Knee
3D Joint Space Evaluation in Knee Osteoarthritis: The Importance of Weight-bearing and Flexion
Rationale: Osteoarthritis (OA) is mainly characterized by cartilage degeneration. In knee OA, measuring the distance between the tibia and femur, known as the joint space width (JSW), is an often-used method to quantify the…
- Trial name
- 3DJSW-MRI (NCT05950854)
- Testing
- Weight-bearing MRI
- Where
- Netherlands
- Volunteers
- 21 people
- Sponsor
- Mylène Jansen
Osteoarthritis
Early Neuromuscular Electrical Stimulation For Quadriceps Muscle Activation Deficits Following Total Knee Replacement
The purpose of this study is to determine whether early intervention with neuromuscular electrical stimulation (NMES) for muscle strengthening immediately after total knee arthroplasty (TKA) is more effective than voluntary…
- Trial name
- NCT00800254
- Testing
- Neuromuscular Electrical Stimulation (NMES), Standard Rehabilitation Protocol
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- University of Colorado, Denver
Osteoarthritis, Rheumatoid Arthritis
6 Week Open-label Trial With Lumiracoxib 200mg o.d. in Primary Knee Osteoarthritis or Rheumatoid Arthritis
This study tested the safety, tolerability and efficacy of lumiracoxib - a COX-2 inhibitor- in patients with primary knee osteoarthritis or rheumatoid arthritis.
- Trial name
- NCT00170872
- Testing
- Lumiracoxib
- Volunteers
- 135 people
- Sponsor
- Novartis
Osteoarthritis Knee, Total Knee Replacement
How Total Knee Prosthesis Dessigns Influence in Quality of Live
The purpose of this study is to determine whether different kind of prostesis designs influences in the quality of life of patients
- Trial name
- NCT02050438
- Testing
- Total Knee Arthroplasty
- Where
- Spain
- Volunteers
- 135 people
- Sponsor
- Corporacion Parc Tauli
Osteoarthritis, Knee
Liposomal Bupivacaine Versus Standard of Care in Total Knee Surgery
The purpose of this study is to determine whether liposomal bupivacaine is effective in the management of pain following total knee arthroplasty, as compared to standard of care analgesia.
- Trial name
- NCT02219087
- Testing
- Liposomal bupivacaine, Standard of Care
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- OhioHealth
Osteoarthrosis, Knee
Total Knee Replacement With the Attune vs. the Press Fit Condylar (PFC) Sigma.
100 knees with primary osteoarthritis and scheduled for a total knee replacement (TKR) will be recruited from our waiting list. The patients will be randomized to become operated with the Attune or PFC total knee arthroplasty.
- Trial name
- Att16SM (NCT03077958)
- Testing
- Total Knee Replacement (2 different design)
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Sahlgrenska University Hospital
Knee Osteoarthritis
Comparative Usability Evaluation of Sustained Acoustic Medicine (SAM) Devices and Topical Gel for OA Knee Pain
The purpose of this study is to evaluate the usability of the ultrasound devices and common pain relief gel. The ability of the three treatment approaches to reduce pain, stiffness, and functionality as measured by NRS scale and…
- Trial name
- NCT05050448
- Testing
- Sustained Acoustic Device with 2.5% Diclofenac Patch, 1% Diclofenac Topical Gel
- Where
- 3 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- ZetrOZ, Inc.
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