Clinical trials: Knee Osteoarthrosis
Osteoarthritis of Knee, Edema
Microcurrent Stimulation Reduces Post-Operative Swelling and Healing Time Following Knee Replacement Surgery
The purpose of this study is to determine if patients undergoing a total knee arthroplasty (TKA) experience a clinically significant reduction in healing time when treated post operatively with a specific form of micro and…
- Conditions
- Osteoarthritis of Knee, Edema, Wounds and Injuries
- Trial name
- NCT02623660
- Testing
- ODIN1, Standard Care, Diagnostic Device Testing
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Bioelectric Research Corporation
Knee Osteoarthritis
Physiotherapy in Knee Osteoarthritis
Osteoarthritis symptoms can be managed with non-drug treatments such as patient education, exercise or weight loss interventions. Cryotherapy is one of the effective method to reduce joint inflammation, pain and improve function.
- Trial name
- NCT05636059
- Testing
- Therapeutic exercise, Exercise + cryotherapy, Exercise + joint mobilization
- Where
- Lithuania
- Volunteers
- 63 people
- Sponsor
- Lithuanian Sports University
Osteoarthritis
Prospective Double-blinded Randomised Comparison of Profix Mobile to Fixed Bearing Knee Replacements
This is a randomised control trial comparing two different prosthetic designs used in total knee arthroplasty. Participants were randomised to receive either of the two prostheses and then were followed up of a period of 7 years…
- Trial name
- NCT02157220
- Testing
- Fixed bearing prosthesis, Mobile bearing prosthesis
- Where
- Australia
- Volunteers
- 77 people
- Sponsor
- The University of New South Wales
Osteoarthritis
Doxycycline and OA Progression
This study will determine whether doxycycline decreases the severity or rate of progression of osteoarthritis (OA) in the knee. Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most popular agents used to treat OA, but…
- Trial name
- NCT00000403
- Testing
- Doxycycline
- Where
- 6 sites in United States
- Volunteers
- 432 people
- Sponsor
- Indiana University
Osteoarthritis, Knee
A Multiple Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of JNJ-39439335 in Patients With Osteoarthritis
The purpose of this study is to evaluate the safety of multiple oral doses of JNJ-39439335 and to assess how JNJ-39439335 is absorbed (taken in), distributed, metabolized (broken down), and eliminated from the body (referred to…
- Trial name
- NCT01343303
- Testing
- JNJ-39439335, Naproxen
- Where
- South Africa
- Volunteers
- 43 people
- Sponsor
- Janssen Research & Development, LLC
Osteoarthritis, Knee
Study to Evaluate the Effect of FX006 on Synovial Inflammation in Patients With OA of the Knee
This is an open-label study assessing the effect of the administration of a single intra-articular (IA) injection of FX006 32 mg on synovial volume in patients with osteoarthritis (OA) of the knee.
- Trial name
- NCT03529942
- Testing
- FX006 32 mg
- Where
- 10 sites in United States, United Kingdom
- Volunteers
- 129 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Osteoarthritis Knees Both
Reparel Knee Sleeve vs. TED Hose for Post-op Swelling, Pain and Range of Motion After Total Knee Replacement
This prospective study will evaluate pain, swelling, ROM as well as narcotic use in post-operative total knee arthroplasty patients using novel Non-Compressive Bioactive Garment (NCBG) versus current standard of care gradient…
- Trial name
- NCT04751942
- Testing
- Non-compressive Bioactive Garment, thrombo-embolic deterrent
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Osteoarthritis, Knee
Effects of Movement Retraining on Knee Loading in Individuals With Knee Osteoarthritis
This study investigates how well individuals with knee osteoarthritis can learn to alter their calf muscle activation using haptic biofeedback while walking and evaluates how these changes affect knee loading.
- Trial name
- NCT06208631
- Testing
- Gait retraining
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Stanford University
Knee Osteoarthristis
Femoral Nerve Mobilization for Patients With Knee Osteoarthritis
Background: Knee osteoarthritis (KO) is considered as a cause of disability among the elderly, causing pain, reduced quality of life, and decreased functionality.
- Trial name
- RCT (NCT07329205)
- Testing
- traditional physical therapy, Femoral nerve mobilization
- Where
- Saudi Arabia
- Volunteers
- 50 people
- Sponsor
- Prince Sattam Bin Abdulaziz University
Osteoarthritis, Knee
P.F.C. Sigma Fixed Versus P.F.C. RP Mobile Bearing Total Knee Systems
This post-market clinical follow-up study was designed to compile long-term knee replacement outcomes of the PFC Sigma fixed and PFC Sigma mobile Rotating Platform (RP) knee systems.
- Trial name
- NCT00208286
- Testing
- PFC Sigma Fixed Bearing, PFC Sigma Mobile Bearing
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- DePuy International
Knee Osteoarthriis and Oxidative Stress
Do Obese Patients With Primary Knee Osteoarthritis Benefit From a Single Bout of Moderate Intensity Aerobic Exercise?
Background: Obesity and degenerative joint disease are typically concomitant . Each are in the course of aerobic focus and excited inflammatory response.
- Trial name
- NCT03927339
- Testing
- pre and post excercise group
- Where
- Egypt
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Pain, Osteoarthritis
Impact of Peripheral Nerve Blockade on Outcomes After Total Knee Replacement
Pain is common after knee replacement surgery and can impact a variety of patient outcomes. Peripheral nerve blocks provide improved pain control and may improve function.
- Trial name
- NCT02742961
- Testing
- Peripheral nerve block
- Where
- Canada
- Volunteers
- 178,214 people
- Sponsor
- Ottawa Hospital Research Institute
Osteoarthritis, Knee, Osteoarthritis
Low Intensity Pulsed Ultrasound Versus High Intensity Continuous Ultrasound Therapy in Knee Osteoarthritis
To compare the effects of low intensity pulsed ultrasound with high intensity continuous ultrasound in knee osteoarthritis
- Conditions
- Osteoarthritis, Knee, Osteoarthritis, Rheumatic Diseases, Musculoskeletal Diseases
- Trial name
- NCT04406337
- Testing
- Low intensity pulsed ultrasound, High intensity continuous ultrasound
- Where
- Burma
- Volunteers
- 86 people
- Sponsor
- Ministry of Health and Sports, Myanmar
Osteoarthritis of Knee
Efficacy of Intra-Articular Injection of Etanercept for Moderate and Severe Knee Osteoarthritis
Primary aim: evaluate efficacy of intra-articular injection of etanercept for moderate and severe knee osteoarthritis. Second aim: investigate the potentiality of serum cytokines (TNF-α, Interleukin 1-α (IL1-α), IL1-β, matrix…
- Trial name
- EIAIETNKOA (NCT02722772)
- Testing
- Etanercept, Health education, exercise and diet guidance
- Where
- China
- Volunteers
- 60 people
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Persons With Mild to Moderate Knee Osteoarthritis
Safety and Efficacy Study of Bee Venom to Treat Knee Osteoarthritis
Study wishes to determine if the use of injectable bee venom is a safe and effective treatment for persons with mild to moderate knee Osteoarthritis and would result in decreased report of pain and discomfort, increased function…
- Trial name
- NCT00253942
- Testing
- Injecting bee venom as a treatment for OA
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Rheumatology Therapeutics Medical Center
Knee Osteoarthritis, Arthroplasty Complications
Treadmill Perturbation Training for Fall Prevention After Total Knee Replacement
The goal of this clinical trial is to learn about preventing falls in people who have total knee replacement surgery using treadmill perturbation training.
- Trial name
- NCT05736666
- Testing
- Treadmill-based perturbation training, Education Control
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Illinois Chicago
Knee Osteoarthritis
Tidal Irrigation Versus Intra-articular Steroid Injection in the Treatment of Knee Osteoarthritis
Previous studies have indicated that patient expectations, beliefs and preferences may have an impact on treatment outcomes. The KIVIS study was primarily designed to compare two effective treatments for knee osteoarthritis…
- Trial name
- NCT01303666
- Testing
- Intra-articular CSI, TI of the knee
- Volunteers
- 150 people
- Sponsor
- Portsmouth Hospitals NHS Trust
Knee Arthroplasty
Clinical and Economic Comparison of Robot Assisted Versus Manual Knee Replacement
The purpose of this study is to document and compare the surgical and after surgery costs, recovery time, and outcomes of two procedure types: Robotic assisted surgery replacing one compartment of the knee Manual (robot is not…
- Trial name
- NCT01705886
- Testing
- Total Knee Arthroplasty, MAKO® Robot Assisted Medial Knee Arthroplasty, RESTORIS Multicompartmental Knee System
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Northwest Surgical Specialists, Vancouver
Knee Osteoarthritis
Retrospective Evaluation of the Long-term Effectiveness of the CR500™ SINGLE-DOSE GEL Medical Device in Patients With Knee Osteoarthritis (KOA)
Evaluate the long-term efficacy of the CR500™ therapy in patients with knee OA.
- Trial name
- NCT07322770
- Testing
- CR 500™ SINGLE-DOSE GEL
- Where
- Italy
- Volunteers
- 35 people
- Sponsor
- Contrad Swiss SA
Osteoarthritis of the Knee
Axial Alignment in Patients Operated Using the Visionaire Patient Matched Cutting Blocks
Title: PATIENT-MATCHED INSTRUMENTATION VS. STANDARD INSTRUMENTATION: A RANDOMIZED CLINICAL TRIAL COMPARING POSTOPERATIVE AXIAL ALIGNMENT and COMPONENT POSITION Short Title: Visionaire Alignment Methodology: Monocentric, Single…
- Trial name
- Visionaire (NCT01224522)
- Testing
- Visionaire, Standard surgical technique
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- Smith & Nephew Orthopaedics AG
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