Clinical trials: Knee Osteoarthrosis
Knee Osteoarthritis
Follow-up of Osteo-articular Biomarkers After Spa Therapy in a Population With Knee Osteoarthritis and Their Correlation With the Clinical Evolution
Spa therapy is used in the treatment of various diseases and mainly osteoarthritis. Knee osteoarthritis is a very common rheumatic disease whose prevalence increases with longer life span and is a public health problem.
- Trial name
- BIOMARTHROSE (NCT04308369)
- Testing
- Blood collection arm
- Where
- France
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- CHI MONT DE MARSAN ET PAYS DES SOURCES
Knee Osteoarthritis
Gamification in Knee Replacement Rehabilitation
After total knee arthroplasty (TKA), knee is usually swollen, painful, and stiff. The main goal of post-operative physical rehabilitation is to achieve full extension and flexion of the knee to avoid contractures and stiffness.
- Trial name
- BEE-RCT (NCT03717727)
- Testing
- Exergame, Control
- Where
- 4 sites in Finland
- Volunteers
- 52 people
- Sponsor
- University of Jyvaskyla
Knee Osteoarthritis, Osteoarthritis, Knee
US-Guided Saphenous Block in Knee OA
The purpose of this prospective, randomized, open-label, active-controlled clinical trial is to evaluate the clinical and sonographic effects of ultrasound-guided (US-guided) high-volume saphenous nerve block combined with…
- Conditions
- Knee Osteoarthritis, Osteoarthritis, Knee, Gonarthrosis, Knee Pain
- Trial name
- SAPH-KNEE-OA (NCT07868770)
- Testing
- Intra-articular corticosteroid injection, Ultrasound-Guided High-Volume Saphenous Nerve Block, Home-Based Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Osteoarthritis, Knee
Is Botox Effective in Relieving Pain From Knee Osteoarthritis?
Patients with painful knee osteoarthritis will be randomly allocated to one of three groups. Each group will receive a knee injection of: 1) cortisone, 2) low dose Botox, or 3) high dose Botox.
- Trial name
- NCT00279903
- Testing
- Botulinum toxin type A (Btx-A), Cortisone
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Mayo Clinic
Knee Osteoarthritis, Aging
Effects of Specific Balance Training Prior TKR Surgery in the Early Postoperative Outcomes
Knee osteoarthritis is one of the most common pathologies in old people, and the leading cause of pain and disability. Symptoms include joint pain, stiffness, limited mobility, functional impairment and proprioceptive deficit.
- Trial name
- PRE_TKR_BLC (NCT02995668)
- Testing
- Strength-Function, Balance-Proprioception
- Where
- Spain
- Volunteers
- 82 people
- Sponsor
- University of Valencia
Osteoarthrosis
Effect of Methylprednisolone on Glucose Homeostasis in Patients Undergoing Total Hip- and Knee-arthroplasty
This study evaluates the pathophysiological effects of a single dose of Methylprednisolone administered prior to total hip- and knee-arthroplasty surgery. The investigators examine the effect on blood glucose homeostasis.
- Trial name
- NCT02332603
- Testing
- Methylprednisolone, Isotonic Sodium Chloride
- Where
- Denmark
- Volunteers
- 134 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Non-inflammatory Degenerative Joint Disease, Osteoarthritis
Study to Evaluate the Safety and Effectiveness of REAL INTELLIGENCE™ CORI™ in Unicondylar Knee Arthroplasty (UKA) Procedures
This is a prospective study to demonstrate the safety and effectiveness of CORI and to register CORI in China mainland.
- Conditions
- Non-inflammatory Degenerative Joint Disease, Osteoarthritis, Avascular Necrosis, Requires Correction of Functional Deformity
- Trial name
- CORI RCT UKA (NCT04797897)
- Testing
- CORI, Conventional
- Where
- 3 sites in Australia, Hong Kong and 1 more
- Volunteers
- 4 people
- Sponsor
- Smith & Nephew, Inc.
Osteoarthritis
Study of Meloxicam Capsules to Treat Osteoarthritis Pain
The purpose of this study is to determine whether Meloxicam [Test] Capsules are safe and effective for the treatment of osteoarthritis pain of the knee or hip.
- Trial name
- NCT01787188
- Testing
- Meloxicam Test Capsules
- Where
- 40 sites in United States
- Volunteers
- 403 people
- Sponsor
- Iroko Pharmaceuticals, LLC
Osteoarthritis, Knee
All-Polyethylene Tibias in TKA: PS vs CS Implants
This is a randomized control trial where patients will be randomized to receive one of two types of total knee arthroplasty (TKA) all-polyethylene (AP) tibial components: cruciate retaining (CR) or posterior stabilized (PS).
- Trial name
- NCT03569670
- Testing
- Posterior stabilized all-polyethylene tibial component, Cruciate retaining all-polyethylene tibial component
- Where
- Canada
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Osteoarthritis, Knee/Rehabilitation
Ecoguided Genicular Nerve Block
Osteoarthritis is a pathology with high prevalence in the world and is increasing due to sedentary lifestyles. Recent researches that claim for conservative treatment have shown the utility of genicular nerve blocks for relief of…
- Trial name
- NCT06619080
- Testing
- Genicular nerve block with bupivacaine and corticosteroids, Genicular nerve block with bupivacaine, Genicular nerve block with saline
- Where
- Spain
- Volunteers
- 102 people
- Sponsor
- Hospital Universitario Fundación Alcorcón
Knee Osteoarthritis
Habitual Physical Activity and Sedentary Behavior Following Total Knee Arthroplasty
The purpose of this study is to determine whether habitual physical activity and sedentary behaviour improve six weeks and between three to six months after total knee replacement surgery in people with osteoarthritis.
- Trial name
- NCT02675062
- Where
- South Africa
- Volunteers
- 80 people
- Sponsor
- University of Witwatersrand, South Africa
Knee Osteoarthritis, Syndrome
Characteristics of LKDS and PBSS of KOA Based on the Enhancement of Inflammatory Response by TGF-β/Smad Pathway Inhibited
1. Through research and analysis, the levels of upstream and downstream factors related to TGF-β/Smad signaling pathway and inflammatory response factor related factors in serum, blood cells, articular fluid, urine, tongue…
- Conditions
- Knee Osteoarthritis, Syndrome, Traditional Chinese Medicine
- Trial name
- NCT05218122
- Testing
- cross-sectional study without intervention
- Where
- China
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- Dongzhimen Hospital, Beijing
Knee Osteoarthritis, Arthropathy of Knee
The Impaction of Exercise Training on Bone Mineral Density in Patients After Total Knee Arthroplasty
Rehabilitation after total knee arthroplasty (TKA) should consider control of postoperative pain and swelling, protection of the healing graft, restoration of full range of motion symmetric to the contralateral knee…
- Trial name
- NCT02928562
- Testing
- exercise
- Where
- Taiwan
- Volunteers
- 110 people
- Sponsor
- Chang Gung Memorial Hospital
Osteoarthritis (OA) of the Knee
Optimization of Obesity for Total Knee Replacement With Glucagon-like Peptide-1 Receptor Agonist
Studies have shown that obese patients undergoing total knee replacement (TKR) surgery face a higher risk of perioperative issues such as increased use of pain medication, surgical site infections, and the need for revision…
- Trial name
- NPO-OOPS-TKR (NCT06807970)
- Testing
- Glucagon-like peptide-1 receptor agonists (GLP 1 RA), Control (Standard treatment)
- Where
- Hong Kong
- Volunteers
- 54 people
- Sponsor
- The University of Hong Kong
Osteoarthritis, Knee
Prediction of Response to Intra-articular Injections of Hyaluronic Acid for Knee Osteoarthritis
The purpose of this study is to evaluate whether the investigators can develop a computer algorithm to predict which individual patients will respond to injections of hyaluronic acid (HA) products for knee osteoarthritis.
- Trial name
- NCT01557868
- Testing
- hylan G-F 20, 1% sodium hyaluronate
- Where
- United States
- Volunteers
- 198 people
- Sponsor
- American Orthopaedic Society for Sports Medicine
Knee Osteoarthritis, Energy Transfer Capacitative and Resistive Therapy
Efficacy of TECAR Therapy in Patients With Knee Osteoarthritis
Objective: The aim of the present study was to investigate the treatment efficacy of TECAR therapy, a modern application that has been increasingly used in recent years, compared to conventional physical therapy applications in…
- Trial name
- NCT06418360
- Testing
- TECAR, conventional physical therapy; Transcutaneous Electrical Nerve Stimulation, hotpack
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Knee Osteoarthritis
Different Volumes of Durolane in Knee OA
The purpose of the study is to assess the safety and efficacy profiles of new single-injection volumes of Durolane in patients with knee OA.
- Trial name
- NCT01265459
- Testing
- Durolane 3 ml, Durolane 4,5 ml, Durolane 6 ml
- Where
- 3 sites in Sweden
- Volunteers
- 68 people
- Sponsor
- Galderma R&D
Osteoarthritis, Knee
Finnish Unicompartmental and Total Knee Arthroplasty Investigation
Unicondylar knee arthroplasty (UKA) can be used as the treatment of knee OA isolated to a single compartment instead of TKA. Both UKA and TKA have been used for decades as a treatment of knee OA.
- Trial name
- FUNCTION (NCT02481427)
- Testing
- Unicondylar Knee Replacement, Total Knee Replacement
- Where
- 3 sites in Finland
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Arthrosis
Effect of Skanlab Regarding Knee Arthrosis
The purpose is to find out the effect of Skanlab at knee arthrosis.
- Trial name
- NCT02649296
- Testing
- Skanlab bodywave
- Where
- Norway
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Oslo Metropolitan University
Osteoarthritis, Knee
Acupuncture Safety/Efficacy in Knee Osteoarthritis
The goal of this research is to determine the efficacy and safety of Traditional Chinese Acupuncture (TCA) in patients with osteoarthritis of the knee.
- Trial name
- NCT00010946
- Testing
- Acupuncture
- Where
- 3 sites in United States
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
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