Clinical trials: Knee Osteoarthrosis
Osteoarthritis,Knee
Efficacy of Multimodal Perioperative Analgesia With Periarticular Drug Injection in Total Knee Arthroplasty(TKA)
The purpose of this study is to compare different medication combinations used in a periarticular injection after total knee replacement surgery(TKR).
- Trial name
- NCT01042093
- Testing
- Ropivacaine, Toradol, Clonidine
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Towson Orthopaedic Associates
Knee Osteoarthritis, Knee Pain Chronic
Dexamethasone for iPACK Block With ACB in Total Knee Arthroplasty
Effect of adding Dexamethasone to Infiltration between the Popliteal Artery and Capsule of the Knee Block with ACB in Patients undergoing Total Knee Arthroplasty
- Conditions
- Knee Osteoarthritis, Knee Pain Chronic, Knee Arthritis
- Trial name
- NCT06470204
- Testing
- Ropivacaine, Ropivacaine+Dexamethasone
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- Poznan University of Medical Sciences
Knee Osteoarthritis
Survival Study of the Genutech® Total Knee Arthroplasty
Prospective cohort sudy of patients undergoing a Genutech® total knee arthroplasty
- Trial name
- NCT06899932
- Where
- Spain
- Volunteers
- 500 people
- Sponsor
- Hospital de Sant Rafael
Knee Osteoarthristis
Evaluating the Impact of a Meta Quest 3 Gamified VR Rehabilitation Program in Knee Osteoarthritis
The goal of this clinical trial is to learn if a gamified virtual reality (VR) rehabilitation program can effectively reduce pain, improve functionality, and enhance balance in adults aged 40-64 years diagnosed with knee…
- Trial name
- NCT06735963
- Testing
- Meta Quest 3 Virtual Reality, Exercise, Electrotherapy
- Where
- Saudi Arabia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Umm Al-Qura University
Osteoarthritis, Knee Arthritis
The Effect of Telerehabilitation-Based Exercise and Training on Outcome Measures in Patients With Knee Osteoarthritis
Video exercise component of the telerehabilitation would provide additional contribution to the patients. The aim of this study is to compare the effects of telerehabilitation-based exercise program and conventional (given on…
- Trial name
- NCT05209893
- Testing
- Telerehabilitation, Paper Based Rehabilitation
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Ege University
Postoperative Anemia, Knee Osteoarthritis
Effect of Preoperative Ferric Carboxymaltose After Simultaneous Bilateral Total Knee Arthroplasty
The primary purpose of this study is to evaluate the safety and efficacy of preoperative intravenous ferric carboxymaltose in patients with anemia undergoing Simultaneous Bilateral Total knee replacement in terms of Quality of…
- Conditions
- Postoperative Anemia, Knee Osteoarthritis, Total Knee Arthroplasty
- Trial name
- NCT03561506
- Testing
- Ferric carboxymaltose, 0.9% Normal Saline
- Volunteers
- 80 people
- Sponsor
- The Catholic University of Korea
Knee Osteoarthristis
BFR Training and Knee Osteoarthritis
Knee osteoarthritis (KOA) is a chronic, progressive degenerative joint disease characterized by cartilage and bone degeneration, synovial inflammation, and structural changes.
- Trial name
- NCT07590323
- Testing
- Standard Treatment, Pain neuroscience education, Blood flow restriction training
- Where
- Saudi Arabia
- Volunteers
- 90 people
- Sponsor
- University of Hail
Knee Osteoarthritis
A Phase 3 Study to Assess the Efficacy and Safety of PK101 in Patients With Knee Osteoarthritis
The purpose of this study is to compare the efficacy and the safety of PK101 in patients with knee osteoarthritis.
- Trial name
- NCT04858659
- Testing
- PK101, PK101-002
- Where
- South Korea
- Volunteers
- 354 people
- Sponsor
- PMG Pharm Co., Ltd
Osteoarthritis
Effects of Shoes Insoles on Symptoms and Disease Progression in Knee Osteoarthritis
It is hypothesised that laterally wedged insoles will result in reduced knee pain and cartilage volume loss after 12 months of wear, compared to control insoles.
- Trial name
- NCT00415259
- Testing
- Laterally wedged shoe insoles, Control insole group
- Where
- Australia
- Volunteers
- 200 people
- Sponsor
- University of Melbourne
Osteoarthritis of Knee
Phase IV Clinical Trial to Evaluate the Efficacy and Safety of PlbCR and Aceclofenac in the Treatment of Patients With Osteoarthritis of the Knee
A multicenter, randomized, double-blinded, parallel, active-controlled, phase IV clinical trial to evaluate the efficacy and safety of PlbCR and aceclofenac in the treatment of patients with osteoarthritis of the knee
- Trial name
- NCT02682524
- Testing
- Pelubiprofen CR 45mg tab., Aceclofenac 100mg tab.
- Where
- South Korea
- Volunteers
- 191 people
- Sponsor
- Daewon Pharmaceutical Co., Ltd.
Osteoarthritis, Knee, Osteoarthritis of the Knee
Cannabinoid Interactions With Central and Peripheral Pain Mechanisms in Osteoarthritis of the Knee
This clinical trial is being done to better understand how daily treatment with Tetrahydrocannabinol (THC), Cannabidiol (CBD), or the combination of CBD plus THC affects knee osteoarthritis pain and other related symptoms.
- Trial name
- NCT04992624
- Testing
- Cannabidiol (CBD), Tetrahydrocannabinol (Marinol® or generic equivalent (e.g., dronabinol)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Steven E Harte, PhD
Osteoarthritis, Knee
MAKO Total Knee Artroplasty
The purpose of this study is to determine the early clinical and radiographic outcomes of robotically assisted total knee arthroplasty with the MAKO surgical robot using the Triathlon knee system.
- Trial name
- NCT05744895
- Testing
- Device: Robotic MAKO total knee, FocusMotion knee brace, Fitbit tracking device
- Where
- United States
- Volunteers
- 123 people
- Sponsor
- Washington University School of Medicine
Osteo Arthritis Knee
Cartilage Adaptation and Response to Interleukins and Exercise
This study will examine the effect of exercise on the turnover of collagen in articular cartilage and the content of cytokines in the synovial fluid from human adults with osteoarthritis.
- Trial name
- CARTILEX (NCT03410745)
- Testing
- Exercise.
- Where
- Denmark
- Volunteers
- 32 people
- Sponsor
- Bispebjerg Hospital
Osteoarthritis
Unicondylar Knee Arthroplasty Versus Total Knee Arthroplasty in Patients With Anteromedial Osteoarthritis of the Knee
This study is a randomized controlled trial comparing total knee arthroplasty (TKA) to unicompartmental knee arthroplasty (UKA) in patients with no to moderate anteromedial knee osteoarthritis.
- Trial name
- NCT02430129
- Testing
- Total knee arthroplasty, Unicompartment knee arthroplasty, Persona
- Where
- Canada
- Volunteers
- 38 people
- Sponsor
- Alberta Hip and Knee Clinic
Osteoarthritis of the Knee
Targeted Rehabilitation to Improve Outcome After Knee Replacement- A Physiotherapy Study
The TRIO-physio study is looking at how well patients with osteoarthritis recover after knee replacement surgery (also known as Total Knee Arthroplasty (TKA)). Currently around 20% of patients are not satisfied after TKA.
- Trial name
- TRIO-Physio (NCT01849445)
- Testing
- Intensive physiotherapy, Home physiotherapy exercises
- Where
- 6 sites in United Kingdom
- Volunteers
- 334 people
- Sponsor
- University of Edinburgh
Pain, Postoperative, Anesthesia, Local
Ultrasound-guided Regional Anesthesia vs Local Infiltration Anesthesia With Dexmedetomidine and Ropivacaine
Evaluation of the Impact of dexmedetomidine as an adjunct for local infiltrations analgesia and ultrasound-based regional anaesthesia as pain medication in regard to patients' opioid need the first 48 hours after the total knee…
- Conditions
- Pain, Postoperative, Anesthesia, Local, Gonarthrosis
- Trial name
- NCT04697537
- Testing
- Ultrasound guided regional anesthesia, Local infiltration analgesia
- Where
- Austria
- Volunteers
- 50 people
- Sponsor
- Medical University of Graz
Knee Osteoarthritis, Total Knee Replacement
TKR Rehabilitation Through the Immersive Virtual Reality in Aquatic Scenarios
This study is a multicenter non-randomized single-blind controlled trial, aimed at investigating the feasibility and efficacy of hydrotherapy based on IVR, for the patients with TKR(Total Knee Replacement), on the function, gait…
- Trial name
- HYDROKNEERVANA (NCT04241172)
- Testing
- Experimental: Immersive Virtual Reality (HIVR), Traditional Hydrotherapy (TH), Traditional Rehabilitation (TR)
- Where
- Italy
- Volunteers
- 96 people
- Sponsor
- IRCCS San Raffaele Roma
Knee Osteoarthritis
Serum COMP and MMP-3 in Knee Osteoarthritis
Knee osteoarthritis is a common degenerative joint disease characterized by pain, stiffness, and functional limitation, significantly affecting quality of life.
- Trial name
- KOACOMP (NCT07528872)
- Testing
- Observational Study
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Osteoarthritis, Knee
Knee Osteoarthritis Treatment With Platelet-rich Plasma
Knee osteoarthritis (KOA) is a disease characterized by cartilage degeneration, synovium inflammation, bone remodeling, osteophyte formation, inflammations and loss of articular function.
- Trial name
- NCT05824806
- Testing
- PRP Protocol A, PRP Protocol B, Hyaluronic acid
- Where
- Brazil
- Volunteers
- 90 people
- Sponsor
- Instituto Nacional de Traumatologia e Ortopedia
Osteoarthritis, Knee
A Long-Term Safety Study of IDEA-033 in Comparison to Oral Naproxen for the Treatment of Osteoarthritis of the Knee
The purpose of this study is to evaluate the long-term safety of IDEA-033 (an anti-inflammatory pain-relieving drug applied to the skin) in comparison to naproxen (an anti-inflammatory pain-relieving drug taken by mouth) for the…
- Trial name
- NCT00265304
- Testing
- Ketoprofen
- Where
- 93 sites in United States
- Volunteers
- 550 people
- Sponsor
- IDEA AG
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