Clinical trials: Knee Osteoarthrosis
Knee Osteoarthritis, Knee Arthroplasty
Evaluation of Fixation Achievable in Revision Total Knee Arthroplasty Implementing Latest-Generation Implant Technology
This is a prospective randomized control trial that aims to investigate fixation of implants after revision total knee replacement.
- Trial name
- NCT03276351
- Testing
- Long-Stemmed with Hybrid Fixation, Short-Stemmed with Augmented Fixation
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Total Knee Arthroplasty Secondary to Osteoarthritis, 18 Years and Older
Preoperative Genicular Radiofrequency and Functional Outcomes After Total Knee Arthroplasty
Knee osteoarthritis (OA) is a degenerative joint disease characterized by progressive cartilage wear, leading to pain, stiffness, and joint swelling.
- Trial name
- NCT07727551
- Testing
- Radiofrequency ablation of the genicular nerve, 42 degrees Celsius for 120 seconds
- Where
- Belgium
- Volunteers
- 44 people
- Sponsor
- Anesthesiology department Iris South Hospitals
Osteoarthritis, Knee, Chronic Pain
Understanding Pain Mechanisms in Knee Osteoarthritis
UP-KNEE study is a feasibility, double-blind, placebo-controlled randomised parallel study in participants with radiographically defined knee OA, and with self-reported chronic knee pain.
- Trial name
- UP-KNEE (NCT05561010)
- Testing
- Intra-articular injection of bupivacaine in the knee joint
- Volunteers
- 50 people
- Sponsor
- Nottingham University Hospitals NHS Trust
Osteoarthritis, Knee, Osteoarthritis, Hip
Barriers and Faciliators for Physical Activity in People With RMDs
The aim of this project is to systematically survey and explore barriers and facilitators for the implementation of physical activity according to the physical activity recommendations of the European Alliance of Associations for…
- Conditions
- Osteoarthritis, Knee, Osteoarthritis, Hip, Rheumatoid Arthritis, Axial Spondyloarthritis
- Trial name
- COPA (NCT06514443)
- Testing
- survey
- Volunteers
- 400 people
- Sponsor
- Anne-Kathrin Rausch
Chronic Knee Pain, Osteoarthritis, Knee
Radiofrequency For Chronic Knee Pain Post-Arthroplasty
Chronic knee osteoarthritis (OA) is one of the most common diseases with increasing prevalence in advanced age. Knee OA results in movement restriction, sleep disturbance, and disability.
- Trial name
- DEFIANT (NCT02931435)
- Testing
- Nerve Block with Radiofrequency Ablation
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Randall Brewer, MD, CPI
Osteoarthritis
Efficacy Test of Curcuminoid Standardized Turmeric Capsules to Improving Inflammatory Biomarkers in Osteoarthritis Genu
The goal of this clinical trial is to learn if Curcuminoid Standardized Turmeric Capsules works to treat Osteoarthritis Genu in adults. It will also learn about the safety of Curcuminoid Standardized Turmeric Capsules.
- Trial name
- ETCS (NCT07183215)
- Testing
- Curcuminoid Standardized Turmeric Capsules
- Where
- Indonesia
- Volunteers
- 72 people
- Sponsor
- Gadjah Mada University
Osteoarthritis, Mindfulness
A Mindfulness Program (MBSR) in the Management of Symptomatic Hip and Knee Osteoarthritis
Symptomatic osteoarthritis (OA) is the most common joint disease and the leading cause of disability in industrialized countries.
- Conditions
- Osteoarthritis, Mindfulness, MBSR
- Trial name
- MINDFULNESS_OA (NCT03644615)
- Testing
- Mindfluness and usual care, Usual care
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Montpellier
Osteoarthritis, Knee
A Study to Assess the Efficacy and Safety of AXS-02 in Subjects With Knee OA Associated With Bone Marrow Lesions
This is a randomized, double-blind, placebo-controlled, 24-week study to evaluate the efficacy and safety of AXS-02 in subjects with knee osteoarthritis associated with bone marrow lesions.
- Trial name
- COAST-1 (NCT02746068)
- Testing
- AXS-02
- Where
- 61 sites in United States, Australia
- Volunteers
- 346 people
- Sponsor
- Axsome Therapeutics, Inc.
Arthroplasty, Osteoarthritis, Knee
The Effects of Prehabilitative Exercise on Functional Recovery Following Total Knee Arthroplasty
The primary aim of this study is to determine the effects of pre-surgery exercise known as Prehabilitation, on functional outcomes for patients following Total Knee Arthroplasty (TKA) surgery.
- Trial name
- NCT03227120
- Testing
- Prehabilitation exercise
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Carilion Clinic
Osteochondritis Dissecans, Osteoarthritis
ACI-C Versus AMIC. A Randomized Trial Comparing Two Methods for Repair of Cartilage Defects in the Knee
ACI-C versus AMIC: A controlled randomized trial comparing Autologous Chondrocyte Implantation ( ACI) and Autologous Matrix Induced Chondrogenesis (AMIC) for repair of cartilage defects in the knee.
- Conditions
- Osteochondritis Dissecans, Osteoarthritis, Cartilage Injury, Osteonecrosis
- Trial name
- NCT01458782
- Testing
- Treatment of cartilage defects in the knee
- Where
- Norway
- Volunteers
- 41 people
- Sponsor
- University Hospital of North Norway
Knee Osteoarthritis
Efficacy of OSTENIL PLUS (Hyaluronic Acid) Versus SYNVISC-ONE in Patients With Tibiofemoral Osteoarthritis
The main objective of the study was to demonstrate the non-inferiority of the efficacy of a single intra-articular injection of OSTENIL PLUS compared to that of a single intra-articular injection of the reference product…
- Trial name
- NCT03203408
- Testing
- OSTENIL PLUS, SYNVISC-ONE
- Volunteers
- 290 people
- Sponsor
- TRB Chemedica
Knee Osteoarthritis (Knee OA)
An Implementation Science Approach to Evaluating Self-Administered Acupressure for Knee Osteoarthritis in Older-Aged Adults in the Community
This study aims to evaluate the implementation and effectiveness of a self-administered acupressure (SAA) program for knee osteoarthritis (OA) among older adults in Hong Kong community centers.
- Trial name
- NCT07329023
- Testing
- Experimental Group: Self-Administered Acupressure (SAA), Control Group: General Health Education
- Where
- Hong Kong
- Volunteers
- 368 people
- Sponsor
- The Hong Kong Polytechnic University
Gonarthrosis
Assessment of Patient Satisfaction After Arthroplasty: A Comparative Study by Implant Type
The main objective of this study is to evaluate the benefit of personalized prostheses compared to conventional prostheses on patient satisfaction 24 months after total knee arthroplasty.
- Trial name
- ESPACE (NCT04460989)
- Testing
- arthroplasty
- Where
- France
- Volunteers
- 480 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Knee Osteoarthritis
Tempo-controlled Low-load Resistance Training in Patients With Knee Osteoarthritis.
This randomized controlled trial aims to evaluate the effects of tempo-controlled low-load resistance training compared to conventional low-load resistance training on pain, muscle performance, and functional disability in…
- Trial name
- NCT07908589
- Testing
- Tempo-controlled low-load resistance training, Conventional Physiotherapy Training
- Where
- Pakistan
- Volunteers
- 32 people
- Sponsor
- University of Management and Technology Lahore
Osteoarthritis, Knee
Mechanisms of Treatment Effects Using Cultured, Allogeneic Mesenchymal Stromal Stem Cells (MSCs) in Knee Osteoarthritis
The goal of this clinical trial is to pharmacologically evaluate the effects of culturued allogeneic umbilical cord blood-derived mesenchymal stromal stem cell (UCB-MSCs) in the treatment of end-stage knee osteoarthritis…
- Trial name
- NCT06078059
- Testing
- Knee aspiration + UCB-MSCs, Knee aspiration
- Where
- Slovenia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Pain, Acute, Pain, Chronic
Evaluation of the Effect of a Food Supplement Based on Hydrolyzed Collagen on Joint Function.
This clinical study evaluates the effect of taking a hydrolyzed collagen-based supplement on pain, function and quality of life in a moderately physically active population.
- Conditions
- Pain, Acute, Pain, Chronic, Knee Osteoarthritis, Knee Injuries
- Trial name
- COLART (NCT05917925)
- Testing
- COLLAGEN (COL)
- Where
- Spain
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Francisco Javier Martínez Noguera
Depression, Anxiety, Pain
Rational-emotional Behavioral Therapy (REBT) in Patients With Osteoarthritis and Concomitant Diseases Before Arthroplasty
The objective of this study was evaluation of the effectiveness of REBT on the emotional state of orthopedic patients with comorbidities before and after arthroplasty.
- Trial name
- REBT (NCT05971797)
- Testing
- REBT
- Where
- Russia
- Volunteers
- 95 people
- Sponsor
- Federal State Budgetary Organization, Federal Center for Traumatology, Orthopedics and Arthroplasty
Osteoarthritis, Knee, Obesity
Weight Loss Intervention Before Total Knee Replacement
The purpose of this study is to compare the efficacy in a group of patients who must follow the current procedure for treatment of artificial knee, compared with a group of patients who must undergo an 8-week weight loss program…
- Trial name
- NCT01469403
- Testing
- 8 weeks weight loss program, Cambridge.
- Where
- Denmark
- Volunteers
- 76 people
- Sponsor
- University of Aarhus
Osteoarthritis
14022 ATTUNE Cementless RP Clinical Performance Evaluation
The primary objective of this study is to examine the change from pre-operative baseline to two year postoperative functional performance improvement for the ATTUNE primary, cementless TKA RP system as measured with the KOOS…
- Trial name
- NCT02839850
- Testing
- Cementless Total Knee Arthroplasty
- Where
- 20 sites in United States, Austria and 7 more
- Volunteers
- 540 people
- Sponsor
- DePuy Orthopaedics
Knee Osteoarthritis
Lipogems Prospective Study
The purpose of this study is to study the clinical outcomes and effects of the injection of fat-derived stem cells (the scientific name being "adipose derived autologous stem cell transplantation (ADAT)") as an addition to knee…
- Trial name
- NCT03922490
- Testing
- Lipogems Device PLUS debridement, Debridement only
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Hospital for Special Surgery, New York
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