Clinical trials: Knee Osteoarthrosis
Osteoarthritis of the Knee
PRP Treatment of Osteoarthritic Knee With a New Autologous Blood Product (CytoRich)
This study is aimed at evaluating the efficacy and safety of Cytorich compared to platelet-rich plasma (PRP) in alleviating pain and improving function in subjects with knee OA.
- Trial name
- NCT03543800
- Testing
- Cytorich PRP kit, PRP kit
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Antnor
Osteoarthritis
A Randomized Control Trial to Assess Early Clinical and Functional Outcome of the ROCC and LCS Total Knee Implant Designs
This is a prospective Randomised Control Trial to compare the Early Clinical and Functional Outcome of the ROCC and LCS total knee arthroplasty implant designs.
- Trial name
- NCT00755144
- Testing
- LCS Knee, ROCC Knee
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- Zimmer Biomet
Gonarthrosis, Coxarthrosis
Radiotherapy 3 vs 6 Gy in Gonarthrosis and Coxarthrosis
This is a non-inferiority study in which the investigators compare two low-dose radiotherapy schemes, which are recommended from DEGRO Clinical Practice Guidelines (3 Gy vs 6 Gy) for the treatment of osteoarthritis and other…
- Trial name
- RAGOCO (NCT04424628)
- Testing
- Low dose radiotherapy A, Low dose radiotherapy B
- Where
- Spain
- Volunteers
- 338 people
- Sponsor
- Fundacion GenesisCare
Radiofrequency Ablation, Knee Arthritis Osteoarthritis
Comparison of the Effectiveness of Conventional and Pulse Radiofrequency Therapy in Advanced Knee Osteoarthritis in Elderly Patients: An Observational Study
Knee osteoarthritis (OA) is a very common joint disease, causing pain and loss of function. Osteoarthritis, including knee OA, is a significant cause of morbidity and disability in older adults and negatively impacts the…
- Trial name
- pain (NCT07113028)
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Osteoarthritis of Knee
Efficacy and Safety of DKM420 in Patients With Osteoarthritis of Knee
To prove the non-inferiority of DKM420 by evaluating the injecting efficacy and safety DKM 420 and control for patients who have osteoarthritis of Knee.
- Trial name
- NCT06021444
- Testing
- DKM420, Conjuran
- Where
- South Korea
- Volunteers
- 250 people
- Sponsor
- Dongkook Pharmaceutical Co., Ltd.
Osteoarthritis of the Knee
Phase 2 Efficacy Trial of OLT1177 Gel in Subjects With Moderate to Severe Pain Associated With OA of the Knee
The purpose of this trial is to investigate the efficacy and safety of OLT1177 Gel in subjects with moderate to severe pain associated with osteoarthritis of the knee following cessation of pain therapy.
- Trial name
- NCT01768975
- Testing
- OLT1177 Gel
- Where
- 3 sites in United States
- Volunteers
- 79 people
- Sponsor
- Olatec Therapeutics, Inc.
Knee Osteoarthritis, Survey, Family Life
Prevalence of Self-disclosed Knee Trouble and Use of Treatments Among Elderly Individuals
Although knee pain is prevalent among community-dwelling older adults, little is known about how people in general handle their pain.
- Conditions
- Knee Osteoarthritis, Survey, Family Life, Complementary Therapies, Pain
- Trial name
- NCT03472300
- Testing
- Survey about knee pain and treatment
- Where
- Denmark
- Volunteers
- 9,600 people, healthy volunteers welcome
- Sponsor
- Frederiksberg University Hospital
Osteoarthritis, Knee
Functional Outcome and Analgesia in TKA: Radiofrequency vs Continuous Adductor Canal Block
This randomized, double blind controlled trial is designed to investigate the potential benefits of radiofrequency in terms of analgesia and functional outcome, compared to the conventional continuous adductor canal block, for…
- Trial name
- NCT02680392
- Testing
- Pulsed and Continuous Radiofrequency, Continuous Adductor Canal Block
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Knee Osteoarthritis
Cryoneurolysis Versus Radiofrequency in Knee Osteoarthritis
The project will evaluate the effectiveness of Cryoneurolysis versus radiofrequency procedures in adult patients who are resistant to traditional treatment for knee pain. They are a drug-free pain management procedure.
- Trial name
- NCT07664371
- Testing
- Cryoneurolysis, pulsed radiofrequency (RF), cooled radiofrequency
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Tanta University
Knee Osteoarthritis
Development and Improvement of an Acceptance and Commitment-based Treatment for the Prevention of Chronic Pain After Total Knee Arthroplasty
Reducing the incidence of chronic post-surgical pain after Total Knee Arthroplasty (TKA) is paramount. NOPAIN, a technology-enhanced Acceptance and Commitment-based treatment, will be developed, tested and improved for this…
- Trial name
- NOPAIN (NCT05769998)
- Testing
- Acceptance and Commitment-based treatment, Treatment as usual
- Where
- Italy
- Volunteers
- 210 people
- Sponsor
- Istituto Auxologico Italiano
Total Knee Anthroplasty, Osteoarthritis(Primary)
COntralateral CorticoSTeroid Injection in Total Knee Arthroplasty
Through a triple-blinded randomized control trial, the primary purpose of this pilot study is to assess the efficacy of administering peri-operative contralateral corticosteroid injection in patients undergoing TKA.
- Conditions
- Total Knee Anthroplasty, Osteoarthritis(Primary), Osteoarthritis (OA) of the Knee, Bilateral Knee Osteoarthritis
- Trial name
- COSTI (NCT06809998)
- Testing
- Corticosteroid Injection - 80mg methylprednisolone (total volume 2ml) with 6 mL of 1% Bupivacaine without epinephrine (Total Volume 8 mL)., Band-Aid
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Unity Health Toronto
Pain, Osteoarthritis of the Knee
A Proof-of-Concept Study Assessing NEO6860 in Osteoarthritis Pain
The purpose of this study is to assess NEO6860, a modality selective TRPV1 antagonist, in patients with pain associated with osteoarthritis of the knee.
- Trial name
- NCT02712957
- Testing
- NEO6860, Naproxen
- Where
- 3 sites in Canada
- Volunteers
- 54 people
- Sponsor
- Neomed Institute
Osteoarthritis, Knee
A Phase 2 Study to Evaluate the Efficacy and Safety of JointStem in Treatment of Osteoarthritis
This study is a double-blind, randomized, controlled study with two arms to evaluate JointStem as a treatment for subjects with osteoarthritis.
- Trial name
- NCT02674399
- Testing
- JointStem, Synvisc-One
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- Nature Cell Co. Ltd.
Necrosis of Femoral Head, Knee Osteoarthritis
Ketamine Prevent POCD
Previous study demonstrated that neuroinflammation induced by surgery is the main cause of the postoperative cognitive dysfunction. As an agonist of NMDA receptor, ketamine is proved to be an anti-inflammation agent.
- Trial name
- KPPOCD (NCT02220400)
- Testing
- Ketamine
- Where
- 3 sites in China
- Volunteers
- 484 people
- Sponsor
- RenJi Hospital
Knee Osteoarthritis (OA)
Instrument-Assisted Soft Tissue Mobilization as an Adjunct to Therapeutic Exercises in Individuals With Knee Osteoarthritis
To determine the efficacy of IASTM as an adjunct to therapeutic exercises on pain, range of motion, and functional performance in individuals with knee OA.
- Trial name
- NCT07710209
- Testing
- IATSM, Therapeutic Exercise
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- Foundation of Medical Research and Laboratories, Pakistan
Meniscal Tear
Early Surgery Versus Conservative Therapy for Meniscal Injuries in Older Patients
The purpose of this study is to determine the effectiveness of both arthroscopic knee surgery and physical therapy in the treatment of non-obstructive meniscal injuries in older patients.
- Trial name
- ESCAPE (NCT01850719)
- Testing
- Arthroscopic Partial Meniscectomy, Physical Therapy
- Where
- 10 sites in Netherlands
- Volunteers
- 321 people
- Sponsor
- Onze Lieve Vrouwe Gasthuis
Osteoarthritis, Knee
MRI Markers of Cartilage Damage in Knee With Osteoarthritis
The objectives of this study are: to identify and develop techniques to minimize precision errors in magnetic resonance imaging (MRI) evaluation of knee cartilage, and to determine if results from newly-identified MRI techniques…
- Trial name
- NCT00820430
- Testing
- Magnetic Resonance Imaging
- Where
- 5 sites in United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- American College of Radiology
Osteoarthritis, Knee, Meniscus; Degeneration
Knowledge Translation and Exercise for Degenerative Meniscal Tears and Early Osteoarthritis: KNEE-DEeP Study
Knee pain due to a degenerative meniscal tear (DMT) or early osteoarthritis (OA) is a frequent presentation in middle-aged and older adults.
- Trial name
- KNEE-DEeP (NCT06576557)
- Testing
- KNEE-DEeP intervention- Knowledge translation and exercise for early degenerative knee pain
- Where
- Ireland
- Volunteers
- 36 people
- Sponsor
- University of Limerick
Osteoarthritis, Knee
Treatment of Osteoarthritic Knee With High Tibial Osteotomy and Implantation of Allogenic Human Umbilical Cord Blood-derived Stem Cells.
The purpose of this study is to evaluate the clinical results after implantation of human umbilical cord blood-derived mesenchymal stem cells(hUCB-MSCs) and High tibia osteotomy in patients with medial compartment…
- Trial name
- NCT04234412
- Testing
- umbilical cord blood stem cell implantation for osteoarthritis treatment
- Volunteers
- 10 people
- Sponsor
- Uijeongbu St. Mary Hospital
Osteoarthritis, Knee
A Long-Term Safety and Efficacy Study of Lorecivivint in Subjects With Osteoarthritis of the Knee
Study OA-07 was a randomized, double-blind, placebo-controlled, Phase 3, multicenter, 2-year clinical trial that enrolled subjects from the recently completed Study OA-11 (NCT03928184).
- Trial name
- NCT04520607
- Testing
- Lorecivivint
- Where
- 42 sites in United States
- Volunteers
- 276 people
- Sponsor
- Biosplice Therapeutics, Inc.
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