Clinical trials: Knee Osteoarthrosis
Knee Osteoarthritis
Single Cutting Guides System for the Installation of a Total Knee Replacement
The knee prosthesis is a validated treatment for end-stage of knee osteoarthritis, and this intervention usually provides a significant improvement in the quality of life of patients.
- Trial name
- NCT02429245
- Testing
- Retrospective study
- Volunteers
- 20 people
- Sponsor
- University Hospital, Strasbourg, France
Pain, Chronic, Osteoarthritis, Knee
Effects of Action Observation Therapy on Pain, Functional Level and Brain Hemodynamic in Patients With Knee Osteoarthritis
In this project, investigators aim to investigate the effects of action observation therapy on pain, fear of movement, functional level and brain hemodynamics in patients with knee osteoarthritis.
- Trial name
- NCT03245073
- Testing
- Action observation therapy, Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Acibadem University
Osteoarthritis, Knee
Evaluation of the Evolution of Imaging Markers of Cartilage Degradation in Patients With Knee Osteoarthritis Receiving DROGLICAN
A previous multicenter trial led by Bioiberica S.A. has confirmed the efficacy and safety of DROGLICAN for the treatment of osteoarthritis (OA) in patients with severe pain.
- Trial name
- DRIP (NCT02821468)
- Testing
- Droglican, Paracetamol or oral NSAIDs excluding COX2 inhibitors
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Bioiberica
Osteoarthritis, Knee
Technology and System for Minimally Invasive TKA Surgery Robot
Developed a robot for minimally invasive TKA surgery and prepare for the subsequent CFDA application of the minimally invasive total knee replacement robot system.
- Trial name
- NCT04953988
- Testing
- Robotic TKA, Manual operation
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Osteoarthritis, Hip, Osteoarthritis, Knee
A Safety and Effectiveness Study of Acetaminophen (4000 mg/Day) and Naproxen (750 mg/Day) in the Treatment of Osteoarthritis of the Hip or Knee
The purpose of this study is to compare the long-term safety and effectiveness of acetaminophen (4000 mg per day) and naproxen (750 mg per day) in the treatment of osteoarthritis of the hip or knee.
- Trial name
- NCT00240773
- Testing
- acetaminophen, naproxen
- Volunteers
- 581 people
- Sponsor
- Johnson & Johnson Consumer and Personal Products Worldwide
Osteoarthritis (OA) of the Knee, Fracture
LinkSymphoKnee (LSK) Total Knee Replacement System Study - Ultra-congruent (UC)
To collect information about implant performance and patient clinical outcomes in patients undergoing primary total knee arthroplasty with the LinkSymphoKnee total knee replacement system with ultra-congruent tibial bearing…
- Conditions
- Osteoarthritis (OA) of the Knee, Fracture, Rheumatoid Arthritis
- Trial name
- NCT06670651
- Testing
- total knee arthroplasty device
- Where
- 2 sites in United States
- Volunteers
- 600 people
- Sponsor
- LinkBio Corp.
Knee Pain Chronic, Osteoarthritis
Persona Total Knee Arthroplasty Outcomes Study
The primary objective of this study is to obtain implant survivorship and clinical outcomes data for commercially available Persona fixed bearing knee implants used in total knee arthroplasty.
- Conditions
- Knee Pain Chronic, Osteoarthritis, Rheumatoid Arthritis, Traumatic Arthritis
- Trial name
- NCT02255383
- Testing
- Zimmer Persona Total Knee System
- Where
- 14 sites in United States
- Volunteers
- 737 people
- Sponsor
- Zimmer Biomet
Knee Osteoarthritis
Efficacy and Safety of Lumiracoxib in Patients With Primary Knee Osteoarthritis (OA)
This study will evaluate the efficacy and safety of using lumiracoxib in the treatment of patients with knee osteoarthritis (OA)
- Trial name
- NCT00367315
- Testing
- Lumiracoxib
- Where
- 2 sites in Germany, Switzerland
- Volunteers
- 1,684 people
- Sponsor
- Novartis
Pain, Postoperative, Osteoarthritis, Knee
Analgesic Efficacy of Pre-operative Dose of Ketorolac and Gabapentin
Evaluation of the analgesic efficacy of a pre-operative dose of ketorolac and gabapentin in reducing post-operative pain scores in patients undergoing TKA
- Trial name
- NCT07047040
- Testing
- Ketorolac Tromethamine 30 MG/ML Prefilled Syringe, Gabapentin, Empty Medication Capsules
- Where
- Egypt
- Volunteers
- 86 people
- Sponsor
- Assiut University
Osteoarthritis, Knee
Dry Needling and Exercise Program in Osteoarthritis
Osteoarthrosis (OA) is a chronic degenerative disease that affects the joints, knee OA is the most prevalent type, affecting 265 million people worldwide, more than 40% of adults over 45 years of age, being one of the greatest…
- Trial name
- NCT06816940
- Testing
- CONTROL GROUP:, EXPERIMENTAL GROUP
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Manuel Albornoz Cabello
Knee Osteoarthristis
Neuromuscular Facilitation Protocol on Pain, Range and Function in KOA
An individual can suffer from knee osteoarthritis, which is a degenerative condition, and while standard physical therapy can assist in some way, improved joint mechanics and decreased functional limitations can be achieved…
- Trial name
- NCT07872280
- Testing
- Standard physical therapy, Neuromuscular Facilitation Protocol
- Where
- Pakistan
- Volunteers
- 54 people
- Sponsor
- Riphah International University
Osteoarthritis
Exploration of the Synovial Fluid Inflammation Mediators Under Diacerhein in Knee Osteoarthritis
Some inflammation mediators, notably IL-1, are implied in the joint degeneration phenomena of osteoarthritis. The aim of this study is to confirm in vivo the favourable effect of diacerhein on IL-1 and also to appreciate its…
- Trial name
- NCT00440661
- Testing
- Diacerhein
- Where
- Canada
- Volunteers
- 96 people
- Sponsor
- Laboratoires NEGMA
Gonarthrosis
Efficacy Ultrasound-guided Genicular Nerve Radiofrequency Treatment
Radiofrequency (RF) application is a treatment method that temporarily blocks pain transmission in the nerve where the application is made, through the heat emitted by radio waves.
- Trial name
- NCT06479642
- Testing
- Genicular nerve pulse radiofrequency ablation 3, Genicular nerve pulse radiofrequency ablation 4
- Volunteers
- 72 people
- Sponsor
- Yunus Burak Bayır
Osteoarthritis of Knee
Knee Injections for Obese Patients With Knee Arthritis
The purpose of this study is to assess obese patients with knee arthritis and determine the non-inferiority of a low dose steroid treatment vs. standard dose steroid treatment for two knee outcome measures: pain and function.
- Trial name
- NCT06782529
- Testing
- Triamcinolone Acetonide Low Dose, Triamcinolone Acetonide Standard Dose
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Mayo Clinic
Osteoarthritis, Knee
Antibiotic Loaded Bone Cement in Prevention of Periprosthetic Joint Infections in Primary Total Knee Arthroplasty
Introduction: The current evidence on the efficacy of Antibiotic Loaded Bone Cement (ALBC) in reducing the risk of periprosthetic joint infections (PJI) after primary joint reconstruction is insufficient.
- Trial name
- ALBA (NCT04135170)
- Testing
- ALBC vs plain bone cement
- Where
- Norway
- Volunteers
- 9,172 people, healthy volunteers welcome
- Sponsor
- The Norwegian Arthroplasty Register
Knee Osteoarthritis
Diagnostic Value of a Biomarker of Non-surgical Knee Osteoarthritis
Osteoarthritis is a very common pathology, especially in an aging population, and a source of disability. Based on standard radiography, the diagnosis is performed late based on the loss of the cartilage thickness.
- Trial name
- GENU-PERF (NCT04324554)
- Testing
- MRI of the right knee
- Where
- France
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Lille Catholic University
Hip Osteoarthritis, Knee Osteoarthritis
Hip and Knee Scores
Patient-reported outcome measures (PROMs) are currently used for evaluating orthopaedic procedures. Nevertheless, there is no consensus in the different studies, making them difficult to compare .
- Trial name
- HIP-KNEE (NCT04057651)
- Where
- France
- Volunteers
- 800 people
- Sponsor
- University Hospital, Lille
Chronic Knee Pain, Osteoarthritis, Knee
JointADventure: A Worksite Activity-Diet Intervention for Chronic Knee Pain
JointADventure: A worksite activity-diet intervention for chronic knee pain is a randomized controlled trial evaluation of a physical activity and nutritional worksite intervention to decrease symptoms and disability associated…
- Trial name
- NCT01977872
- Testing
- A worksite activity-diet intervention
- Where
- 2 sites in United States
- Volunteers
- 38 people
- Sponsor
- Northwestern University
Osteoarthritis, Knee, Meniscus; Degeneration
High Tibial Osteotomy With/Without Arthroscopy.
This study will compare Hight Tibial Osteotomy with or without arthroscopically repair intra-articular knee lesions in patients with early stages of Osteoarthritis.The purpose of this study is evaluate if addition of arthroscopy…
- Trial name
- NCT05128851
- Testing
- HTO, Arthroscopy treatment, Micro fractures
- Where
- Poland
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Centre of Postgraduate Medical Education
Knee Arthroplasty, Total, Robotic Surgical Procedures
ROSA® Knee System V1.5 Pilot Study
This pilot study seeks to evaluate the initial safety and usability of new features for the ROSA® Knee System, v1.5 and plan design modifications as needed. The primary objectives will be assessed by measuring: 1.
- Conditions
- Knee Arthroplasty, Total, Robotic Surgical Procedures, Joint Diseases, Knee Osteoarthritis
- Trial name
- NCT07009912
- Testing
- Total Knee Arthroplasty
- Where
- New Zealand
- Volunteers
- 40 people
- Sponsor
- Zimmer Biomet